J D Higley
Affiliation: National Institutes of Health
- Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmissionJ D Higley
Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, Poolesville, Maryland 20837, USA
Ann N Y Acad Sci 836:39-56. 1997..These genetic influences on serotonin functioning are further influenced by early rearing experiences, particularly parental deprivation...
- The utility of the non-human primate; model for studying gene by environment interactions in behavioral researchC S Barr
NIAAA DICBR, NIH, Clinical Studies, Primate Unit, Bldg 112, Poolesville, MD 20837, USA
Genes Brain Behav 2:336-40. 2003....
- Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonatesM Champoux
Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Poolesville, MD 20837, USA
Mol Psychiatry 7:1058-63. 2002..These results demonstrate the contributions of rearing environment and genetic background, and their interaction, in a nonhuman primate model of behavioral development...
- Early experience and sex interact to influence limbic-hypothalamic-pituitary-adrenal-axis function after acute alcohol administration in rhesus macaques (Macaca mulatta)C S Barr
National Institutes of Health, NIAAA, NIH Animal Center, Poolesville, Maryland 20837, USA
Alcohol Clin Exp Res 28:1114-9. 2004..We wanted to determine whether sex and early life parental absence would interact to influence alcohol-induced alterations in LHPA-axis activity after exposure to ethanol in macaques...
- Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primatesC Fahlke
Laboratory of Clinical Studies Primate Unit, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Alcohol Clin Exp Res 24:644-50. 2000..The purpose of this study was to assess the impact of early rearing and stress-induced rise of plasma cortisol collected during infancy as a biological predictors of adult alcohol consumption in nonhuman primates...
- Initial ethanol exposure results in decreased heart rate variability in ethanol-naive rhesus monkeysA J Bennett
Laboratory of Clinical Studies, Primate Unit, Division of Intramural Clinical and Biochemical Research, National Institute on Alcohol Abuse and Alcoholism, PO Box 529, Fisher Avenue, Poolesville, MD 20837, USA
Eur J Pharmacol 433:169-72. 2001..57+/-24.57; ethanol: interbeat interval=308.14+/-20.45). Taken together with data that show autonomic disregulation in alcoholics, these findings provide further evidence of deleterious ethanol effects on cardiac signal dynamics...
- Early experience and serotonin transporter gene variation interact to influence primate CNS functionA J Bennett
National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies Primate Unit, Poolesville, MD 20837, USA
Mol Psychiatry 7:118-22. 2002....
- Biobehavioural correlates of hand preference in free-ranging female primatesG C Westergaard
LABS of Virginia, Inc, Yemassee, SC, 29902, USA
Laterality 9:267-85. 2004....
- Serotonin transporter availability correlates with alcohol intake in non-human primatesA Heinz
Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD, USA
Mol Psychiatry 8:231-4. 2003..81, P=0.006). These observations indicate that there may be a direct relationship between serotonin transporter availability and alcohol intake after controlling for aggression and alcohol response on first exposure...
- Individual differences in alcohol-induced aggression. A nonhuman-primate modelJ D Higley
National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Alcohol Res Health 25:12-9. 2001..These differences appear to be associated with early rearing experiences and remain stable throughout the individual's life...
- A computerized apparatus designed to automatically dispense, measure, and record alcohol consumption by individual members of a rhesus macaque social group: trait-like drinking across social- and single-cage conditionsG S Flory
1301 MSRB III, Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 0632, USA
Methods 38:178-84. 2006....
- CSF 5-HIAA concentration as an early screening tool for predicting significant life history outcomes in female specific-pathogen-free (SPF) rhesus macaques (Macaca mulatta) maintained in captive breeding groupsG C Westergaard
Division of Research and Development, LABS of Virginia, Inc, 95 Castle Hall Road, PO Box 557, Yemassee, SC 29945, USA
J Med Primatol 32:95-104. 2003....
- Neurobiological correlates of the disposition and maintenance of alcoholismA Heinz
Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
Pharmacopsychiatry 36:S255-8. 2003..New treatment options include pharmacological approaches and indicate that behavior or motivational therapy and the attendance of patient groups may equally reduce the relapse risk...