Research Topics
| Joseph R HibbelnSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorderJoseph R Hibbeln
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
Biol Psychiatry 53:431-41. 2003..Prior reports of abnormalities of essential fatty acid metabolism among schizophrenic patients may have been an artifact of patients' smoking behavior and differences in dietary intake of omega-3 fatty acids...- Fatty acid formula supplementation and neuromotor development in rhesus monkey neonatesMaribeth Champoux
Laboratory of Comparative Ethology, NICHD, Poolesville, Maryland 20837, USA
Pediatr Res 51:273-81. 2002..Supplementation did not affect measures of activity or state control, indicating no effect on temperament. These data support the assertion that preformed DHA and arachidonic acid in infant formulas are required for optimal development... - Increasing homicide rates and linoleic acid consumption among five Western countries, 1961-2000Joseph R Hibbeln
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
Lipids 39:1207-13. 2004..Low linoleate diets may prevent behavioral maladies that correctional institutions, social service programs, and mental health providers intend to treat... - Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for interventionJoseph R Hibbeln
National Institute on Alcohol Abuse and Alcoholism, Bethesda, 20892, USA
Int Rev Psychiatry 18:107-18. 2006..Ensuring optimal intakes of omega-3 fatty acids during early development and adulthood shows considerable promise in preventing aggression and hostility... - Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversityJoseph R Hibbeln
Laboratory of Membrane Biochemistry and Biophysics and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 2088, USA
Am J Clin Nutr 83:1483S-1493S. 2006.... - Omega-3 status and cerebrospinal fluid corticotrophin releasing hormone in perpetrators of domestic violenceJoseph R Hibbeln
Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
Biol Psychiatry 56:895-7. 2004..Prostaglandins E2 and F2alpha, which increase corticotrophin-releasing hormone RNA expression in this pathway, are reduced by dietary intakes of omega-3 fats... - Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort studyJoseph R Hibbeln
Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA
Lancet 369:578-85. 2007..We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal seafood intake during pregnancy... - From homicide to happiness--a commentary on omega-3 fatty acids in human society. Cleave Award LectureJoseph R Hibbeln
Section on Nutritional Neurosciences, Laboratory of Membrane Biochenmistr and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 2088, USA
Nutr Health 19:9-19. 2007.... 
Considerations regarding neuropsychiatric nutritional requirements for intakes of omega-3 highly unsaturated fatty acidsJoseph R Hibbeln
LMBB, National Institutes Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Rm 3N 07, MSC 9410, Bethesda, MD 20892, USA
Prostaglandins Leukot Essent Fatty Acids 81:179-86. 2009..Adverse neurodevelopmental and neuropsychiatric outcomes have been established as signs of nutrient deficiencies and may be applicable to insufficient dietary intakes of omega-3 highly unsaturated fatty acids (n-3 HUFAs)...
Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysisChristopher E Ramsden
Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
BMJ 346:e8707. 2013..To evaluate the effectiveness of replacing dietary saturated fat with omega 6 linoleic acid, for the secondary prevention of coronary heart disease and death...- Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th centuryTanya L Blasbalg
Section on Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
Am J Clin Nutr 93:950-62. 2011..The consumption of omega-3 (n-3) and omega-6 (n-6) essential fatty acids in Western diets is thought to have changed markedly during the 20th century... - Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humansChristopher E Ramsden
Section on Nutritional Neurosciences, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Prostaglandins Leukot Essent Fatty Acids 87:135-41. 2012..Future studies evaluating the clinical implications of diet-induced OXLAM reductions are warranted... - Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawalRobert J Pawlosky
Laboratory of Metabolic Control, National Cancer Institute NIH, Bethesda, MD, USA
J Lipid Res 50:154-61. 2009.... - Compartmental analyses of plasma n-3 essential fatty acids among male and female smokers and nonsmokersRobert J Pawlosky
Laboratory of Metabolic Control, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
J Lipid Res 48:935-43. 2007..03) that was greater compared with nonsmokers. Smoking increased the bioavailability of n-3 FAs from plasma, accelerated the fractional synthetic rates, and heightened the percent formation of some long-chain n-3 PUFAs in men and women... - Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjectsRobert J Pawlosky
Food Composition Laboratory, Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, MD, USA
Am J Clin Nutr 77:565-72. 2003..Diets rich in 20- and 22-carbon PUFAs may inhibit desaturase expression or activity and decrease the synthesis of long-chain unsaturated fatty acids... - Assessing the environment for regulatory change for eicosapentaenoic acid and docosahexaenoic acid nutrition labelingAmy M Brownawell
Life Sciences Research Office, Bethesda, Maryland, USA
Nutr Rev 67:391-7. 2009.... - Low vitamin D status and suicide: a case-control study of active duty military service membersJohn C Umhau
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
PLoS ONE 8:e51543. 2013.... - Fast transmethylation of serum lipids using microwave irradiationYu Hong Lin
Laboratory of Membrane Biochemistry and Biophysics, Section of Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Lipids 47:1109-17. 2012..This methodology may be applied in both the absolute and relative quantification of serum total fatty acids... - Automated high-throughput fatty acid analysis of umbilical cord serum and application to an epidemiological studyYu Hong Lin
Section of Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3N 07, MSC 9410, Bethesda, MD 20892 9410, USA
Lipids 47:527-39. 2012..Automated fatty acid analysis coupled with automated data processing greatly facilitates the high throughput, 72 samples transesterified in 6 h, required for large population-based studies... - Low omega-6 vs. low omega-6 plus high omega-3 dietary intervention for chronic daily headache: protocol for a randomized clinical trialChristopher E Ramsden
Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD, USA
Trials 12:97. 2011..Secondary clinical outcomes include headache-specific quality-of-life, and headache frequency and intensity... - n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trialsChristopher E Ramsden
Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD, USA
Br J Nutr 104:1586-600. 2010..16; 95 % CI 0.95, 1.42). Advice to specifically increase n-6 PUFA intake, based on mixed n-3/n-6 RCT data, is unlikely to provide the intended benefits, and may actually increase the risks of CHD and death... - Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesityAnita R Alvheim
National Institute of Nutrition and Seafood Research, Bergen, Norway
Obesity (Silver Spring) 20:1984-94. 2012..The adipogenic effect of LA can be prevented by consuming sufficient EPA and DHA to reduce the AA-PL pool and normalize endocannabinoid tone... - Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysisJoseph R Hibbeln
Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park 5, Room 150, 12420 Parklawn Drive, Rockville, MD 20892, USA
J Affect Disord 69:15-29. 2002..We postulated that the DHA content of mothers' milk and seafood consumption would both predict prevalence rates of postpartum depression across countries... - Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteersSarah M Conklin
Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States
Psychiatry Res 152:1-10. 2007..These findings suggest that omega-3 fatty acid status is associated with variability in affect regulation, personality and impulse control... - Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusersLaure Buydens-Branchey
Psychiatry Service, DVA New York Harbor Healthcare System, Brooklyn, NY 11209, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:568-75. 2008.... - Polyunsaturated fatty acid status and relapse vulnerability in cocaine addictsLaure Buydens-Branchey
Department of Psychiatry, State University of New York Health Science Center at Brooklyn and Veterans Affairs New York Harbor Healthcare System, Brooklyn Campus 11S BK, 800 Poly Place, Brooklyn, NY 11209, USA
Psychiatry Res 120:29-35. 2003.... - Visual acuity and retinal function in infant monkeys fed long-chain PUFABrett G Jeffrey
Department of Paediatrics and Child Health, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, Adelaide, SA 5042, Australia
Lipids 37:839-48. 2002..The results suggest that supplementation of the infant monkey diet with 1.0% DHA and 1.0% AA neither harms nor provides substantial benefit to the development of visual acuity or retinal function in the first four postnatal months... - Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide riskM Elizabeth Sublette
Department of Neuroscience, NY State Psychiatric Institute, Columbia University, Unit 42, 1051 Riverside Dr, New York, NY 10032, USA
Am J Psychiatry 163:1100-2. 2006..If confirmed, this finding would have implications for the neurobiology of suicide and reduction of suicide risk... - High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticismSarah M Conklin
Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
Psychosom Med 69:932-4. 2007..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults... - Polyunsaturated fatty acid status and aggression in cocaine addictsLaure Buydens-Branchey
Department of Psychiatry, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11209, USA
Drug Alcohol Depend 71:319-23. 2003..We also explored the possibility that their FA levels would change after a 2 week stay on an inpatient unit where a standard diet would be provided... - Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled studyMarlene P Freeman
Women s Mental Health Center, University of Texas Southwestern Medical Center, Dallas TX, USA
J Affect Disord 110:142-8. 2008..This study was designed to investigate the feasibility, safety, and efficacy of omega-3 fatty acids for perinatal depression in addition to supportive psychotherapy... - Cross-national comparisons of seafood consumption and rates of bipolar disordersSimona Noaghiul
New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, USA
Am J Psychiatry 160:2222-7. 2003..These data provide a cross-national context for understanding ongoing clinical intervention trials of omega-3 fatty acids in bipolar disorders... - Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patientsJennifer I Harris
Department of Medicine, Center for Clinical Pharmacology, School of Medicine, University of Pittsburgh, 4015 O'Hara Street, Old Engineering Hall, Room 506, Pittsburgh, PA 15260, USA
Prostaglandins Leukot Essent Fatty Acids 71:263-9. 2004..5 to 18.8 (P<.01), and tended to increase the AA:DHA ratio (P=.053). Thus, simvastatin lowered serum fatty acid concentrations while also altering the relative percentages of important PUFAs... - Lipids and essential fatty acids in patients presenting with self-harmMalcolm R Garland
Department of Adult Psychiatry, Galway University Hospital and the Clinical Sciences Institute, National University of Ireland, Ireland
Br J Psychiatry 190:112-7. 2007..Low cholesterol has been reliably demonstrated in people who self-harm... - The Lancet and the Royal Society are both right and wrongMichael A Crawford
Lancet 366:714-5. 2005 - Omega-3 fatty acids: evidence basis for treatment and future research in psychiatryMarlene P Freeman
Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
J Clin Psychiatry 67:1954-67. 2006..To determine if the available data support the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders... - Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trialBrian Hallahan
Department of Psychiatry, Beaumont Hospital and The Royal College of Surgeons in Ireland, Ireland
Br J Psychiatry 190:118-22. 2007..Trials have demonstrated benefits of long-chain omega-3 essential fatty acid (n-3 EFA) supplementation in a variety of psychiatric disorders...