Robert N Hoover

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The evolution of epidemiologic research: from cottage industry to "big" science
    Robert N Hoover
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852, USA
    Epidemiology 18:13-7. 2007
  2. pmc That recognised risk factors can explain past and present international differences in breast cancer incidence: misconceptions 5
    R N Hoover
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Cancer 107:408-10. 2012
  3. pmc Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men
    William D Finkle
    Consolidated Research, Inc, Los Angeles, California, United States of America
    PLoS ONE 9:e85805. 2014
  4. doi request reprint Bigger, better, sooner--scaling up for success
    Michael J Thun
    Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
    Cancer Epidemiol Biomarkers Prev 21:571-5. 2012
  5. doi request reprint Adverse health outcomes in women exposed in utero to diethylstilbestrol
    Robert N Hoover
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    N Engl J Med 365:1304-14. 2011
  6. doi request reprint The sound and the fury: was it all worth it?
    Robert N Hoover
    Division of Epidemiology and Genetics, Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892, USA
    Epidemiology 19:780-2; discussion 789-93. 2008
  7. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
  8. pmc Estrogen metabolism and risk of breast cancer in postmenopausal women
    Barbara J Fuhrman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Natl Cancer Inst 104:326-39. 2012
  9. doi request reprint Medical conditions among adult offspring prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Epidemiology 24:430-8. 2013
  10. ncbi request reprint Preeclampsia risk in women exposed in utero to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Obstet Gynecol 110:113-20. 2007

Detail Information

Publications98

  1. ncbi request reprint The evolution of epidemiologic research: from cottage industry to "big" science
    Robert N Hoover
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852, USA
    Epidemiology 18:13-7. 2007
  2. pmc That recognised risk factors can explain past and present international differences in breast cancer incidence: misconceptions 5
    R N Hoover
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Cancer 107:408-10. 2012
    ..If this is not recognised, opportunities for research on breast cancer aetiology may be lost...
  3. pmc Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men
    William D Finkle
    Consolidated Research, Inc, Los Angeles, California, United States of America
    PLoS ONE 9:e85805. 2014
    ..An association between testosterone therapy (TT) and cardiovascular disease has been reported and TT use is increasing rapidly...
  4. doi request reprint Bigger, better, sooner--scaling up for success
    Michael J Thun
    Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
    Cancer Epidemiol Biomarkers Prev 21:571-5. 2012
    ..The need for this will continue to increase in the foreseeable future. It will also be important to analyze and publish aggregated data much earlier in the discovery process than typical for past efforts...
  5. doi request reprint Adverse health outcomes in women exposed in utero to diethylstilbestrol
    Robert N Hoover
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    N Engl J Med 365:1304-14. 2011
    ..Several adverse outcomes have been linked to such exposure, but their cumulative effects are not well understood...
  6. doi request reprint The sound and the fury: was it all worth it?
    Robert N Hoover
    Division of Epidemiology and Genetics, Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892, USA
    Epidemiology 19:780-2; discussion 789-93. 2008
    ....
  7. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
    ..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
  8. pmc Estrogen metabolism and risk of breast cancer in postmenopausal women
    Barbara J Fuhrman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Natl Cancer Inst 104:326-39. 2012
    ....
  9. doi request reprint Medical conditions among adult offspring prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Epidemiology 24:430-8. 2013
    ..Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking...
  10. ncbi request reprint Preeclampsia risk in women exposed in utero to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Obstet Gynecol 110:113-20. 2007
    ..To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters...
  11. pmc Low level alcohol intake, cigarette smoking and risk of breast cancer in Asian-American women
    Linda Morris Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Breast Cancer Res Treat 120:203-10. 2010
    ....
  12. pmc Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study
    Jasmine Q Lew
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
    Am J Epidemiol 170:308-17. 2009
    ..73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI: 0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breast cancer, specifically hormone receptor-positive tumors...
  13. doi request reprint Childhood soy intake and breast cancer risk in Asian American women
    Larissa A Korde
    National Cancer Institute, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 18:1050-9. 2009
    ..When Asian women migrate to the United States, their breast cancer risk increases over several generations and approaches that for U.S. Whites. Thus, modifiable factors, such as diet, may be responsible...
  14. ncbi request reprint Serum concentrations of estrogens, sex hormone binding globulin, and androgens and risk of breast hyperplasia in postmenopausal women
    Catherine Schairer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Room 8020 MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:1660-5. 2005
    ..We sought to determine whether serum concentrations of estrogens, androgens, and sex hormone binding globulin in postmenopausal women were related to the presence of mammary hyperplasia, an established breast cancer risk factor...
  15. pmc Breast cancer epidemiology according to recognized breast cancer risk factors in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Cohort
    James V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    BMC Cancer 9:84. 2009
    ..We therefore evaluated known risk factors for breast cancer in a cancer screening trial that does not have breast cancer as a study endpoint but is large enough to provide numerous analytic opportunities for breast cancer...
  16. pmc Genetic variation at chromosome 8q24 in osteosarcoma cases and controls
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
    Carcinogenesis 31:1400-4. 2010
    ..Future large studies of osteosarcoma genetic risk factors are warranted to improve our understanding of the genetic contribution to this cancer of adolescents and young adults...
  17. pmc Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment
    Qizhai Li
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Genet Epidemiol 33:432-41. 2009
    ....
  18. pmc Soy intake is associated with increased 2-hydroxylation and decreased 16alpha-hydroxylation of estrogens in Asian-American women
    Barbara J Fuhrman
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5003, Rockville, MD 20852 7246, USA
    Cancer Epidemiol Biomarkers Prev 18:2751-60. 2009
    ..In a sample of Asian-American women, we investigated the associations of usual adult soy intake with the urinary concentrations of 15 estrogens and estrogen metabolites (EM) measured using liquid chromatography-tandem mass spectrometry...
  19. pmc Reproductive factors and menopausal hormone therapy and bladder cancer risk in the NIH-AARP Diet and Health Study
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 133:462-72. 2013
    ..34-0.83) compared with women who did not report MHT use. No association was observed for estrogen only users (HR=0.82; 95% CI: 0.58-1.15). Our results suggest a putative role for sex hormones in the etiology of bladder cancer among women...
  20. doi request reprint Fine mapping of 14q24.1 breast cancer susceptibility locus
    Phoebe Lee
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 131:479-90. 2012
    ..Therefore, we conclude that rs999737 is an optimal tag SNP for common variants in the 14q24.1 region and thus narrow the candidate variants that should be investigated in follow-up laboratory evaluation...
  21. pmc A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    BMC Cancer 11:209. 2011
    ..We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways...
  22. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  23. pmc Large-scale fine mapping of the HNF1B locus and prostate cancer risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 20:3322-9. 2011
    ..This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. Further studies are needed to investigate the biological basis of the association of variants in 17q12 with prostate cancer...
  24. doi request reprint Mortality from solid tumors among workers in formaldehyde industries: an update of the NCI cohort
    Laura E Beane Freeman
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Ind Med 56:1015-26. 2013
    ..Formaldehyde, a widely used chemical, is considered a human carcinogen...
  25. pmc Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, Bethesda, MD 20892 7105, USA
    Cancer Causes Control 23:779-84. 2012
    ..This study sought to compare an extensive profile of biological markers in both maternal and umbilical cord samples in preeclamptic and uncomplicated pregnancies of a predominantly African-American population...
  26. pmc Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer
    Charles C Chung
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute NIH, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    Hum Mol Genet 20:2869-78. 2011
    ..We estimate that at least 63 common variants should be considered in future studies designed to investigate the biological basis of the multiple association signals...
  27. pmc Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility
    Hong Lou
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:7933-8. 2009
    ..Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility...
  28. ncbi request reprint Cancer risk in women prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 121:356-60. 2007
    ..Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure...
  29. pmc Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010
    ..2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7))...
  30. pmc Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium
    Joanne W Elena
    Division of Cancer Control and Population Science, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Causes Control 24:13-25. 2013
    ..This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan)...
  31. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  32. pmc Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Obstet Gynecol 199:653.e1-10. 2008
    ..The objective of the study was to determine whether blood pressure increases are associated with maternal angiogenic factors in uncomplicated and preeclamptic pregnancies...
  33. pmc Body mass index and risk of death in Asian Americans
    Yikyung Park
    Yikyung Park, Cari M Kitahara, Steven C Moore, Amy Berrington de Gonzalez, D Michal Freedman, Robert N Hoover, Martha S Linet, Mark Purdue, Catherine Schairer, and Patricia Hartge are with the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Sophia Wang and Leslie Bernstein are with the Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and the City of Hope, Duarte, CA Ellen T Chang is with Health Sciences Practice, Exponent Inc, Menlo Park, CA Alan J Flint and Walter C Willett are with the Department of Nutrition, Harvard School of Public Health, Boston, MA J Michael Gaziano, Howard D Sesso, and Walter C Willett are with the Division of Preventive Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA Kim Robien is with Departments of Epidemiology and Biostatistics and Exercise Science, School of Public Health and Health Services, George Washington University, Washington, DC Emily White is with the Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle Bradley J Willcox is with the Pacific Health Research and Education Institute and Queen s Medical Center, Honolulu, HI Michael J Thun is with the Department of Epidemiology, Utrecht University
    Am J Public Health 104:520-5. 2014
    ..We investigated the association between body mass index (BMI) and mortality among Asian Americans...
  34. pmc Genome-wide association study identifies two susceptibility loci for osteosarcoma
    Sharon A Savage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA
    Nat Genet 45:799-803. 2013
    ..2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma...
  35. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  36. pmc Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, 6120 Executive Blvd EPS, Bethesda, MD 20892 7105, USA
    Cancer Causes Control 22:1587-95. 2011
    ....
  37. ncbi request reprint Maternal androgen and estrogen concentrations are not associated with blood pressure changes in uncomplicated pregnancies
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7246, USA
    Cancer Epidemiol Biomarkers Prev 15:2013-5. 2006
    ..These data are not consistent with the hypothesis that elevated androgen concentrations mediate the observed reduction in maternal breast cancer risk associated with increases in blood pressure over the pregnancy...
  38. pmc Comparison of liquid chromatography-tandem mass spectrometry, RIA, and ELISA methods for measurement of urinary estrogens
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, Bethesda, MD 20892 7105, USA
    Cancer Epidemiol Biomarkers Prev 19:292-300. 2010
    ..2% and < or =17.8%). Comparison with the LC-MS/MS method suggests that the widely used RIA and ELISA estrogen metabolite measures may be problematic, especially at low estrogen metabolite levels characteristic of postmenopausal women...
  39. pmc Prospective evaluation of serum sarcosine and risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 34:2281-5. 2013
    ..95-1.59, P-interaction = 0.01). This study found that elevated levels of serum sarcosine are associated with an increased prostate cancer risk and evidence to suggest that sarcosine may be an early biomarker for this disease. ..
  40. ncbi request reprint Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Executive Plaza South, Suite 320, MSC7232, Bethesda, Maryland 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 15:334-41. 2006
    ..In addition, these three aspects of energy balance may act jointly in determining breast cancer risk...
  41. ncbi request reprint Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 320, Rockville, MD 20852, USA
    Am J Clin Nutr 83:895-904. 2006
    ..Several epidemiologic studies suggest that higher folate intakes are associated with lower breast cancer risk, particularly in women with moderate alcohol consumption...
  42. pmc Breast cancer incidence in Mongolia
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Cancer Causes Control 23:1047-53. 2012
    ..Mongolia's breast cancer experience is of interest because of its shared genetics but vastly different diet compared with other parts of Asia...
  43. pmc Pregnancy weight gain is not associated with maternal or mixed umbilical cord estrogen and androgen concentrations
    Jessica M Faupel-Badger
    Division of Cancer Prevention and Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7105, USA
    Cancer Causes Control 20:263-7. 2009
    ..Our results are not consistent with an effect of pregnancy weight gain being mediated by this pathway as reflected by hormone concentrations at the end of pregnancy...
  44. pmc A case-control study of smoking and bladder cancer risk: emergent patterns over time
    Dalsu Baris
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    J Natl Cancer Inst 101:1553-61. 2009
    ....
  45. pmc Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Mol Genet 18:3749-57. 2009
    ..8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones...
  46. pmc Height at diagnosis and birth-weight as risk factors for osteosarcoma
    Lisa Mirabello
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 22:899-908. 2011
    ..Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma...
  47. doi request reprint Challenges and opportunities in research on early-life events/exposures and cancer development later in life
    Somdat Mahabir
    Modifiable Risk Factors Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Cancer Causes Control 23:983-90. 2012
    ..This in turn has the potential to transform cancer prevention strategies through interventions in early-life rather than later in life, as is the current practice, where it is perhaps less effective...
  48. pmc Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute Cohort
    Laura E Beane Freeman
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Natl Cancer Inst 101:751-61. 2009
    ....
  49. pmc Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium
    Shannon M Lynch
    National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Am J Epidemiol 170:403-13. 2009
    ..This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis...
  50. ncbi request reprint Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma
    Sharon A Savage
    Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:1667-74. 2007
    ..Osteosarcoma, the most common malignant primary bone tumor, typically occurs during the adolescent growth spurt. Germ-line genetic variation in genes critical in growth regulation could confer altered risk of osteosarcoma...
  51. ncbi request reprint Exploring the underlying hormonal mechanisms of prenatal risk factors for breast cancer: a review and commentary
    Rebecca Troisi
    Room 854, Dartmouth Hitchcock Medical Center, 7297 Rubin Building, One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 16:1700-12. 2007
    ..In addition, investigations should explore the possibility that in utero exposures may not act directly on the breast, but may alter other physiologic pathways such as hormone metabolism that have their effect on risk later in life...
  52. ncbi request reprint Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies
    Rebecca Troisi
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7246, USA
    Int J Epidemiol 32:455-60. 2003
    ..Alterations in pregnancy hormone concentrations, particularly lower in utero exposure to oestrogen, are hypothesized to mediate this association...
  53. ncbi request reprint Associations of maternal and umbilical cord hormone concentrations with maternal, gestational and neonatal factors (United States)
    Rebecca Troisi
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892 7246, USA
    Cancer Causes Control 14:347-55. 2003
    ..However, data on hormonal levels related to these characteristics of pregnancy are sparse, particularly those from studies of the fetal circulation...
  54. pmc A genome-wide association study of prognosis in breast cancer
    Elizabeth M Azzato
    Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1140-3. 2010
    ..Traditional clinicopathologic features of breast cancer do not account for all the variation in survival. Germline genetic variation may provide additional prognostic information...
  55. ncbi request reprint Germ-line genetic variation of TP53 in osteosarcoma
    Sharon A Savage
    Pediatric Oncology Branch, CCR, NCI, NIH, Bethesda, Maryland
    Pediatr Blood Cancer 49:28-33. 2007
    ..We hypothesized that genetic variation in TP53 could be associated with OS risk based on its critical role in cell growth and effect of somatic mutations in OS tumors...
  56. pmc Brain cancer incidence trends in relation to cellular telephone use in the United States
    Peter D Inskip
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza South, Room 7052, Bethesda, MD 20892, USA
    Neuro Oncol 12:1147-51. 2010
    ..Overall, these incidence data do not provide support to the view that cellular phone use causes brain cancer...
  57. ncbi request reprint Quantifying epidemiologic risk factors using non-parametric regression: model selection remains the greatest challenge
    Philip S Rosenberg
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Biostatistics Branch, 6120 Executive Boulevard, EPS 7006, Rockville, MD 20852, USA
    Stat Med 22:3369-81. 2003
    ..Nonetheless, the semi-parametric approach appears to be a practical advance...
  58. ncbi request reprint Correlation of serum hormone concentrations in maternal and umbilical cord samples
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:452-6. 2003
    ..Studies using maternal hormone concentrations as a proxy for the fetal environment should consider the misclassification resulting with the use of this marker...
  59. pmc Maternal angiogenic profile in pregnancies that remain normotensive
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, Rockville, MD USA
    Eur J Obstet Gynecol Reprod Biol 158:189-93. 2011
    ..We sought to determine if maternal characteristics are associated with angiogenic profile in the first and second trimester of normotensive pregnancies...
  60. ncbi request reprint Obesity and cancer risk among white and black United States veterans
    Claudine Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Room 8115, Bethesda, MD 20892, USA
    Cancer Causes Control 15:35-43. 2004
    ..Obesity has been linked to excess risk for many cancers, but the evidence remains tenuous for some types. Although the prevalence of obesity varies by race, few studies of obesity-related cancer risk have included non-white subjects...
  61. ncbi request reprint Why do Black Americans have a higher risk of pancreatic cancer than White Americans?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Epidemiology 14:45-54. 2003
    ..For several decades, the incidence of pancreatic cancer has been 50% to 90% higher among blacks than among whites in the United States. The purpose of this study was to identify risk factors that may contribute to this racial disparity...
  62. pmc Identification of a new prostate cancer susceptibility locus on chromosome 8q24
    Meredith Yeager
    Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nat Genet 41:1055-7. 2009
    ..3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24...
  63. pmc Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer
    Meredith Yeager
    Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Hum Genet 126:743-50. 2009
    ..No sites were observed to be polymorphic within the exons of MSMB...
  64. doi request reprint Cord serum estrogens, androgens, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 in Chinese and U.S. Caucasian neonates
    Rebecca Troisi
    Dartmouth Hitchcock Medical Center, Room 854, 7297 Rubin Building, One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 17:224-31. 2008
    ..The meaning of the change in findings for estrogens after controlling for factors related to the pregnancy is unclear with regard to explaining international breast cancer differences...
  65. pmc A genome-wide association study of prostate cancer in West African men
    Michael Blaise Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Rm 7 E106, MSC 9774, Bethesda, MD, 20892 9774, USA
    Hum Genet 133:509-21. 2014
    ..05. Further genetic studies of prostate cancer in West African men are needed to confirm our promising susceptibility loci. ..
  66. ncbi request reprint Perinatal characteristics and bone cancer risk in offspring--a Scandinavian population-based study
    Rebecca Troisi
    Divisions of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Acta Oncol 53:830-8. 2014
    ..We investigated perinatal factors in relation to bone cancer subtypes, osteosarcoma (OS), Ewing Sarcoma (ES) and chondrosarcoma (CS)...
  67. pmc Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies
    Cari M Kitahara
    Authors Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Core Genotyping Facility, National Cancer Institute, SAIC Frederick, Inc, Gaithersburg, Maryland Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, California Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Division of Preventive Medicine Division of Aging, Brigham and Women s Hospital, Harvard Medical School Massachusetts Veterans Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, Massachusetts Fred Hutchinson Cancer Research Center Department of Epidemiology, University of Washington, Seattle, Washington Vanderbilt University Medical Center, Nashville, Tennessee Department of Radiation Sciences, Oncology, Umea University, Umeå and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 23:47-54. 2014
    ..Brain glioma is a relatively rare and fatal malignancy in adulthood with few known risk factors. Some observational studies have reported inverse associations between diabetes and subsequent glioma risk, but possible mechanisms are unclear...
  68. pmc Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892 7236, USA
    Blood 107:904-6. 2006
    ..In the largest study to date, we suggest that the excess risk of MM in African Americans results from an increase in risk of MGUS rather than an increased risk of progression from MGUS to MM...
  69. ncbi request reprint Urinary estrogen metabolites and their ratio among Asian American women
    Roni T Falk
    Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, MSC 7234, Suite 7070, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:221-6. 2005
    ..Our study suggests that the ratio of 2-OHE(1):16alpha-OHE(1) may be a marker for lifestyle influences on estrogen metabolism associated with westernization...
  70. ncbi request reprint Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk
    Nancy Potischman
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 4005 EPN, 6130 Executive Boulevard, Bethesda, Maryland 20892 7344, USA
    Cancer Epidemiol Biomarkers Prev 14:1514-20. 2005
    ..These data are consistent with hypotheses that in utero hormonal exposures may explain some of the ethnic group differences in cancer risk...
  71. pmc Hepatitis C virus infection and risk of posttransplantation lymphoproliferative disorder among solid organ transplant recipients
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Blood 110:4599-605. 2007
    ..14-8.42; P interaction = .007). Our findings suggest that HCV is not a major risk factor for PTLD, which is consistent with the model in which an intact immune system is necessary for development of HCV-related lymphoproliferation...
  72. pmc Genome-wide association study of glioma and meta-analysis
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Genet 131:1877-88. 2012
    ..Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk...
  73. pmc Population substructure and control selection in genome-wide association studies
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 3:e2551. 2008
    ..A study using suboptimal controls can have acceptable type I error when an effective strategy for the correction of PS is employed...
  74. ncbi request reprint Estrogen and androgen concentrations are not lower in the umbilical cord serum of pre-eclamptic pregnancies
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 12:1268-70. 2003
    ..06 and P = 0.12, respectively). These data do not support the hypothesis that the lower breast cancer risk in daughters of pre-eclamptic pregnancies is explained by lower in utero estrogen exposure...
  75. ncbi request reprint Serum concentrations of IGF-I, IGFBP-3 and c-peptide and risk of hyperplasia and cancer of the breast in postmenopausal women
    Catherine Schairer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 108:773-9. 2004
    ..5 (95% CI 0.7-3.0) and 1.6 (95% CI 0.8-3.2), respectively (p trend = 0.35 and 0.25, respectively). Our results suggest that insulin and insulin resistance may play a role in breast pathology in postmenopausal women...
  76. ncbi request reprint Methods for etiologic and early marker investigations in the PLCO trial
    Richard B Hayes
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
    Mutat Res 592:147-54. 2005
    ..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial...
  77. ncbi request reprint Mortality rates among augmentation mammoplasty patients: an update
    Louise A Brinton
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Epidemiology 17:162-9. 2006
    ..A large follow-up study of cosmetic breast implant patients previously suggested an overall decrease in mortality but increased risks of brain and respiratory cancers and of suicides...
  78. ncbi request reprint A reproducibility study for a fluoride assay in bone
    Nancy Medina
    NIH National Cancer Institute, Biostatistics Branch, EPN 403, 6130 Executive Boulevard, MSC 7368, Bethesda, MD 20892 7368, USA
    Cancer Epidemiol Biomarkers Prev 15:1035-7. 2006
    ..Here, the estimated ICC is 0.86, and the estimated downward bias is only 14%. Hence, the ICC is strong enough so that the estimates of the relative risk will suffer little attenuation from lab measurements...
  79. ncbi request reprint Reproducibility studies and interlaboratory concordance for androgen assays of male plasma hormone levels
    Thomas R Fears
    Biostatistics Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:785-9. 2002
    ..This reliability study design is, however, entirely appropriate for the typical case-control study which utilizes only one sample per subject...
  80. ncbi request reprint Population-density and county-level variation in breast cancer mortality rates among white women residing in the Northeastern and Southern United States
    Susan R Sturgeon
    Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Cancer Causes Control 14:923-31. 2003
    ..We assessed the contribution of variation in risk factor prevalence to population-density and county-level variation in breast cancer mortality rates...
  81. ncbi request reprint Time to pregnancy and secondary sex ratio in men exposed prenatally to diethylstilbestrol
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
    Am J Epidemiol 166:765-74. 2007
    ..92 (95% confidence interval: 0.80, 1.04) comparing the exposed with the unexposed. In conclusion, prenatal DES exposure was not associated with a significant decrease in either fecundability or secondary sex ratio...
  82. ncbi request reprint Risk of breast cancer in women exposed to diethylstilbestrol in utero: prelimiinary results (United States)
    Julie R Palmer
    Slone Epidemiology Unit, Boston University School of Medicine, MA 02215, USA
    Cancer Causes Control 13:753-8. 2002
    ..We evaluated the relation of in-utero DES exposure to the risk of adult breast cancer...
  83. ncbi request reprint Hypospadias in sons of women exposed to diethylstilbestrol in utero
    Julie R Palmer
    Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
    Epidemiology 16:583-6. 2005
    ..Dutch investigators have reported a 20-fold increase in risk of hypospadias among sons of women who were exposed to DES in utero. We assessed this relation in data from an ongoing study of DES-exposed persons...
  84. doi request reprint Offspring of women exposed in utero to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation
    Linda Titus-Ernstoff
    Department of Community and Family Medicine, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Epidemiology 19:251-7. 2008
    ..Specifically, these studies show an elevated incidence of reproductive tumors in the female offspring of prenatally-exposed mice...
  85. doi request reprint The association between in utero cigarette smoke exposure and age at menopause
    William C Strohsnitter
    Department of Obstetrics and Gynecology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Epidemiol 167:727-33. 2008
    ..The possibility that active cigarette smoking modifies this effect is also suggested...
  86. ncbi request reprint Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status
    Andrew G Glass
    Oncology Research, Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, USA
    J Natl Cancer Inst 99:1152-61. 2007
    ..We examined the potential association between menopausal hormone therapy use and recent changes in breast cancer incidence...
  87. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  88. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  89. ncbi request reprint Serum concentrations of estrogens, sex hormone-binding globulin, and androgens and risk of breast cancer in postmenopausal women
    Laila Adly
    Department of Epidemiology and Biostatistics, School of Public Health and Health Services, George Washington University, Washington, DC, USA
    Int J Cancer 119:2402-7. 2006
    ..6 (95% CI 0.7-3.6); p-trend = 0.13). Higher serum concentrations of estrogens were associated with increased breast cancer risk in postmenopausal women. Androgen levels were not independently associated with substantially increased risk...
  90. ncbi request reprint Age at natural menopause in women exposed to diethylstilbestrol in utero
    Elizabeth E Hatch
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Am J Epidemiol 164:682-8. 2006
    ..Age at menopause has been related, albeit inconsistently, to several exposures, but, to the authors' knowledge, this is the first study to suggest that a prenatal exposure may influence reproductive lifespan...
  91. ncbi request reprint Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES)
    Linda Titus-Ernstoff
    Department of Community and Family Medicine, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Int J Epidemiol 35:862-8. 2006
    ..We report menstrual and reproductive characteristics in a unique cohort comprising daughters of women exposed prenatally to DES...
  92. ncbi request reprint Prenatal diethylstilbestrol exposure and risk of breast cancer
    Julie R Palmer
    Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 15:1509-14. 2006
    ..The findings support the hypothesis that prenatal hormone levels influence breast cancer risk...
  93. ncbi request reprint Reproductive outcomes in men with prenatal exposure to diethylstilbestrol
    Kimberly M Perez
    Department of Social and Preventive Medicine, University of Buffalo, State of New York, Buffalo, New York, USA
    Fertil Steril 84:1649-56. 2005
    ..To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes...
  94. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  95. ncbi request reprint Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts
    Lawrence S Engel
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 67:5545-52. 2007
    ..The results from these three cohorts suggest that concentrations of certain PCBs in blood are associated with increased risk of NHL...
  96. pmc Common variants of FUT2 are associated with plasma vitamin B12 levels
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA
    Nat Genet 40:1160-2. 2008
    ..This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels...
  97. pmc Secondary sex ratio among women exposed to diethylstilbestrol in utero
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1314-9. 2007
    ..Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ratio...
  98. pmc Bladder cancer mortality and private well use in New England: an ecological study
    Joseph D Ayotte
    US Geological Survey, New Hampshire Vermont Water Science Center, Pembroke, USA
    J Epidemiol Community Health 60:168-72. 2006
    ..To investigate the possible relation between bladder cancer mortality among white men and women and private water use in New England, USA, where rates have been persistently raised and use of private water supplies (wells) common...