B Horwitz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint How can EEG/MEG and fMRI/PET data be combined?
    Barry Horwitz
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 17:1-3. 2002
  2. ncbi request reprint The elusive concept of brain connectivity
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 19:466-70. 2003
  3. ncbi request reprint Neural modeling and functional brain imaging: an overview
    B Horwitz
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Neural Netw 13:829-46. 2000
  4. ncbi request reprint Activation of Broca's area during the production of spoken and signed language: a combined cytoarchitectonic mapping and PET analysis
    Barry Horwitz
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
    Neuropsychologia 41:1868-76. 2003
  5. ncbi request reprint Predicting human functional maps with neural net modeling
    B Horwitz
    Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 8:137-42. 1999
  6. ncbi request reprint Brain network interactions in auditory, visual and linguistic processing
    Barry Horwitz
    Voice, Speech, Language Branch, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
    Brain Lang 89:377-84. 2004
  7. pmc Functional connectivity of the angular gyrus in normal reading and dyslexia
    B Horwitz
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8939-44. 1998
  8. pmc A link between neuroscience and informatics: large-scale modeling of memory processes
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Methods 44:338-47. 2008
  9. ncbi request reprint Relating fMRI and PET signals to neural activity by means of large-scale neural models
    Barry Horwitz
    Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Neuroinformatics 2:251-66. 2004
  10. ncbi request reprint Integrating neuroscientific data across spatiotemporal scales
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420 MSC 1591, Bethesda, MD 20892, USA
    C R Biol 328:109-18. 2005

Detail Information

Publications47

  1. ncbi request reprint How can EEG/MEG and fMRI/PET data be combined?
    Barry Horwitz
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 17:1-3. 2002
  2. ncbi request reprint The elusive concept of brain connectivity
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 19:466-70. 2003
    ..Until it is understood what each definition means in terms of an underlying neural substrate, comparisons of functional and/or effective connectivity across studies may appear inconsistent and should be performed with great caution...
  3. ncbi request reprint Neural modeling and functional brain imaging: an overview
    B Horwitz
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Neural Netw 13:829-46. 2000
    ....
  4. ncbi request reprint Activation of Broca's area during the production of spoken and signed language: a combined cytoarchitectonic mapping and PET analysis
    Barry Horwitz
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
    Neuropsychologia 41:1868-76. 2003
    ..These findings implicate BA45 as the part of Broca's area that is fundamental to the modality-independent aspects of language generation...
  5. ncbi request reprint Predicting human functional maps with neural net modeling
    B Horwitz
    Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 8:137-42. 1999
    ..A delayed match-to-sample visual task is used to illustrate this approach...
  6. ncbi request reprint Brain network interactions in auditory, visual and linguistic processing
    Barry Horwitz
    Voice, Speech, Language Branch, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6C420, MSC 1591, Bethesda, MD 20892, USA
    Brain Lang 89:377-84. 2004
    ..Thus, this type of modeling provides a way to understand the neural bases for the sensorimotor and cognitive tasks of interest...
  7. pmc Functional connectivity of the angular gyrus in normal reading and dyslexia
    B Horwitz
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8939-44. 1998
    ....
  8. pmc A link between neuroscience and informatics: large-scale modeling of memory processes
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Methods 44:338-47. 2008
    ....
  9. ncbi request reprint Relating fMRI and PET signals to neural activity by means of large-scale neural models
    Barry Horwitz
    Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Neuroinformatics 2:251-66. 2004
    ....
  10. ncbi request reprint Integrating neuroscientific data across spatiotemporal scales
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg 10, Rm 6C420 MSC 1591, Bethesda, MD 20892, USA
    C R Biol 328:109-18. 2005
    ..It will be demonstrated that the models are capable of exhibiting the salient features of both electrophysiological neuronal activities and fMRI values that are in agreement with empirically observed data...
  11. ncbi request reprint Relating neuronal dynamics for auditory object processing to neuroimaging activity: a computational modeling and an fMRI study
    F T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 21:1701-20. 2004
    ..These findings provide support for our hypotheses concerning how auditory objects are processed by primate neocortex...
  12. ncbi request reprint Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementia
    P Pietrini
    Laboratory of Neurosciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 154:1063-9. 1997
    ....
  13. ncbi request reprint Frequency variation of a pattern-flash visual stimulus during PET differentially activates brain from striate through frontal cortex
    M J Mentis
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroimage 5:116-28. 1997
    ..The reproducibility and systematically changing rCBF responses to this passive stimulus suggest that it could be successfully used as a disease probe to evaluate neural function and drug effects in cognitively impaired patients...
  14. ncbi request reprint Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: a positron emission tomography regional cerebral blood flow study in healthy humans
    M L Furey
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 1366, USA
    Brain Res Bull 51:213-8. 2000
    ....
  15. ncbi request reprint Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease: a magnetic resonance imaging analysis
    H Hampel
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Arch Neurol 55:193-8. 1998
    ..Pathological studies in Alzheimer disease indicate the specific loss of layer III and V large pyramidal neurons in association cortex. These neurons give rise to long corticocortical connections within and between the cerebral hemispheres...
  16. ncbi request reprint Region-specific corpus callosum atrophy correlates with the regional pattern of cortical glucose metabolism in Alzheimer disease
    S J Teipel
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Arch Neurol 56:467-73. 1999
    ..Atrophy of the corpus callosum as the major tract of intracortical connective fibers may reflect decreased cortical functional integration in AD...
  17. ncbi request reprint Functional interactions of the inferior frontal cortex during the processing of words and word-like stimuli
    A L Bokde
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 30:609-17. 2001
    ..These results demonstrate a task-dependent functional fractionation of the LIFG in terms of its functional links with posterior brain areas...
  18. ncbi request reprint Simulating transcranial magnetic stimulation during PET with a large-scale neural network model of the prefrontal cortex and the visual system
    F T Husain
    Language Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroimage 15:58-73. 2002
    ..We also found that regions both directly and indirectly connected to the stimulating site were affected by TMS...
  19. doi request reprint Investigating the neural basis for fMRI-based functional connectivity in a blocked design: application to interregional correlations and psycho-physiological interactions
    Jieun Kim
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Imaging 26:583-93. 2008
    ..These results highlight the way in which neural modeling can be used to help validate the inferences one can make about functional connectivity based on fMRI data...
  20. pmc Hierarchical auditory processing directed rostrally along the monkey's supratemporal plane
    Yukiko Kikuchi
    Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health, and Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:13021-30. 2010
    ....
  21. ncbi request reprint fMRI study comparing names versus pictures of objects
    Andrei Sevostianov
    Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 16:168-75. 2002
    ....
  22. pmc Neural mechanisms of auditory discrimination of long-duration tonal patterns: a neural modeling and fMRI study
    Antonio Ulloa
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    J Integr Neurosci 7:501-27. 2008
    ..Other fMRI studies of auditory perception and discrimination have also found correlation of fMRI activation of those areas with similar tasks and thus provide further support to our findings...
  23. ncbi request reprint A functional lesion in developmental dyslexia: left angular gyral blood flow predicts severity
    J M Rumsey
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain Lang 70:187-204. 1999
    ..01). This suggests that greater reliance on this region normally facilitates reading, but impairs reading in dyslexia. Thus, developmental dyslexia may share a common localization with alexia...
  24. ncbi request reprint The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer disease
    A L Bokde
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Neurol 58:480-6. 2001
    ..The different patterns of hypometabolism indicate the differential development of the lesions between the AD and AD + VS groups...
  25. ncbi request reprint Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memory
    Michael F Glabus
    Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
    Cereb Cortex 13:1352-61. 2003
    ..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM...
  26. ncbi request reprint Integrating electrophysiological and anatomical experimental data to create a large-scale model that simulates a delayed match-to-sample human brain imaging study
    M A Tagamets
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Cereb Cortex 8:310-20. 1998
    ..We show that in addition to performing the task, the integrated summed synaptic activities of the model are similar to experimental PET data...
  27. pmc Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing production
    Kristina Simonyan
    Laryngeal and Speech Section, Medical Neurology Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892, USA
    J Neurosci 29:14912-23. 2009
    ..Significant left-hemispheric lateralization of functional networks during simple but highly learned voice production suggests the readiness of the LMC network for production of a complex voluntary behavior, such as human speech...
  28. pmc Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging study
    Jason F Smith
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
    Neuroimage 50:826-36. 2010
    ..Neuroimaging analysis at a sub-trial temporal resolution, as used here, may further clarify the role of the hippocampal complex in memory consolidation...
  29. pmc Identification and validation of effective connectivity networks in functional magnetic resonance imaging using switching linear dynamic systems
    Jason F Smith
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1407, USA
    Neuroimage 52:1027-40. 2010
    ..Our results suggest that the SLDS model framework is an effective means to address several problems with modeling connectivity including measuring overall model adequacy and identifying important regions missing from models...
  30. pmc Experimental-neuromodeling framework for understanding auditory object processing: integrating data across multiple scales
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Rm 8S235 D, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Physiol Paris 100:133-41. 2006
    ..The results predict a particular set of bottom-up cortical processing mechanisms that implement perceptual grouping, and also attest to the robustness of our model...
  31. ncbi request reprint Frontal cortex functional connectivity changes during sound categorization
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroreport 17:617-21. 2006
    ....
  32. ncbi request reprint Neural bases of categorization of simple speech and nonspeech sounds
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 27:636-51. 2006
    ....
  33. ncbi request reprint Investigating the neural basis of the auditory continuity illusion
    Fatima T Husain
    Brain Imaging and Modeling Section, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
    J Cogn Neurosci 17:1275-92. 2005
    ..These simulation results not only attest to the robustness of the model, but further predict the primary role of the anatomical connectivity of the auditory processing areas in mediating the continuity illusion...
  34. pmc Investigating the neural basis for functional and effective connectivity. Application to fMRI
    Barry Horwitz
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communications Disorders, National Institutes of Health, Building 10, Room 6C420, MSC 1591, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 360:1093-108. 2005
    ..These results provide a partial validation for using fMRI functional connectivity to assess brain interregional relations...
  35. pmc How well does structural equation modeling reveal abnormal brain anatomical connections? An fMRI simulation study
    Jieun Kim
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, Bldg 10, Rm 8S235, MSC 1407, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 45:1190-8. 2009
    ....
  36. ncbi request reprint Neural modeling and functional brain imaging: the interplay between the data-fitting and simulation approaches
    Barry Horwitz
    Section on Brain Imaging and Modeling, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Int Rev Neurobiol 66:267-90. 2005
  37. ncbi request reprint Effect of attention on central auditory processing: an fMRI study
    Andrei Sevostianov
    National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland, USA
    Int J Neurosci 112:587-606. 2002
    ..Extratemporal regions activated by attending to targets in either ear included the anterior cingulate cortex, supramarginal gyrus, and dorsolateral prefrontal cortex...
  38. pmc Distinguishing the processing of gestures from signs in deaf individuals: an fMRI study
    Fatima T Husain
    Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Brain Res 1276:140-50. 2009
    ....
  39. ncbi request reprint Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease
    Jack S Krasuski
    Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD, USA
    Am J Psychiatry 159:74-81. 2002
    ....
  40. ncbi request reprint Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging, after correction for brain atrophy
    Vicente Ibanez
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 63:147-54. 2004
    ..Thus, statistically significant age reductions in regional brain glucose metabolism, corrected for brain atrophy, are not detectable in healthy normotensive men scanned while in the resting state...
  41. doi request reprint Simulated neural dynamics of decision-making in an auditory delayed match-to-sample task
    Shihua Wen
    Mathematics Department, University of Maryland, College Park, MD 20742, USA
    Biol Cybern 99:15-27. 2008
    ....
  42. ncbi request reprint "What" and "where" in visual working memory: a computational neurodynamical perspective for integrating FMRI and single-neuron data
    Gustavo Deco
    Institucion Catalana de Recerca, Estudis Avançats ICREA and Universitat Pompeu Fabra
    J Cogn Neurosci 16:683-701. 2004
    ....
  43. ncbi request reprint Discrimination and categorization of speech and non-speech sounds in an MEG delayed-match-to-sample study
    Huan Luo
    Neuroscience and Cognitive Science Program, University of Maryland College Park, 20742, USA
    Neuroimage 28:59-71. 2005
    ..The fact that the dissociation between speech and non-speech occurred in auditory areas, but not frontal areas, points to different categorization mechanisms and networks for newly learned (non-speech) and natural (speech) categories...
  44. ncbi request reprint Systems level modeling of a neuronal network subserving intrinsic alertness
    Felix M Mottaghy
    Department of Nuclear Medicine H H U, Düsseldorf and KME, Research Center Julich, Germany
    Neuroimage 29:225-33. 2006
    ....
  45. ncbi request reprint Large-scale neural models and dynamic causal modelling
    Lucy Lee
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 30:1243-54. 2006
    ..Specifically, Bayesian model comparison confirms the validity of DCM in relation to a well-characterised and comprehensive neuronal model...
  46. ncbi request reprint Using partial correlation to enhance structural equation modeling of functional MRI data
    Guillaume Marrelec
    INSERM, U678, F 75013 Paris, France
    Magn Reson Imaging 25:1181-9. 2007
    ....
  47. ncbi request reprint Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndrome
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig Macimilian University, Munich, Germany
    Am J Psychiatry 160:1870-8. 2003
    ..This study investigated whether atrophy of the corpus callosum and hippocampus occurs in nondemented subjects with Down's syndrome and compared the degree of age-related atrophy between these structures...