Keith A Horvath

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Transapical aortic valve replacement under real-time magnetic resonance imaging guidance: experimental results with balloon-expandable and self-expanding stents
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Eur J Cardiothorac Surg 39:822-8. 2011
  2. ncbi request reprint Improvement of myocardial contractility in a porcine model of chronic ischemia using a combined transmyocardial revascularization and gene therapy approach
    Keith A Horvath
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    J Thorac Cardiovasc Surg 129:1071-7. 2005
  3. pmc Midterm results of transapical aortic valve replacement via real-time magnetic resonance imaging guidance
    Keith A Horvath
    National Heart, Lung, and Blood Institute, National Institutes of Health the Cardiothoracic Surgery Research Program, Bethesda, MD 20892, USA
    J Thorac Cardiovasc Surg 139:424-30. 2010
  4. ncbi request reprint Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging
    Keith A Horvath
    Division of Cardiothoracic Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Ann Thorac Surg 74:481-6; discussion 487. 2002
  5. ncbi request reprint What is the optimal channel density for transmyocardial laser revascularization?
    Samdeep K Mouli
    Division of Cardiothoracic Surgery, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Thorac Surg 78:1326-31; discussion 1326-31. 2004
  6. pmc Real-time magnetic resonance imaging guidance for cardiovascular procedures
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute NHLBI, NIH, Bethesda, MD 20892, USA
    Semin Thorac Cardiovasc Surg 19:330-5. 2007
  7. doi request reprint Marrow stromal cells differentiate into vasculature after allogeneic transplantation into ischemic myocardium
    Yifu Zhou
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1550, USA
    Ann Thorac Surg 91:1206-12. 2011
  8. pmc Robotic system for transapical aortic valve replacement with MRI guidance
    Ming Li
    Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Med Image Comput Comput Assist Interv 11:476-84. 2008
  9. doi request reprint Ex-vivo expanded baboon CD4+ CD25 Hi Treg cells suppress baboon anti-pig T and B cell immune response
    Avneesh K Singh
    Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, MD 20892, USA
    Xenotransplantation 19:102-11. 2012
  10. pmc Real-time interactive MRI-guided cardiac surgery: aortic valve replacement using a direct apical approach
    Elliot R McVeigh
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 56:958-64. 2006

Detail Information

Publications34

  1. pmc Transapical aortic valve replacement under real-time magnetic resonance imaging guidance: experimental results with balloon-expandable and self-expanding stents
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Eur J Cardiothorac Surg 39:822-8. 2011
    ..Whether there are different advantages to SE or BE stents is unknown. We report rtMRI-guided tAVI in a porcine model using both SE and BE stents, and compare the differences between the stents...
  2. ncbi request reprint Improvement of myocardial contractility in a porcine model of chronic ischemia using a combined transmyocardial revascularization and gene therapy approach
    Keith A Horvath
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    J Thorac Cardiovasc Surg 129:1071-7. 2005
    ....
  3. pmc Midterm results of transapical aortic valve replacement via real-time magnetic resonance imaging guidance
    Keith A Horvath
    National Heart, Lung, and Blood Institute, National Institutes of Health the Cardiothoracic Surgery Research Program, Bethesda, MD 20892, USA
    J Thorac Cardiovasc Surg 139:424-30. 2010
    ..To assist the surgeon and improve the success of the operation, we have performed transapical aortic valve replacements using real-time magnetic resonance imaging guidance...
  4. ncbi request reprint Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging
    Keith A Horvath
    Division of Cardiothoracic Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Ann Thorac Surg 74:481-6; discussion 487. 2002
    ....
  5. ncbi request reprint What is the optimal channel density for transmyocardial laser revascularization?
    Samdeep K Mouli
    Division of Cardiothoracic Surgery, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Thorac Surg 78:1326-31; discussion 1326-31. 2004
    ..Transmyocardial laser revascularization (TMR) has demonstrated reproducible relief of angina in patients with end-stage coronary disease. However, the optimum dose or channel density has not been elucidated...
  6. pmc Real-time magnetic resonance imaging guidance for cardiovascular procedures
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute NHLBI, NIH, Bethesda, MD 20892, USA
    Semin Thorac Cardiovasc Surg 19:330-5. 2007
    ..Instruments and devices can be marked to enhance visualization and tracking, all of which is an advance over standard X-ray or ultrasonic imaging...
  7. doi request reprint Marrow stromal cells differentiate into vasculature after allogeneic transplantation into ischemic myocardium
    Yifu Zhou
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1550, USA
    Ann Thorac Surg 91:1206-12. 2011
    ..In this animal study, we employed MSCs isolated from transgenic pigs designed to express enhanced green fluorescent proteins as the donor to study the fate of the cells after allogeneic transplantation...
  8. pmc Robotic system for transapical aortic valve replacement with MRI guidance
    Ming Li
    Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Med Image Comput Comput Assist Interv 11:476-84. 2008
    ..Preliminary evaluation of the parameters of the robotic system demonstrates it can provide sufficient capability to successfully assist the surgeon...
  9. doi request reprint Ex-vivo expanded baboon CD4+ CD25 Hi Treg cells suppress baboon anti-pig T and B cell immune response
    Avneesh K Singh
    Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, MD 20892, USA
    Xenotransplantation 19:102-11. 2012
    ..In this study, we evaluated the role of these Treg cells in suppressing proliferative response of baboon T and B cells to pig xenoantigens...
  10. pmc Real-time interactive MRI-guided cardiac surgery: aortic valve replacement using a direct apical approach
    Elliot R McVeigh
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 56:958-64. 2006
    ..MRI-guided beating-heart surgery may provide patients with a less morbid and more durable solution to structural heart disease...
  11. pmc Direct injection of autologous mesenchymal stromal cells improves myocardial function
    Yifu Zhou
    Cellular Biology Section, Cardiothoracic Surgery Research Program, NHLBI, National Institutes of Health, 10 Center Drive, MSC 1550, Building 10, Room 2N246, Bethesda, MD 20892 1550, USA
    Biochem Biophys Res Commun 390:902-7. 2009
    ..This suggests that the angiogenesis engendered by cell treatment may be physiologically meaningful by improving the contractility of ischemic myocardium...
  12. doi request reprint Blood transfusion and infection after cardiac surgery
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Ann Thorac Surg 95:2194-201. 2013
    ....
  13. ncbi request reprint Clinical results of sole therapy TMR treatment
    Keith A Horvath
    Cardiothoracic Surgery Research Program, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Semin Thorac Cardiovasc Surg 18:46-51. 2006
    ..In addition to significant symptomatic relief both short- and long-term objective data were also garnered in these studies. A review of the history, study design, and outcomes is provided...
  14. doi request reprint Pneumatic actuated robotic assistant system for aortic valve replacement under MRI guidance
    Ming Li
    National Institutes of Health, Bethesda, MD 20892, USA
    IEEE Trans Biomed Eng 58:443-51. 2011
    ..The system provides different user interfaces at various stages of the procedure. We present the development and evaluation of the components and the system in ex-vivo experiments...
  15. doi request reprint Transmyocardial laser revascularization
    Keith A Horvath
    Cardiothoracic Surgery Research, National Heart, Lung and Blood Institute NIH, Bethesda, Maryland 20892, USA
    J Card Surg 23:266-76. 2008
    ..Additional therapies to enhance the angiogenic response include combining TMR with stem cell-based treatments, which appear to be promising future endeavors...
  16. pmc Does laser type impact myocardial function following transmyocardial laser revascularization?
    Soren K Estvold
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Lasers Surg Med 42:746-51. 2010
    ....
  17. pmc The visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle
    Paul D Jobsis
    National Heart, Lung, and Blood Institute, National Institutes of Health, MSC 1061, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 293:H3379-87. 2007
    ..Alterations in this layer may occur in various disease states that effect diastolic function...
  18. doi request reprint The universal bed model for patient care improves outcome and lowers cost in cardiac surgery
    Abbas Emaminia
    Cardiothoracic Surgery Research Program, National Institutes of Health Heart Center at Suburban Hospital, Bethesda, MD, USA
    J Thorac Cardiovasc Surg 143:475-81. 2012
    ..We hypothesized that the universal bed model in the context of cardiac surgery would improve outcomes and efficacy...
  19. ncbi request reprint Impact of unstable angina on outcomes of transmyocardial laser revascularization combined with coronary artery bypass grafting
    Keith A Horvath
    National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Thorac Surg 80:2082-5. 2005
    ..The objective of this study was to investigate the preoperative risk profile of patients undergoing TMR plus coronary artery bypass graft surgery (CABG) and to determine the impact of unstable angina on outcomes...
  20. pmc Rapid and dynamic alterations of gene expression profiles of adult porcine bone marrow-derived stem cell in response to hypoxia
    Suna Wang
    Cellular Biology Section, Cardiothoracic Surgery Research Program, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Stem Cell Res 4:117-28. 2010
    ..This study provides a global view of molecular events in the cells during exposure to hypoxia and revealed a set of novel candidate hypoxic targets...
  21. pmc Minimally invasive cardiac surgery: transapical aortic valve replacement
    Ming Li
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 10, B1D47, Bethesda, MD 20892, USA
    Minim Invasive Surg 2012:145381. 2012
    ..Ex vivo experimentation results indicate that a robotic system can also be employed in in vivo models...
  22. ncbi request reprint The Ross procedure in adults: intermediate-term results
    David A Fullerton
    Division of Cardiothoracic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Ann Thorac Surg 76:471-6; discussion 476-7. 2003
    ..We employed a surgical strategy to standardize the operation in order to avoid more readily a geometric mismatch...
  23. ncbi request reprint Results of prospective randomized controlled trials of transmyocardial laser revascularization
    Keith A Horvath
    Division of Cardiothoracic Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Heart Surg Forum 5:33-9; discussion 39-40. 2002
    ..While all of these trials are similar, they are not identical and this review provides an update and comparison of the results...
  24. ncbi request reprint Mechanisms and results of transmyocardial laser revascularization
    Keith A Horvath
    Northwestern University, Chicago, IL 60611, USA
    Cardiology 101:37-47. 2004
    ..The results of using TMR as a treatment for angina show a dramatic improvement in symptoms and quality of life. This paper reviews the current status of TMR techniques, mechanisms and results...
  25. ncbi request reprint Topical application of bacitracin ointment is associated with decreased risk of mediastinitis after median sternotomy
    Robroy H MacIver
    Northwestern Memorial Hospital, Chicago, Illinois, USA
    Heart Surg Forum 9:E750-3. 2006
    ..The purpose of this study was to investigate the impact that topical antibacterials would have on the postoperative mediastinitis rate...
  26. doi request reprint Off-pump surgery for giant right coronary artery aneurysms
    Abbas Emaminia
    National Institutes of Health NIH Heart Center, Bethesda, Maryland, USA
    J Card Surg 26:596-9. 2011
    ..We report two cases of giant right coronary artery aneurysms successfully treated by off-pump resection of the aneurysm and bypass grafting. The controversy surrounding the proper management of such cases is discussed...
  27. ncbi request reprint The incidence of emboli during cardiac surgery: a histopathologic analysis of 2297 patients
    Keith A Horvath
    National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Heart Surg Forum 8:E161-6. 2005
    ..Recently, as a result of worldwide trials deploying the Embol-X intraaortic filter during cardiac surgery, such emboli were captured and processed for histopathologic analysis...
  28. ncbi request reprint Transmyocardial laser revascularization
    Keith A Horvath
    Division of Cardiothoracic Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Ann Thorac Surg 73:1355-6. 2002
  29. ncbi request reprint Characterization and expansion of baboon CD4+CD25+ Treg cells for potential use in a non-human primate xenotransplantation model
    Cynthia M Porter
    Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, Mayland 20892, USA
    Xenotransplantation 14:298-308. 2007
    ..Baboons are a preferred preclinical animal model for xenogeneic organ transplantation experiments, and the characterization of baboon Treg cells will be beneficial to future tolerance studies in this animal model...
  30. ncbi request reprint The Society of Thoracic Surgeons practice guideline series: transmyocardial laser revascularization
    Charles R Bridges
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 77:1494-502. 2004
    ....
  31. ncbi request reprint Percutaneous laser revascularization does not equal transmyocardial laser revascularization
    Keith A Horvath
    J Am Coll Cardiol 48:2354; author reply 2355. 2006
  32. ncbi request reprint Emboli capture using the Embol-X intraaortic filter in cardiac surgery: a multicentered randomized trial of 1,289 patients
    Michael K Banbury
    The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 76:508-15; discussion 515. 2003
    ..Particulate emboli are thought to play a significant role in the development of cardiac surgical complications. Intraaortic filtration of particulate emboli may reduce the burden of this morbidity in cardiac patients...
  33. ncbi request reprint Light and ice cream
    Keith A Horvath
    Ann Thorac Surg 82:771; author reply 771-2. 2006
  34. ncbi request reprint The art and science of transmyocardial laser revascularization
    Keith A Horvath
    J Am Coll Cardiol 41:2298; author reply 2298-9. 2003