Barry Horwitz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Functional biomarkers for neurodegenerative disorders based on the network paradigm
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 5D39, 10 Center Drive, MSC 1402, Bethesda, MD, USA
    Prog Neurobiol 95:505-9. 2011
  2. pmc Neural mechanisms of auditory discrimination of long-duration tonal patterns: a neural modeling and fMRI study
    Antonio Ulloa
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    J Integr Neurosci 7:501-27. 2008
  3. pmc Early sensory cortex is activated in the absence of explicit input during crossmodal item retrieval: evidence from MEG
    Ajay S Pillai
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, United States
    Behav Brain Res 238:265-72. 2013
  4. pmc Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging study
    Jason F Smith
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
    Neuroimage 50:826-36. 2010
  5. pmc Dissociating neural correlates of meaningful emblems from meaningless gestures in deaf signers and hearing non-signers
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Brain Res 1478:24-35. 2012
  6. pmc Hierarchical auditory processing directed rostrally along the monkey's supratemporal plane
    Yukiko Kikuchi
    Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health, and Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:13021-30. 2010
  7. ncbi request reprint Neural bases of categorization of simple speech and nonspeech sounds
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 27:636-51. 2006
  8. doi request reprint Investigating the neural basis for fMRI-based functional connectivity in a blocked design: application to interregional correlations and psycho-physiological interactions
    Jieun Kim
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Imaging 26:583-93. 2008
  9. pmc Temporal microstructure of cortical networks (TMCN) underlying task-related differences
    Arpan Banerjee
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 62:1643-57. 2012
  10. pmc Distinguishing the processing of gestures from signs in deaf individuals: an fMRI study
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Brain Res 1276:140-50. 2009

Detail Information

Publications33

  1. pmc Functional biomarkers for neurodegenerative disorders based on the network paradigm
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 5D39, 10 Center Drive, MSC 1402, Bethesda, MD, USA
    Prog Neurobiol 95:505-9. 2011
    ..It then goes on to explain why the emphasis of much recent work has shifted to network-based biomarkers, as opposed to those that examine individual brain regions. A number of examples are referenced that illustrate the points made...
  2. pmc Neural mechanisms of auditory discrimination of long-duration tonal patterns: a neural modeling and fMRI study
    Antonio Ulloa
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    J Integr Neurosci 7:501-27. 2008
    ..Other fMRI studies of auditory perception and discrimination have also found correlation of fMRI activation of those areas with similar tasks and thus provide further support to our findings...
  3. pmc Early sensory cortex is activated in the absence of explicit input during crossmodal item retrieval: evidence from MEG
    Ajay S Pillai
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, United States
    Behav Brain Res 238:265-72. 2013
    ..These findings support theories which posit that modality-specific regions of cortex are involved in the storage and retrieval of sensory-specific items from long-term memory...
  4. pmc Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging study
    Jason F Smith
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
    Neuroimage 50:826-36. 2010
    ..Neuroimaging analysis at a sub-trial temporal resolution, as used here, may further clarify the role of the hippocampal complex in memory consolidation...
  5. pmc Dissociating neural correlates of meaningful emblems from meaningless gestures in deaf signers and hearing non-signers
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Brain Res 1478:24-35. 2012
    ..These results suggest that whereas the signers interpreted emblems to be comparable to words, the non-signers treated emblems as similar to pictorial descriptions of the world and engaged the mirror neuron system...
  6. pmc Hierarchical auditory processing directed rostrally along the monkey's supratemporal plane
    Yukiko Kikuchi
    Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health, and Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:13021-30. 2010
    ....
  7. ncbi request reprint Neural bases of categorization of simple speech and nonspeech sounds
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 27:636-51. 2006
    ....
  8. doi request reprint Investigating the neural basis for fMRI-based functional connectivity in a blocked design: application to interregional correlations and psycho-physiological interactions
    Jieun Kim
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Imaging 26:583-93. 2008
    ..These results highlight the way in which neural modeling can be used to help validate the inferences one can make about functional connectivity based on fMRI data...
  9. pmc Temporal microstructure of cortical networks (TMCN) underlying task-related differences
    Arpan Banerjee
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 62:1643-57. 2012
    ..Therefore, we propose TMCN as a viable computational tool for extracting network timing in various cognitive tasks...
  10. pmc Distinguishing the processing of gestures from signs in deaf individuals: an fMRI study
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Brain Res 1276:140-50. 2009
    ....
  11. pmc Experimental-neuromodeling framework for understanding auditory object processing: integrating data across multiple scales
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Rm 8S235 D, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Physiol Paris 100:133-41. 2006
    ..The results predict a particular set of bottom-up cortical processing mechanisms that implement perceptual grouping, and also attest to the robustness of our model...
  12. ncbi request reprint Frontal cortex functional connectivity changes during sound categorization
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroreport 17:617-21. 2006
    ....
  13. ncbi request reprint Investigating the neural basis of the auditory continuity illusion
    Fatima T Husain
    Brain Imaging and Modeling Section, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
    J Cogn Neurosci 17:1275-92. 2005
    ..These simulation results not only attest to the robustness of the model, but further predict the primary role of the anatomical connectivity of the auditory processing areas in mediating the continuity illusion...
  14. ncbi request reprint Brain network interactions in auditory, visual and linguistic processing
    Barry Horwitz
    Voice, Speech, Language Branch, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
    Brain Lang 89:377-84. 2004
    ..Thus, this type of modeling provides a way to understand the neural bases for the sensorimotor and cognitive tasks of interest...
  15. pmc Investigating the neural basis for functional and effective connectivity. Application to fMRI
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Building 10, Room 6C420, MSC 1591, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 360:1093-108. 2005
    ..These results provide a partial validation for using fMRI functional connectivity to assess brain interregional relations...
  16. pmc Identification and validation of effective connectivity networks in functional magnetic resonance imaging using switching linear dynamic systems
    Jason F Smith
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
    Neuroimage 52:1027-40. 2010
    ..Our results suggest that the SLDS model framework is an effective means to address several problems with modeling connectivity including measuring overall model adequacy and identifying important regions missing from models...
  17. pmc Functional connectivity and laterality of the motor and sensory components in the volitional swallowing network
    Soren Y Lowell
    Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, 5D 38, 10 Center Drive, MSC 1416, Bethesda, MD 20892 1416, USA
    Exp Brain Res 219:85-96. 2012
    ..19). The greater connectivity from the left hemisphere insula to brain regions within and across hemispheres suggests that the insula is a primary integrative region for volitional swallowing in humans...
  18. ncbi request reprint Neural modeling and functional brain imaging: the interplay between the data-fitting and simulation approaches
    Barry Horwitz
    Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Int Rev Neurobiol 66:267-90. 2005
  19. pmc Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing production
    Kristina Simonyan
    Laryngeal and Speech Section, Medical Neurology Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892, USA
    J Neurosci 29:14912-23. 2009
    ..Significant left-hemispheric lateralization of functional networks during simple but highly learned voice production suggests the readiness of the LMC network for production of a complex voluntary behavior, such as human speech...
  20. pmc How well does structural equation modeling reveal abnormal brain anatomical connections? An fMRI simulation study
    Jieun Kim
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, Bldg 10, Rm 8S235, MSC 1407, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 45:1190-8. 2009
    ....
  21. pmc Evidence of left inferior frontal-premotor structural and functional connectivity deficits in adults who stutter
    Soo Eun Chang
    Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20852, USA
    Cereb Cortex 21:2507-18. 2011
    ..Our data provide strongest support for deficient left hemisphere inferior frontal to premotor connectivity as a neural correlate of stuttering...
  22. ncbi request reprint Relating fMRI and PET signals to neural activity by means of large-scale neural models
    Barry Horwitz
    Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Neuroinformatics 2:251-66. 2004
    ....
  23. pmc Identifying effective connectivity parameters in simulated fMRI: a direct comparison of switching linear dynamic system, stochastic dynamic causal, and multivariate autoregressive models
    Jason F Smith
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda, MD, USA
    Front Neurosci 7:70. 2013
    ..All methods perform above chance levels at identifying correct connectivity parameters. The sLDSf method was superior in parameter estimation accuracy to both DCM and MAR for all types of comparisons...
  24. pmc A link between neuroscience and informatics: large-scale modeling of memory processes
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Methods 44:338-47. 2008
    ....
  25. pmc Effective Connectivity Modeling for fMRI: Six Issues and Possible Solutions Using Linear Dynamic Systems
    Jason F Smith
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda, MD, USA
    Front Syst Neurosci 5:104. 2011
    ..The LDS framework can also be extended to statistically combine fMRI and EEG data. The LDSf framework is a promising foundation for effective connectivity analysis...
  26. pmc Assessing crossmodal matching of abstract auditory and visual stimuli in posterior superior temporal sulcus with MEG
    Jessica R Gilbert
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, United States
    Brain Cogn 82:161-70. 2013
    ..These findings support an early role for pSTS in the processing of dynamic, auditory stimuli, and do not support claims that pSTS is responsible for associating two stimuli irrespective of their modality...
  27. ncbi request reprint Integrating neuroscientific data across spatiotemporal scales
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420 MSC 1591, Bethesda, MD 20892, USA
    C R Biol 328:109-18. 2005
    ..It will be demonstrated that the models are capable of exhibiting the salient features of both electrophysiological neuronal activities and fMRI values that are in agreement with empirically observed data...
  28. ncbi request reprint Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memory
    Michael F Glabus
    Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
    Cereb Cortex 13:1352-61. 2003
    ..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM...
  29. ncbi request reprint Activation of Broca's area during the production of spoken and signed language: a combined cytoarchitectonic mapping and PET analysis
    Barry Horwitz
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
    Neuropsychologia 41:1868-76. 2003
    ..These findings implicate BA45 as the part of Broca's area that is fundamental to the modality-independent aspects of language generation...
  30. doi request reprint Can quantum probability help analyze the behavior of functional brain networks?
    Arpan Banerjee
    Brain Imaging and Modeling Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1402 http www nidcd nih gov research scientists pages horwitzb aspx
    Behav Brain Sci 36:278-9. 2013
    ..Here, we suggest that these concepts can be extended to analyze neurophysiological measurements of cognitive tasks in humans, especially in functional neuroimaging investigations of large-scale brain networks...
  31. ncbi request reprint Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging, after correction for brain atrophy
    Vicente Ibanez
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 63:147-54. 2004
    ..Thus, statistically significant age reductions in regional brain glucose metabolism, corrected for brain atrophy, are not detectable in healthy normotensive men scanned while in the resting state...
  32. pmc Task-specific modulation of human auditory evoked response in a delayed-match-to-sample task
    Feng Rong
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda, MD, USA
    Front Psychol 2:85. 2011
    ..Our findings support the view that early evoked cortical responses to incoming acoustic stimuli can be modulated by task-specific cognitive functions by means of frontal-temporal functional interactions...
  33. ncbi request reprint The elusive concept of brain connectivity
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 19:466-70. 2003
    ..Until it is understood what each definition means in terms of an underlying neural substrate, comparisons of functional and/or effective connectivity across studies may appear inconsistent and should be performed with great caution...