Research Topics
| Yasutaka HoshinoSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Rotavirus serotypes: classification and importance in epidemiology, immunity, and vaccine developmentY Hoshino
Epidemiology Section, National Institutes of Health, Bethesda, MD 20892, USA
J Health Popul Nutr 18:5-14. 2000..Thus, the first licensed rotavirus vaccine (RRV-based quadrivalent vaccine) was designed to cover the epidemiologically important VP7 serotype 1, 2, 3, and 4...
Rotavirus serotype G9 strains belonging to VP7 gene phylogenetic sequence lineage 1 may be more suitable for serotype G9 vaccine candidates than those belonging to lineage 2 or 3Yasutaka Hoshino
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
J Virol 78:7795-802. 2004..These findings may have important implications for the development of G9 rotavirus vaccine candidates, as the strain with the broadest reactivity (i.e., a prime strain) would certainly be the ideal strain for inclusion in a vaccine...- Construction and characterization of rhesus monkey rotavirus (MMU18006)- or bovine rotavirus (UK)-based serotype G5, G8, G9 or G10 single VP7 gene substitution reassortant candidate vaccinesYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive, MSC 8026, Bethesda, MD 20892 8026, USA
Vaccine 21:3003-10. 2003..These candidate vaccines could be evaluated singly in special populations or in combination with a RRV- or an UK-based quadrivalent vaccine to broaden its G serotype specificity... - A porcine G9 rotavirus strain shares neutralization and VP7 phylogenetic sequence lineage 3 characteristics with contemporary human G9 rotavirus strainsYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892 8026, USA
Virology 332:177-88. 2005..Furthermore, by sequence analysis, the A2 VP7 was shown to belong to lineage 3 G9. These findings raise intriguing questions regarding possible explanations for the emergence of variations among the G9 strains... - Porcine rotavirus strain Gottfried-based human rotavirus candidate vaccines: construction and characterizationYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
Vaccine 23:3791-9. 2005.... - Horizontal transmission of rhesus monkey rotavirus-based quadrivalent vaccine during a phase 3 clinical trial in Caracas, VenezuelaYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 50, Rm 6308, 50 South Drive, Bethesda, MD 20892 8026, USA
J Infect Dis 187:791-800. 2003..5 mL of a 10% stool suspension. Reassortants of vaccine virus and wild-type human rotavirus were not detected... - Generation and characterization of six single VP4 gene substitution reassortant rotavirus vaccine candidates: each bears a single human rotavirus VP4 gene encoding P serotype 1A[8] or 1B[4] and the remaining 10 genes of rhesus monkey rotavirus MMU18006 orYasutaka Hoshino
Epidemiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892 8026, USA
Vaccine 20:3576-84. 2002..Similarly, three single VP4 gene (P1A[8] or P1B[4]) substitution reassortants have also been generated in a background of 10 bovine (UK) rotavirus genes for addition to a second generation UK-based quadrivalent vaccine... - Characterization of neutralization specificities of outer capsid spike protein VP4 of selected murine, lapine, and human rotavirus strainsYasutaka Hoshino
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
Virology 299:64-71. 2002..P serotype 13[20] was assigned to murine rotavirus EHP strain VP4, which was shown to be distinct from all the P serotypes/genotypes examined in the present study... - A rotavirus strain isolated from pig-tailed macaque (Macaca nemestrina) with diarrhea bears a P6[1]:G8 specificityYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
Virology 345:1-12. 2006..Because of its unique simian serotype, this virus may prove to be valuable in challenge studies in a non-human primate model in studies of rotavirus immunity... - Human rotavirus strains bearing VP4 gene P[6] allele recovered from asymptomatic or symptomatic infections share similar, if not identical, VP4 neutralization specificitiesYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
Virology 316:1-8. 2003..In addition, a close VP4 serotypic relationship between human P[6] rotavirus strains and the porcine P[6] rotavirus Gottfried strain was confirmed... - The VP7 genes of two G9 rotaviruses isolated in 1980 from diarrheal stool samples collected in Washington, DC, are unique molecularly and serotypicallyDianjun Cao
Epidemiology Section, Laboratory of Infectious Diseases, NIAID, NIH, Building 50, Room 6308, Bethesda, MD 20902, USA
J Virol 82:4175-9. 2008..Unexpectedly, however, the VP7s of the 1980 G9 viruses were more closely related serotypically to lineage 3 VP7s than to lineage 2 VP7, which may be supported by amino acid sequence analyses of the VP7 proteins... - Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidatesXiaobo Wen
Rotavirus Vaccine Development Section, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
Vaccine 30:6121-6. 2012..Our data indicated that the ΔVP8* proteins may be a plausible additional candidate as new parenteral rotavirus vaccines... - Species-specific but not genotype-specific primary and secondary isotype-specific NSP4 antibody responses in gnotobiotic calves and piglets infected with homologous host bovine (NSP4[A]) or porcine (NSP4[B]) rotavirusLijuan Yuan
Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Virology 330:92-104. 2004..Thus, in an approach to immunization with a live oral rotavirus vaccine, the NSP4 protein does not appear to play an important role in protection against rotavirus disease and infection... - Acrylamide concentration affects the relative position of VP7 gene of serotype G2 strains as determined by polyacrylamide gel electrophoresisJerri Ross
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
J Clin Virol 42:374-80. 2008.... - Homotypic and heterotypic serum isotype-specific antibody responses to rotavirus nonstructural protein 4 and viral protein (VP) 4, VP6, and VP7 in infants who received selected live oral rotavirus vaccinesLijuan Yuan
Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 189:1833-45. 2004..Antibody titers to homotypic and/or heterotypic NSP4s were positively correlated with those to VP6 before and after vaccination... - Development and validation of DNA microarray for genotyping group A rotavirus VP4 (P[4], P[6], P[8], P[9], and P[14]) and VP7 (G1 to G6, G8 to G10, and G12) genesShinjiro Honma
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
J Clin Microbiol 45:2641-8. 2007..Moreover, because the hybridization patterns exhibited by rotavirus strains of different genotypes can vary, this method may be ideal for analyzing the genetic polymorphisms of the VP7 or VP4 genes of rotaviruses... - A longitudinal cohort study in calves evaluated for rotavirus infections from 1 to 12 months of age by sequential serological assaysDianjun Cao
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, Bethesda, MD 20892, USA
Arch Virol 154:755-63. 2009..In addition, a second infection was more likely to be caused by different G and/or P types. Analyses of serum samples showed that the most frequent G-P combination was G8P6[1], followed by G8P7[5], G8P8[11] and G6P6[1]... - Whole genome sequence and phylogenetic analyses reveal human rotavirus G3P[3] strains Ro1845 and HCR3A are examples of direct virion transmission of canine/feline rotaviruses to humansTakeshi Tsugawa
Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Building 50, Room 6308, 50 South Drive, MSC 8026, Bethesda, MD 20892 8026, USA
Virology 380:344-53. 2008.... - Resistance to rotavirus infection in adult volunteers challenged with a virulent G1P1A[8] virus correlated with serum immunoglobulin G antibodies to homotypic viral proteins 7 and 4Lijuan Yuan
Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
J Infect Dis 200:1443-51. 2009..To identify correlates of resistance to rotavirus infection, we analyzed levels of serum immunoglobulin (Ig) A and IgG antibodies to various rotaviral antigens in 16 of the 18 volunteers... - A hexavalent human rotavirus-bovine rotavirus (UK) reassortant vaccine designed for use in developing countries and delivered in a schedule with the potential to eliminate the risk of intussusceptionAlbert Z Kapikian
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 192:S22-9. 2005..e., ages 3-4 months through age 9 months). In this way, there may be the potential to eliminate or at least significantly decrease the risk of intussusception associated with rotavirus vaccination... - Concentration of acrylamide in a polyacrylamide gel affects VP4 gene coding assignment of group A equine rotavirus strains with P[12] specificityLaShanda M Long-Croal
Rotavirus Vaccine Development Section, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
Virol J 7:136. 2010..It is universally acknowledged that genome segment 4 of group A rotavirus, the major etiologic agent of severe diarrhea in infants and neonatal farm animals, encodes outer capsid neutralization and protective antigen VP4... - Identification of parental origin of cognate dsRNA genome segment(s) of rotavirus reassortants by constant denaturant gel electrophoresisRonald W Jones
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892-8026, USA
J Clin Virol 26:347-54. 2003..The CDGE provides a simple and reliable assay system for identification of parental gene origins of a rotavirus reassortant... - Porcine rotavirus bearing an aberrant gene stemming from an intergenic recombination of the NSP2 and NSP5 genes is defective and interferingDianjun Cao
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 82:6073-7. 2008..The former two populations were viable, whereas the latter population was defective and interfering... - Cell-line-induced mutation of the rotavirus genome alters expression of an IRF3-interacting proteinKaren Kearney
Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
EMBO J 23:4072-81. 2004..These data demonstrate that host cell type and propagation conditions affect the capacity of RRV to produce the virulence gene product NSP1, an important consideration in producing RRV-based vaccines... - Effect of intragenic rearrangement and changes in the 3' consensus sequence on NSP1 expression and rotavirus replicationJ T Patton
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
J Virol 75:2076-86. 2001.... - Development of a microtiter plate hybridization-based PCR-enzyme-linked immunosorbent assay for identification of clinically relevant human group A rotavirus G and P genotypesNorma Santos
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CCS Bl I, Ilha do Fundao, Rio de Janeiro 21 941 590, Brazil
J Clin Microbiol 46:462-9. 2008.... - To serotype or not to serotype: that is still the questionAlbert Z Kapikian
J Infect Dis 195:611-4. 2007 - Rotavirus diarrhea in children and adults in a southern city of Brazil in 2003: distribution of G/P types and finding of a rare G12 strainEduardo Pietruchinski
Departamento de Microbiologia, , Universidade Estadual de Londrina, Londrina, PR, Brazil
J Med Virol 78:1241-9. 2006..The cell-culture grown HC91 strain was shown to belong to serotype G12 by neutralization... - Safety, efficacy, and immunogenicity of 2 doses of bovine-human (UK) and rhesus-rhesus-human rotavirus reassortant tetravalent vaccines in Finnish childrenTimo Vesikari
Vaccine Research Center, University of Tampere Medical School, Tampere, Finland
J Infect Dis 194:370-6. 2006..A corresponding tetravalent (types G1, G2, G3, and G4) reassortant vaccine based on bovine-human (UK) rotavirus reassortant tetravalent (BRV-TV) vaccine was developed concurrently... - Surveillance of rotavirus strains in Rio de Janeiro, Brazil, from 1997 to 1999Norma Santos
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ 21 941 590, Brazil
J Clin Microbiol 41:3399-402. 2003..Genotypes G9P[8], G9P[6], and a mixture of G9 and other G or P types represented 15.9% (25 of 157) of the isolates. Mixed infections were detected in 25 (15.9%) samples, and rotaviruses in 15 samples (9.6%) were not typed... - Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccineNorma Santos
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21 941 590, Brazil
Rev Med Virol 15:29-56. 2005..g. a geographical P-G type adjustment in the formulation of next generation multivalent vaccines)... - VP7 gene polymorphism of serotype G9 rotavirus strains and its impact on G genotype determination by PCRNorma Santos
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CCS Bl I, Ilha do Fundao, Rio de Janeiro, RJ 21 941 590, Brazil
Virus Res 93:127-38. 2003.... - VP7 gene polymorphism of serotype G9 rotavirus strains and its impact on G genotype determination by PCRNorma Santos
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CCS Bl I, Ilha do Fundao, RJ 21 941 590, Rio de Janeiro, Brazil
Virus Res 90:1-14. 2002..the magnitude of difference in nucleotide homology at respective primer binding site between homotypic (G9) and heterotypic (G3 or G4) primers present in a primer pool employed... - Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)Maryna C Eichelberger
Center for Immunization Research, Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA
J Med Virol 66:407-16. 2002..Each of these vaccines appeared to be well-tolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates... - Rotavirus surveillance in the city of Rio de Janeiro-Brazil during 2000-2004: detection of unusual strains with G8P[4] or G10P[9] specificitiesEduardo M Volotão
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
J Med Virol 78:263-72. 2006..Two samples (1.6%) presented mixed P genotypes (P[6] + P[8]). Two unusual strains were isolated: a G8P[4] strain isolated from a non-hospitalized child with diarrhea and a G10P[9] strain isolated from a hospitalized child with diarrhea... - Neonatal administration of rhesus rotavirus tetravalent vaccineTimo Vesikari
University of Tampere Medical School, Biokatu 10, 33520 Tampere, Finland
Pediatr Infect Dis J 25:118-22. 2006..We hypothesized that giving the first dose of RRV-TV vaccine during the neonatal period might reduce the reactogenicity of RRV-TV vaccine without compromising the utilization of the vaccine... - Predominance of rotavirus genotype G9 during the 1999, 2000, and 2002 seasons among hospitalized children in the city of Salvador, Bahia, Brazil: implications for future vaccine strategiesNorma Santos
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21 941 590, Brazil
J Clin Microbiol 43:4064-9. 2005..The next generation of rotavirus vaccines will need to provide adequate protection against disease caused by G9 viruses... - Nocardia cyriacigeorgica is a significant pathogen responsible for nocardiosis in Japan and ThailandAkiko Kageyama
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8673, Japan
Mycopathologia 160:15-9. 2005.... - Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. I. Taxonomy, fermentation, isolation and biological activitiesYasutaka Hoshino
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, Chiba 260-8673, Japan
J Antibiot (Tokyo) 57:797-802. 2004..The antibiotic is also active against Gram-positive bacteria such as Micrococcus luteus. We observed higher activity for fungi in an acidic medium than in a neutral medium... - Nocardia terpenica sp. nov., isolated from Japanese patients with nocardiosisYasutaka Hoshino
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8673, Japan
Int J Syst Evol Microbiol 57:1456-60. 2007..nov. is proposed for the two strains. The type strain is IFM 0706(T) (=JCM 13033(T)=DSM 44935(T)=NBRC 100888(T))...