M J Hooth

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan
    Michelle J Hooth
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicology 301:85-93. 2012
  2. pmc Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:716-22. 2009
  3. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice
    M J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 42:1757-68. 2004
  4. ncbi request reprint Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice
    Michelle J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicology 204:123-40. 2004
  5. pmc Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene (TCAB)
    B P Singh
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233 USA
    Toxicol Pathol 38:372-81. 2010
  6. pmc Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years
    M D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, NIEHS, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 47:729-33. 2009
  7. doi request reprint Validation and application of a method for the determination of total chromium in rat tissues by inductively coupled plasma mass spectrometry
    Keith E Levine
    RTI International, Research Triangle Park, NC 27709, USA
    Arch Environ Contam Toxicol 58:883-91. 2010
  8. ncbi request reprint Subchronic sodium chlorate exposure in drinking water results in a concentration-dependent increase in rat thyroid follicular cell hyperplasia
    M J Hooth
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 29:250-9. 2001
  9. ncbi request reprint The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive
    Michelle J Hooth
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 69:322-31. 2002
  10. ncbi request reprint Analysis of preneoplastic and neoplastic renal lesions in Tsc2 mutant Long-Evans (Eker) rats following exposure to a mixture of drinking water disinfection by-products
    Kevin S McDorman
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
    Toxicology 187:1-12. 2003

Detail Information

Publications10

  1. pmc Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan
    Michelle J Hooth
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicology 301:85-93. 2012
    ....
  2. pmc Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:716-22. 2009
    ..Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI)...
  3. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice
    M J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 42:1757-68. 2004
    ..Squamous cell papillomas and carcinomas of the forestomach were observed in male and female mice but the incidences were within the NTP historical control range and were not considered to be related to trans-cinnamaldehyde exposure...
  4. ncbi request reprint Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice
    Michelle J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicology 204:123-40. 2004
    ..Treatment-related nonneoplastic lesions did not occur in mice. Treatment-related neoplastic lesions did not occur in rats or mice...
  5. pmc Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene (TCAB)
    B P Singh
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233 USA
    Toxicol Pathol 38:372-81. 2010
    ....
  6. pmc Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years
    M D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, NIEHS, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 47:729-33. 2009
    ..In male rats, a statistically significant increase in the incidence of preputial gland adenoma at 10,000 ppm was considered an equivocal finding. CPM was not carcinogenic to female rats or to male or female mice...
  7. doi request reprint Validation and application of a method for the determination of total chromium in rat tissues by inductively coupled plasma mass spectrometry
    Keith E Levine
    RTI International, Research Triangle Park, NC 27709, USA
    Arch Environ Contam Toxicol 58:883-91. 2010
    ..After validation, the method was applied to analyze samples collected in support of two chronic toxicity and carcinogenesis studies conducted by the National Toxicology Program...
  8. ncbi request reprint Subchronic sodium chlorate exposure in drinking water results in a concentration-dependent increase in rat thyroid follicular cell hyperplasia
    M J Hooth
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 29:250-9. 2001
    ..Follicular cell hyperplasia was not present in male or female B6C3F1 mice. These data can be used to estimate the human health risk that would be associated with using ClO2, rather than chlorine, to disinfect drinking water...
  9. ncbi request reprint The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive
    Michelle J Hooth
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 69:322-31. 2002
    ..This study suggests that the default assumption of additivity may overestimate the carcinogenic effect of chemical mixtures in drinking water...
  10. ncbi request reprint Analysis of preneoplastic and neoplastic renal lesions in Tsc2 mutant Long-Evans (Eker) rats following exposure to a mixture of drinking water disinfection by-products
    Kevin S McDorman
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
    Toxicology 187:1-12. 2003
    ..These data suggest that current default risk assessments assuming additivity may overstate the cancer risk associated with exposure to mixtures of DBPs at low concentrations...