O Hikosaka

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Why skill matters
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cogn Sci 17:434-41. 2013
  2. ncbi request reprint Central mechanisms of motor skill learning
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Building 49, Room 2A50, Bethesda, Maryland 20892, USA
    Curr Opin Neurobiol 12:217-22. 2002
  3. pmc Brain mechanisms for switching from automatic to controlled eye movements
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Prog Brain Res 171:375-82. 2008
  4. pmc New insights on the subcortical representation of reward
    Okihide Hikosaka
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Curr Opin Neurobiol 18:203-8. 2008
  5. ncbi request reprint A new approach to the functional systems of the brain
    Okihide Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Hongo, Tokyo, Japan
    Epilepsia 43:9-15. 2002
  6. ncbi request reprint Long-term retention of motor skill in macaque monkeys and humans
    O Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
    Exp Brain Res 147:494-504. 2002
  7. ncbi request reprint GABAergic output of the basal ganglia
    O Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institute of Health, 49 Convent Drive, Bldg 49, Rm 2A50, Bethesda, MD 20892 4435, USA
    Prog Brain Res 160:209-26. 2007
  8. ncbi request reprint Basal ganglia orient eyes to reward
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurophysiol 95:567-84. 2006
  9. ncbi request reprint Basal ganglia mechanisms of reward-oriented eye movement
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institute of Health, Bethesda, MD 20892 4435, USA
    Ann N Y Acad Sci 1104:229-49. 2007
  10. pmc Habenula: crossroad between the basal ganglia and the limbic system
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:11825-9. 2008

Detail Information

Publications67

  1. pmc Why skill matters
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cogn Sci 17:434-41. 2013
    ..Object skill thus plays a crucial role in increasing rewards per unit time. ..
  2. ncbi request reprint Central mechanisms of motor skill learning
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Building 49, Room 2A50, Bethesda, Maryland 20892, USA
    Curr Opin Neurobiol 12:217-22. 2002
    ..This architecture accounts for the seemingly diverse features of motor learning...
  3. pmc Brain mechanisms for switching from automatic to controlled eye movements
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Prog Brain Res 171:375-82. 2008
    ..Our data suggest that the pre-SMA resolves response conflict so that the desired action can be selected. Possible neuronal circuits through which the pre-SMA might exert its switching functions will be discussed...
  4. pmc New insights on the subcortical representation of reward
    Okihide Hikosaka
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Curr Opin Neurobiol 18:203-8. 2008
    ..Such reward-related neurons are found in the areas which have been associated with stress, pain, mood, emotion, memory, and arousal. These results suggest that reward needs to be understood in a larger framework of animal behavior...
  5. ncbi request reprint A new approach to the functional systems of the brain
    Okihide Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Hongo, Tokyo, Japan
    Epilepsia 43:9-15. 2002
    ..The proposed neural architecture would operate in a flexible manner to acquire and execute multiple sequential procedures...
  6. ncbi request reprint Long-term retention of motor skill in macaque monkeys and humans
    O Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
    Exp Brain Res 147:494-504. 2002
    ..This occurs separately but concurrently. This conclusion is consistent with the hypothesis that at least two neural mechanisms operate independently to represent a motor skill...
  7. ncbi request reprint GABAergic output of the basal ganglia
    O Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institute of Health, 49 Convent Drive, Bldg 49, Rm 2A50, Bethesda, MD 20892 4435, USA
    Prog Brain Res 160:209-26. 2007
    ..Intricate hand-finger movements do not occur in isolation; they are always associated with appropriate motor sets, such as eye-head orientation and posture...
  8. ncbi request reprint Basal ganglia orient eyes to reward
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurophysiol 95:567-84. 2006
    ..These data support a specific form of reinforcement learning theories, but also suggest further refinement of the theory...
  9. ncbi request reprint Basal ganglia mechanisms of reward-oriented eye movement
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institute of Health, Bethesda, MD 20892 4435, USA
    Ann N Y Acad Sci 1104:229-49. 2007
    ....
  10. pmc Habenula: crossroad between the basal ganglia and the limbic system
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:11825-9. 2008
    ..Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and drug-induced psychosis...
  11. pmc Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Trends Cogn Sci 14:154-61. 2010
    ..We discuss how breaking a routine to allow more adaptive behavior requires a fine-tuned recruitment of the frontal cortical-basal ganglia neural network...
  12. pmc The habenula: from stress evasion to value-based decision-making
    Okihide Hikosaka
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Nat Rev Neurosci 11:503-13. 2010
    ..As a highly conserved structure in the brain, the habenula provides a fundamental mechanism for both survival and decision-making...
  13. ncbi request reprint Responses to task-irrelevant visual features by primate prefrontal neurons
    J Lauwereyns
    Department of Physiology, Juntendo University, Tokyo 113-0033, Japan
    J Neurophysiol 86:2001-10. 2001
    ..Thus these data suggest that irrelevant features lead to partial activation of neurons even toward the output of the decision-making process in primate prefrontal cortex...
  14. ncbi request reprint Role of tonically active neurons in primate caudate in reward-oriented saccadic eye movement
    Y Shimo
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113-8421, Japan
    J Neurosci 21:7804-14. 2001
    ..These features of TANs might be explained by their cytoarchitecture, namely, as large aspiny neurons...
  15. ncbi request reprint Neural representation of a rhythm depends on its interval ratio
    K Sakai
    Department of Physiology, Juntendo University School of Medicine, Tokyo 113 0033, Japan
    J Neurosci 19:10074-81. 1999
    ..These results suggested that there are two neural representations for rhythm depending on the interval ratio, which correspond to metrical and nonmetrical representations...
  16. pmc Midbrain dopamine neurons signal preference for advance information about upcoming rewards
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 63:119-26. 2009
    ..Our data show that single dopamine neurons process both primitive and cognitive rewards, and suggest that current theories of reward-seeking must be revised to include information-seeking...
  17. ncbi request reprint Presaccadic omnidirectional burst activity in the basal interstitial nucleus in the monkey cerebellum
    Y Takikawa
    Department of Physiology, School of Medicine, Juntendo University, Tokyo, Japan
    Exp Brain Res 121:442-50. 1998
    ..In contrast, burst duration was highly correlated with saccade duration regardless of the type of saccade. These results suggest that BIN neurons may carry information to determine the timing of saccades...
  18. pmc The globus pallidus sends reward-related signals to the lateral habenula
    Simon Hong
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Neuron 60:720-9. 2008
    ..These results suggest that GPi may initiate reward-related signals through its effects on the LHb, which then influences the dopaminergic and serotonergic systems...
  19. ncbi request reprint A neural correlate of response bias in monkey caudate nucleus
    Johan Lauwereyns
    Laboratory of Sensorimotor Research, National Eye Institute, Building 49, Room 2A50, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 418:413-7. 2002
    ..We conclude that this neuronal mechanism creates an advance bias that favours a spatial response when it is associated with a high reward value...
  20. ncbi request reprint Role of primate substantia nigra pars reticulata in reward-oriented saccadic eye movement
    Makoto Sato
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    J Neurosci 22:2363-73. 2002
    ..These results suggest that the CD-SNr-SC mechanism would promote saccades oriented to reward...
  21. ncbi request reprint Reward-dependent spatial selectivity of anticipatory activity in monkey caudate neurons
    Yoriko Takikawa
    Department of Physiology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Neurophysiol 87:508-15. 2002
    ..Assuming that the CD neurons have access to saccadic motor outputs, the precue activity would create a motivational bias toward the contralateral space, even before an instruction is given by the cue stimulus...
  22. ncbi request reprint Feature-based anticipation of cues that predict reward in monkey caudate nucleus
    Johan Lauwereyns
    Department of Physiology, Juntendo University School of Medicine, Hongo 2 1 1, 113 0033, Bunkyo ku, Tokyo, Japan
    Neuron 33:463-73. 2002
    ..This neuronal code influences the general activity level in response to visual features without improving the quality of visual discrimination...
  23. pmc Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 28:5331-43. 2008
    ..These results suggest that the DRN, probably including serotonin neurons, signals the reward value associated with the current behavior...
  24. ncbi request reprint Lateral habenula as a source of negative reward signals in dopamine neurons
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 447:1111-5. 2007
    ..These results suggest that the inhibitory input from the lateral habenula plays an important role in determining the reward-related activity of dopamine neurons...
  25. ncbi request reprint A possible role of midbrain dopamine neurons in short- and long-term adaptation of saccades to position-reward mapping
    Yoriko Takikawa
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    J Neurophysiol 92:2520-9. 2004
    ..This might trigger a switch between the learned sets. These results suggest that midbrain DA neurons play an essential role in adapting oculomotor behavior to frequent switches in position-reward mapping...
  26. ncbi request reprint [Decision-making and learning by cortico-basal ganglia network]
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institute of Health, Bethesda, MD 20892 4435, USA
    Brain Nerve 60:799-813. 2008
    ..This enhancement of the indirect mechanism may be caused by a punishment-predictive signal which originates from the lateral habenula and is mediated by dopamine neurons...
  27. pmc Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement
    Masaki Isoda
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:7209-18. 2008
    ..We suggest that the STN mediates the control signal originated from the medial frontal cortex and implements the behavioral switching function using its connections with other basal ganglia nuclei and the superior colliculus...
  28. ncbi request reprint Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 26:12885-95. 2006
    ..We propose that the caudate plays a causal role in behavioral changes by integrating selective sensorimotor and reward information in a temporally specific manner...
  29. pmc A neural correlate of motivational conflict in the superior colliculus of the macaque
    Masaki Isoda
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Neurophysiol 100:1332-42. 2008
    ..Our data suggest that motivational conflict activates movement neurons in both colliculi, thereby delaying saccade initiation through intercollicular inhibitory interactions...
  30. ncbi request reprint Abnormalities of voluntary saccades in Gilles de la Tourette's syndrome: pathophysiological consideration
    Yoshiko Nomura
    Segawa Neurological Clinic for Children, Tokyo, Japan
    Brain Dev 25:S48-54. 2003
    ....
  31. ncbi request reprint Role of the basal ganglia in the control of purposive saccadic eye movements
    O Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
    Physiol Rev 80:953-78. 2000
    ..The interaction between cortical and dopaminergic inputs to CD neurons may underlie the behavioral adaptation toward purposeful saccades...
  32. ncbi request reprint Minimal synaptic delay in the saccadic output pathway of the superior colliculus studied in awake monkey
    N Miyashita
    Department of Physiology, School of Medicine, Juntendo University, Tokyo, Japan
    Exp Brain Res 112:187-96. 1996
    ..2 +/- 0.8 ms (SD; contralateral eye) for abducens nucleus stimulation. The time difference between SC- and BN-evoked eye movements (about 3 ms) was consistent with a disynaptic connection from the SC to the premotor BNs...
  33. ncbi request reprint Reward-predicting activity of dopamine and caudate neurons--a possible mechanism of motivational control of saccadic eye movement
    Reiko Kawagoe
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    J Neurophysiol 91:1013-24. 2004
    ....
  34. pmc Negative motivational control of saccadic eye movement by the lateral habenula
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    Prog Brain Res 171:399-402. 2008
    ..We will then describe our own study. Finally, we will discuss how the lateral habenula, as well as dopamine neurons, contributes to the reward-based control of saccadic eye movements...
  35. ncbi request reprint Visual and anticipatory bias in three cortical eye fields of the monkey during an adaptive decision-making task
    Brian Coe
    Department of Physiology, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    J Neurosci 22:5081-90. 2002
    ....
  36. ncbi request reprint Reward-dependent gain and bias of visual responses in primate superior colliculus
    Takuro Ikeda
    Department of Physiology, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neuron 39:693-700. 2003
    ....
  37. ncbi request reprint Modulation of saccadic eye movements by predicted reward outcome
    Yoriko Takikawa
    Department of Physiology, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Exp Brain Res 142:284-91. 2002
    ..These results provide important constraints to the neuronal mechanism underlying reward-oriented behavior because it must satisfy these rules...
  38. ncbi request reprint What and when: parallel and convergent processing in motor control
    K Sakai
    Department of Physiology, Juntendo University School of Medicine, Tokyo 113, Japan
    J Neurosci 20:2691-700. 2000
    ..Furthermore, our results suggest that these activations related to response selection and timing adjustment were distinct from sensory or motor processes...
  39. pmc Representation of negative motivational value in the primate lateral habenula
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, US National Institutes of Health, 49 Convent Drive, Bethesda, Maryland 20892 4435, USA
    Nat Neurosci 12:77-84. 2009
    ..These results suggest that the lateral habenula has the potential to adaptively control both reward-seeking and punishment-avoidance behaviors, presumably through its projections to dopaminergic and serotonergic systems...
  40. ncbi request reprint Effects of motivational conflicts on visually elicited saccades in monkeys
    Katsumi Watanabe
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Exp Brain Res 152:361-7. 2003
    ....
  41. ncbi request reprint A neural correlate of oculomotor sequences in supplementary eye field
    Xiaofeng Lu
    Department of Physiology, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
    Neuron 34:317-25. 2002
    ..Furthermore, such activity was often selective for one among several sequences that included the combination (S neuron). These results suggest that the SEF contributes to the generation of saccades in many learned sequences...
  42. ncbi request reprint Switching from automatic to controlled action by monkey medial frontal cortex
    Masaki Isoda
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Neurosci 10:240-8. 2007
    ..Our data suggest that the pre-SMA resolves response conflict so that the desired action can be selected...
  43. ncbi request reprint Temporal development of asymmetric reward-induced bias in macaques
    Long Ding
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurophysiol 97:57-61. 2007
    ..These results have important implications on the neural correlates of reward-induced bias...
  44. pmc Multiple timescales of memory in lateral habenula and dopamine neurons
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD 20892, USA
    Neuron 67:499-510. 2010
    ..Our data show that the habenula-dopamine pathway contains multiple timescales of memory and provide evidence for their role in motivated behavior...
  45. pmc Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 67:144-55. 2010
    ..Our data suggest that the habenula-dopamine pathway motivates anticipation through a combination of tonic reward-related and phasic salience-related signals...
  46. ncbi request reprint Role of dopamine in the primate caudate nucleus in reward modulation of saccades
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 26:5360-9. 2006
    ..These results suggest that reward-dependent changes in saccadic eye movements depend partly on dopaminergic modulation of neuronal activity in the caudate nucleus...
  47. ncbi request reprint Comparison of reward modulation in the frontal eye field and caudate of the macaque
    Long Ding
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:6695-703. 2006
    ..Thus, both the FEF and basal ganglia may contribute to reward bias in saccade generation, with the FEF providing spatially relevant reward information and the basal ganglia providing additional reward-specific information...
  48. pmc A pallidus-habenula-dopamine pathway signals inferred stimulus values
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bldg 49, Rm 2A50, Bethesda, Maryland 20892 4435, USA
    J Neurophysiol 104:1068-76. 2010
    ..Our data indicate that the pallidus-habenula-dopamine pathway signals reward values estimated through both experience and inference...
  49. pmc Coding of task reward value in the dorsal raphe nucleus
    Ethan S Bromberg-Martin
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:6262-72. 2010
    ..A smaller component of neural activity reflected detection of reward delivery. Our data suggest that the dorsal raphe nucleus encodes participation in a behavioral task in terms of its future motivational outcomes...
  50. pmc Two types of dopamine neuron distinctly convey positive and negative motivational signals
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 459:837-41. 2009
    ..A similar anatomical difference was observed for their responses to actual airpuffs. These findings suggest that different groups of dopamine neurons convey motivational signals in distinct manners...
  51. ncbi request reprint A code for behavioral inhibition on the basis of color, but not motion, in ventrolateral prefrontal cortex of macaque monkey
    M Sakagami
    Department of Physiology, Juntendo University, School of Medicine, Bunkyo, Tokyo, Japan 113 8421
    J Neurosci 21:4801-8. 2001
    ..These results suggest that neurons in ventrolateral prefrontal cortex contribute to stimulus-response association in complex task situations by inhibiting behavioral responses on the basis of visual information from the ventral stream...
  52. ncbi request reprint Differential activation of monkey striatal neurons in the early and late stages of procedural learning
    Shigehiro Miyachi
    Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
    Exp Brain Res 146:122-6. 2002
    ....
  53. ncbi request reprint [Changes and disorders in voluntary saccades during development and aging]
    O Hikosaka
    Department of Physiology, Juntendo University School of Medicine, Tokyo
    No To Hattatsu 29:213-9. 1997
    ..These comparisons suggest that the functions of the basal ganglia are immature in young children while they become deteriorated in elderly people...
  54. ncbi request reprint Effects of explicit knowledge of workspace rotation in visuomotor sequence learning
    Katsumi Watanabe
    Research Center for Advanced Science and Technology, University of Tokyo, Meguro ku, Tokyo, Japan
    Exp Brain Res 174:673-8. 2006
    ..The lack of influence of explicit knowledge on the speed of performance is consistent with the two-loop model of visuomotor sequence learning (Nakahara et al. in J Cogn Neurosci 13:626-647, 2001)...
  55. ncbi request reprint Influence of reward expectation on visuospatial processing in macaque lateral prefrontal cortex
    Shunsuke Kobayashi
    Department of Neurology, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
    J Neurophysiol 87:1488-98. 2002
    ....
  56. ncbi request reprint Self-organization in the basal ganglia with modulation of reinforcement signals
    Hiroyuki Nakahara
    Laboratory for Mathematical Neuroscience, RIKEN Brain Science Institute 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    Neural Comput 14:819-44. 2002
    ..Simulations based on the model are shown to produce various types of neural activity similar to those found in experiments...
  57. ncbi request reprint Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency
    Katsumi Watanabe
    Institute of Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 6, 1 1 1, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Neurophysiol 94:1879-87. 2005
    ..We suggest that anticipatory activity of caudate neurons reflects the reversal set of reward-position contingency...
  58. ncbi request reprint Neural correlates of rewarded and unrewarded eye movements in the primate caudate nucleus
    Katsumi Watanabe
    Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    J Neurosci 23:10052-7. 2003
    ..The neuronal activity of unrewarded-saccade neurons might reflect the required execution of unrewarded eye movements on the way to future reward...
  59. ncbi request reprint Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward
    Shunsuke Kobayashi
    Brain Science Research Center, Tamagawa University Research Institute, 6 1 1, Tamagawa gakuen, Machida, Tokyo 194 8610, Japan
    Exp Brain Res 176:341-55. 2007
    ..Different types of spatial tuning in the two brain areas may contribute to different types of goal-directed behavior...
  60. ncbi request reprint Extended LATER model can account for trial-by-trial variability of both pre- and post-processes
    Hiroyuki Nakahara
    Laboratory for Integrated Theoretical Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama, Japan
    Neural Netw 19:1027-46. 2006
    ..The ELATER model is useful for investigating decision making by taking account of trial-by-trial variability of both pre- and post-processes...
  61. ncbi request reprint Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex
    Shunsuke Kobayashi
    Brain Science Research Center, Tamagawa University Research Institute, Machida, Tokyo 194 0041, Japan
    Neuron 51:861-70. 2006
    ..Our results demonstrate that information about positive and negative reinforcers is processed differentially in prefrontal cortex, which could contribute to the role of this structure in goal-directed behavior...
  62. ncbi request reprint Positive and negative modulation of motor response in primate superior colliculus by reward expectation
    Takuro Ikeda
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
    J Neurophysiol 98:3163-70. 2007
    ..The two kinds of reward-coding may be useful for the animal to select an appropriate behavior in a complex environment...
  63. ncbi request reprint Correlation of primate caudate neural activity and saccade parameters in reward-oriented behavior
    Hideaki Itoh
    Department of Mathematical Engineering and Information Physics, The University of Tokyo, Tokyo 113 8656, Japan
    J Neurophysiol 89:1774-83. 2003
    ..These results suggest that, while a majority of CD neurons receive reward-related signals, only some of them can make a significant contribution to change saccadic outputs based on expected reward...
  64. ncbi request reprint Dopamine neurons can represent context-dependent prediction error
    Hiroyuki Nakahara
    Lab for Mathematical Neuroscience, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Neuron 41:269-80. 2004
    ..This history effect corresponded to the prediction error based on the conditional probability of reward and could be simulated only by implementing the relevant context into the TD model...
  65. ncbi request reprint Chunking during human visuomotor sequence learning
    Katsuyuki Sakai
    Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 152:229-42. 2003
    ..Together with our previous unit-recording and imaging studies that used the same learning paradigm, we predict specific roles of the dominant parietal area, basal ganglia, and presupplementary motor area in the chunking...
  66. ncbi request reprint The role of the dorsal striatum in reward and decision-making
    Bernard W Balleine
    Department of Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 27:8161-5. 2007
    ..We review key evidence from recent studies in rodent, nonhuman primate, and human subjects...
  67. ncbi request reprint Emergence of rhythm during motor learning
    Katsuyuki Sakai
    Department of Cognitive Neuroscience, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Trends Cogn Sci 8:547-53. 2004
    ..In this way, organized motor skill can be performed automatically and flexibly...