Alison Burgess Hickman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Transposition of hAT elements links transposable elements and V(D)J recombination
    Liqin Zhou
    Howard Hughes Medical Institute and Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Nature 432:995-1001. 2004
  2. ncbi request reprint Unexpected structural diversity in DNA recombination: the restriction endonuclease connection
    A B Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 5:1025-34. 2000
  3. ncbi request reprint Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 10:327-37. 2002
  4. pmc Integrating prokaryotes and eukaryotes: DNA transposases in light of structure
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Crit Rev Biochem Mol Biol 45:50-69. 2010
  5. pmc Mechanism of IS200/IS605 family DNA transposases: activation and transposon-directed target site selection
    Orsolya Barabas
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 132:208-20. 2008
  6. pmc The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA
    Donald R Ronning
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    EMBO J 23:2972-81. 2004
  7. ncbi request reprint The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA
    Mol Cell 13:403-14. 2004
  8. pmc DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    EMBO J 29:3840-52. 2010
  9. ncbi request reprint A mob of reps
    Fred Dyda
    Laboratory of Molecular Biology, HHS NIH NIDDK, Building 5, Room 303, Bethesda, MD 20892, USA
    Structure 11:1310-1. 2003
  10. pmc The amino acid linker between the endonuclease and helicase domains of adeno-associated virus type 5 Rep plays a critical role in DNA-dependent oligomerization
    Jenna E Maggin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:3337-46. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Transposition of hAT elements links transposable elements and V(D)J recombination
    Liqin Zhou
    Howard Hughes Medical Institute and Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Nature 432:995-1001. 2004
    ....
  2. ncbi request reprint Unexpected structural diversity in DNA recombination: the restriction endonuclease connection
    A B Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 5:1025-34. 2000
    ..This result indicates that the range of biological processes that utilize restriction enzyme-like folds also includes DNA transposition...
  3. ncbi request reprint Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 10:327-37. 2002
    ..The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily...
  4. pmc Integrating prokaryotes and eukaryotes: DNA transposases in light of structure
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Crit Rev Biochem Mol Biol 45:50-69. 2010
    ..Detailed understanding of transposition pathways is a prerequisite for the long-term goal of exploiting DNA transposons as genetic tools and as a basis for genetic medical applications...
  5. pmc Mechanism of IS200/IS605 family DNA transposases: activation and transposon-directed target site selection
    Orsolya Barabas
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 132:208-20. 2008
    ..Our structural results explain why the transposon ends are asymmetric and how the transposon selects a target site for integration, and they allow us to propose a molecular model for the entire transposition reaction...
  6. pmc The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA
    Donald R Ronning
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    EMBO J 23:2972-81. 2004
    ....
  7. ncbi request reprint The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 USA
    Mol Cell 13:403-14. 2004
    ..Use of these different interfaces generates the structural asymmetry necessary to regulate later events in viral replication and integration...
  8. pmc DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    EMBO J 29:3840-52. 2010
    ..Finally, the observed active site rearrangements when the transposase binds a metal ion in which it is inactive provide a clear rationale for metal ion specificity...
  9. ncbi request reprint A mob of reps
    Fred Dyda
    Laboratory of Molecular Biology, HHS NIH NIDDK, Building 5, Room 303, Bethesda, MD 20892, USA
    Structure 11:1310-1. 2003
    ..The two classes are united by the same endonucleolytic mechanism and a conserved Mg(2+) binding site containing multiple histidine ligands unique to this superfamily...
  10. pmc The amino acid linker between the endonuclease and helicase domains of adeno-associated virus type 5 Rep plays a critical role in DNA-dependent oligomerization
    Jenna E Maggin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:3337-46. 2012
    ..We conclude that the linker is likely a key contributor to Rep68/78 DNA-dependent oligomerization and may play an important role in mediating Rep68/78's conversion from site-specific DNA binding to nonspecific DNA unwinding...
  11. ncbi request reprint Binding and unwinding: SF3 viral helicases
    Alison Burgess Hickman
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 5 Center Drive MSC 0560, Bethesda, MD 20892 0560, USA
    Curr Opin Struct Biol 15:77-85. 2005
    ..At these forks, the SF3 helicases act as replicative helicases. The simian virus 40 SF3 helicase forms a hexameric ring, anticipated to be characteristic of the entire superfamily...
  12. ncbi request reprint Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina
    Christina Marchetti Bradley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 15:643-53. 2007
    ..The surface involved in binding lamin A/C is proposed based on results from alanine-scanning mutagenesis and a solid-phase overlay binding assay...
  13. doi request reprint The emerging diversity of transpososome architectures
    Fred Dyda
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Q Rev Biophys 45:493-521. 2012
    ..Given that there are a number of common functional requirements for transposition, it is remarkable how these are satisfied by complex assemblies that are so architecturally different...
  14. pmc Purification, crystallization and preliminary crystallographic analysis of the Hermes transposase
    Zhanita N Perez
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:587-90. 2005
    ..An N-terminally deleted version of the Hermes transposase (residues 79-612) has been overexpressed and purified, and crystals that diffract to 2.1 A resolution have been obtained at 277 K by the hanging-drop method...
  15. ncbi request reprint Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding
    Tomas Obsil
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 5 Center Drive, MSC 0560, Bethesda, Maryland 20892, USA
    Biochemistry 42:15264-72. 2003
    ....
  16. doi request reprint In vitro reconstitution of a single-stranded transposition mechanism of IS608
    Catherine Guynet
    Laboratoire de Microbiologie et Genetique Moleculaires, CNRS UMR5100, 118 Rte de Narbonne, F31062 Toulouse Cedex, France
    Mol Cell 29:302-12. 2008
    ..This single-strand transposition mode has important implications not only for dispersion of IS608 but also for the other members of this very large IS family...