Mark J Hoenerhoff

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC 27519, USA
    Toxicol Pathol 41:826-41. 2013
  2. doi Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 39:678-99. 2011
  3. doi Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer
    Arun R Pandiri
    Cellular and Molecular Pathology Branch, National Toxicology Program NTP, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 40:1141-59. 2012
  4. doi Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation
    Schantel A Hayes
    Charles River Laboratories, Pathology Associates, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 44:71-87. 2016
  5. doi Spontaneous mesotheliomas in F344/N rats are characterized by dysregulation of cellular growth and immune function pathways
    Pamela E Blackshear
    Integrated Laboratory Systems, Inc, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 42:863-76. 2014
  6. doi Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice
    Sachin Bhusari
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:1114-26. 2015
  7. doi Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women
    Janice B Harvey
    Cellular and Molecular Pathology Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    Toxicol Pathol 43:1103-13. 2015
  8. doi Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal
    Hue Hua L Hong
    Cellular and Molecular Pathology Branch, Division of the National Toxicology Program NTP, National Institute of Environmental Health Science NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:872-82. 2015
  9. pmc Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways
    Pamela E Blackshear
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Integrated Laboratory Systems, Inc, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:171-85. 2015
  10. doi Perfluorooctanoic Acid (PFOA)-induced Liver Lesions in Two Strains of Mice Following Developmental Exposures: PPARα Is Not Required
    Adam J Filgo
    Curriculum in Toxicology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina, USA NTP Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:558-68. 2015

Collaborators

Detail Information

Publications15

  1. doi Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC 27519, USA
    Toxicol Pathol 41:826-41. 2013
    ..The molecular changes observed in HCC from GBE-treated animals may be of relevance to those seen in human HCC and other types of cancer, and provide important data on potential mechanisms of GBE hepatocarcinogenesis. ..
  2. doi Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 39:678-99. 2011
    ....
  3. doi Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer
    Arun R Pandiri
    Cellular and Molecular Pathology Branch, National Toxicology Program NTP, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 40:1141-59. 2012
    ....
  4. doi Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation
    Schantel A Hayes
    Charles River Laboratories, Pathology Associates, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 44:71-87. 2016
    ....
  5. doi Spontaneous mesotheliomas in F344/N rats are characterized by dysregulation of cellular growth and immune function pathways
    Pamela E Blackshear
    Integrated Laboratory Systems, Inc, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 42:863-76. 2014
    ..Alterations in these pathways in turn trigger molecular responses that stimulate cell proliferation and promote tumor survival and progression. ..
  6. doi Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice
    Sachin Bhusari
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:1114-26. 2015
    ..Furthermore, mouse HB is similar to the human disease at the pathway level and therefore is likely a relevant model for evaluating human cancer hazard. ..
  7. doi Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women
    Janice B Harvey
    Cellular and Molecular Pathology Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    Toxicol Pathol 43:1103-13. 2015
    ..The morphologic and molecular features of uterine carcinomas in TBBPA-exposed rats resemble those of high-grade type I tumors in women, and these data suggest that exposure to TBBPA may pose an increased cancer risk. ..
  8. doi Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal
    Hue Hua L Hong
    Cellular and Molecular Pathology Branch, Division of the National Toxicology Program NTP, National Institute of Environmental Health Science NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:872-82. 2015
    ..Thus, the mutation data (G to T transversions) and Ames assay results suggest that oxidative damage to DNA may be a contributing factor in CMD-induced pulmonary carcinogenesis in rodents. ..
  9. pmc Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways
    Pamela E Blackshear
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Integrated Laboratory Systems, Inc, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:171-85. 2015
    ..These data suggest that a chronic, pro-inflammatory environment associated with VDC exposure may exacerbate disturbances in oncogene, growth factor, and cell cycle regulation, resulting in an increased incidence of mesothelioma. ..
  10. doi Perfluorooctanoic Acid (PFOA)-induced Liver Lesions in Two Strains of Mice Following Developmental Exposures: PPARα Is Not Required
    Adam J Filgo
    Curriculum in Toxicology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina, USA NTP Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 43:558-68. 2015
    ..Low-dose gestational exposures to PFOA induced latent PPARα-independent liver toxicity that was observed in aged mice. Evidence of liver toxicity in PPARα-KO mice warrants further investigation into PPARα-independent pathways. ..
  11. pmc Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies
    Christopher Koivisto
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 40:751-63. 2012
    ..This is the first study to describe the immunophenotype of islet cell tumors in the F344 rat and to show that islet cell tumors in the F344 rat exhibit similarities in protein expression to the human counterpart...
  12. doi Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene
    Sachin Bhusari
    1Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 42:555-64. 2014
    ..In conclusion, TCAB is carcinogenic at multiple sites in male and female B6C3F1 mice through mechanisms involving Tp53 and Kras mutation. ..
  13. doi Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors
    Arun R Pandiri
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 39:1065-74. 2011
    ..In conclusion, the AVNWLE-induced large intestinal tumors in F344 rats share several similarities with hCRC at the morphological and molecular levels...
  14. pmc A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27519, USA
    Toxicol Pathol 37:835-48. 2009
    ..These studies also emphasize the importance of molecular evaluation of chemically induced rodent tumors for providing greater public health significance for NTP evaluated compounds...
  15. doi Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA)
    Erin M Quist
    NTP Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Cellular and Molecular Pathology Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Comparative Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    Toxicol Pathol 43:546-57. 2015
    ..These findings suggest that peroxisome proliferation is not a component of PFOA-induced hepatic toxicity in animals that are prenatally exposed to low doses of PFOA. ..