Sylvia C Hewitt

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements
    Jeanne E O'Brien
    Division of Reproductive Endocrinology and Infertility, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:26683-92. 2006
  2. pmc Research resource: whole-genome estrogen receptor α binding in mouse uterine tissue revealed by ChIP-seq
    Sylvia C Hewitt
    Receptor Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 26:887-98. 2012
  3. pmc Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:63-70. 2011
  4. pmc Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene
    Sylvia C Hewitt
    Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 24:4660-7. 2010
  5. pmc Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:2676-85. 2010
  6. pmc Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol
    Sylvia C Hewitt
    National Institute of Environment Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 23:2111-6. 2009
  7. ncbi request reprint The five W's of progesterone receptors A and B: now we know where and when
    Sylvia C Hewitt
    National Institute of Environmental Health Sciences, 111 Alexander Drive, MD E4 01, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:5501-2. 2006
  8. ncbi request reprint Progesterone action and responses in the alphaERKO mouse
    S C Hewitt
    LRDT, Receptor Biology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Steroids 65:551-7. 2000
  9. ncbi request reprint Lessons in estrogen biology from knockout and transgenic animals
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 277009, USA
    Annu Rev Physiol 67:285-308. 2005
  10. ncbi request reprint Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism
    Sylvia Curtis Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 19:657-68. 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements
    Jeanne E O'Brien
    Division of Reproductive Endocrinology and Infertility, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:26683-92. 2006
    ..We conclude that nonclassical pathway signaling via ERalpha plays a critical physiologic role in the uterine response to estrogen...
  2. pmc Research resource: whole-genome estrogen receptor α binding in mouse uterine tissue revealed by ChIP-seq
    Sylvia C Hewitt
    Receptor Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 26:887-98. 2012
    ....
  3. pmc Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:63-70. 2011
    ..Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds...
  4. pmc Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene
    Sylvia C Hewitt
    Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 24:4660-7. 2010
    ..Our Ex3α ERα model will be useful in studies of complete or selective ablation of ERα in target tissues...
  5. pmc Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:2676-85. 2010
    ..Additionally, full ER alpha function is needed to mediate other cellular signals of the growth factor for uterine growth...
  6. pmc Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol
    Sylvia C Hewitt
    National Institute of Environment Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 23:2111-6. 2009
    ..In summary, this study provides a comprehensive analysis of uterine genes regulated by E(2) via ERE and non-ERE pathways...
  7. ncbi request reprint The five W's of progesterone receptors A and B: now we know where and when
    Sylvia C Hewitt
    National Institute of Environmental Health Sciences, 111 Alexander Drive, MD E4 01, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:5501-2. 2006
  8. ncbi request reprint Progesterone action and responses in the alphaERKO mouse
    S C Hewitt
    LRDT, Receptor Biology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Steroids 65:551-7. 2000
    ....
  9. ncbi request reprint Lessons in estrogen biology from knockout and transgenic animals
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 277009, USA
    Annu Rev Physiol 67:285-308. 2005
    ..Here, we review the ever-increasing body of knowledge in the field of estrogen biology, especially as applied to the female reproductive processes...
  10. ncbi request reprint Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism
    Sylvia Curtis Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 19:657-68. 2005
    ..Our results suggest that the estrogen response in the uterus involves E2-specific ER(alpha)-mediated responses as well as responses resulting from convergence of growth factor and ER-initiated activities...
  11. ncbi request reprint Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues
    Sylvia Curtis Hewitt
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Reproduction 125:143-9. 2003
    ..These observed phenotypes elucidate the relative roles of the oestrogen receptors in reproductive functions of female rodents...
  12. ncbi request reprint Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen
    Sylvia Curtis Hewitt
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:2070-83. 2003
    ....
  13. ncbi request reprint Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, North Carolina 27709, USA
    Endocrinology 147:2203-14. 2006
    ..Given its activity in our uterine model, the use of estren as a bone-selective clinical compound needs to be reconsidered...
  14. pmc Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype
    Eugenia H Goulding
    Gamete Biology Group, Laboratory of Reproduction and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Endocrinol 207:281-8. 2010
    ....
  15. pmc Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model
    Bonnie J Deroo
    Receptor Biology Section, NIEHS, NIH, Research Triangle Park, North Carolina 27709, USA
    Mol Reprod Dev 76:733-50. 2009
    ..In conclusion, our genomic data support the physiological observation that estradiol is one of the primary hormonal signals driving ductal elongation during pubertal mammary development...
  16. ncbi request reprint Update on animal models developed for analyses of estrogen receptor biological activity
    Kenneth S Korach
    Laboratory of Reproductive and Developmental Toxicology, Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Steroid Biochem Mol Biol 86:387-91. 2003
    ..ERbeta is involved most dramatically in the ovary as is ERalpha. More detailed studies in combination with tissue specific or inducible ER knock outs will be important for future research...
  17. ncbi request reprint Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane
    Hiroaki Aoyama
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P O Box 12233, MD C2 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 209:226-35. 2005
    ..These data suggest that upregulated expression of ERalpha may be important in the induction of endometrial neoplasms in BE-treated mice...
  18. ncbi request reprint Estradiol regulates the thioredoxin antioxidant system in the mouse uterus
    Bonnie J Deroo
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 145:5485-92. 2004
    ..We conclude that the rapid E2-mediated activation of the Txn pathway is an important step in the response of the mammalian uterus to estrogen...
  19. pmc Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses
    Wipawee Winuthayanon
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 107:19272-7. 2010
    ....
  20. pmc The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α
    Wipawee Winuthayanon
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:433-9, 439e1-5. 2013
    ..Objective: We aimed to elucidate the mechanism(s) of D3 action and compare it with that of 17β-estradiol (E2) using both in vitro and in vivo uterine models...
  21. pmc Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model
    Katherine A Burns
    Receptor Biology Section, Research Triangle Park, North Carolina 27790, USA
    Endocrinology 153:3960-71. 2012
    ..In sum, these results suggest ER in both endometriosis-like lesions and their environment influence lesion characteristics, and understanding these interactions may play a critical role in elucidating this enigmatic disease...
  22. pmc An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo
    Kerstin W Sinkevicius
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Endocrinology 149:2970-9. 2008
    ....