Andrew Holmes

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding
    Andrew Holmes
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 15:1359-61. 2012
  2. pmc Individual differences in recovery from traumatic fear
    Andrew Holmes
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institute of Health, Bethesda, MD, USA
    Trends Neurosci 36:23-31. 2013
  3. pmc Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice
    Maxine Norcross
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2N09, Rockville, MD, 20852 9411, USA
    Psychopharmacology (Berl) 200:413-24. 2008
  4. pmc GluN2B in corticostriatal circuits governs choice learning and choice shifting
    Jonathan L Brigman
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse NIAAA, US National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Neurosci 16:1101-10. 2013
  5. pmc Chronic alcohol produces neuroadaptations to prime dorsal striatal learning
    Lauren Depoy
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 110:14783-8. 2013
  6. pmc Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress
    Janel M Boyce-Rustay
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Neuropharmacology 55:803-11. 2008
  7. pmc Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes
    Marguerite C Camp
    Laboratory of Behavioral and Genomic Neuroscience, NIAAA, Bethesda, MD, USA
    Neuropsychopharmacology 37:1534-47. 2012
  8. pmc Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 10 Room 1E 5330, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1578-89. 2009
  9. pmc Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF
    Carolyn Graybeal
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 14:1507-9. 2011
  10. pmc Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site
    Lauren Debrouse
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 37:223-33. 2013

Collaborators

Detail Information

Publications27

  1. pmc Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding
    Andrew Holmes
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 15:1359-61. 2012
    ..These findings suggest that alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear...
  2. pmc Individual differences in recovery from traumatic fear
    Andrew Holmes
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institute of Health, Bethesda, MD, USA
    Trends Neurosci 36:23-31. 2013
    ....
  3. pmc Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice
    Maxine Norcross
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2N09, Rockville, MD, 20852 9411, USA
    Psychopharmacology (Berl) 200:413-24. 2008
    ..Adverse effects of treatment with serotonin reuptake inhibitor (SRI) antidepressants have been reported in human adolescents. However, the long-term effects of chronic SRI treatment during adolescence in rodents remain unclear...
  4. pmc GluN2B in corticostriatal circuits governs choice learning and choice shifting
    Jonathan L Brigman
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse NIAAA, US National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Neurosci 16:1101-10. 2013
    ..Our convergent data demonstrate how corticostriatal GluN2B circuits govern the ability to learn and shift choice behavior. ..
  5. pmc Chronic alcohol produces neuroadaptations to prime dorsal striatal learning
    Lauren Depoy
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 110:14783-8. 2013
    ..The shift to striatal dominance over behavior may be a critical step in the progression of alcoholism. ..
  6. pmc Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress
    Janel M Boyce-Rustay
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Neuropharmacology 55:803-11. 2008
    ....
  7. pmc Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes
    Marguerite C Camp
    Laboratory of Behavioral and Genomic Neuroscience, NIAAA, Bethesda, MD, USA
    Neuropsychopharmacology 37:1534-47. 2012
    ..Collectively, these data provide convergent support for the utility of the S1 strain as a tractable model for elucidating the neural, molecular and genetic basis of persistent, excessive fear...
  8. pmc Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 10 Room 1E 5330, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1578-89. 2009
    ..These findings demonstrate that gene deletion of GLAST produces select phenotypic abnormalities related to the negative and cognitive symptoms of schizophrenia...
  9. pmc Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF
    Carolyn Graybeal
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 14:1507-9. 2011
    ..Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems...
  10. pmc Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site
    Lauren Debrouse
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 37:223-33. 2013
    ..Here, we pharmacologically interrogated this hypothesis in mice...
  11. pmc Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Neurosci 30:2318-26. 2009
    ..These findings raise the possibility that calcium signaling and other plasticity molecules may contribute to the hippocampal plasticity and behavioral deficits observed in GluR1 KO mice...
  12. pmc Reward-related behavioral paradigms for addiction research in the mouse: performance of common inbred strains
    Lauren Lederle
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e15536. 2011
    ..Overall, these assays provide robust paradigms for future studies using the mouse to elucidate the neural, molecular and genetic factors underpinning reward-related behaviors relevant to addiction research...
  13. pmc Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice
    Jessica L Ihne
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852 9411, USA
    Neuropharmacology 62:464-73. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  14. pmc Prefrontal single-unit firing associated with deficient extinction in mice
    Paul J Fitzgerald
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA Electronic address
    Neurobiol Learn Mem 113:69-81. 2014
    ..Elucidating the precise nature of these roles could help inform understanding of the pathophysiology of fear-related anxiety disorders. ..
  15. pmc Strains and stressors: an analysis of touchscreen learning in genetically diverse mouse strains
    Carolyn Graybeal
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e87745. 2014
    ..Together, these findings provide a valuable reference to inform the choice of strains and genetic backgrounds in future studies using touchscreen-based tasks. ..
  16. doi request reprint Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning
    Rebecca J Yang
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852 9411, USA
    Neuropsychopharmacology 33:2595-604. 2008
    ....
  17. pmc Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist
    Rose Marie Karlsson
    Laboratory for Clinical and Translational Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:810-4. 2008
    ....
  18. pmc Comparison of dopamine D1 and D5 receptor knockout mice for cocaine locomotor sensitization
    Rose Marie Karlsson
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane Rm 2N09, Rockville, MD 20852 9411, USA
    Psychopharmacology (Berl) 200:117-27. 2008
    ..The relative roles of D1R and D5R subtypes in mediating these effects are not clear...
  19. pmc Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcoholism and Alcohol Abuse, NIH, 10 Center Drive, 1 5330, Bethesda, MD 20892 1108, USA
    Neuropharmacology 63:181-9. 2012
    ..Endocannabinoid signaling appears to be down-regulated upstream of the CB1 receptor as a result of the GLAST deletion, and is a candidate mechanism behind the reduction of alcohol reward observed...
  20. doi request reprint Amygdala FAAH and anandamide: mediating protection and recovery from stress
    Ozge Gunduz-Cinar
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health, Bethesda, MD, USA Electronic address
    Trends Pharmacol Sci 34:637-44. 2013
    ..These preclinical findings propose restoring deficient BLA AEA levels by pharmacologically inhibiting FAAH as a mechanism to therapeutically mitigate the effects of traumatic stress...
  21. pmc Role of major NMDA or AMPA receptor subunits in MK-801 potentiation of ethanol intoxication
    Benjamin Palachick
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane Room 2N09, Rockville, MD 20852 9411, USA
    Alcohol Clin Exp Res 32:1479-92. 2008
    ..N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 (dizocilpine) interact with EtOH at the behavioral level, but the molecular basis of this interaction is unclear...
  22. pmc Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?
    Paul J Fitzgerald
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20852 9411, USA
    Neurobiol Dis 40:608-21. 2010
    ..Collectively, these findings demonstrate mania-related abnormalities in GluA1 KO and, combined with previous findings, suggest this mutant may provide a novel model of features of schizoaffective disorder...
  23. pmc Glutamatergic targets for new alcohol medications
    Andrew Holmes
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Psychopharmacology (Berl) 229:539-54. 2013
    ....
  24. pmc Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD 20852, USA
    Trends Pharmacol Sci 31:2-7. 2010
    ..More work is needed before this drug can be approved as a pharmacological adjunct for extinction-based therapies. More generally, the case of yohimbine may serve as a model for the development of other extinction facilitators...
  25. pmc How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
    ..We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species...
  26. pmc Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning
    Jonathan L Brigman
    Sections on Behavioral Science and Genetics, Synaptic Pharmacology, and Neuronal Structure, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    J Neurosci 30:4590-600. 2010
    ....
  27. ncbi request reprint The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, NIH, National Institute of Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 1 15330, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 195:547-57. 2008
    ..Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors...