A Holmes

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors
    Carly Kiselycznyk
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 2:5. 2012
  2. ncbi Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, 5625 Fishers Lane Room 2N09, Rockville, MD 20852 9411, USA
    Neurosci Biobehav Rev 32:1293-314. 2008
  3. ncbi Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction?
    A Holmes
    Laboratory for Integrative Neuroscience, Section on Behavioral Science and Genetics, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    CNS Neurol Disord Drug Targets 5:225-32. 2006
  4. ncbi Early life genetic, epigenetic and environmental factors shaping emotionality in rodents
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health, Bethesda, MD 20892 1256, Rockville, MD 20852, USA
    Neurosci Biobehav Rev 29:1335-46. 2005
  5. ncbi Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes
    Andrew Holmes
    Section on Behavioral Science and Genetics, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropharmacology 47:1117-34. 2004
  6. ncbi Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior
    Andrew Holmes
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Building 10, Room 3C217, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 178:276-85. 2005
  7. ncbi Stress-induced prefrontal reorganization and executive dysfunction in rodents
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, MD 20852 9411, USA
    Neurosci Biobehav Rev 33:773-83. 2009
  8. ncbi Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background
    A Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892 1375, USA
    Genes Brain Behav 2:365-80. 2003
  9. ncbi Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing
    Poonam Mathur
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Rockville, MD 20852 9411, USA
    Pharmacol Biochem Behav 91:453-60. 2009
  10. ncbi Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice
    Maxine Norcross
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2N09, Rockville, MD, 20852 9411, USA
    Psychopharmacology (Berl) 200:413-24. 2008

Collaborators

Detail Information

Publications82

  1. ncbi Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors
    Carly Kiselycznyk
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 2:5. 2012
    ..abstract:..
  2. ncbi Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, 5625 Fishers Lane Room 2N09, Rockville, MD 20852 9411, USA
    Neurosci Biobehav Rev 32:1293-314. 2008
    ..The current article provides an update on this rapidly evolving field of research...
  3. ncbi Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction?
    A Holmes
    Laboratory for Integrative Neuroscience, Section on Behavioral Science and Genetics, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    CNS Neurol Disord Drug Targets 5:225-32. 2006
    ....
  4. ncbi Early life genetic, epigenetic and environmental factors shaping emotionality in rodents
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health, Bethesda, MD 20892 1256, Rockville, MD 20852, USA
    Neurosci Biobehav Rev 29:1335-46. 2005
    ....
  5. ncbi Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes
    Andrew Holmes
    Section on Behavioral Science and Genetics, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropharmacology 47:1117-34. 2004
    ..In this article, we provide an update of recent studies in dopamine receptor knockout mice and discuss the limitations and future promise of this approach...
  6. ncbi Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior
    Andrew Holmes
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Building 10, Room 3C217, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 178:276-85. 2005
    ....
  7. ncbi Stress-induced prefrontal reorganization and executive dysfunction in rodents
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, MD 20852 9411, USA
    Neurosci Biobehav Rev 33:773-83. 2009
    ....
  8. ncbi Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background
    A Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892 1375, USA
    Genes Brain Behav 2:365-80. 2003
    ..Furthermore, these data highlight the utility of conducting behavioral phenotyping of mutant mice on multiple genetic backgrounds...
  9. ncbi Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing
    Poonam Mathur
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Rockville, MD 20852 9411, USA
    Pharmacol Biochem Behav 91:453-60. 2009
    ..This work could ultimately have implications for elucidating the pathophysiology of learning dysfunction in neuropsychiatric disorders and ageing...
  10. ncbi Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice
    Maxine Norcross
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2N09, Rockville, MD, 20852 9411, USA
    Psychopharmacology (Berl) 200:413-24. 2008
    ..Adverse effects of treatment with serotonin reuptake inhibitor (SRI) antidepressants have been reported in human adolescents. However, the long-term effects of chronic SRI treatment during adolescence in rodents remain unclear...
  11. ncbi Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress
    Janel M Boyce-Rustay
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Neuropharmacology 55:803-11. 2008
    ....
  12. ncbi Ethanol-related behaviors in serotonin transporter knockout mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Alcohol Clin Exp Res 30:1957-65. 2006
    ..Increasing evidence supports a role for 5-hydroxytryptamine (5-HT) and the 5-HT transporter (5-HTT) in modulating the neural and behavioral actions of ethanol (EtOH) and other drugs of abuse...
  13. ncbi Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Psychopharmacology (Berl) 187:455-66. 2006
    ..While there is compelling evidence that NMDA receptors modulate behavioral effects of ethanol, there is little understanding of how the subunit composition of the NMDA receptor mediates these effects...
  14. ncbi Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice
    A Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda MD 20892 1375, USA
    Genes Brain Behav 1:55-69. 2002
    ..A DBA/2J background may be particularly useful for investigating the genetic basis of emotional memory using fear conditioning...
  15. ncbi An investigation of the behavioral actions of ethanol across adolescence in mice
    Kathryn Hefner
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, 5625 Fishers Lane Rm 2N09, Rockville, MD 20852 9411, USA
    Psychopharmacology (Berl) 191:311-22. 2007
    ..Previous studies have found marked differences in sensitivity to the behavioral effects of EtOH in adolescent rats as compared to adults, but relatively few studies have been conducted in mice...
  16. ncbi Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression
    Andrew Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 1375, USA
    Biol Psychiatry 54:953-9. 2003
    ..Serotonin transporter null mutant mice provide a model system to study how genetic variation in serotonin transporter function affects risk for neuropsychiatric disease...
  17. ncbi Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice
    Kathryn Hefner
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, Rockville, MD 20852, USA
    Behav Brain Res 176:210-5. 2007
    ..Understanding the neural basis of these ontogenic changes could provide insight into the pathogenesis and treatment of affective disorders that have their origins in adolescence...
  18. ncbi Role of major NMDA or AMPA receptor subunits in MK-801 potentiation of ethanol intoxication
    Benjamin Palachick
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane Room 2N09, Rockville, MD 20852 9411, USA
    Alcohol Clin Exp Res 32:1479-92. 2008
    ..N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 (dizocilpine) interact with EtOH at the behavioral level, but the molecular basis of this interaction is unclear...
  19. ncbi Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues
    D B Fegley
    National Institute of Mental Health National Institutes of Health, Bethesda, MD, USA
    Genes Brain Behav 7:933-42. 2008
    ..Current data support the hypothesis that TIP39 modulates anxiety-related behaviors following environmental provocation...
  20. ncbi Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Behav Brain Res 186:133-7. 2008
    ..In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behavior-specific manner...
  21. ncbi Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for mice
    Alicia Izquierdo
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute of Alcohol Abuse and Alcoholism, NIH, Rockville, USA
    Behav Brain Res 171:181-8. 2006
    ..When combined with emerging molecular techniques uniquely suited to this species such as genetic engineering and RNA modification this paradigm could provide a powerful new tool for behavioral neuroscience...
  22. ncbi Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States
    Physiol Behav 91:77-86. 2007
    ..These data provide further evidence that stress alters the intoxicating effects of high doses of ethanol in a behaviorally selective manner...
  23. ncbi Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performance
    C C Wrenn
    Section on Behavioral Genomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuropeptides 36:413-26. 2002
    ..Several interpretations of these findings are discussed, including the possibility that a threshold level of galanin overexpression is sufficient to impair performance on learning and memory tasks in mice...
  24. ncbi Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain
    Kathryn Hefner
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, Maryland 20852, USA
    J Neurosci 28:8074-85. 2008
    ..This common inbred strain provides a novel model for studying impaired fear extinction in anxiety disorders...
  25. ncbi Effects of repeated maternal separation on prepulse inhibition of startle across inbred mouse strains
    R A Millstein
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, MD 20852, USA
    Genes Brain Behav 5:346-54. 2006
    ..The development and validation of a reliable mouse model of early life stress remains an important research goal...
  26. ncbi Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter
    Dong Kyu Kim
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropharmacology 49:798-810. 2005
    ....
  27. ncbi Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain
    M Camp
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, USA
    Genes Brain Behav 8:744-52. 2009
    ..Taken together, these data show that impaired fear extinction is a phenotypic feature common across 129 substrains, and provide preliminary evidence that impaired fear extinction in 129S1 may reflect a pro-fear incubation-like process...
  28. ncbi Genetic, pharmacological and lesion analyses reveal a selective role for corticohippocampal GLUN2B in a novel repeated swim stress paradigm
    C Kiselycznyk
    Laboratory for Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852 9411, USA
    Neuroscience 193:259-68. 2011
    ..Current findings provide further support for GluN2B as a key mechanism underlying stress responsivity, and a novel pharmacotherapeutic target for stress-related neuropsychiatric disorders...
  29. ncbi Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders
    D L Murphy
    Laboratory of Clinical Science, Building 10, Room 3D41, 10 Center Drive, NIMH, NIH DHHS, Bethesda, MD 20892 1264, USA
    Genes Brain Behav 2:350-64. 2003
    ....
  30. ncbi Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors
    L M Wiedholz
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD 20852, USA
    Mol Psychiatry 13:631-40. 2008
    ..Present findings provide novel insight into the potential role of GluR1, AMPA receptors and glutamate x DA interactions in the pathophysiology of schizophrenia and other neuropsychiatric conditions...
  31. ncbi Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice
    Jenna C Carroll
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Behav Genet 37:214-22. 2007
    ..Data provide further evidence of emotional abnormalities following genetic disruption of the 5-HTT...
  32. ncbi Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning
    Rebecca J Yang
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852 9411, USA
    Neuropsychopharmacology 33:2595-604. 2008
    ....
  33. ncbi Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Neurosci 30:2318-26. 2009
    ..These findings raise the possibility that calcium signaling and other plasticity molecules may contribute to the hippocampal plasticity and behavioral deficits observed in GluR1 KO mice...
  34. ncbi Behavioral profile of wild mice in the elevated plus-maze test for anxiety
    A Holmes
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Viale di Scienze, 43100, Parma, Italy
    Physiol Behav 71:509-16. 2000
    ....
  35. ncbi Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test
    A Holmes
    Ethopharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Behav Brain Res 122:159-67. 2001
    ....
  36. ncbi Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 10 Room 1E 5330, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1578-89. 2009
    ..These findings demonstrate that gene deletion of GLAST produces select phenotypic abnormalities related to the negative and cognitive symptoms of schizophrenia...
  37. ncbi Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?
    Paul J Fitzgerald
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20852 9411, USA
    Neurobiol Dis 40:608-21. 2010
    ..Collectively, these findings demonstrate mania-related abnormalities in GluA1 KO and, combined with previous findings, suggest this mutant may provide a novel model of features of schizoaffective disorder...
  38. ncbi Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning
    Jonathan L Brigman
    Sections on Behavioral Science and Genetics, Synaptic Pharmacology, and Neuronal Structure, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    J Neurosci 30:4590-600. 2010
    ....
  39. ncbi Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD 20852, USA
    Trends Pharmacol Sci 31:2-7. 2010
    ..More work is needed before this drug can be approved as a pharmacological adjunct for extinction-based therapies. More generally, the case of yohimbine may serve as a model for the development of other extinction facilitators...
  40. ncbi Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice
    Jonathan L Brigman
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, MD 20852 9411, USA
    Cereb Cortex 20:1955-63. 2010
    ..These findings could have important implications for understanding and treating cognitive inflexibility in neuropsychiatric disease...
  41. ncbi Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist
    Rose Marie Karlsson
    Laboratory for Clinical and Translational Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:810-4. 2008
    ....
  42. ncbi Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:1031-44. 2003
    ..These behavioral findings in the first galanin receptor null mutant mouse are consistent with the hypothesis that galanin exerts anxiolytic actions via the GAL-R1 receptor under conditions of relatively high stress...
  43. ncbi The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, NIH, National Institute of Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 1 15330, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 195:547-57. 2008
    ..Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors...
  44. ncbi Genetic relationship between anxiety-related and fear-related behaviors in BXD recombinant inbred mice
    Jonathan L Brigman
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Rockville, Maryland 20852 9411, USA
    Behav Pharmacol 20:204-9. 2009
    ..These data add to evidence that murine measures of fear-like and anxiety-like traits reflect distinct constructs mediated by dissociable gene variants...
  45. ncbi Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit
    Jonathan L Brigman
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, Maryland 20852, USA
    Learn Mem 15:50-4. 2008
    ..The present findings demonstrate a significant and selective deficit in discrimination learning following loss of NR2A...
  46. ncbi How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
    ..We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species...
  47. ncbi Comparison of dopamine D1 and D5 receptor knockout mice for cocaine locomotor sensitization
    Rose Marie Karlsson
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane Rm 2N09, Rockville, MD 20852 9411, USA
    Psychopharmacology (Berl) 200:117-27. 2008
    ..The relative roles of D1R and D5R subtypes in mediating these effects are not clear...
  48. ncbi A pharmacological analysis of mice with a targeted disruption of the serotonin transporter
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 195:147-66. 2007
    ..Partial or complete ablation of serotonin transporter (SERT) expression in mice leads to altered responses to serotonin receptor agonists and other classes of drugs...
  49. ncbi Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice
    Takanori Esaki
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:5582-7. 2005
    ..These findings have implications for understanding the potential long-term consequences of genetic and pharmacological disruption of 5-HT neurotransmission on cerebral functions during critical periods of postnatal development...
  50. ncbi Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior
    Andrew Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:2077-88. 2003
    ..5-HTT null mutant mice provide a model to investigate the role of the 5-HTT in mood and anxiety disorders...
  51. ncbi Short-term and long-term effects of postnatal exposure to an adult male in C57BL/6J mice
    Kathryn Hefner
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852 9411, USA
    Behav Brain Res 182:344-8. 2007
    ..Further studies will be needed to determine whether alternative mouse strains, exposure protocols or adult behavioral assays will produce a different pattern of short-term and long-term effects...
  52. ncbi Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USA
    Neuropsychopharmacology 31:2405-14. 2006
    ..Present results support a role for the NR2A subunit in the modulation of emotional behaviors in rodents and provide insight into the role of glutamate in the pathophysiology and treatment of mood and anxiety disorders...
  53. ncbi Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders
    Andrew Holmes
    Section on Behavioral Science and Genetics, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 24:580-8. 2003
    ....
  54. ncbi Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor
    Craige C Wrenn
    Laboratory of Behavioural Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
    Eur J Neurosci 19:1384-96. 2004
    ..The generally normal phenotype of GAL-R1 null mutants supports the use of this line for identification of the receptor subtypes that mediate the cognitive deficits produced by exogenous galanin...
  55. ncbi Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice
    Nathan R Rustay
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropeptides 39:239-43. 2005
    ..The growing body of rodent literature implicating excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer's disease...
  56. ncbi Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, NIH, Bethesda, MD 20892 1264, USA
    J Neurosci Res 79:756-71. 2005
    ....
  57. ncbi Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Synapse 56:222-5. 2005
    ..These findings confirm a major role for NMDA receptors in the acute intoxicating actions of ethanol and provide tentative support for a prepotent role of the NR2B subunit in these effects...
  58. ncbi Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice
    Alicia Izquierdo
    Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Rockville, Maryland 20852, USA
    J Neurosci 26:5733-8. 2006
    ..Present findings suggest that trauma may compromise the functional integrity of the mPFC with implications for the pathophysiology of certain neuropsychiatric disorders...
  59. ncbi Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine
    Andrew Holmes
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, LS2 9JT, Leeds, United Kingdom
    Eur J Pharmacol 459:221-30. 2003
    ..Present findings provide further evidence demonstrating that prior test history is a critical consideration in mouse studies of anxiety-related behavior...
  60. ncbi Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice
    Andrew Holmes
    Section on Behavioral Neuropharmacology, National Institute of Mental Health, NIH, Bethesda, MD 20892 1375, USA
    J Mol Neurosci 18:151-65. 2002
    ..A specific role for galanin in extreme anxiety states represents an attractive target for the development of novel anxiolytic treatments...
  61. ncbi Reduced aggression in mice lacking the serotonin transporter
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 161:160-7. 2002
    ..As a key regulator of central serotonergic activity, dysfunction of the serotonin transporter (5-HTT) represents a potential mechanism mediating pathological aggression...
  62. ncbi Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice
    Jefferson W Kinney
    Section on Behavioral Genomics, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Learn Mem 9:178-90. 2002
    ..These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks...
  63. ncbi The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors
    Heather K Caldwell
    Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Neuropeptides 40:325-37. 2006
    ..Surprisingly, our findings indicate that there is no interaction between either the Avpr1a or Avpr1b and ethanol on motor coordination, hypothermia, mood, or voluntary ethanol consumption...
  64. ncbi Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892-1264, USA
    Cell Mol Neurobiol 26:755-80. 2006
    ....
  65. ncbi Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains
    Rachel A Millstein
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 2N09, Rockville, MD 20852, USA
    Neurosci Biobehav Rev 31:3-17. 2007
    ..Data demonstrate that the MS procedure employed does not provide a robust model of early life stress effects on the anxiety- and depression-related behaviors in the mouse strains tested...
  66. ncbi Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892 1375, USA
    Neuropsychopharmacology 27:914-23. 2002
    ..5-HTT knockout mice provide a valuable tool for delineating the neuropsychopharmacological actions of antidepressants...
  67. ncbi Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice
    Rose Marie Karlsson
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm Laboratory of Clinical Science, NIAAA, NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 80:427-36. 2005
    ..These findings provide a basis for future studies of mice with targeted gene mutations, directed at delineating the anatomical regions and receptor subtypes mediating the effects of NPY and GAL on emotion...
  68. ncbi Stress-induced impairments in prefrontal-mediated behaviors and the role of the N-methyl-D-aspartate receptor
    C Graybeal
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892 9304, USA
    Neuroscience 211:28-38. 2012
    ..Future work in this area could open up new avenues for developing pharmacotherapies for ameliorating cognitive dysfunction in neuropsychiatric disease...
  69. ncbi Targeted gene mutation approaches to the study of anxiety-like behavior in mice
    A Holmes
    Section on Behavioral Pharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892 1375, USA
    Neurosci Biobehav Rev 25:261-73. 2001
    ..With enhanced spatial and temporal control over gene mutations, in combination with an improved battery of behavioral tests, gene mutant mice will provide an increasingly valuable tool for understanding the neural substrates of anxiety...
  70. ncbi Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease
    R M Karlsson
    Laboratory of Clinical and Translational Science, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20892, U S A
    Amino Acids 31:231-9. 2006
    ....
  71. ncbi Behavioral characterization of dopamine D5 receptor null mutant mice
    A Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1375, USA
    Behav Neurosci 115:1129-44. 2001
    ....
  72. ncbi Restraint stress and exogenous corticosterone differentially alter sensitivity to the sedative-hypnotic effects of ethanol in inbred long-sleep and inbred short-sleep mice
    Clarissa Carlin Parker
    Center for Neuroscience, Boulder, CO, USA
    Alcohol 42:477-85. 2008
    ....
  73. ncbi Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain
    Leonardo H Tonelli
    Laboratory of Behavioral Neuroimmunology, Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21201 1549, MD, USA
    Neuropsychopharmacology 33:1038-48. 2008
    ..These results further our understanding of the role that the immune system may play in the pathophysiology of depression...
  74. ncbi Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 26:6431-8. 2006
    ..The present findings provide new insights into the actions of ethanol on brain function and behavior...
  75. ncbi Vulnerability to mild predator stress in serotonin transporter knockout mice
    Robert Adamec
    Department of Psychology, Memorial University, 232 Elizabeth Avenue, St John s, Nfld, Canada A1B 3X9
    Behav Brain Res 170:126-40. 2006
    ..Findings suggest a role for abnormalities in 5-HT transmission in vulnerability to some of the lasting anxiogenic effects of species relevant stressors and possibly in vulnerability to PTSD...
  76. ncbi The ascent of mouse: advances in modelling human depression and anxiety
    John F Cryan
    Neuroscience Research, Novartis Institutes for BioMedical Research, Basel CH 4055, Switzerland
    Nat Rev Drug Discov 4:775-90. 2005
    ..Here, we assess the current status of research into developing appropriate tests for assessing such behaviours...
  77. ncbi Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0431, USA
    J Neurosci 24:10868-77. 2004
    ..Thus, the present results demonstrate that medial hypothalamic 5-HT1A receptors regulate stress responses and locomotor activity but may not regulate exploratory anxiety-like behaviors...
  78. ncbi The role of galanin in modulating stress-related neural pathways
    Craige C Wrenn
    Pharmacology at Drake University, College of Pharmacy and Health Sciences, Des Moines, IA 50311, USA
    Drug News Perspect 19:461-7. 2006
    ..This link suggests that galaninergic drugs could provide a novel therapeutic option for psychopathologies, such as post-traumatic stress syndrome, in which abnormal memory and emotion are intertwined...
  79. ncbi Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells
    Lijun Wang
    Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia
    Circ Res 97:891-9. 2005
    ..Thus, interventions that target the SphK-signaling pathway may have the potential to prevent vascular lesions under hyperglycemic conditions...
  80. ncbi Genetics of emotional regulation: the role of the serotonin transporter in neural function
    Ahmad R Hariri
    Department of Psychiatry and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Trends Cogn Sci 10:182-91. 2006
    ..The study of the 5-HTT provides a new foundation for understanding the neurobiological and genetic basis of emotional regulation and affective illness...
  81. ncbi Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Behav Genet 37:223-43. 2007
    ..Other candidates include Large, and Thra. Responses to drugs of abuse and locomotor activity were the most notable behavioral correlates of the BLAc traits...
  82. ncbi Recent developments in the use of animal models of psychiatric disease--introduction to special issue
    Gene S Fisch
    Department of Statistics, Yeshiva College, Yeshiva University, New York, NY 10031, USA
    Behav Genet 37:259-63. 2007