V M Hirsch

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Phylogeny and natural history of the primate lentiviruses, SIV and HIV
    V M Hirsch
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA Vanessa
    Curr Opin Genet Dev 5:798-806. 1995
  2. pmc Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia
    V M Hirsch
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Twinbrook II Facility, Rockville, Maryland 20852, USA
    J Virol 72:6482-9. 1998
  3. pmc Characterization of a novel simian immunodeficiency virus (SIV) from L'Hoest monkeys (Cercopithecus l'hoesti): implications for the origins of SIVmnd and other primate lentiviruses
    V M Hirsch
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Virol 73:1036-45. 1999
  4. pmc Biologic studies of chimeras of highly and moderately virulent molecular clones of simian immunodeficiency virus SIVsmPBj suggest a critical role for envelope in acute AIDS virus pathogenesis
    M Haddrick
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, 12441 Parklawn Dr, Rockville, MD 20852, USA
    J Virol 75:6645-59. 2001
  5. ncbi request reprint The role of nonhuman primates in the development of an AIDS vaccine
    N Nathanson
    Office of AIDS Research and the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 2340, USA
    AIDS 13:S113-20. 1999
  6. pmc Characterization of a macaque recombinant monoclonal antibody that binds to a CD4-induced epitope and neutralizes simian immunodeficiency virus
    J Glamann
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Virol 74:7158-63. 2000
  7. pmc Characterization of novel simian immunodeficiency viruses from red-capped mangabeys from Nigeria (SIVrcmNG409 and -NG411)
    B E Beer
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Virol 75:12014-27. 2001

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Phylogeny and natural history of the primate lentiviruses, SIV and HIV
    V M Hirsch
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA Vanessa
    Curr Opin Genet Dev 5:798-806. 1995
    ..nemestrina). Studies of variation within infected individuals have been facilitated by adaptation of the techniques of heteroduplex analysis and single-stranded conformational polymorphism of PCR generated fragments...
  2. pmc Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia
    V M Hirsch
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Twinbrook II Facility, Rockville, Maryland 20852, USA
    J Virol 72:6482-9. 1998
    ..This study underscores the critical role of persistent replication in the genetic evolution of SIV...
  3. pmc Characterization of a novel simian immunodeficiency virus (SIV) from L'Hoest monkeys (Cercopithecus l'hoesti): implications for the origins of SIVmnd and other primate lentiviruses
    V M Hirsch
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Virol 73:1036-45. 1999
    ..Regarded in this light, lentivirus infections of primates not belonging to the Cercopithecus genus may have resulted from cross-species transmission in the not-too-distant past...
  4. pmc Biologic studies of chimeras of highly and moderately virulent molecular clones of simian immunodeficiency virus SIVsmPBj suggest a critical role for envelope in acute AIDS virus pathogenesis
    M Haddrick
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II Facility, 12441 Parklawn Dr, Rockville, MD 20852, USA
    J Virol 75:6645-59. 2001
    ..Introduction of the PBj6.9 G119, however, did not confer full virulence to the parental PBj6.9 virus, implicating one or all of the other four substitutions in the virulence of SIVsmPBj6.6...
  5. ncbi request reprint The role of nonhuman primates in the development of an AIDS vaccine
    N Nathanson
    Office of AIDS Research and the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 2340, USA
    AIDS 13:S113-20. 1999
    ..The components of a rational process of vaccine development are well established and only remain to be welded into one coherent program...
  6. pmc Characterization of a macaque recombinant monoclonal antibody that binds to a CD4-induced epitope and neutralizes simian immunodeficiency virus
    J Glamann
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Virol 74:7158-63. 2000
    ..These findings suggest the presence of at least one CD4-induced neutralization epitope on SIV, as is the case with human immunodeficiency virus type 1...
  7. pmc Characterization of novel simian immunodeficiency viruses from red-capped mangabeys from Nigeria (SIVrcmNG409 and -NG411)
    B E Beer
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Virol 75:12014-27. 2001
    ..SIVrcm, SIVsm, SIVmndGB1, and all four SIVlhoest isolates but not SIVsun (from sun-tailed monkeys) replicated efficiently in human PBMC, suggesting that the ability to infect the human host can vary within one lineage...