J D Higley

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission
    J D Higley
    Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, Poolesville, Maryland 20837, USA
    Ann N Y Acad Sci 836:39-56. 1997
  2. ncbi request reprint The utility of the non-human primate; model for studying gene by environment interactions in behavioral research
    C S Barr
    NIAAA DICBR, NIH, Clinical Studies, Primate Unit, Bldg 112, Poolesville, MD 20837, USA
    Genes Brain Behav 2:336-40. 2003
  3. ncbi request reprint Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates
    M Champoux
    Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Poolesville, MD 20837, USA
    Mol Psychiatry 7:1058-63. 2002
  4. ncbi request reprint Early experience and sex interact to influence limbic-hypothalamic-pituitary-adrenal-axis function after acute alcohol administration in rhesus macaques (Macaca mulatta)
    C S Barr
    National Institutes of Health, NIAAA, NIH Animal Center, Poolesville, Maryland 20837, USA
    Alcohol Clin Exp Res 28:1114-9. 2004
  5. ncbi request reprint Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primates
    C Fahlke
    Laboratory of Clinical Studies Primate Unit, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 24:644-50. 2000
  6. ncbi request reprint Initial ethanol exposure results in decreased heart rate variability in ethanol-naive rhesus monkeys
    A J Bennett
    Laboratory of Clinical Studies, Primate Unit, Division of Intramural Clinical and Biochemical Research, National Institute on Alcohol Abuse and Alcoholism, PO Box 529, Fisher Avenue, Poolesville, MD 20837, USA
    Eur J Pharmacol 433:169-72. 2001
  7. ncbi request reprint Early experience and serotonin transporter gene variation interact to influence primate CNS function
    A J Bennett
    National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies Primate Unit, Poolesville, MD 20837, USA
    Mol Psychiatry 7:118-22. 2002
  8. ncbi request reprint Biobehavioural correlates of hand preference in free-ranging female primates
    G C Westergaard
    LABS of Virginia, Inc, Yemassee, SC, 29902, USA
    Laterality 9:267-85. 2004
  9. ncbi request reprint Serotonin transporter availability correlates with alcohol intake in non-human primates
    A Heinz
    Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD, USA
    Mol Psychiatry 8:231-4. 2003
  10. ncbi request reprint Individual differences in alcohol-induced aggression. A nonhuman-primate model
    J D Higley
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Alcohol Res Health 25:12-9. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission
    J D Higley
    Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, Poolesville, Maryland 20837, USA
    Ann N Y Acad Sci 836:39-56. 1997
    ..These genetic influences on serotonin functioning are further influenced by early rearing experiences, particularly parental deprivation...
  2. ncbi request reprint The utility of the non-human primate; model for studying gene by environment interactions in behavioral research
    C S Barr
    NIAAA DICBR, NIH, Clinical Studies, Primate Unit, Bldg 112, Poolesville, MD 20837, USA
    Genes Brain Behav 2:336-40. 2003
    ....
  3. ncbi request reprint Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates
    M Champoux
    Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Poolesville, MD 20837, USA
    Mol Psychiatry 7:1058-63. 2002
    ..These results demonstrate the contributions of rearing environment and genetic background, and their interaction, in a nonhuman primate model of behavioral development...
  4. ncbi request reprint Early experience and sex interact to influence limbic-hypothalamic-pituitary-adrenal-axis function after acute alcohol administration in rhesus macaques (Macaca mulatta)
    C S Barr
    National Institutes of Health, NIAAA, NIH Animal Center, Poolesville, Maryland 20837, USA
    Alcohol Clin Exp Res 28:1114-9. 2004
    ..We wanted to determine whether sex and early life parental absence would interact to influence alcohol-induced alterations in LHPA-axis activity after exposure to ethanol in macaques...
  5. ncbi request reprint Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primates
    C Fahlke
    Laboratory of Clinical Studies Primate Unit, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 24:644-50. 2000
    ..The purpose of this study was to assess the impact of early rearing and stress-induced rise of plasma cortisol collected during infancy as a biological predictors of adult alcohol consumption in nonhuman primates...
  6. ncbi request reprint Initial ethanol exposure results in decreased heart rate variability in ethanol-naive rhesus monkeys
    A J Bennett
    Laboratory of Clinical Studies, Primate Unit, Division of Intramural Clinical and Biochemical Research, National Institute on Alcohol Abuse and Alcoholism, PO Box 529, Fisher Avenue, Poolesville, MD 20837, USA
    Eur J Pharmacol 433:169-72. 2001
    ..57+/-24.57; ethanol: interbeat interval=308.14+/-20.45). Taken together with data that show autonomic disregulation in alcoholics, these findings provide further evidence of deleterious ethanol effects on cardiac signal dynamics...
  7. ncbi request reprint Early experience and serotonin transporter gene variation interact to influence primate CNS function
    A J Bennett
    National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies Primate Unit, Poolesville, MD 20837, USA
    Mol Psychiatry 7:118-22. 2002
    ....
  8. ncbi request reprint Biobehavioural correlates of hand preference in free-ranging female primates
    G C Westergaard
    LABS of Virginia, Inc, Yemassee, SC, 29902, USA
    Laterality 9:267-85. 2004
    ....
  9. ncbi request reprint Serotonin transporter availability correlates with alcohol intake in non-human primates
    A Heinz
    Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD, USA
    Mol Psychiatry 8:231-4. 2003
    ..81, P=0.006). These observations indicate that there may be a direct relationship between serotonin transporter availability and alcohol intake after controlling for aggression and alcohol response on first exposure...
  10. ncbi request reprint Individual differences in alcohol-induced aggression. A nonhuman-primate model
    J D Higley
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Alcohol Res Health 25:12-9. 2001
    ..These differences appear to be associated with early rearing experiences and remain stable throughout the individual's life...
  11. ncbi request reprint A computerized apparatus designed to automatically dispense, measure, and record alcohol consumption by individual members of a rhesus macaque social group: trait-like drinking across social- and single-cage conditions
    G S Flory
    1301 MSRB III, Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 0632, USA
    Methods 38:178-84. 2006
    ....
  12. ncbi request reprint CSF 5-HIAA concentration as an early screening tool for predicting significant life history outcomes in female specific-pathogen-free (SPF) rhesus macaques (Macaca mulatta) maintained in captive breeding groups
    G C Westergaard
    Division of Research and Development, LABS of Virginia, Inc, 95 Castle Hall Road, PO Box 557, Yemassee, SC 29945, USA
    J Med Primatol 32:95-104. 2003
    ....
  13. ncbi request reprint Neurobiological correlates of the disposition and maintenance of alcoholism
    A Heinz
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S255-8. 2003
    ..New treatment options include pharmacological approaches and indicate that behavior or motivational therapy and the attendance of patient groups may equally reduce the relapse risk...