R D Higgins

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Race, Candida sepsis, and retinopathy of prematurity
    Misrak Tadesse
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, Washington, DC 20007, USA
    Biol Neonate 81:86-90. 2002
  2. ncbi request reprint Executive summary of the workshop on oxygen in neonatal therapies: controversies and opportunities for research
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, NICHD, NIH, 6100 Executive Blvd, Room 4B03B, MSC 7510, Bethesda, MD 20892, USA
    Pediatrics 119:790-6. 2007
  3. ncbi request reprint Regression of retinopathy by squalamine in a mouse model
    Rosemary D Higgins
    Department of Pediatrics, Georgetown University, Wshington, DC 20007, USA
    Pediatr Res 56:144-9. 2004
  4. ncbi request reprint Executive summary of the workshop on the border of viability
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatrics 115:1392-6. 2005
  5. pmc Hypothermia: novel approaches for premature infants
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, NICHD, NIH 6100 Executive Blvd, Room 4B03B MSC 7510 Bethesda, MD 20892, USA
    Early Hum Dev 87:S17-8. 2011
  6. ncbi request reprint Captopril and vascular endothelial growth factor in a mouse model of retinopathy
    Rosemary D Higgins
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, Washington, DC, USA
    Curr Eye Res 27:123-9. 2003
  7. pmc Executive summary of the workshop on infection in the high-risk infant
    R D Higgins
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Perinatol 30:379-83. 2010
  8. ncbi request reprint Hypoxic ischemic encephalopathy and hypothermia: a critical look
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Obstet Gynecol 106:1385-7. 2005
  9. pmc Hypothermia for hypoxic ischemic encephalopathy in infants > or =36 weeks
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Early Hum Dev 85:S49-52. 2009
  10. ncbi request reprint Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development NIH, 6100 Executive Boulevard, MSC 7510, Bethesda, MD 20892, USA
    J Pediatr 148:170-175. 2006

Detail Information

Publications65

  1. ncbi request reprint Race, Candida sepsis, and retinopathy of prematurity
    Misrak Tadesse
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, Washington, DC 20007, USA
    Biol Neonate 81:86-90. 2002
    ....
  2. ncbi request reprint Executive summary of the workshop on oxygen in neonatal therapies: controversies and opportunities for research
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, NICHD, NIH, 6100 Executive Blvd, Room 4B03B, MSC 7510, Bethesda, MD 20892, USA
    Pediatrics 119:790-6. 2007
    ..This article provides a summary of the discussions, focusing on major knowledge gaps, with prioritized suggestions for studies in this area...
  3. ncbi request reprint Regression of retinopathy by squalamine in a mouse model
    Rosemary D Higgins
    Department of Pediatrics, Georgetown University, Wshington, DC 20007, USA
    Pediatr Res 56:144-9. 2004
    ..Further, squalamine given late in the course of OIR improves retinopathy by inducing regression of retinal neovessels and abrogating invasion of new vessels beyond the inner-limiting membrane of the retina...
  4. ncbi request reprint Executive summary of the workshop on the border of viability
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatrics 115:1392-6. 2005
    ..This article provides a summary of the discussions, focusing on major knowledge gaps and prioritized suggestions for studies in this area...
  5. pmc Hypothermia: novel approaches for premature infants
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, NICHD, NIH 6100 Executive Blvd, Room 4B03B MSC 7510 Bethesda, MD 20892, USA
    Early Hum Dev 87:S17-8. 2011
    ..A summary of evidence for hypothermia and premature infants is presented in this brief report...
  6. ncbi request reprint Captopril and vascular endothelial growth factor in a mouse model of retinopathy
    Rosemary D Higgins
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, Washington, DC, USA
    Curr Eye Res 27:123-9. 2003
    ..The objective of this study was to determine the effect of captopril, an angiotensin converting enzyme (ACE) inhibitor, on retinal VEGF, VEGF-R1, and VEGF-R2 expression in a mouse model of oxygen induced retinopathy (OIR)...
  7. pmc Executive summary of the workshop on infection in the high-risk infant
    R D Higgins
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Perinatol 30:379-83. 2010
    ..In this paper, we provide a summary of the discussions, focusing on major knowledge gaps, and prioritized suggestions for research in this area...
  8. ncbi request reprint Hypoxic ischemic encephalopathy and hypothermia: a critical look
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Obstet Gynecol 106:1385-7. 2005
    ..Therapeutic hypothermia offers a potentially promising therapy for hypoxic ischemic encephalopathy. Hypothermia for encephalopathy should be considered an evolving therapy because of lack of long-term safety and efficacy data...
  9. pmc Hypothermia for hypoxic ischemic encephalopathy in infants > or =36 weeks
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Early Hum Dev 85:S49-52. 2009
    ..Hypothermia for neonatal HIE is continuing to evolve as a therapy. Studies, gaps in knowledge and opportunities for research are presented herein...
  10. ncbi request reprint Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development NIH, 6100 Executive Boulevard, MSC 7510, Bethesda, MD 20892, USA
    J Pediatr 148:170-175. 2006
  11. ncbi request reprint Lack of effect of gender on retinopathy in the mouse
    R D Higgins
    Department of Paediatrics, Georgetown University Children s Medical Center, Washington, DC 20007, USA
    Clin Experiment Ophthalmol 29:323-6. 2001
    ..The reported effect of gender on retinopathy of prematurity has been controversial. The goal of this study was to determine the effect of gender on oxygen-induced retinopathy in a mouse model...
  12. ncbi request reprint Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
    ....
  13. ncbi request reprint Antenatal dexamethasone and decreased severity of retinopathy of prematurity
    R D Higgins
    Department of Pediatrics, New York University Medical Center and Bellevue Hospital Center, New York City, USA
    Arch Ophthalmol 116:601-5. 1998
    ..To assess risk factors associated with the development of retinopathy of prematurity (ROP) in an urban population...
  14. ncbi request reprint Hyperoxia stimulates endothelin-1 secretion from endothelial cells; modulation by captopril and nifedipine
    R D Higgins
    Georgetown University Medical Center, Department of Pediatrics, Washington, DC 20007, USA
    Curr Eye Res 17:487-93. 1998
    ..Premature birth results in a relative systemic hyperoxia, compared to the in utero oxygen milieu. We tested the hypothesis that hyperoxia increases ET-1 expression as a possible mechanism for vasoconstriction in the retinal vasculature...
  15. ncbi request reprint Squalamine improves retinal neovascularization
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Invest Ophthalmol Vis Sci 41:1507-12. 2000
    ..The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model...
  16. ncbi request reprint Captopril improves retinal neovascularization via endothelin-1
    M Tadesse
    Georgetown University Children's Medical Center, Department of Pediatrics, Division of Neonatology, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Invest Ophthalmol Vis Sci 42:1867-72. 2001
    ..ET-1 expression is increased from P7 to P17, altered by hyperoxic exposure and relative hypoxic recovery and modulated by captopril in a mouse model of OIR...
  17. ncbi request reprint Characteristics of extremely low-birth-weight infant survivors with unimpaired outcomes at 30 months of age
    P Kumar
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Perinatol 33:800-5. 2013
    ..To evaluate characteristics of unimpaired outcome in extremely low-birth-weight (ELBW) survivors...
  18. ncbi request reprint Ibuprofen improves oxygen-induced retinopathy in a mouse model
    Jotishna Sharma
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, Washington, DC, USA
    Curr Eye Res 27:309-14. 2003
    ..The goal of the study was to test the hypothesis that ibuprofen would improve oxygen-induced retinopathy in a mouse model...
  19. ncbi request reprint Evolving blood pressure dynamics for extremely preterm infants
    B Batton
    1 Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH, USA 2 Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, IL, USA
    J Perinatol 34:301-5. 2014
    ..To examine changes in arterial blood pressure (ABP) after birth in extremely preterm infants...
  20. doi request reprint Outcomes of extremely preterm infants following severe intracranial hemorrhage
    A S Davis
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, USA
    J Perinatol 34:203-8. 2014
    ..Severe intracranial hemorrhage (ICH) is an important prognostic variable in extremely preterm (EPT) infants. We examined imaging and clinical variables that predict outcomes in EPT infants with severe ICH...
  21. pmc Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants
    Deanne Wilson-Costello
    Rainbow Babies and Children s Hospital, Division of Neonatology, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Pediatrics 123:e430-7. 2009
    ....
  22. ncbi request reprint Dexamethasone alters TNF-alpha expression in retinopathy
    P Yossuck
    Department of Pediatrics, Division of Neonatology, Georgetown University Children's Medical Center, Washington, DC 20007, USA
    Mol Genet Metab 72:164-7. 2001
    ..It increased markedly during the vasoproliferative phase and was suppressed by dexamethasone. Modulation of TNF-alpha expression may provide a potential site of action for future therapeutic targets...
  23. ncbi request reprint Neuropeptide Y expression in a mouse model of oxygen-induced retinopathy
    Helen Z Yoon
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, Washington, DC 20007, USA
    Clin Experiment Ophthalmol 30:424-9. 2002
    ..The goal of this study was to determine the expression of NPY and its receptors, NPY Y1 and NPY Y2, in a mouse model of oxygen-induced retinopathy...
  24. ncbi request reprint Optimizing care and outcome for late-preterm (near-term) infants: a summary of the workshop sponsored by the National Institute of Child Health and Human Development
    Tonse N K Raju
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Pediatrics 118:1207-14. 2006
    ..Knowledge gaps were identified, and research priorities were listed. This article provides a summary of the meeting...
  25. pmc Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Pediatrics 124:517-26. 2009
    ..Limited information is available on the outcomes of infants managed with SNIPPV...
  26. ncbi request reprint Safe and effective devices and instruments for use in the neonatal intensive care units: NICHD Workshop summary
    Tonse N K Raju
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    Biomed Instrum Technol 43:408-18. 2009
    ..The discussants addressed topics in cardiopulmonary, cerebrovascular, metabolic, and infectious conditions of the neonate. The authors provide a summary of the workshop discussions in this paper...
  27. ncbi request reprint Evaluating retinopathy of prematurity screening guidelines for 24- to 27-week gestational age infants
    K A Kennedy
    Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA
    J Perinatol 34:311-8. 2014
    ..To determine whether current retinopathy of prematurity (ROP) screening guidelines adequately identify treatable ROP in a contemporary cohort of extremely low gestation infants...
  28. pmc Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy
    Abbot R Laptook
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02906, USA
    Pediatrics 124:1619-26. 2009
    ..The objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy...
  29. pmc Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Arch Pediatr Adolesc Med 162:748-55. 2008
    ..To determine special outpatient services (SOS) use, need, associated factors, and neurodevelopmental and functional outcomes among extremely preterm infants at 18 to 22 months' corrected age...
  30. ncbi request reprint Somatostatin analogs inhibit neonatal retinal neovascularization
    Rosemary D Higgins
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, 3800 Reservoir Road, NW M3400, Washington, DC, 20007, USA
    Exp Eye Res 74:553-9. 2002
    ..Growth as measured by animal weight was unaffected by either treatment. Woc4D and octreotide inhibited retinal neovascularization in an equally effective manner in the mouse model of oxygen induced retinopathy...
  31. pmc Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatrics 122:e791-8. 2008
    ..Whole-body hypothermia reduced the frequency of death or moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a randomized, controlled multicenter trial...
  32. pmc Neonatal candidiasis: epidemiology, risk factors, and clinical judgment
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
    Pediatrics 126:e865-73. 2010
    ..We quantified risk factors that predict infection in premature infants at high risk and compared clinical judgment with a prediction model of invasive candidiasis...
  33. pmc Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy
    William Oh
    Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr 153:375-8. 2008
    ..To assess the association between urinary lactate to creatinine ratio (ULCR) and neurodevelopmental outcome in term infants with hypoxic ischemic encephalopathy and examine the effect of hypothermia on the change in ULCR...
  34. ncbi request reprint Inhaled nitric oxide for premature infants with severe respiratory failure
    Krisa P Van Meurs
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    N Engl J Med 353:13-22. 2005
    ..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants...
  35. ncbi request reprint Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 118:2084-93. 2006
    ..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy...
  36. pmc Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants
    J L Wynn
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Pediatrics Neonatology, Nashville, TN, USA
    J Perinatol 33:613-8. 2013
    ..We compared serotype-specific antibody responses to heptavalent pneumococcal conjugate vaccine (PCV7) in very low birth weight infants (<1500 g,VLBWs) with and without blood stream infection (BSI) during their birth hospitalization...
  37. pmc Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis
    R Wadhawan
    Department of Pediatrics, Women and Infants Hospital, Providence, RI, USA
    J Perinatol 34:64-70. 2014
    ....
  38. pmc Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure
    N Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Perinatol 28:420-6. 2008
    ..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure...
  39. ncbi request reprint Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Pediatrics 117:84-92. 2006
    ..Neonatal candidiasis is associated with substantial morbidity and mortality rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been reported...
  40. pmc Predicting time to hospital discharge for extremely preterm infants
    Susan R Hintz
    Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine and Lucile Packard Children s Hospital, Palo Alto, CA 94304, USA
    Pediatrics 125:e146-54. 2010
    ..Accurate models for predicting time to hospital discharge could aid in resource planning, family counseling, and stimulate quality-improvement initiatives...
  41. pmc Perinatal systemic inflammatory response syndrome and retinopathy of prematurity
    Beena G Sood
    Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Res 67:394-400. 2010
    ..We conclude that perinatal inflammation may be involved in the pathogenesis of ROP...
  42. pmc Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollment
    Wade D Rich
    Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
    Pediatrics 126:e215-21. 2010
    ....
  43. pmc Maternal age, multiple birth, and extremely low birth weight infants
    Betty R Vohr
    Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr 154:498-503.e2. 2009
    ..To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers...
  44. pmc Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants
    Edward F Bell
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 126:222-31. 2010
    ....
  45. pmc Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes
    Abbot Laptook
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley St, Providence, RI 02906, USA
    Pediatrics 122:491-9. 2008
    ....
  46. pmc Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months
    Conrad R Cole
    Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 122:e573-82. 2008
    ....
  47. ncbi request reprint Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
    Pediatrics 115:1645-51. 2005
    ..Increased survival rates for extremely preterm, extremely low birth weight infants during the postsurfactant era have been reported, but data on changes in neurosensory and developmental impairments are sparse...
  48. pmc Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 126:443-56. 2010
    ....
  49. ncbi request reprint Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    Pediatr Infect Dis J 24:635-9. 2005
    ..We previously reported a change in the distribution of pathogens associated with EOS from predominantly gram-positive to primarily gram-negative organisms...
  50. ncbi request reprint Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    JAMA 292:2357-65. 2004
    ..Neonatal infections are frequent complications of extremely low-birth-weight (ELBW) infants receiving intensive care...
  51. pmc Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants
    Girija Natarajan
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Res 67:77-82. 2010
    ..003). The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted...
  52. pmc Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months
    Regina A Gargus
    Department of Pediatrics, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA
    Pediatrics 124:112-21. 2009
    ..The goal was to identify, among extremely low birth weight (<or=1000 g) live births, the proportion of infants who were unimpaired at 18 to 22 months of corrected age...
  53. pmc Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 123:1132-41. 2009
    ..The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days...
  54. ncbi request reprint Persistent beneficial effects of breast milk ingested in the neonatal intensive care unit on outcomes of extremely low birth weight infants at 30 months of age
    Betty R Vohr
    Department of Pediatrics, Brown Medical School, Providence, Rhode Island, USA
    Pediatrics 120:e953-9. 2007
    ..The objective of this study was to determine whether these effects of breast milk in infants with extremely low birth weight persisted at 30 months' corrected age...
  55. ncbi request reprint Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    N Engl J Med 353:1574-84. 2005
    ..Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain...
  56. pmc Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide
    Susan R Hintz
    NICHD Neonatal Research Network
    J Pediatr 151:16-22, 22.e1-3. 2007
    ....
  57. doi request reprint Neurodevelopmental outcomes of extremely low birth weight infants exposed prenatally to dexamethasone versus betamethasone
    Ben H Lee
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatrics 121:289-96. 2008
    ..We compared the development of adverse neurodevelopmental outcomes at corrected ages of 18 to 22 months for extremely low birth weight infants exposed prenatally to dexamethasone, betamethasone, or no steroid...
  58. pmc Intensive care for extreme prematurity--moving beyond gestational age
    Jon E Tyson
    Center for Clinical Research and Evidence Based Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
    N Engl J Med 358:1672-81. 2008
    ..Decisions regarding whether to administer intensive care to extremely premature infants are often based on gestational age alone. However, other factors also affect the prognosis for these patients...
  59. ncbi request reprint Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization
    Markku Koulu
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Ann Med 36:232-40. 2004
    ..In addition, we investigated the role of the NPY Y2-receptor as a putative mediator of angiogenic NPY signaling in the retina...
  60. ncbi request reprint Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Acta Paediatr 95:1239-48. 2006
    ..To determine whether gender-specific responses to perinatal and neonatal events and exposures explain the male disadvantage in early childhood outcomes...
  61. ncbi request reprint Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone
    Ben H Lee
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatrics 117:1503-10. 2006
    ....
  62. pmc Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infants
    Eduardo Broitman
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Pediatr 151:500-5, 505.e1-2. 2007
    ..To determine the relative contribution of clinical data versus head ultrasound scanning (HUS) in predicting neurodevelopmental impairment (NDI) in extremely low birth weight infants...
  63. pmc Aggressive vs. conservative phototherapy for infants with extremely low birth weight
    Brenda H Morris
    University of Texas Medical School, Houston, TX 77030, USA
    N Engl J Med 359:1885-96. 2008
    ..It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g or less)...
  64. ncbi request reprint Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted age
    Martin L Blakely
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Pediatrics 117:e680-7. 2006
    ....
  65. pmc Interobserver reliability and accuracy of cranial ultrasound scanning interpretation in premature infants
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Pediatr 150:592-6, 596.e1-5. 2007
    ..To assess interobserver reliability between 2 central readers of cranial ultrasound scanning (CUS) and accuracy of local, compared with central, interpretations...