Research Topics
| B HorwitzSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
How can EEG/MEG and fMRI/PET data be combined?Barry Horwitz
Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Hum Brain Mapp 17:1-3. 2002- The elusive concept of brain connectivityBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 19:466-70. 2003..Until it is understood what each definition means in terms of an underlying neural substrate, comparisons of functional and/or effective connectivity across studies may appear inconsistent and should be performed with great caution... - Neural modeling and functional brain imaging: an overviewB Horwitz
Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Neural Netw 13:829-46. 2000.... - Activation of Broca's area during the production of spoken and signed language: a combined cytoarchitectonic mapping and PET analysisBarry Horwitz
Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
Neuropsychologia 41:1868-76. 2003..These findings implicate BA45 as the part of Broca's area that is fundamental to the modality-independent aspects of language generation... - Predicting human functional maps with neural net modelingB Horwitz
Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Hum Brain Mapp 8:137-42. 1999..A delayed match-to-sample visual task is used to illustrate this approach... - Brain network interactions in auditory, visual and linguistic processingBarry Horwitz
Voice, Speech, Language Branch, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
Brain Lang 89:377-84. 2004..Thus, this type of modeling provides a way to understand the neural bases for the sensorimotor and cognitive tasks of interest... 
Functional connectivity of the angular gyrus in normal reading and dyslexiaB Horwitz
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 95:8939-44. 1998....- A link between neuroscience and informatics: large-scale modeling of memory processesBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Methods 44:338-47. 2008.... - Relating fMRI and PET signals to neural activity by means of large-scale neural modelsBarry Horwitz
Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Neuroinformatics 2:251-66. 2004.... - Integrating neuroscientific data across spatiotemporal scalesBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420 MSC 1591, Bethesda, MD 20892, USA
C R Biol 328:109-18. 2005..It will be demonstrated that the models are capable of exhibiting the salient features of both electrophysiological neuronal activities and fMRI values that are in agreement with empirically observed data... - Relating neuronal dynamics for auditory object processing to neuroimaging activity: a computational modeling and an fMRI studyF T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 21:1701-20. 2004..These findings provide support for our hypotheses concerning how auditory objects are processed by primate neocortex... - Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementiaP Pietrini
Laboratory of Neurosciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA
Am J Psychiatry 154:1063-9. 1997.... - Frequency variation of a pattern-flash visual stimulus during PET differentially activates brain from striate through frontal cortexM J Mentis
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroimage 5:116-28. 1997..The reproducibility and systematically changing rCBF responses to this passive stimulus suggest that it could be successfully used as a disease probe to evaluate neural function and drug effects in cognitively impaired patients... - Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: a positron emission tomography regional cerebral blood flow study in healthy humansM L Furey
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 1366, USA
Brain Res Bull 51:213-8. 2000.... - Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease: a magnetic resonance imaging analysisH Hampel
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Arch Neurol 55:193-8. 1998..Pathological studies in Alzheimer disease indicate the specific loss of layer III and V large pyramidal neurons in association cortex. These neurons give rise to long corticocortical connections within and between the cerebral hemispheres... - Region-specific corpus callosum atrophy correlates with the regional pattern of cortical glucose metabolism in Alzheimer diseaseS J Teipel
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Arch Neurol 56:467-73. 1999..Atrophy of the corpus callosum as the major tract of intracortical connective fibers may reflect decreased cortical functional integration in AD... - Functional interactions of the inferior frontal cortex during the processing of words and word-like stimuliA L Bokde
Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 30:609-17. 2001..These results demonstrate a task-dependent functional fractionation of the LIFG in terms of its functional links with posterior brain areas... - Simulating transcranial magnetic stimulation during PET with a large-scale neural network model of the prefrontal cortex and the visual systemF T Husain
Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroimage 15:58-73. 2002..We also found that regions both directly and indirectly connected to the stimulating site were affected by TMS... 
Investigating the neural basis for fMRI-based functional connectivity in a blocked design: application to interregional correlations and psycho-physiological interactionsJieun Kim
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Magn Reson Imaging 26:583-93. 2008..These results highlight the way in which neural modeling can be used to help validate the inferences one can make about functional connectivity based on fMRI data...- Hierarchical auditory processing directed rostrally along the monkey's supratemporal planeYukiko Kikuchi
Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health, and Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:13021-30. 2010.... - fMRI study comparing names versus pictures of objectsAndrei Sevostianov
Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Hum Brain Mapp 16:168-75. 2002.... - Neural mechanisms of auditory discrimination of long-duration tonal patterns: a neural modeling and fMRI studyAntonio Ulloa
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
J Integr Neurosci 7:501-27. 2008..Other fMRI studies of auditory perception and discrimination have also found correlation of fMRI activation of those areas with similar tasks and thus provide further support to our findings... - A functional lesion in developmental dyslexia: left angular gyral blood flow predicts severityJ M Rumsey
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Brain Lang 70:187-204. 1999..01). This suggests that greater reliance on this region normally facilitates reading, but impairs reading in dyslexia. Thus, developmental dyslexia may share a common localization with alexia... - The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer diseaseA L Bokde
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Arch Neurol 58:480-6. 2001..The different patterns of hypometabolism indicate the differential development of the lesions between the AD and AD + VS groups... - Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memoryMichael F Glabus
Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
Cereb Cortex 13:1352-61. 2003..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM... - Integrating electrophysiological and anatomical experimental data to create a large-scale model that simulates a delayed match-to-sample human brain imaging studyM A Tagamets
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Cereb Cortex 8:310-20. 1998..We show that in addition to performing the task, the integrated summed synaptic activities of the model are similar to experimental PET data... - Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing productionKristina Simonyan
Laryngeal and Speech Section, Medical Neurology Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892, USA
J Neurosci 29:14912-23. 2009..Significant left-hemispheric lateralization of functional networks during simple but highly learned voice production suggests the readiness of the LMC network for production of a complex voluntary behavior, such as human speech... - Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging studyJason F Smith
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
Neuroimage 50:826-36. 2010..Neuroimaging analysis at a sub-trial temporal resolution, as used here, may further clarify the role of the hippocampal complex in memory consolidation... - Identification and validation of effective connectivity networks in functional magnetic resonance imaging using switching linear dynamic systemsJason F Smith
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
Neuroimage 52:1027-40. 2010..Our results suggest that the SLDS model framework is an effective means to address several problems with modeling connectivity including measuring overall model adequacy and identifying important regions missing from models... - Experimental-neuromodeling framework for understanding auditory object processing: integrating data across multiple scalesFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Rm 8S235 D, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Physiol Paris 100:133-41. 2006..The results predict a particular set of bottom-up cortical processing mechanisms that implement perceptual grouping, and also attest to the robustness of our model... - Frontal cortex functional connectivity changes during sound categorizationFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroreport 17:617-21. 2006.... - Neural bases of categorization of simple speech and nonspeech soundsFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Hum Brain Mapp 27:636-51. 2006.... - Investigating the neural basis of the auditory continuity illusionFatima T Husain
Brain Imaging and Modeling Section, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
J Cogn Neurosci 17:1275-92. 2005..These simulation results not only attest to the robustness of the model, but further predict the primary role of the anatomical connectivity of the auditory processing areas in mediating the continuity illusion... - Investigating the neural basis for functional and effective connectivity. Application to fMRIBarry Horwitz
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Building 10, Room 6C420, MSC 1591, Bethesda, MD 20892, USA
Philos Trans R Soc Lond B Biol Sci 360:1093-108. 2005..These results provide a partial validation for using fMRI functional connectivity to assess brain interregional relations... - How well does structural equation modeling reveal abnormal brain anatomical connections? An fMRI simulation studyJieun Kim
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, Bldg 10, Rm 8S235, MSC 1407, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 45:1190-8. 2009.... - Neural modeling and functional brain imaging: the interplay between the data-fitting and simulation approachesBarry Horwitz
Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Int Rev Neurobiol 66:267-90. 2005 - Effect of attention on central auditory processing: an fMRI studyAndrei Sevostianov
National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland, USA
Int J Neurosci 112:587-606. 2002..Extratemporal regions activated by attending to targets in either ear included the anterior cingulate cortex, supramarginal gyrus, and dorsolateral prefrontal cortex... - Distinguishing the processing of gestures from signs in deaf individuals: an fMRI studyFatima T Husain
Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Brain Res 1276:140-50. 2009.... - Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's diseaseJack S Krasuski
Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD, USA
Am J Psychiatry 159:74-81. 2002..These structures are affected early in Alzheimer's disease in Down's syndrome, and their evaluation may help identify people in the preclinical stages of Alzheimer's disease... - Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging, after correction for brain atrophyVicente Ibanez
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Brain Res Bull 63:147-54. 2004..Thus, statistically significant age reductions in regional brain glucose metabolism, corrected for brain atrophy, are not detectable in healthy normotensive men scanned while in the resting state... - Simulated neural dynamics of decision-making in an auditory delayed match-to-sample taskShihua Wen
Mathematics Department, University of Maryland, College Park, MD 20742, USA
Biol Cybern 99:15-27. 2008.... - "What" and "where" in visual working memory: a computational neurodynamical perspective for integrating FMRI and single-neuron dataGustavo Deco
Institucion Catalana de Recerca,
J Cogn Neurosci 16:683-701. 2004.... - Discrimination and categorization of speech and non-speech sounds in an MEG delayed-match-to-sample studyHuan Luo
Neuroscience and Cognitive Science Program, University of Maryland College Park, 20742, USA
Neuroimage 28:59-71. 2005..The fact that the dissociation between speech and non-speech occurred in auditory areas, but not frontal areas, points to different categorization mechanisms and networks for newly learned (non-speech) and natural (speech) categories... - Systems level modeling of a neuronal network subserving intrinsic alertnessFelix M Mottaghy
Department of Nuclear Medicine H-H-U, , , Germany
Neuroimage 29:225-33. 2006.... - Large-scale neural models and dynamic causal modellingLucy Lee
Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 30:1243-54. 2006..Specifically, Bayesian model comparison confirms the validity of DCM in relation to a well-characterised and comprehensive neuronal model... - Using partial correlation to enhance structural equation modeling of functional MRI dataGuillaume Marrelec
INSERM, U678, F 75013 Paris, France
Magn Reson Imaging 25:1181-9. 2007.... - Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndromeStefan J Teipel
Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig Macimilian University, Munich, Germany
Am J Psychiatry 160:1870-8. 2003..This study investigated whether atrophy of the corpus callosum and hippocampus occurs in nondemented subjects with Down's syndrome and compared the degree of age-related atrophy between these structures...