Research Topics
Genomes and Genes
| Lifang HouSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, PolandFang Fang Zhang
Department of Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Int J Cancer 121:2060-4. 2007..Furthermore, heavy drinkers of alcohol who were genetically prone to accumulate acetaldehyde may face an increased risk of stomach cancer...- Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancerL Hou
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8123, Bethesda, MD 20852 7242, USA
Carcinogenesis 28:118-23. 2007..IL1A (-889 C>T) and the three examined IL12A variants were unrelated to gastric cancer risk. Our findings suggest that two Th1-related polymorphisms (TNFA -308 A>G and IFNGR2 Ex7-128 C>T) may increase the risk of gastric cancer... - Commuting physical activity and risk of colon cancer in Shanghai, ChinaLifang Hou
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Am J Epidemiol 160:860-7. 2004..54 for men; OR = 7.42, 95% CI: 2.84, 10.01 for women). Our results suggest that regular and frequent physical activity over a long period of time protects from colon cancer and significantly modifies the body mass index-associated risk... - CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenomaLifang Hou
Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Carcinogenesis 26:1122-8. 2005..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions... 
Body mass index and colon cancer risk in Chinese people: menopause as an effect modifierLifang Hou
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd EPS Suite 511, MSC 7240, Bethesda, MD 20892 7240, USA
Eur J Cancer 42:84-90. 2006..91) and 0.7 (95% CI 0.5-0.95), respectively. Our findings suggest that BMI predicts colon cancer risk in both genders. Among women, however, the risk is modified by menopause status, possibly through altered endogenous oestrogen levels...- CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, ChinaLifang Hou
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville MD 20852 7236, USA
Int J Cancer 118:2847-53. 2006.... - Body mass index, agricultural pesticide use, and cancer incidence in the Agricultural Health Study cohortGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
Cancer Causes Control 21:1759-75. 2010..87, 95% CI = 0.82-0.92) but was null in users of carbofuran (p-interaction = 0.02). These findings suggest that certain pesticides may modify the effects of BMI on the risks of colon and lung cancers... - Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health studyClaudine Samanic
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
Environ Health Perspect 114:1521-6. 2006..There was no apparent risk for non-Hodgkin lymphoma. CONCLUSIONS: Although associations between exposure and lung and colon cancer were observed, we did not find clear evidence for an association between dicamba exposure and cancer risk... - Interleukin-8 polymorphisms are not associated with gastric cancer risk in a Polish populationSharon A Savage
Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Bethesda, MD 20892-4605, USA
Cancer Epidemiol Biomarkers Prev 15:589-91. 2006 - Pendimethalin exposure and cancer incidence among pesticide applicatorsLifang Hou
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Epidemiology 17:302-7. 2006..The trends for lung cancer risk were inconsistent for different exposure metrics. CONCLUSIONS: We did not find a clear association of lifetime pendimethalin exposure either with overall cancer incidence or with specific cancer sites... - Genetic polymorphisms in folate metabolism and the risk of stomach cancerFang Fang Zhang
Division of Cancer Epidemiology and Genetics, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, USA
Cancer Epidemiol Biomarkers Prev 16:115-21. 2007..Our study did not identify strong genetic determinants in the folate metabolism pathway for stomach cancer risk... - Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish populationRajeev Mahajan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Jpn J Clin Oncol 38:626-33. 2008..7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology... - Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancerNeal D Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
Carcinogenesis 30:71-7. 2009..These findings should be interpreted cautiously until replicated in other studies... - Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study CohortGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Cancer 124:2495-500. 2009..Organochlorines were not associated with an excess risk of pancreatic cancer in this study. These findings suggest that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer... - Heterocyclic aromatic amine pesticide use and human cancer risk: results from the U.S. Agricultural Health StudyStella Koutros
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Int J Cancer 124:1206-12. 2009..The use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans... - Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health StudyJennifer A Rusiecki
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Int J Cancer 118:3118-23. 2006.... - Metabolic polymorphisms, smoking, and oral cancer in Puerto RicoHeng Xie
Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
Oncol Res 14:315-20. 2004..4). In conclusion, cigarette use significantly increased the risk of oral cancer in this population. The GSTM1-present genotype was associated with higher tobacco-associated risk for oral cancer among heavy smokers than the null genotype... - Facial papules, spontaneous pneumothorax, and renal tumorsJorge R Toro
Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892-7231, USA
J Am Acad Dermatol 48:111-4. 2003 - Environmental chemical exposures and human epigeneticsLifang Hou
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Int J Epidemiol 41:79-105. 2012..To complete our discussion, we also briefly summarize the diseases that have been linked to environmental chemicals-related epigenetic changes... - COX1 and COX2 polymorphisms and gastric cancer risk in a Polish populationLifang Hou
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA
Anticancer Res 27:4243-7. 2007..Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied... - Mannose-binding lectin-2 genetic variation and stomach cancer riskAndrea Baccarelli
EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
Int J Cancer 119:1970-5. 2006..5, 95% CI 1.6-7.6; p = 0.001). Our findings suggest that the codon 52 D MBL2 variant causing a cysteine > arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk... - Sun exposure and non-Hodgkin lymphoma: a population-based, case-control studyLori K Soni
Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL, United States
Eur J Cancer 43:2388-95. 2007..In conclusion, our data suggest that total hours of sun exposure is associated with a lower risk of NHL, and the inverse association is not modified by vitamin D intake, is stronger among farmer, and may vary by subtypes... - Air pollution, smoking, and plasma homocysteineAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 115:176-81. 2007..Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, particularly in the presence of a preexisting proinflammatory status such as that found in cigarette smokers...