A Hildesheim

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A prospective study of absolute risk and determinants of human papillomavirus incidence among young women in Costa Rica
    Megan Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    BMC Infect Dis 13:308. 2013
  2. pmc A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, DHHS, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:33. 2012
  3. pmc Determinants of seropositivity among HPV-16/18 DNA positive young women
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    BMC Infect Dis 10:238. 2010
  4. ncbi request reprint Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 10:1145-53. 2001
  5. ncbi request reprint Chapter 27: Research needs following initial licensure of virus-like particle HPV vaccines
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Vaccine 24:S3/227-32. 2006
  6. ncbi request reprint Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trial
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    JAMA 298:743-53. 2007
  7. ncbi request reprint Simultaneous measurement of several cytokines using small volumes of biospecimens
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1477-84. 2002
  8. ncbi request reprint Host and viral genetics and risk of cervical cancer: a review
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7062, EPS MSC 7234, Rockville, MD 20852, USA
    Virus Res 89:229-40. 2002
  9. ncbi request reprint Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7062, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1780-9. 2002
  10. ncbi request reprint Oral contraceptives as risk factors for cervical adenocarcinomas and squamous cell carcinomas
    J V Lacey
    National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 8:1079-85. 1999

Detail Information

Publications111 found, 100 shown here

  1. pmc A prospective study of absolute risk and determinants of human papillomavirus incidence among young women in Costa Rica
    Megan Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    BMC Infect Dis 13:308. 2013
    ..High risk human papillomaviruses (HR-HPV) are known to be extremely common, sexually transmitted infections, but more information is needed regarding the absolute risks of type-specific HR-HPV infections in the years following sexual debut...
  2. pmc A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, DHHS, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:33. 2012
    ..We examined vaginal pH and the risk of HPV infection, cytological abnormalities, and C. trachomatis infection...
  3. pmc Determinants of seropositivity among HPV-16/18 DNA positive young women
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    BMC Infect Dis 10:238. 2010
    ..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18...
  4. ncbi request reprint Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 10:1145-53. 2001
    ..Formaldehyde exposure is less clearly linked to NPC, whereas exposure to solvents is unlikely to be involved in NPC pathogenesis...
  5. ncbi request reprint Chapter 27: Research needs following initial licensure of virus-like particle HPV vaccines
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Vaccine 24:S3/227-32. 2006
    ..Public health authorities in various countries will play a pivotal role in determining if these questions are answered in a timely manner...
  6. ncbi request reprint Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trial
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    JAMA 298:743-53. 2007
    ..Viruslike particle human papillomavirus (HPV) vaccines were designed to prevent HPV infection and development of cervical precancers and cancer. Women with oncogenic HPV infections might consider vaccination as therapy...
  7. ncbi request reprint Simultaneous measurement of several cytokines using small volumes of biospecimens
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1477-84. 2002
    ..73 (95% confidence interval, 0.67-0.80), respectively, for IFN-gamma. These results indicate the applicability of the LINCOplex assay for the simultaneous measurement of multiple cytokines using small amounts of biological material...
  8. ncbi request reprint Host and viral genetics and risk of cervical cancer: a review
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7062, EPS MSC 7234, Rockville, MD 20852, USA
    Virus Res 89:229-40. 2002
    ..A consistent association between HPV16 non-European variants and risk of disease is also evident from published work. These findings are discussed. Gaps in our understanding and future research needs are also discussed...
  9. ncbi request reprint Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7062, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1780-9. 2002
    ..We used high-resolution HLA genotyping in a case-control study in Taiwan to systematically evaluate the association between various HLA alleles and NPC...
  10. ncbi request reprint Oral contraceptives as risk factors for cervical adenocarcinomas and squamous cell carcinomas
    J V Lacey
    National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 8:1079-85. 1999
    ....
  11. pmc HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Cancer 84:1219-26. 2001
    ..Among HPV-positive women, multiparity and smoking are risk factors for HSIL/CA. Oral contraceptive use may be associated with HSIL/CA in subgroups of women...
  12. ncbi request reprint A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation
    Patti E Gravitt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:477-84. 2003
    ..The nonrandom distribution of multiple infections by case-control status and the apparent differential effect of viral load by genotype warrant caution when using HC 2 measurements to infer viral load associations with SIL and cancer...
  13. pmc Determinants of human papillomavirus 16 serological conversion and persistence in a population-based cohort of 10 000 women in Costa Rica
    S S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    Br J Cancer 91:1269-74. 2004
    ..Higher HPV-16 viral load at enrollment was associated with seroconversion, and higher antibody titres at enrollment were associated with seropersistence...
  14. ncbi request reprint HPV DNA testing in cervical cancer screening: results from women in a high-risk province of Costa Rica
    M Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    JAMA 283:87-93. 2000
    ..Human papillomaviruses (HPVs) are known to cause most cervical cancer worldwide, but the utility of HPV DNA testing in cervical cancer prevention has not been determined...
  15. ncbi request reprint An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papillomavirus (HPV)
    P E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 10:1021-7. 2001
    ..90-4.1). The results of this study suggest that cervical inflammation may be associated with high-grade lesions and may be a cofactor for high-grade cervical lesions in women infected with oncogenic HPV...
  16. ncbi request reprint Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
    J D Carreon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Tissue Antigens 66:321-4. 2005
    ..No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes...
  17. pmc Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 203:814-22. 2011
    ..Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking...
  18. ncbi request reprint Human papillomavirus type 16 and risk of preinvasive and invasive vulvar cancer: results from a seroepidemiological case-control study
    A Hildesheim
    Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 7374, USA
    Obstet Gynecol 90:748-54. 1997
    ..To examine whether human papillomavirus (HPV) type 16 is involved in the etiology of vulvar carcinomas...
  19. pmc Seroprevalence of human papillomavirus-16, -18, -31, and -45 in a population-based cohort of 10000 women in Costa Rica
    S S Wang
    National Cancer Institute, Bethesda, MD 20892 7234, USA
    Br J Cancer 89:1248-54. 2003
    ..DNA- and sero-positive women showed the highest risk for concurrent CIN3/cancer, followed by DNA-positive, sero-negative women...
  20. pmc Collection of cervical secretions does not adversely affect Pap smears taken immediately afterward
    A Hildesheim
    Interdisciplinary Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 7374, USA
    Clin Diagn Lab Immunol 5:491-3. 1998
    ..Results from the present study suggest that the collection of cervical secretions with Weck-cel sponges does not adversely impact the quality of subsequently obtained Pap smears...
  21. ncbi request reprint Human leukocyte antigen class I/II alleles and development of human papillomavirus-related cervical neoplasia: results from a case-control study conducted in the United States
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7374, USA
    Cancer Epidemiol Biomarkers Prev 7:1035-41. 1998
    ....
  22. ncbi request reprint CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 89:1207-12. 1997
    ..We conducted a case-control study to investigate whether such variations affect the risk of developing nasopharyngeal cancer...
  23. ncbi request reprint Immune activation in cervical neoplasia: cross-sectional association between plasma soluble interleukin 2 receptor levels and disease
    A Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 6:807-13. 1997
    ..Also, future efforts should be aimed at determining whether the associations observed are causally related to disease progression or an effect of the disease...
  24. pmc Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    BMJ 339:b2569. 2009
    ....
  25. ncbi request reprint Associations between smoking and adenocarcinomas and squamous cell carcinomas of the uterine cervix (United States)
    J V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Cancer Causes Control 12:153-61. 2001
    ..Few studies of smoking and cervical carcinoma have addressed the rare cervical adenocarcinomas or used DNA-based tests to control for human papillomavirus (HPV) infection...
  26. pmc A case-control study of endogenous hormones and cervical cancer
    T S Shields
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, MSC 7234, Rockville, MD 20852, USA
    Br J Cancer 90:146-52. 2004
    ..Nonetheless, our results do not support the hypothesis that plasma levels of sex hormones have an important bearing on the risk of cervical neoplasia in HPV-infected women...
  27. ncbi request reprint Epstein-Barr virus seroreactivity among unaffected individuals within high-risk nasopharyngeal carcinoma families in Taiwan
    Amy Pickard
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 111:117-23. 2004
    ..Unaffected individuals from high-risk NPC families have elevated anti-EBV IgA antibody titers. The etiologic and clinical implications of this finding remain to be established...
  28. pmc Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
    Mary Carrington
    Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 201:1069-75. 2005
    ....
  29. ncbi request reprint Obesity as a potential risk factor for adenocarcinomas and squamous cell carcinomas of the uterine cervix
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Cancer 98:814-21. 2003
    ..The authors evaluated whether obesity, which can influence hormone levels, was associated with adenocarcinoma and squamous cell carcinoma...
  30. ncbi request reprint Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica
    S S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 184:1310-4. 2001
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection...
  31. ncbi request reprint Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women
    Alfonso J Garcia-Pineres
    HPV Immunology Laboratory, Science Applications International Corporation Frederick, Inc National Cancer Institute Frederick, Frederick, Maryland, USA
    Cancer Res 66:11070-6. 2006
    ..Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect...
  32. ncbi request reprint Correlates of IL-10 and IL-12 concentrations in cervical secretions
    Patti E Gravitt
    Interdisciplinary Studies Section, Environmental Epidemiology Branch, DCEG, National Cancer Institute, 6120 Executive Blvd, EPS 7059, Bethesda, Maryland 20852, USA
    J Clin Immunol 23:175-83. 2003
    ..Future analyses of cervical cytokine levels and HPV infection should control for the inherent variation of local cytokine levels due to hormonal influences, hemoglobin contamination, pH, and cervical secretion volume differences...
  33. ncbi request reprint Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma
    Lori E Dodd
    National Cancer Institute, 6120 Executive Boulevard, Room 7062, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 15:2216-25. 2006
    ..Our results suggest that nitrosamine activation and DNA repair are important in NPC. The consistent down-regulation of expression on chromosome 14q32 suggests loss of heterozygosity in this region...
  34. ncbi request reprint Cytokine and immunoglobulin concentrations in cervical secretions: reproducibility of the Weck-cel collection instrument and correlates of immune measures
    A Hildesheim
    Interdisciplinary Studies Section, Environmental Epidemiology Branch, DCEG, National Cancer Institute, Bethesda, MD 20892 7374, USA
    J Immunol Methods 225:131-43. 1999
    ..In addition, various correlates of cytokine and immunoglobulin concentrations were identified...
  35. ncbi request reprint A study on immunological responses to exposures encountered in corn farming
    R Vermeulen
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD 20892, USA
    J Biochem Mol Toxicol 19:172. 2005
  36. ncbi request reprint Evaluation of self-collected cervicovaginal cell samples for human papillomavirus testing by polymerase chain reaction
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California 94501, USA
    Cancer Epidemiol Biomarkers Prev 10:95-100. 2001
    ..We have demonstrated that a self-collected Dacron swab sample of cervicovaginal cells is a technically feasible alternative to clinician-administered cervical cell collection in natural history studies of HPV and cervical cancer...
  37. pmc An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results
    John T Schiller
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA
    Vaccine 26:K53-61. 2008
    ..The results of these studies have led to the approval of Gardasil and Cervarix by national regulatory agencies in a number of countries...
  38. ncbi request reprint Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality
    Melinda Butsch Kovacic
    Division of Cancer Epidemiology and Genetics and Cancer Prevention Fellowship Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:10112-9. 2006
    ..The lack of evident severe abnormalities associated with HPV18 and related HPV types might have implications for screening for poorly detected glandular and alpha7-related lesions...
  39. doi request reprint Human papillomavirus infection and the primary and secondary prevention of cervical cancer
    Douglas R Lowy
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Cancer 113:1980-93. 2008
    ..The manner in which vaccination and screening programs are integrated will need to be considered carefully so that they are efficient in reducing the overall incidence of cervical cancer...
  40. pmc Comparison of two PCR-based human papillomavirus genotyping methods
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5004, EPS MSC 7234, Bethesda, MD 20892 7234
    J Clin Microbiol 46:3437-45. 2008
    ..Both approaches are suitable for monitoring the impact of HPV16/18 vaccines in clinical trials...
  41. pmc Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
    J Natl Cancer Inst 100:513-7. 2008
    ..These findings suggest that the medical community should emphasize persistence of cervical HPV infection, not single-time detection of HPV, in management strategies and health messages...
  42. ncbi request reprint Evaluation of the association with cervical cancer of polymorphisms in syndecan-1, a heparan sulfate proteoglycan involved with viral cell entry
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, Suite 550, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:2504-8. 2007
    ..S. Study. Our results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix. An association between SDC-1 Pro-27 polymorphism and cervical adenocarcinoma cannot be ruled out...
  43. ncbi request reprint The natural history of human papillomavirus infection and cervical intraepithelial neoplasia among young women in the Guanacaste cohort shortly after initiation of sexual life
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, Maryland 20859, USA
    Sex Transm Dis 34:494-502. 2007
    ..We wanted to explore early HPV natural history and CIN 3 prospectively...
  44. pmc Comparison of the SPF10-LiPA system to the Hybrid Capture 2 Assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in Guanacaste, Costa Rica
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
    J Clin Microbiol 45:1447-54. 2007
    ..The crude agreement between the two assays was 88%, with a kappa value of 0.75 (95% confidence limits, 0.73 to 0.76). We observed very good agreement between HC2 and SPF(10)-LiPA for carcinogenic HPV type detection...
  45. ncbi request reprint A comparison of cervical and vaginal human papillomavirus
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
    Sex Transm Dis 34:849-55. 2007
    ..Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells...
  46. ncbi request reprint Pathological characteristics of cervical adenocarcinoma in a multi-center US-based study
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Bethesda, MD 20852 7234, USA
    Gynecol Oncol 103:541-6. 2006
    ..We report a detailed pathology review of cervical adenocarcinoma subtypes, comparing growth patterns and appearance of non-neoplastic epithelium to inform possible clues for disease progression and early detection...
  47. pmc Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 5104, Rockville, MD 20852 7234, USA
    J Infect Dis 199:20-30. 2009
    ..We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer...
  48. pmc The epidemiology of oral HPV infection among a multinational sample of healthy men
    Aimee R Kreimer
    National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 20:172-82. 2011
    ..Oral human papillomavirus type-16 (HPV16) infection is a risk factor for oropharyngeal cancer. We examined oral HPV infection among healthy men...
  49. pmc Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    J Natl Cancer Inst 102:1794-804. 2010
    ..In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV...
  50. pmc Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infections
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
    J Natl Cancer Inst 102:1653-62. 2010
    ..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown...
  51. doi request reprint Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa Rica
    Sarah Coseo
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
    Sex Transm Dis 37:706-14. 2010
    ..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25...
  52. doi request reprint National Institutes of Health Center for Human Immunology Conference, September 2009
    Robert B Nussenblatt
    Laboratory of Immunology, National Eye Institute, Maryland 20892, USA
    Ann N Y Acad Sci 1200:E1-23. 2010
    ..The human immunology meeting was held in the Clinical Center of the National Institutes of Health, Bethesda, Maryland, on September 3 and 4, 2009...
  53. pmc A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia
    Mark Schiffman
    Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 70:3159-69. 2010
    ..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity...
  54. pmc Comparison of mRNA and protein measures of cytokines following vaccination with human papillomavirus-16 L1 virus-like particles
    Fatma M Shebl
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7074, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 19:978-81. 2010
    ..Few studies have directly compared results obtained using gene expression and multiplex protein assays for corresponding gene products...
  55. pmc Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trials
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    BMJ 340:c712. 2010
    ..To assess whether vaccination against human papillomavirus (HPV) increases the risk of miscarriage...
  56. pmc Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
    Arch Virol 155:367-70. 2010
    ..The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16...
  57. pmc Determinants and correlation of systemic and cervical concentrations of total IgA and IgG
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:2672-6. 2009
    ..17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels...
  58. pmc Association of human leukocyte antigens with nasopharyngeal carcinoma in high-risk multiplex families in Taiwan
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Hum Immunol 70:910-4. 2009
    ..This finding requires replication in larger studies...
  59. pmc The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: a need for reappraisal
    Cindy M Chang
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7074, Rockville, MD 20892, USA
    Virus Res 143:209-21. 2009
    ....
  60. doi request reprint Factors associated with fluctuations in IgA and IgG levels at the cervix during the menstrual cycle
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 199:455-63. 2009
    ..The objective of this analysis was to describe patterns and determinants of cervical immunoglobulin A (IgA) and G (IgG) levels during the menstrual cycle...
  61. pmc Human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical disease
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072 Rockville, MD 20852, USA
    J Infect Dis 203:910-20. 2011
    ..We investigated coinfection patterns for 25 human papillomavirus (HPV) types and assessed the risk conferred by multiple HPV types toward cervical disease...
  62. pmc Second cancers after squamous cell carcinoma and adenocarcinoma of the cervix
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 27:967-73. 2009
    ..We assessed whether these cofactor differences translate into differences in second cancer risk...
  63. pmc Assessment of human papillomavirus in lung tumor tissue
    Jill Koshiol
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7248, USA
    J Natl Cancer Inst 103:501-7. 2011
    ..Lung cancer kills more than 1 million people worldwide each year. Whereas several human papillomavirus (HPV)-associated cancers have been identified, the role of HPV in lung carcinogenesis remains controversial...
  64. ncbi request reprint Age-related changes of the cervix influence human papillomavirus type distribution
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Cancer Res 66:1218-24. 2006
    ..These patterns need to be confirmed in other studies and populations. We suggest that these genetically distinct groups of HPV types may differ in tissue preferences, which may contribute to their differences in carcinogenic potential...
  65. ncbi request reprint Restricted cross-reactivity of hybrid capture 2 with nononcogenic human papillomavirus types
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1394-9. 2002
    ....
  66. ncbi request reprint Human leukocyte antigen class I alleles and cervical neoplasia: no heterozygote advantage
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:419-20. 2002
  67. ncbi request reprint PCR testing of pooled longitudinally collected cervical specimens of women to increase the efficiency of studying human papillomavirus infection
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7074, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:256-60. 2005
    ..3% (95% CI, 74.7-91.4%), respectively. We conclude that pooling specimens and testing by PCR may be useful for discriminating HPV DNA-positive from completely negative specimen sets in women who are likely to have been HPV DNA-negative.>..
  68. ncbi request reprint Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical adenocarcinoma and squamous cell carcinoma: Northeastern United States
    Sean F Altekruse
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 188:657-63. 2003
    ..We examined human papillomavirus genotypes and sexual and reproductive risk factors for cervical adenocarcinoma and squamous cell carcinoma...
  69. ncbi request reprint Stability of archived liquid-based cervical cytologic specimens
    Philip E Castle
    The National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, Maryland 20892 7234, USA
    Cancer 99:89-96. 2003
    ..However, long-term DNA stability and cytologic stability of these biospecimens have not been evaluated...
  70. ncbi request reprint A study of the impact of adding HPV types to cervical cancer screening and triage tests
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
    J Natl Cancer Inst 97:147-50. 2005
    ..The minimal increases in sensitivity and in negative predictive value achieved by adding HPV types to DNA tests must be weighed against the projected burden to thousands of women falsely labeled as being at high risk of cervical cancer...
  71. ncbi request reprint Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 13:1355-60. 2004
    ..Whereas our data support the diagnostic potential for p16INK4a, further prospective studies with detailed follow-up determining the prognostic capacity of this marker are needed...
  72. ncbi request reprint A population-based study of vaginal human papillomavirus infection in hysterectomized women
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 190:458-67. 2004
    ..e., A3/A4/A15) may have a predilection for vaginal epithelium...
  73. pmc Comparison of ophthalmic sponges for measurements of immune markers from cervical secretions
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    Clin Diagn Lab Immunol 11:399-405. 2004
    ..These findings require confirmation...
  74. ncbi request reprint Comparisons of HPV DNA detection by MY09/11 PCR methods
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Med Virol 68:417-23. 2002
    ..Our data also suggest that studies reporting HPV DNA detection by PCR need to report the type of polymerase used, as well as other assay specifics, and underscore the need for worldwide standards of testing...
  75. ncbi request reprint Evaluation of risk factors for nasopharyngeal carcinoma in high-risk nasopharyngeal carcinoma families in Taiwan
    Xiaohong Rose Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7014, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:900-5. 2005
    ..The results from the two methods were similar indicating that the risk estimates from conditional logistic regression were unbiased...
  76. ncbi request reprint Robustness of inference on measured covariates to misspecification of genetic random effects in family studies
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7244, USA
    Genet Epidemiol 24:14-23. 2003
    ..The model is applied to data from a family study on nasopharyngeal carcinoma in Taiwan...
  77. ncbi request reprint Variation of the killer cell immunoglobulin-like receptors and HLA-C genes in nasopharyngeal carcinoma
    Melinda Butsch Kovacic
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Room 7101, Bethesda, MD 20853, USA
    Cancer Epidemiol Biomarkers Prev 14:2673-7. 2005
    ....
  78. ncbi request reprint Distribution of Epstein-Barr viral load in serum of individuals from nasopharyngeal carcinoma high-risk families in Taiwan
    Xiaohong Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA
    Int J Cancer 118:780-4. 2006
    ....
  79. ncbi request reprint The carcinogenicity of human papillomavirus types reflects viral evolution
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MA, USA
    Virology 337:76-84. 2005
    ..These results present several clear clues and research directions in our ongoing efforts to understand HPV carcinogenesis...
  80. ncbi request reprint A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 191:1808-16. 2005
    ..In some populations, HPV prevalence demonstrates a second peak in older women. Longitudinal data may help to explain this second peak...
  81. ncbi request reprint Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7234, USA
    Cancer 100:1035-44. 2004
    ..Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the cervix by race and disease stage for the past 25 years...
  82. ncbi request reprint Cervical concentrations of interleukin-10 and interleukin-12 do not correlate with plasma levels
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892 7234, USA
    J Clin Immunol 22:23-7. 2002
    ....
  83. ncbi request reprint Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  84. ncbi request reprint Immune profiling of plasma and cervical secretions using recycling immunoaffinity chromatography
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 12:1449-56. 2003
    ....
  85. pmc Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA
    Int J Cancer 124:1622-5. 2009
    ..0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors...
  86. pmc Neither one-time negative screening tests nor negative colposcopy provides absolute reassurance against cervical cancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
    Int J Cancer 125:1649-56. 2009
    ....
  87. pmc CD83 polymorphisms and cervical cancer risk
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA
    Gynecol Oncol 114:319-22. 2009
    ....
  88. pmc Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7248, USA
    Cancer Epidemiol Biomarkers Prev 18:1631-7. 2009
    ..Although genetic variation in TP53 might affect the natural history of HPV and cervical cancer, further work is needed to elucidate the possible mechanism...
  89. pmc Circulating levels of immune and inflammatory markers and long versus short survival in early-stage lung cancer
    C Bodelon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Ann Oncol 24:2073-9. 2013
    ..Associations between markers of inflammation and survival from lung cancer have been observed...
  90. pmc Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families
    C M Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 7073, Rockville, MD, USA
    Br J Cancer 106:206-9. 2012
    ....
  91. ncbi request reprint Barrier and spermicidal contraceptive methods and risk of invasive cervical cancer
    A Hildesheim
    Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892
    Epidemiology 1:266-72. 1990
    ..The potential ability of spermicides to reduce cervical cancer risk by neutralizing viral agents warrants further attention...
  92. ncbi request reprint Clinical trial designs for the early clinical development of therapeutic cancer vaccines
    R M Simon
    Branch of Biometric Research, Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7434, USA
    J Clin Oncol 19:1848-54. 2001
    ..Several conclusions for expediting the clinical development of effective cancer vaccines are proposed...
  93. pmc Human papillomavirus (HPV) genotyping using paired exfoliated cervicovaginal cells and paraffin-embedded tissues to highlight difficulties in attributing HPV types to specific lesions
    Patti E Gravitt
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E6535, Baltimore, MD 21205, USA
    J Clin Microbiol 45:3245-50. 2007
    ....
  94. ncbi request reprint HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood
    Ligia A Pinto
    SAIC Frederick, Inc NCI Frederick, Room 120, Building 469, Frederick, MD 21702, USA
    Vaccine 23:3555-64. 2005
    ....
  95. pmc Cytokine and chemokine profiles following vaccination with human papillomavirus type 16 L1 Virus-like particles
    Alfonso Garcia-Pineres
    HPV Immunology Laboratory, SAIC Frederick, Inc NCI Frederick, Frederick, Maryland 21702, USA
    Clin Vaccine Immunol 14:984-9. 2007
    ..Cytokine profiling studies using samples from efficacy trials may provide important information about discriminators of long-term protection against HPV...
  96. ncbi request reprint Epidemiologic profile of type-specific human papillomavirus infection and cervical neoplasia in Guanacaste, Costa Rica
    Rolando Herrero
    Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, San Jose, Costa Rica
    J Infect Dis 191:1796-807. 2005
    ..Detailed epidemiologic studies of cervical type-specific human papillomavirus (HPV) infection in large populations are scarce...
  97. ncbi request reprint Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma
    Seung Myung Dong
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 11:3-6. 2002
    ..It remains to be demonstrated whether quantitative PCR analysis of HPV DNA in plasma may have utility in patients at high risk of recurrent disease...
  98. ncbi request reprint Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma
    Srikumar Sengupta
    Institute for Molecular Virology, McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
    Cancer Res 66:7999-8006. 2006
    ....
  99. ncbi request reprint High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 121:2787-93. 2007
    ..The extent to which these observations can be translated into clinical practice must be rigorously examined in the context of the method of viral load measurement and the type-specific differences observed for incident >/=CIN2...
  100. ncbi request reprint Past, present, and future of HPV research: highlights from the 19th International Papillomavirus Conference-HPV2001
    Luisa Lina Villa
    Virology Department, Ludwig Institute for Cancer Research, R Professor Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, Brazil
    Virus Res 89:163-73. 2002
    ..Highlights derive from the analysis of more than 500 papers presented at the Conference...
  101. ncbi request reprint Family history as a co-factor for adenocarcinoma and squamous cell carcinoma of the uterine cervix: results from two studies conducted in Costa Rica and the United States
    Alice de M Zelmanowicz
    Programa de Pós Graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Cancer 116:599-605. 2005
    ..These results are consistent with a role of host factors in the pathogenesis of squamous cell cervical cancer, although familial aggregation due to shared environmental exposures cannot be ruled out...