D R Hodge

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi IL-6 induces expression of the Fli-1 proto-oncogene via STAT3
    David R Hodge
    Intramural Research Support Program, NCI Cancer Research and Development Center at Frederick, Bld. 560, Rm. 31-76, Frederick, MD 21702, USA
    Biochem Biophys Res Commun 292:287-91. 2002
  2. ncbi Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cancer Biol Ther 3:188-94. 2004
  3. ncbi Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cancer Biol Ther 4:585-92. 2005
  4. ncbi Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Cancer Res 65:4673-82. 2005
  5. ncbi Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells
    D R Hodge
    Intramural Research Support Program, SAIC Frederick, NCI Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, MD 21702, USA
    J Biol Chem 276:39508-11. 2001
  6. ncbi Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells
    Benjamin Peng
    Cytokine Molecular Mechanisms Section, Laboratory of Molecular Immunoregulation, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 280:4182-7. 2005
  7. ncbi Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line
    Celine Pompeia
    Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Cancer Res 64:3465-73. 2004
  8. ncbi Sequence diversity of SIV(Mne) Nef in vivo and in vitro
    G Heidecker
    SAIC NCI FCRDC, Frederick, Maryland 21702, USA
    J Med Primatol 27:73-80. 1998
  9. ncbi Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
    Cancer Res 65:6255-63. 2005
  10. ncbi NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells
    Weihua Xiao
    Basic Research Program, SAIC Frederick, Frederick, Maryland, USA
    Cancer Biol Ther 3:1007-17. 2004

Collaborators

Detail Information

Publications18

  1. ncbi IL-6 induces expression of the Fli-1 proto-oncogene via STAT3
    David R Hodge
    Intramural Research Support Program, NCI Cancer Research and Development Center at Frederick, Bld. 560, Rm. 31-76, Frederick, MD 21702, USA
    Biochem Biophys Res Commun 292:287-91. 2002
    ..Upregulation of Fli-1 expression can be abrogated by the addition of AG490, a chemical inhibitor of JAK kinases, and by transfecting the cells with a dominant negative STAT3 expression construct...
  2. ncbi Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cancer Biol Ther 3:188-94. 2004
    ..Our data suggests that mechanisms of resistance to induced apoptosis and cellular proliferation are separate and distinct in cytokine dependent myeloma cells...
  3. ncbi Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cancer Biol Ther 4:585-92. 2005
    ..Infection of KAS 6/1 cells with a recombinant adenovirus carrying the MnSOD cDNA reduced the cell proliferation rate by approximately one-half, confirming the detrimental effects of epigenetic silencing of SOD-2 expression...
  4. ncbi Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Cancer Res 65:4673-82. 2005
    ..Therefore, it seems IL-6 is capable of maintaining promoter methylation thus representing one of the possible mechanisms used by inflammatory mediators in the growth and survival of tumors...
  5. ncbi Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells
    D R Hodge
    Intramural Research Support Program, SAIC Frederick, NCI Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, MD 21702, USA
    J Biol Chem 276:39508-11. 2001
    ..Furthermore, IL-6 regulation of transcription factors like Fli-1, which can help to direct cells along opposing differentiation pathways, may in fact be reflected in part by their ability to regulate the methylation of cellular genes...
  6. ncbi Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells
    Benjamin Peng
    Cytokine Molecular Mechanisms Section, Laboratory of Molecular Immunoregulation, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 280:4182-7. 2005
    ....
  7. ncbi Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line
    Celine Pompeia
    Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Cancer Res 64:3465-73. 2004
    ....
  8. ncbi Sequence diversity of SIV(Mne) Nef in vivo and in vitro
    G Heidecker
    SAIC NCI FCRDC, Frederick, Maryland 21702, USA
    J Med Primatol 27:73-80. 1998
    ..Propagation of virus with MAnef in tissue culture resulted in the rapid emergence of variants with newly attenuated nef. These findings suggest that the selective pressure on nef in vivo and in vitro are different...
  9. ncbi Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
    Cancer Res 65:6255-63. 2005
    ..These results show the importance of free radical-mediated dysregulation of autocrine growth factor loops in tumor cells and their effect on cell growth and response to chemotherapy...
  10. ncbi NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells
    Weihua Xiao
    Basic Research Program, SAIC Frederick, Frederick, Maryland, USA
    Cancer Biol Ther 3:1007-17. 2004
    ....
  11. ncbi Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT
    X Y Yang
    Intramural Research Support Program, SAIC Frederick, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 275:4541-4. 2000
    ....
  12. ncbi Transcriptional activation analysis using bioluminescent reporter assays
    D R Hodge
    Laboratory for Molecular Immunoregulation, NCI FCRDC NIH, Frederick, MD, USA
    Mol Biotechnol 16:67-76. 2000
    ..In addition, bioluminescent reporter vectors are more sensitive than previous methods such as the chloramphenicol acetyl transferase (CAT) systems, that require the use of hazardous chemicals and isotopically labeled reagents...
  13. ncbi Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex
    Y Feng
    Biological Mechanisms Section, Laboratory of Leukocyte Biology, NCI FCRDC, Frederick, MD 21702, USA
    Biochem J 339:435-42. 1999
    ..The specific interaction between Plk and tubulins might provide a molecular basis for the physiological functions of Plk in regulating the cell cycle, particularly in establishing the normal bipolar spindle...
  14. ncbi Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein
    D R Hodge
    Laboratory of Leukocyte Biology, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 273:15727-33. 1998
    ..This interaction may account for the Nef-induced perturbations of T-cell signaling and activation pathways in vitro and in vivo...
  15. ncbi Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells
    Weihua Xiao
    Basic Research Program, SAIC Frederick, Laboratory of Molecular Immunoregulation, NCI-Frederick Cancer Research and Development Center; National Institute of Health, Frederick, Maryland 21702, USA
    Prostate 61:354-70. 2004
    ....
  16. ncbi IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase
    David R Hodge
    Laboratory of Cancer Prevention, Cancer Stem Cell Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cancer Genomics Proteomics 4:387-98. 2007
    ....
  17. ncbi The role of IL-6 and STAT3 in inflammation and cancer
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Eur J Cancer 41:2502-12. 2005
    ..Here, we discuss the relationships between cancer and inflammation, and some of the molecular mechanisms involved in mediating the unintended consequences of host defense and tumour survival...
  18. ncbi DNA hypermethylation and partial gene silencing of human thymine- DNA glycosylase in multiple myeloma cell lines
    Benjamin Peng
    School of Dental Science, University of Melbourne, Melbourne, Australia
    Epigenetics 1:138-45. 2006
    ..Hypermethylation of DNA damage repair genes in MM cell lines may provide an explanation for the frequent genomic instability, as well as point mutations, that are encountered in MM...