Joseph R Hibbeln

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder
    Joseph R Hibbeln
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
    Biol Psychiatry 53:431-41. 2003
  2. ncbi request reprint Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates
    Maribeth Champoux
    Laboratory of Comparative Ethology, NICHD, Poolesville, Maryland 20837, USA
    Pediatr Res 51:273-81. 2002
  3. ncbi request reprint Increasing homicide rates and linoleic acid consumption among five Western countries, 1961-2000
    Joseph R Hibbeln
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Lipids 39:1207-13. 2004
  4. ncbi request reprint Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention
    Joseph R Hibbeln
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, 20892, USA
    Int Rev Psychiatry 18:107-18. 2006
  5. pmc Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity
    Anita R Alvheim
    National Institute of Nutrition and Seafood Research, Bergen, Norway
    Obesity (Silver Spring) 20:1984-94. 2012
  6. ncbi request reprint Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity
    Joseph R Hibbeln
    Laboratory of Membrane Biochemistry and Biophysics and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 2088, USA
    Am J Clin Nutr 83:1483S-1493S. 2006
  7. ncbi request reprint Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA
    Lancet 369:578-85. 2007
  8. ncbi request reprint From homicide to happiness--a commentary on omega-3 fatty acids in human society. Cleave Award Lecture
    Joseph R Hibbeln
    Section on Nutritional Neurosciences, Laboratory of Membrane Biochenmistr and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 2088, USA
    Nutr Health 19:9-19. 2007
  9. pmc Considerations regarding neuropsychiatric nutritional requirements for intakes of omega-3 highly unsaturated fatty acids
    Joseph R Hibbeln
    LMBB, National Institutes Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Rm 3N 07, MSC 9410, Bethesda, MD 20892, USA
    Prostaglandins Leukot Essent Fatty Acids 81:179-86. 2009
  10. ncbi request reprint Omega-3 status and cerebrospinal fluid corticotrophin releasing hormone in perpetrators of domestic violence
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Biol Psychiatry 56:895-7. 2004

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder
    Joseph R Hibbeln
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
    Biol Psychiatry 53:431-41. 2003
    ....
  2. ncbi request reprint Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates
    Maribeth Champoux
    Laboratory of Comparative Ethology, NICHD, Poolesville, Maryland 20837, USA
    Pediatr Res 51:273-81. 2002
    ..Supplementation did not affect measures of activity or state control, indicating no effect on temperament. These data support the assertion that preformed DHA and arachidonic acid in infant formulas are required for optimal development...
  3. ncbi request reprint Increasing homicide rates and linoleic acid consumption among five Western countries, 1961-2000
    Joseph R Hibbeln
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Lipids 39:1207-13. 2004
    ..Low linoleate diets may prevent behavioral maladies that correctional institutions, social service programs, and mental health providers intend to treat...
  4. ncbi request reprint Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention
    Joseph R Hibbeln
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, 20892, USA
    Int Rev Psychiatry 18:107-18. 2006
    ..Ensuring optimal intakes of omega-3 fatty acids during early development and adulthood shows considerable promise in preventing aggression and hostility...
  5. pmc Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity
    Anita R Alvheim
    National Institute of Nutrition and Seafood Research, Bergen, Norway
    Obesity (Silver Spring) 20:1984-94. 2012
    ..The adipogenic effect of LA can be prevented by consuming sufficient EPA and DHA to reduce the AA-PL pool and normalize endocannabinoid tone...
  6. ncbi request reprint Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity
    Joseph R Hibbeln
    Laboratory of Membrane Biochemistry and Biophysics and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 2088, USA
    Am J Clin Nutr 83:1483S-1493S. 2006
    ....
  7. ncbi request reprint Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA
    Lancet 369:578-85. 2007
    ..We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal seafood intake during pregnancy...
  8. ncbi request reprint From homicide to happiness--a commentary on omega-3 fatty acids in human society. Cleave Award Lecture
    Joseph R Hibbeln
    Section on Nutritional Neurosciences, Laboratory of Membrane Biochenmistr and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 2088, USA
    Nutr Health 19:9-19. 2007
    ....
  9. pmc Considerations regarding neuropsychiatric nutritional requirements for intakes of omega-3 highly unsaturated fatty acids
    Joseph R Hibbeln
    LMBB, National Institutes Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Rm 3N 07, MSC 9410, Bethesda, MD 20892, USA
    Prostaglandins Leukot Essent Fatty Acids 81:179-86. 2009
    ..Adverse neurodevelopmental and neuropsychiatric outcomes have been established as signs of nutrient deficiencies and may be applicable to insufficient dietary intakes of omega-3 highly unsaturated fatty acids (n-3 HUFAs)...
  10. ncbi request reprint Omega-3 status and cerebrospinal fluid corticotrophin releasing hormone in perpetrators of domestic violence
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Biol Psychiatry 56:895-7. 2004
    ..Prostaglandins E2 and F2alpha, which increase corticotrophin-releasing hormone RNA expression in this pathway, are reduced by dietary intakes of omega-3 fats...
  11. pmc Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial
    Christopher E Ramsden
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina Chapel Hill, NC, USA Electronic address
    Pain 154:2441-51. 2013
    ..2 vs +27.2; P<0.001). A dietary intervention increasing n-3 and reducing n-6 fatty acids reduced headache pain, altered antinociceptive lipid mediators, and improved quality-of-life in this population. ..
  12. doi request reprint Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis
    Christopher E Ramsden
    Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    BMJ 346:e8707. 2013
    ..To evaluate the effectiveness of replacing dietary saturated fat with omega 6 linoleic acid, for the secondary prevention of coronary heart disease and death...
  13. pmc Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century
    Tanya L Blasbalg
    Section on Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 93:950-62. 2011
    ..The consumption of omega-3 (n-3) and omega-6 (n-6) essential fatty acids in Western diets is thought to have changed markedly during the 20th century...
  14. pmc Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools
    Ameer Y Taha
    Brain Physiology and Metabolism Section, Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Electronic address
    Prostaglandins Leukot Essent Fatty Acids 90:151-7. 2014
    ..Dietary linoleic acid (LA, 18:2n-6) lowering in rats reduces n-6 polyunsaturated fatty acid (PUFA) plasma concentrations and increases n-3 PUFA (eicosapentaenoic (EPA) and docosahexaenoic acid (DHA)) concentrations...
  15. pmc Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans
    Christopher E Ramsden
    Section on Nutritional Neurosciences, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Prostaglandins Leukot Essent Fatty Acids 87:135-41. 2012
    ..Future studies evaluating the clinical implications of diet-induced OXLAM reductions are warranted...
  16. ncbi request reprint Compartmental analyses of plasma n-3 essential fatty acids among male and female smokers and nonsmokers
    Robert J Pawlosky
    Laboratory of Metabolic Control, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 48:935-43. 2007
    ..03) that was greater compared with nonsmokers. Smoking increased the bioavailability of n-3 FAs from plasma, accelerated the fractional synthetic rates, and heightened the percent formation of some long-chain n-3 PUFAs in men and women...
  17. pmc Low vitamin D status and suicide: a case-control study of active duty military service members
    John C Umhau
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    PLoS ONE 8:e51543. 2013
    ....
  18. pmc Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal
    Robert J Pawlosky
    Laboratory of Metabolic Control, National Cancer Institute NIH, Bethesda, MD, USA
    J Lipid Res 50:154-61. 2009
    ....
  19. ncbi request reprint Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects
    Robert J Pawlosky
    Food Composition Laboratory, Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, MD, USA
    Am J Clin Nutr 77:565-72. 2003
    ..Diets rich in 20- and 22-carbon PUFAs may inhibit desaturase expression or activity and decrease the synthesis of long-chain unsaturated fatty acids...
  20. pmc Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy
    John C Umhau
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e75333. 2013
    ..In animal models, excessive alcohol consumption is reported to reduce brain DHA concentration, suggesting disturbed brain DHA metabolism. We hypothesized that brain DHA metabolism also is abnormal in chronic alcoholics...
  21. pmc Fast transmethylation of serum lipids using microwave irradiation
    Yu Hong Lin
    Laboratory of Membrane Biochemistry and Biophysics, Section of Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Lipids 47:1109-17. 2012
    ..This methodology may be applied in both the absolute and relative quantification of serum total fatty acids...
  22. pmc Automated high-throughput fatty acid analysis of umbilical cord serum and application to an epidemiological study
    Yu Hong Lin
    Section of Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3N 07, MSC 9410, Bethesda, MD 20892 9410, USA
    Lipids 47:527-39. 2012
    ..Automated fatty acid analysis coupled with automated data processing greatly facilitates the high throughput, 72 samples transesterified in 6 h, required for large population-based studies...
  23. pmc Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet
    Anita Røyneberg Alvheim
    National Institute of Nutrition and Seafood Research NIFES, P O Box 2029, Nordnes, 5817, Bergen, Norway
    Lipids 49:59-69. 2014
    ..Increasing dietary LNA from 1 to 8 en% elevates liver endocannabinoid levels and increases the risk of developing obesity. Thus a high dietary content of LNA (8 en%) increases the adipogenic properties of a low fat diet. ..
  24. ncbi request reprint Assessing the environment for regulatory change for eicosapentaenoic acid and docosahexaenoic acid nutrition labeling
    Amy M Brownawell
    Life Sciences Research Office, Bethesda, Maryland, USA
    Nutr Rev 67:391-7. 2009
    ....
  25. ncbi request reprint Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park 5, Room 150, 12420 Parklawn Drive, Rockville, MD 20892, USA
    J Affect Disord 69:15-29. 2002
    ..We postulated that the DHA content of mothers' milk and seafood consumption would both predict prevalence rates of postpartum depression across countries...
  26. pmc Low omega-6 vs. low omega-6 plus high omega-3 dietary intervention for chronic daily headache: protocol for a randomized clinical trial
    Christopher E Ramsden
    Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD, USA
    Trials 12:97. 2011
    ..Secondary clinical outcomes include headache-specific quality-of-life, and headache frequency and intensity...
  27. doi request reprint n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials
    Christopher E Ramsden
    Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD, USA
    Br J Nutr 104:1586-600. 2010
    ..16; 95 % CI 0.95, 1.42). Advice to specifically increase n-6 PUFA intake, based on mixed n-3/n-6 RCT data, is unlikely to provide the intended benefits, and may actually increase the risks of CHD and death...
  28. pmc Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers
    Laure Buydens-Branchey
    Psychiatry Service, DVA New York Harbor Healthcare System, Brooklyn, NY 11209, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:568-75. 2008
    ....
  29. ncbi request reprint High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism
    Sarah M Conklin
    Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
    Psychosom Med 69:932-4. 2007
    ..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults...
  30. ncbi request reprint Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers
    Sarah M Conklin
    Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Psychiatry Res 152:1-10. 2007
    ..These findings suggest that omega-3 fatty acid status is associated with variability in affect regulation, personality and impulse control...
  31. ncbi request reprint Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk
    M Elizabeth Sublette
    Department of Neuroscience, NY State Psychiatric Institute, Columbia University, Unit 42, 1051 Riverside Dr, New York, NY 10032, USA
    Am J Psychiatry 163:1100-2. 2006
    ..Predicting risk of future suicidal behaviors by essential fatty acid status merits examination...
  32. ncbi request reprint Polyunsaturated fatty acid status and relapse vulnerability in cocaine addicts
    Laure Buydens-Branchey
    Department of Psychiatry, State University of New York Health Science Center at Brooklyn and Veterans Affairs New York Harbor Healthcare System, Brooklyn Campus 11S BK, 800 Poly Place, Brooklyn, NY 11209, USA
    Psychiatry Res 120:29-35. 2003
    ....
  33. ncbi request reprint Visual acuity and retinal function in infant monkeys fed long-chain PUFA
    Brett G Jeffrey
    Department of Paediatrics and Child Health, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, Adelaide, SA 5042, Australia
    Lipids 37:839-48. 2002
    ..The results suggest that supplementation of the infant monkey diet with 1.0% DHA and 1.0% AA neither harms nor provides substantial benefit to the development of visual acuity or retinal function in the first four postnatal months...
  34. ncbi request reprint Cross-national comparisons of seafood consumption and rates of bipolar disorders
    Simona Noaghiul
    New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 160:2222-7. 2003
    ..The authors sought to determine if greater seafood consumption, a measure of omega-3 fatty acid intake, is associated with lower prevalence rates of bipolar disorder in community samples...
  35. ncbi request reprint Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients
    Jennifer I Harris
    Department of Medicine, Center for Clinical Pharmacology, School of Medicine, University of Pittsburgh, 4015 O Hara Street, Old Engineering Hall, Room 506, Pittsburgh, PA 15260, USA
    Prostaglandins Leukot Essent Fatty Acids 71:263-9. 2004
    ..5 to 18.8 (P<.01), and tended to increase the AA:DHA ratio (P=.053). Thus, simvastatin lowered serum fatty acid concentrations while also altering the relative percentages of important PUFAs...
  36. ncbi request reprint Polyunsaturated fatty acid status and aggression in cocaine addicts
    Laure Buydens-Branchey
    Department of Psychiatry, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11209, USA
    Drug Alcohol Depend 71:319-23. 2003
    ..We also explored the possibility that their FA levels would change after a 2 week stay on an inpatient unit where a standard diet would be provided...
  37. ncbi request reprint Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
    Marlene P Freeman
    Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
    J Clin Psychiatry 67:1954-67. 2006
    ..To determine if the available data support the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders...
  38. ncbi request reprint The Lancet and the Royal Society are both right and wrong
    Michael A Crawford
    Lancet 366:714-5. 2005
  39. doi request reprint Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled study
    Marlene P Freeman
    Women s Mental Health Center, University of Texas Southwestern Medical Center, Dallas TX, USA
    J Affect Disord 110:142-8. 2008
    ..This study was designed to investigate the feasibility, safety, and efficacy of omega-3 fatty acids for perinatal depression in addition to supportive psychotherapy...
  40. ncbi request reprint Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial
    Brian Hallahan
    Department of Psychiatry, Beaumont Hospital and The Royal College of Surgeons in Ireland, Ireland
    Br J Psychiatry 190:118-22. 2007
    ..Trials have demonstrated benefits of long-chain omega-3 essential fatty acid (n-3 EFA) supplementation in a variety of psychiatric disorders...
  41. ncbi request reprint Lipids and essential fatty acids in patients presenting with self-harm
    Malcolm R Garland
    Department of Adult Psychiatry, Galway University Hospital and the Clinical Sciences Institute, National University of Ireland, Ireland
    Br J Psychiatry 190:112-7. 2007
    ..Low cholesterol has been reliably demonstrated in people who self-harm...