Research Topics
| Barry HorwitzSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Functional biomarkers for neurodegenerative disorders based on the network paradigmBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 5D39, 10 Center Drive, MSC 1402, Bethesda, MD, USA
Prog Neurobiol 95:505-9. 2011..It then goes on to explain why the emphasis of much recent work has shifted to network-based biomarkers, as opposed to those that examine individual brain regions. A number of examples are referenced that illustrate the points made...
Neural mechanisms of auditory discrimination of long-duration tonal patterns: a neural modeling and fMRI studyAntonio Ulloa
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
J Integr Neurosci 7:501-27. 2008..Other fMRI studies of auditory perception and discrimination have also found correlation of fMRI activation of those areas with similar tasks and thus provide further support to our findings...- Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging studyJason F Smith
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
Neuroimage 50:826-36. 2010..Neuroimaging analysis at a sub-trial temporal resolution, as used here, may further clarify the role of the hippocampal complex in memory consolidation... - Hierarchical auditory processing directed rostrally along the monkey's supratemporal planeYukiko Kikuchi
Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health, and Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:13021-30. 2010.... - Investigating the neural basis for fMRI-based functional connectivity in a blocked design: application to interregional correlations and psycho-physiological interactionsJieun Kim
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Magn Reson Imaging 26:583-93. 2008..These results highlight the way in which neural modeling can be used to help validate the inferences one can make about functional connectivity based on fMRI data... 
Neural bases of categorization of simple speech and nonspeech soundsFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Hum Brain Mapp 27:636-51. 2006....- Temporal microstructure of cortical networks (TMCN) underlying task-related differencesArpan Banerjee
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 62:1643-57. 2012..Therefore, we propose TMCN as a viable computational tool for extracting network timing in various cognitive tasks... - Distinguishing the processing of gestures from signs in deaf individuals: an fMRI studyFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Brain Res 1276:140-50. 2009.... - Experimental-neuromodeling framework for understanding auditory object processing: integrating data across multiple scalesFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Rm 8S235 D, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Physiol Paris 100:133-41. 2006..The results predict a particular set of bottom-up cortical processing mechanisms that implement perceptual grouping, and also attest to the robustness of our model... - Frontal cortex functional connectivity changes during sound categorizationFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroreport 17:617-21. 2006.... - Brain network interactions in auditory, visual and linguistic processingBarry Horwitz
Voice, Speech, Language Branch, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
Brain Lang 89:377-84. 2004..Thus, this type of modeling provides a way to understand the neural bases for the sensorimotor and cognitive tasks of interest... - Investigating the neural basis of the auditory continuity illusionFatima T Husain
Brain Imaging and Modeling Section, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
J Cogn Neurosci 17:1275-92. 2005..These simulation results not only attest to the robustness of the model, but further predict the primary role of the anatomical connectivity of the auditory processing areas in mediating the continuity illusion... - Investigating the neural basis for functional and effective connectivity. Application to fMRIBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Building 10, Room 6C420, MSC 1591, Bethesda, MD 20892, USA
Philos Trans R Soc Lond B Biol Sci 360:1093-108. 2005..These results provide a partial validation for using fMRI functional connectivity to assess brain interregional relations... - Identification and validation of effective connectivity networks in functional magnetic resonance imaging using switching linear dynamic systemsJason F Smith
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
Neuroimage 52:1027-40. 2010..Our results suggest that the SLDS model framework is an effective means to address several problems with modeling connectivity including measuring overall model adequacy and identifying important regions missing from models... - Functional connectivity and laterality of the motor and sensory components in the volitional swallowing networkSoren Y Lowell
Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, 5D 38, 10 Center Drive, MSC 1416, Bethesda, MD 20892 1416, USA
Exp Brain Res 219:85-96. 2012..19). The greater connectivity from the left hemisphere insula to brain regions within and across hemispheres suggests that the insula is a primary integrative region for volitional swallowing in humans... - Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing productionKristina Simonyan
Laryngeal and Speech Section, Medical Neurology Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892, USA
J Neurosci 29:14912-23. 2009..Significant left-hemispheric lateralization of functional networks during simple but highly learned voice production suggests the readiness of the LMC network for production of a complex voluntary behavior, such as human speech... - Evidence of left inferior frontal-premotor structural and functional connectivity deficits in adults who stutterSoo Eun Chang
Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20852, USA
Cereb Cortex 21:2507-18. 2011..Our data provide strongest support for deficient left hemisphere inferior frontal to premotor connectivity as a neural correlate of stuttering... - How well does structural equation modeling reveal abnormal brain anatomical connections? An fMRI simulation studyJieun Kim
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, Bldg 10, Rm 8S235, MSC 1407, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 45:1190-8. 2009.... - Neural modeling and functional brain imaging: the interplay between the data-fitting and simulation approachesBarry Horwitz
Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Int Rev Neurobiol 66:267-90. 2005 - Dissociating neural correlates of meaningful emblems from meaningless gestures in deaf signers and hearing non-signersFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Brain Res 1478:24-35. 2012..These results suggest that whereas the signers interpreted emblems to be comparable to words, the non-signers treated emblems as similar to pictorial descriptions of the world and engaged the mirror neuron system... - Relating fMRI and PET signals to neural activity by means of large-scale neural modelsBarry Horwitz
Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Neuroinformatics 2:251-66. 2004.... - Effective Connectivity Modeling for fMRI: Six Issues and Possible Solutions Using Linear Dynamic SystemsJason F Smith
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda, MD, USA
Front Syst Neurosci 5:104. 2011..The LDS framework can also be extended to statistically combine fMRI and EEG data. The LDSf framework is a promising foundation for effective connectivity analysis... - A link between neuroscience and informatics: large-scale modeling of memory processesBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Methods 44:338-47. 2008.... - Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memoryMichael F Glabus
Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
Cereb Cortex 13:1352-61. 2003..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM... - Activation of Broca's area during the production of spoken and signed language: a combined cytoarchitectonic mapping and PET analysisBarry Horwitz
Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
Neuropsychologia 41:1868-76. 2003..These findings implicate BA45 as the part of Broca's area that is fundamental to the modality-independent aspects of language generation... - Integrating neuroscientific data across spatiotemporal scalesBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420 MSC 1591, Bethesda, MD 20892, USA
C R Biol 328:109-18. 2005..It will be demonstrated that the models are capable of exhibiting the salient features of both electrophysiological neuronal activities and fMRI values that are in agreement with empirically observed data... - Early sensory cortex is activated in the absence of explicit input during crossmodal item retrieval: evidence from MEGAjay S Pillai
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, United States
Behav Brain Res 238:265-72. 2013..These findings support theories which posit that modality-specific regions of cortex are involved in the storage and retrieval of sensory-specific items from long-term memory... - Task-specific modulation of human auditory evoked response in a delayed-match-to-sample taskFeng Rong
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda, MD, USA
Front Psychol 2:85. 2011..Our findings support the view that early evoked cortical responses to incoming acoustic stimuli can be modulated by task-specific cognitive functions by means of frontal-temporal functional interactions... - Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging, after correction for brain atrophyVicente Ibanez
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Brain Res Bull 63:147-54. 2004..Thus, statistically significant age reductions in regional brain glucose metabolism, corrected for brain atrophy, are not detectable in healthy normotensive men scanned while in the resting state... - The elusive concept of brain connectivityBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 19:466-70. 2003..Until it is understood what each definition means in terms of an underlying neural substrate, comparisons of functional and/or effective connectivity across studies may appear inconsistent and should be performed with great caution...