Research Topics
Genomes and Genes
Species | Colin A HodgkinsonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Addictions biology: haplotype-based analysis for 130 candidate genes on a single arrayColin A Hodgkinson
Laboratory of Neurogenetics, NIAAA, 5625 Fishers Lane, Room 3S32 MSC9412, Rockville, MD 20852 1728, USA
Alcohol Alcohol 43:505-15. 2008..To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety...- Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorderColin A Hodgkinson
Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Am J Hum Genet 75:862-72. 2004..These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders... 
The FEZ1 gene shows no association to schizophrenia in Caucasian or African American populationsColin A Hodgkinson
Section of Human Neurogenetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
Neuropsychopharmacology 32:190-6. 2007..Neuropsychopharmacology (2007) 32, 190-196. doi:10.1038/sj.npp.1301177; published online 16 August 2006...- Genome-wide association identifies candidate genes that influence the human electroencephalogramColin A Hodgkinson
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Proc Natl Acad Sci U S A 107:8695-700. 2010..We also found association of SGIP1 with alcoholism, an effect that may be mediated via the same brain mechanisms accessed by theta EEG, and which also provides validation of the use of EEG as an endophenotype for alcoholism... - Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populationsZhifeng Zhou
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville 20852, USA
Arch Gen Psychiatry 62:1109-18. 2005.... - Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populationsInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
J Hum Genet 49:232-45. 2004..The SLC6A2 haplotype map and 25-marker panel (excluding the monomorphic one) is a comprehensive tool for genetic linkage studies on phenotypes related to NET function... - Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each geneInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
J Hum Genet 50:12-20. 2005..The alpha2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknown alpha2-AR functional loci... - Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaquesChristina S Barr
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
Arch Gen Psychiatry 64:369-76. 2007..In humans, a variant of the mu-opioid receptor gene (OPRM1A118G) increases receptor affinity, alcohol-induced euphoria, and risk for alcohol use disorders... - Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigmSimona Spinelli
National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, P O Box 529, Poolesville, MD 20837, USA
Dev Psychopathol 19:977-87. 2007.... - Neurophysiological and genetic distinctions between pure and comorbid anxiety disordersMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
Depress Anxiety 25:383-92. 2008..This refinement of the anxiety phenotype may have implications for therapeutic interventions... - Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primatesChristina S Barr
National Institute on Alcoholism and Alcohol Abuse, Laboratory of Clinical Studies and National Institute of Child Health and Human Development, Laboratory of Comparative Ethology, National Institutes of Health, Poolesville, MD, USA
Arch Gen Psychiatry 61:1146-52. 2004.... - Functional CRH variation increases stress-induced alcohol consumption in primatesChristina S Barr
Laboratory of Clinical and Translational Studies, National Institutes of Health National Institutes on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:14593-8. 2009..Our data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals... - Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaquesStephen G Lindell
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
Arch Gen Psychiatry 67:423-31. 2010..In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence... - The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependenceMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
Biol Psychiatry 67:20-7. 2010..Early life stress has been shown to alter GABRA2 expression in adult rodents. We hypothesized that childhood trauma, GABRA2 variation, and their interaction would influence addiction vulnerability... - Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American IndiansMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
Alcohol Clin Exp Res 30:399-406. 2006.... - GABRG1 and GABRA2 as independent predictors for alcoholism in two populationsMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 34:1245-54. 2009..05) extended haplotypes showed an association with AUD that was determined by GABRA2. Our results suggest that there are likely to be independent, complex contributions from both GABRG1 and GABRA2 to alcoholism vulnerability... - Using ancestry-informative markers to define populations and detect population stratificationMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
J Psychopharmacol 20:19-26. 2006.... - Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaquesChristina S Barr
Primate Unit, Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
Proc Natl Acad Sci U S A 101:12358-63. 2004..This interactive effect may underlie the increased incidence of certain stress-related disorders in women... - A clinical genetic method to identify mechanisms by which pain causes depression and anxietyMitchell B Max
Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
Mol Pain 2:14. 2006..We seek molecules that show a significant statistical interaction between (1) the amount of surgical pain relief, and (2) the alleles of the gene, on depression and anxiety during the first postoperative year... - Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African AmericansInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Eur J Hum Genet 13:341-51. 2005..This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function... - Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populationsGabor Oroszi
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Alcohol Clin Exp Res 29:303-9. 2005..In two ethnically distinct populations, we tested whether the Thr105Ile polymorphism was associated with alcoholism and with harm avoidance, a dimensional measure of anxious personality... - Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populationsJixia Liu
From the Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
Alcohol Clin Exp Res 35:304-16. 2011..We investigated whether variation in alcohol metabolism genes might alter the AD risk in four non-East Asian populations by performing systematic haplotype association analyses to maximize the chances of capturing functional variation... - Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processingJurgen Gallinat
Laboratory for Clinical Psychophysiology, Department of Psychiatry, Free University, Berlin, Germany and National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 54:40-8. 2003..It was predicted that homozygous Met allele carriers have a lower frontal P300 amplitude... - Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populationsJordi Clarimon
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Alcohol Clin Exp Res 31:546-54. 2007..Recent studies, in humans and in rat and monkey models, have suggested that alpha-synuclein may play a role in the development and maintenance of certain addictive disorders... - Genetics of alcoholism using intermediate phenotypesMARY ANNE ENOCH
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
Alcohol Clin Exp Res 27:169-76. 2003..Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson... - Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populationsFrancesca Ducci
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892, USA
Alcohol 41:3-12. 2007..Even in alcoholics with long-term exposure to the anxiogenic effects of repeated cycles of alcohol withdrawal, genetic and other familial influences seem to play a role in moderating anxiety... - Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BPMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 3:e3620. 2008..Our results suggest a likely role for CRH-BP in stress-related alcoholism and highlight the use of the resting EEG as an intermediate phenotype for arousal-related behaviors such as anxiety and addiction... - Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populationsKe Xu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Arch Gen Psychiatry 61:597-606. 2004..Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial... - Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletionAbigail A Marsh
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 189:387-94. 2006..Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed... - Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophreniaTerry E Goldberg
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 60:889-96. 2003..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia... - Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screenInna Belfer
National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA
Int J Stroke 5:145-51. 2010..The aim of this study was to evaluate the role of single-nucleotide polymorphisms (SNPs) and haplotypes in inflammatory genes as they relate to symptomatic carotid atherosclerosis... - Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene clusterMarta Radel
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
Arch Gen Psychiatry 62:47-55. 2005.... - Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primatesChristina S Barr
Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:5277-81. 2008..These findings suggest a role for OPRM1 variation in the expression of attachment behavior in human subjects, especially as a function of separation from the caregiver... - Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorderXian Zhang Hu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Am J Hum Genet 78:815-26. 2006..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD... - Association of COMT Val158Met genotype with executive functioning following traumatic brain injuryRobert H Lipsky
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
J Neuropsychiatry Clin Neurosci 17:465-71. 2005.... - Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphismMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Psychiatr Genet 13:33-41. 2003.... - The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasksElizabeth C Finger
Mood and Anxiety Disorders Program, Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 32:206-15. 2007..Furthermore, they demonstrate behavioral differences in responses to punishing stimuli between long allele homozygotes and short allele carriers when serotonin levels are acutely reduced... - Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholismMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
Am J Med Genet B Neuropsychiatr Genet 141:599-607. 2006..Our results suggest that within the distal GABRA2 region is a functional locus or loci that may differ between populations but that alters risk for alcoholism via the mediating action of anxiety... - Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholicsVibhuti Srivastava
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, MD 20851, USA
Neuropsychopharmacology 35:1120-8. 2010..The risk/protective effect was observed in alcoholics with lower levels of lifetime alcohol consumption. Highest levels of exposure may overwhelm the protective action of the SOD2 enzyme... - An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism riskXianzhang Hu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
Alcohol Clin Exp Res 29:8-16. 2005.... - Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperamentHyungsuk Kim
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 center Dr Building 10 Rm 1N103, Bethesda, MD 20892-1197, USA
Pain 109:488-96. 2004..Our observations demonstrate that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms... - Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assayGuanshan Zhu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Dr, Rockville, MD 20852, USA
Psychopharmacology (Berl) 177:178-84. 2004..The Met158 allele predicts higher mRNA expression in both brain and lymphoblasts. As exemplified here, the RT-coupled 5' nuclease assay is a reliable method for the quantitative evaluation of cis-acting regulatory effects... - Expansion of the human mu-opioid receptor gene architecture: novel functional variantsSvetlana A Shabalina
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Hum Mol Genet 18:1037-51. 2009..Our results provide evidence for an essential role for MOR-1K isoforms in nociceptive signaling and suggest that genetic variations in alternative OPRM1 isoforms may contribute to individual differences in opiate responses... - Imaging genomics applied to anxiety, stress response, and resiliencyKe Xu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcohollism, National Institute of Health, Rockville, MD 20852, USA
Neuroinformatics 4:51-64. 2006..These results suggest that functional variants of 5-HTT and COMT impact brain functions involved in stress and anxiety... - Zhou et al. replyZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 458:E7. 2009..Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results... - Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?Bikash K Mishra
Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
Mol Pain 3:20. 2007..We demonstrate an analytic method that we applied to 14 of these genes in 290 patients with acute sciatica, whose reduction in movement was estimated by items from the Roland-Morris Disability Questionnaire... - Genetic variation in human NPY expression affects stress response and emotionZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 452:997-1001. 2008..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases... - Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletionAllison C Nugent
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
Neuroimage 43:764-74. 2008..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category... - Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcoholZhifeng Zhou
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20849, USA
Proc Natl Acad Sci U S A 108:6626-31. 2011.... - Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humansAlexander Neumeister
Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
Pharmacogenet Genomics 15:143-9. 2005..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk... - Association of multiple DRD2 polymorphisms with anorexia nervosaAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
Neuropsychopharmacology 30:1703-10. 2005..Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN... - Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sampleKe Xu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland 20852, USA
Am J Med Genet 110:45-50. 2002..Therefore, these data do not support an association between the OPRD1 gene and heroin dependence in the Chinese population... - Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stressChristina S Barr
Labortatory of Clinical Studies, Primate Unit, National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, PO Box 529, Building 112, Poolesville, MD 20837, USA
Alcohol Clin Exp Res 27:812-7. 2003..In addition, we have demonstrated that macaques separated from their mothers and reared in peer-only groups are more likely to consume alcohol as adults... - The relationship between two intermediate phenotypes for alcoholism: low voltage alpha EEG and low P300 ERP amplitudeMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
J Stud Alcohol 63:509-17. 2002..A few studies have demonstrated a modest correlation between pre-stimulus alpha power and P300 amplitude. We aimed to test this finding in community volunteers, hypothesizing that LVA would be associated with low P300 amplitude... - Serotonin transporter genetic variation and the response of the human amygdalaAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Science 297:400-3. 2002.... - Genetics of emotionLaura Bevilacqua
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
Trends Cogn Sci 15:401-8. 2011..The effects of these genes can be validated by neuroimaging, neuroendocrine and other studies accessing intermediate phenotypes, deepening our understanding of mechanisms of emotion and variation in emotionality... - The genetics of addictions: uncovering the genesDavid Goldman
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
Nat Rev Genet 6:521-32. 2005.... - Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample sizeInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Anesthesiology 100:1562-72. 2004 - Genetics of human prefrontal functionGeorg Winterer
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Brain Res Brain Res Rev 43:134-63. 2003..Special emphasis is also given to methodological concerns that need to be addressed when conducting research on the genetics of prefrontal function in humans... - Single-nucleotide polymorphism allele frequencies determined by quantitative kinetic assay of pooled DNAKe Xu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism/NIH, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Rockville, MD 20852, USA
Clin Chem 48:1605-8. 2002 - Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypesDavid Goldman
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
ScientificWorldJournal 7:124-30. 2007.... - GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP ratsMARY ANNE ENOCH
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 7:e29369. 2012.... - Problem drinking and alcoholism: diagnosis and treatmentMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
Am Fam Physician 65:441-8. 2002.... - A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behaviorRickard L Sjoberg
Uppsala University Centre for Clinical Research, Central Hospital, Vasteras, Sweden
Neuropsychopharmacology 33:425-30. 2008.... - Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humansMary R Lee
National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America
PLoS ONE 6:e24203. 2011.... - The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionMichael F Egan
Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
Cell 112:257-69. 2003..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF... - Non-human primate models of inheritance vulnerability to alcohol use disordersChristina S Barr
NIH NIAAA, Laboratory of Clinical and Translational Studies, Poolesville, MD 20837, USA
Addict Biol 11:374-85. 2006..Non-human primate models may also have translational value for understanding of how variants within addiction and abuse vulnerability genes influence alcohol-induced neuroadaptation, neuropathology and treatment response... - NPY Leu7Pro and alcohol dependence in Finnish and Swedish populationsGuanshan Zhu
Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, USA
Alcohol Clin Exp Res 27:19-24. 2003..Recently, this polymorphism was also reported to be associated with an actual diagnosis of alcohol dependence... - CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaquesChristina S Barr
Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
Arch Gen Psychiatry 65:934-44. 2008..As such, CRH gene variation may influence risk for alcohol use and dependence... - G x E: a NIAAA workshop on gene-environment interactionsLorraine Gunzerath
NIAAA Office of Scientific Affairs, National Institutes of Health, 6000 Executive Blvd, Suite 409, Bethesda, MD 20892 7003, USA
Alcohol Clin Exp Res 27:540-62. 2003.... - Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood traumaMARY ANNE ENOCH
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA Electronic address
J Psychiatr Res 47:900-7. 2013..25 in individuals without either risk variant. Our findings suggest that the 5' and 3'SLC6A4 functional variants have independent effects on the risk for suicidal behavior in CT exposed individuals... - BDNF polymorphism-dependent OFC and DLPFC plasticity differentially moderates implicit and explicit biasChad E Forbes
Imaging Sciences Training Program, Radiology and Imaging Sciences, Clinical Center and National Institute of Biomedical Imaging and Bioengineering, National, Institutes of Health, Bethesda, MD 20892, USA
Cereb Cortex 22:2602-9. 2012..Findings suggest that plasticity within specific PFC regions modulates the type and degree of social bias that individuals' exhibit... - A population-specific HTR2B stop codon predisposes to severe impulsivityLaura Bevilacqua
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland 20852, USA
Nature 468:1061-6. 2010..Our study shows the potential for identifying and tracing effects of rare alleles in complex behavioural phenotypes using founder populations, and indicates a role for HTR2B in impulsivity... - Striatal dopamine release and genetic variation of the serotonin 2C receptor in humansBrian J Mickey
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 5720, USA
J Neurosci 32:9344-50. 2012..Mesoaccumbal stress sensitivity may mediate the effects of HTR2C variation on risk of neuropsychiatric disorders... 
A large-scale candidate gene analysis of mood disorders: evidence of neurotrophic tyrosine kinase receptor and opioid receptor signaling dysfunctionAnthony J Deo
Department of Psychiatry, Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
Psychiatr Genet 23:47-55. 2013....- A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversityMichael V Osier
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Hum Genet 71:84-99. 2002..It seems unlikely that this haplotype, which is rare or unobserved in other populations, reached such high frequency because of random genetic drift alone... - Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groupsMichael J Minzenberg
Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
Psychiatr Genet 16:117-24. 2006..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder... - The human genome: mutationsMichael Egan
Am J Psychiatry 159:12. 2002 - Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependenceAndreas Heinz
Department of Psychiatry, Campus Charite Mitte, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
Psychopharmacology (Berl) 174:561-70. 2004..The severity and time-course of recovery of these neuroadaptive changes may depend on the genetic constitution of monoamine transporters and receptors and contribute to the relapse risk of alcoholics... - Biological and behavioral markers of alcohol sensitivityKim Fromme
Department of Psychology, The University of Texas at Austin, Austin, Texas 78712, USA
Alcohol Clin Exp Res 28:247-56. 2004..Dr. David Goldman provides concluding remarks... - A functional polymorphism in the COMT gene and performance on a test of prefrontal cognitionAnil K Malhotra
Unit of Molecular Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
Am J Psychiatry 159:652-4. 2002..The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. The current study investigated whether prefrontal cognition varies with COMT genotype... - DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patientsTodd Lencz
Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Am J Psychiatry 163:529-31. 2006.... - Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorderAlessandro Rotondo
Department of Psychiatry, University of Pisa, Italy
Am J Psychiatry 159:23-9. 2002.... - Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortexMichael N Smolka
Central Institute of Mental Health, 68159 Mannheim, Germany
J Neurosci 25:836-42. 2005.... - Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brainRamin V Parsey
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
Am J Psychiatry 163:48-51. 2006.... - Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseasesJinong Feng
Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
Am J Med Genet B Neuropsychiatr Genet 133:50-3. 2005..One uncommon missense variant was found in each of the RARbeta, RARgamma, and RXRgamma genes. We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia... - DISC1 and neurocognitive function in schizophreniaKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
Neuroreport 16:1399-402. 2005..These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia... - A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependenceSalim Mottagui-Tabar
Karolinska Institute, Center for Genomics and Bioinformatics, Stockholm, Sweden
Alcohol Clin Exp Res 29:702-7. 2005..The aim of this study was to examine whether polymorphic variants of the NPY gene are associated with the diagnosis of alcohol dependence... - Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorderLuda Diatchenko
University of North Carolina, Center for Neurosensory Disorders, North Carolina, USA
Am J Med Genet B Neuropsychiatr Genet 141:449-62. 2006.... - Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaquesChristina S Barr
Laboratory of Clinical Studies, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Poolesville, Maryland 20837, USA
Biol Psychiatry 55:733-8. 2004..CONCLUSIONS: These data demonstrate that serotonin transporter gene variation affects LHPA axis activity and that the influence of rh5-HTTLPR on hormonal responses during stress is modulated by early experience... - Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivoBrian J Mickey
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
J Neurosci 28:11354-9. 2008..These results demonstrate a sex-specific interaction between two key molecules of the human serotonergic system, and suggest a neurobiological basis for sexual dimorphism in serotonin-modulated phenotypes... - Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian populationConnie J Mulligan
Department of Anthropology, University of Florida, PO Box 117305, Gainesville, FL 32611, USA
Hum Genet 113:325-36. 2003..These data strengthen the support for ADH as a candidate locus for alcohol dependence and suggest further productive study... - Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomographyMaria A Oquendo
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Arch Gen Psychiatry 64:201-8. 2007..Associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterations in serotonergic neurotransmission in bipolar depression remains scant... - Patterns of menstrual disturbance in eating disordersAndréa Poyastro Pinheiro
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 40:424-34. 2007..To describe menstrual disturbance in eating disorders (ED)... - Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in childrenJennifer H Barnett
University of Cambridge, Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Am J Psychiatry 164:142-9. 2007..This polymorphism affects cognitive function in healthy adults and may contribute to risk for schizophrenia... - Disrupted in schizophrenia 1 genotype and positive symptoms in schizophreniaPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Biol Psychiatry 61:1208-10. 2007.... - COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressorJon Kar Zubieta
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
Science 299:1240-3. 2003..The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli... - Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controlsAlexander Neumeister
Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
Arch Gen Psychiatry 63:978-86. 2006.... - DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophreniaPhilip R Szeszko
Feinstein Institute for Medical Research, Manhasset, NY, USA
Biol Psychol 79:103-10. 2008..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology... - Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
Alcohol Clin Exp Res 32:785-95. 2008..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence... - Investigation of DUSP8 and CALCA in alcohol dependenceRaquel L Hink
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Addict Biol 8:305-12. 2003..Genotyping of this functional variant in 463 Southwestern Native Americans revealed no significant association between the DUSP8 C712T (Ala193Val) polymorphism and alcohol dependence (odds ratio = 1.48 95% CI 0.6-3.92)...