Peter Henson

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. pmc Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells
    P R Hoffmann
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Cell Biol 155:649-59. 2001
  2. pmc C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
  3. ncbi request reprint The phosphatidylserine receptor: a crucial molecular switch?
    P M Henson
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Nat Rev Mol Cell Biol 2:627-33. 2001
  4. ncbi request reprint Dampening inflammation
    Peter M Henson
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver Colorado 80206, USA
    Nat Immunol 6:1179-81. 2005
  5. pmc State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease
    Peter M Henson
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver CO 80206, USA
    Proc Am Thorac Soc 3:512-6. 2006
  6. doi request reprint Apoptosis in the lung: induction, clearance and detection
    P M Henson
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 294:L601-11. 2008
  7. ncbi request reprint Apoptotic cell removal in development and tissue homeostasis
    Peter M Henson
    Program in Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80231, USA
    Trends Immunol 27:244-50. 2006
  8. ncbi request reprint Engulfment: ingestion and migration with Rac, Rho and TRIO
    Peter M Henson
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Biol 15:R29-30. 2005
  9. pmc Cell death, remodeling, and repair in chronic obstructive pulmonary disease?
    Peter M Henson
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Am Thorac Soc 3:713-7. 2006
  10. ncbi request reprint Apoptotic cell removal
    P M Henson
    Program in Cell Biology and Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Curr Biol 11:R795-805. 2001

Detail Information

Publications65

  1. pmc Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells
    P R Hoffmann
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Cell Biol 155:649-59. 2001
    ..We propose that the phagocytosis of apoptotic cells requires two events: tethering followed by PS-stimulated, PSR-mediated macropinocytosis...
  2. pmc C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
    ....
  3. ncbi request reprint The phosphatidylserine receptor: a crucial molecular switch?
    P M Henson
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Nat Rev Mol Cell Biol 2:627-33. 2001
    ..Clearance of apoptotic cells, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what the outcome will be?..
  4. ncbi request reprint Dampening inflammation
    Peter M Henson
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver Colorado 80206, USA
    Nat Immunol 6:1179-81. 2005
    ..This balance and its possible manipulation is a second theme running through the reviews...
  5. pmc State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease
    Peter M Henson
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver CO 80206, USA
    Proc Am Thorac Soc 3:512-6. 2006
  6. doi request reprint Apoptosis in the lung: induction, clearance and detection
    P M Henson
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 294:L601-11. 2008
    ..Because recognition of apoptotic cells by other lung cells has additional effects on inflammation, immunity, and tissue repair, local responses to the dying cells may also have important consequences in addition to the cell death itself...
  7. ncbi request reprint Apoptotic cell removal in development and tissue homeostasis
    Peter M Henson
    Program in Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80231, USA
    Trends Immunol 27:244-50. 2006
    ....
  8. ncbi request reprint Engulfment: ingestion and migration with Rac, Rho and TRIO
    Peter M Henson
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Biol 15:R29-30. 2005
    ..A study now identifies upstream components of this pathway in both worms and mammalian cells involving yet another GTPase, RhoG/MIG-2, and its activator TRIO/UNC-73...
  9. pmc Cell death, remodeling, and repair in chronic obstructive pulmonary disease?
    Peter M Henson
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Am Thorac Soc 3:713-7. 2006
    ..The concept puts emphasis on defective repair as well as initial injury (i.e., persistent alteration of dynamic tissue homeostasis, as a key contributor to COPD), with, it is hoped, additional approaches for mitigation...
  10. ncbi request reprint Apoptotic cell removal
    P M Henson
    Program in Cell Biology and Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Curr Biol 11:R795-805. 2001
    ..Removal may also clinch the apoptotic process itself in cells not yet completely committed to death...
  11. pmc Suppression of macrophage inflammatory responses by PPARs
    Peter Henson
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80231, USA
    Proc Natl Acad Sci U S A 100:6295-6. 2003
  12. ncbi request reprint By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Cell 115:13-23. 2003
    ..However, interaction of these heads with PAMPs on foreign organisms or damaged cells and presentation of the collagenous tails in an aggregated state to calreticulin/CD91, stimulates phagocytosis and proinflammatory responses...
  13. ncbi request reprint Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease
    Konosuke Morimoto
    COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Immunol 176:7657-65. 2006
    ..These findings indicate that statins enhance efferocytosis in vitro and in vivo, and suggest that they may play an important therapeutic role in diseases where efferocytosis is impaired and inflammation is dysregulated...
  14. pmc Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
    Ruby F Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Blood 113:2047-55. 2009
    ....
  15. pmc TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation
    Valeria M Borges
    Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 297:L586-95. 2009
    ..These findings suggest that the presence of TNFalpha in the lung can alter the response of phagocytes to apoptotic cells leading to inflammatory cell recruitment and proinflammatory mediator production...
  16. ncbi request reprint Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
    Cell 123:321-34. 2005
    ....
  17. ncbi request reprint Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo
    Peter R Hoffmann
    Department of Pediatrics, Program in Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:1393-404. 2005
    ....
  18. ncbi request reprint Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP
    Shyra J Gardai
    Program in Cell Biology, The Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:44695-703. 2004
    ..Our data suggest that ERK suppresses stress-induced apoptosis downstream of mitochondrial alterations by maintaining XIAP levels and that oxidants block this effect through activation of p38 and protein phosphatases...
  19. ncbi request reprint Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production
    Yi Qun Xiao
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 176:1209-17. 2006
    ..This was mediated through Src tyrosine kinases and protein phosphatase-1/2A. By contrast, hydrogen peroxide had no effects on TGF-beta-induced Smad2 phosphorylation and SBE-luc reporter gene transcription...
  20. ncbi request reprint Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta
    Yi Qun Xiao
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 277:14884-93. 2002
    ..Our data provide evidence that TGF-beta selectively inhibits inflammatory cytokine production through cross-talk between MAPKs...
  21. ncbi request reprint Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase
    Jerry A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:5260-9. 2002
    ..These findings support the feasibility of p38 MAPK inhibition as a selective intervention to reduce neutrophilic inflammation...
  22. pmc Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
    R William Vandivier
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 109:661-70. 2002
    ..Therefore, defective airway clearance of apoptotic cells in cystic fibrosis and bronchiectasis may be due to elastase-mediated cleavage of phosphatidylserine receptor on phagocytes and may contribute to ongoing airway inflammation...
  23. pmc Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha
    William J Janssen
    Division of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center, K729, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 178:158-67. 2008
    ..Surfactant protein (SP)-A and SP-D are potent modulators of macrophage function and may suppress clearance of apoptotic cells through activation of the transmembrane receptor signal inhibitory regulatory protein alpha (SIRP alpha)...
  24. pmc Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    Mai Lan N Huynh
    Department of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 109:41-50. 2002
    ..In conclusion, apoptotic cell recognition and clearance, via exposure of PS and ligation of its receptor, induce TGF-beta1 secretion, resulting in accelerated resolution of inflammation...
  25. doi request reprint Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner
    Ruby Fernandez-Boyanapalli
    National Jewish Health, Denver, CO 80206, USA
    J Immunol 185:4030-41. 2010
    ..These data support the hypothesis that in addition to correcting immunodeficiency in CGD, IFN-γ priming of Ms restores clearance of apoptotic cells and may thereby contribute to resolution of exaggerated CGD inflammation...
  26. ncbi request reprint Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A
    S Courtney Frasch
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 178:6540-8. 2007
    ..Together, these data show that lyso-PLs bearing various head groups redundantly mobilize G2A latent within secretory vesicles and result in G2A receptor/Galphai/phospholipase C signaling for calcium flux in neutrophils...
  27. pmc NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A
    S Courtney Frasch
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 283:33736-49. 2008
    ....
  28. doi request reprint Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up?
    Donna L Bratton
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Biol 18:R76-9. 2008
    ..Insight into the recognition of this phospholipid signal by phagocytes is provided by papers describing three new, but completely different, PS receptors...
  29. doi request reprint Differentiation of the mammary epithelial cell during involution: implications for breast cancer
    Jenifer Monks
    Webb Waring Center, University of Colorado, Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 14:159-70. 2009
    ..And with the finding that involution may represent a unique susceptibility window for the progression of metastatic breast cancer, we may suggest areas for future research along these lines as well...
  30. ncbi request reprint Apoptosis: giving phosphatidylserine recognition an assist--with a twist
    Valerie A Fadok
    Program in Cell Biology, Dept Pediatrics, National Jewish Medical and Research Center, D509, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Biol 13:R655-7. 2003
  31. ncbi request reprint Development and characterization of a lung-protective method of bone marrow transplantation in the mouse
    William J Janssen
    Division of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    J Immunol Methods 357:1-9. 2010
    ..This system may be applicable to other organ systems in which protection from radiation during bone marrow transplantation is desired...
  32. ncbi request reprint The final step in programmed cell death: phagocytes carry apoptotic cells to the grave
    Aimee M DeCathelineau
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, U S A
    Essays Biochem 39:105-17. 2003
    ....
  33. ncbi request reprint Impaired clearance of apoptotic cells from cystic fibrosis airways
    R William Vandivier
    University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 121:89S. 2002
  34. ncbi request reprint Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils
    S Courtney Frasch
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17625-33. 2004
    ..Of note, PS exposure, phospholipid uptake, and FM 1-43 staining also localized to the uropod following stimulation demonstrating that both PLSCR1 and phospholipid flip-flop characterize this specialized domain of polarized neutrophils...
  35. ncbi request reprint TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms
    Kathleen McPhillips
    Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 178:8117-26. 2007
    ..Overall, the data suggest that macrophages in a TNF-alpha- and oxidant-rich inflammatory environment are less able to remove apoptotic cells and, thereby, may contribute to the local intensity of the inflammatory response...
  36. pmc Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells
    Yi Qun Xiao
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:3575-85. 2008
    ..Strikingly, these induction pathways for TGF-beta production were different from those initiated in the same cells responding to LPS or PMA...
  37. ncbi request reprint Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils
    Shyra Gardai
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:5236-46. 2002
    ..Thus, we propose a role for oxidants and Lyn in SHIP regulation and suggest a novel mechanism for regulating neutrophil apoptosis...
  38. ncbi request reprint Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease
    R William Vandivier
    University of Colorado at Denver Health Sciences Center, COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, 4200 E Ninth Ave, Box C272, Denver, CO 80220, USA
    Chest 129:1673-82. 2006
    ..The recognition of impaired efferocytosis as a contributor to chronic inflammation may ultimately direct us toward the identification of new disease biomarkers, as well as novel therapeutic approaches...
  39. pmc Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress
    Adil Anwar
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Leukoc Biol 86:73-9. 2009
    ..These data represent the first report of Mer activation in response to oxidative stress and demonstrate the ability of Mer RTK to promote macrophage survival in disease states that involve an oxidative stress environment...
  40. ncbi request reprint Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis
    Tomohiro Murakawa
    Department of Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 174:3869-79. 2005
    ..Therefore, there appears to be an intimate relationship between the morphology and level of chimerism of the respiratory epithelium and the degree of airway remodeling following alloimmune injury...
  41. ncbi request reprint Possible roles for apoptosis and apoptotic cell recognition in inflammation and fibrosis
    Peter M Henson
    Program in Cell Biology Department of Pediatric, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 29:S70-6. 2003
  42. ncbi request reprint Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth
    Heiko A Golpon
    Pulmonary Hypertension Center, University of Colorado, Health Sciences Center, Denver, Colorado, USA
    FASEB J 18:1716-8. 2004
    ..We conclude that phagocytosis of apoptotic cells leads to secretion of growth and survival factors by phagocytes that represents a new form of life-promoting cell-cell interaction...
  43. ncbi request reprint Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland
    Jenifer Monks
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Biol Reprod 78:586-94. 2008
    ..Macrophages and other inflammatory cells did not contribute to the clearance of either residual milk or apoptotic cells, which appeared to be due entirely to the epithelium itself...
  44. pmc A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    Susan Sather
    Department of Pediatrics, University of Colorado at Denver, and Health Sciences Center, Aurora, CO 80045, USA
    Blood 109:1026-33. 2007
    ..Furthermore, soluble Mer decreased platelet aggregation in vitro and prevented fatal collagen/epinephrine-induced thromboembolism in mice, suggesting a potential therapeutic use for soluble Mer in the treatment of clotting disorders...
  45. ncbi request reprint Statins enhance clearance of apoptotic cells through modulation of Rho-GTPases
    Konosuke Morimoto
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, 80220, USA
    Proc Am Thorac Soc 3:516-7. 2006
  46. pmc Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins
    Lars Peter Erwig
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 103:12825-30. 2006
    ..These observations have direct implications for the clearance of dying cells and the roles played by different phagocytes in antigen digestion and presentation...
  47. ncbi request reprint Oxidant-mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte-macrophage colony-stimulating factor
    Shyra J Gardai
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 170:556-66. 2003
    ..These data demonstrate that oxidant-induced mitochondrial injury is pivotal in eosinophil apoptosis, and is enhanced by GC-induced prolonged JNK activation that is in turn inhibited by GM-CSF...
  48. ncbi request reprint Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Biol Chem 279:21085-95. 2004
    ....
  49. pmc Fibroblast foci are not discrete sites of lung injury or repair: the fibroblast reticulum
    Carlyne D Cool
    Departments of Medicine and Pathology, University of Colorado Health Sciences Center and Interstitial Lung Disease Program, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 174:654-8. 2006
    ..We hypothesized that, rather than isolated, these lesions are part of an organized neoplasm...
  50. ncbi request reprint Recognition ligands on apoptotic cells: a perspective
    Shyra J Gardai
    Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    J Leukoc Biol 79:896-903. 2006
    ..Loss or inactivation of the don't eat me CD47 effects accompanies apoptosis and now allow the cells to be recognized and cleared...
  51. pmc Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis
    Ashok N Babu
    Department of Surgery, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 117:3774-85. 2007
    ..One implication of this study is that bronchial artery revascularization at the time of lung transplantation may decrease the risk of subsequent airway fibrosis...
  52. ncbi request reprint Resolution of lung inflammation by CD44
    Priit Teder
    Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 296:155-8. 2002
    ..This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation...
  53. ncbi request reprint Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex
    R William Vandivier
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine and Pathology, University of Colorado Health Sciences Center, nd Denver, CO, USA
    J Immunol 169:3978-86. 2002
    ....
  54. ncbi request reprint Collectins: opsonins for apoptotic cells and regulators of inflammation
    Lynda M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Curr Dir Autoimmun 9:143-61. 2006
    ..Here will discuss our current understanding of the process of collectin recognition of dying and damaged cells and its implications for autoimmune and inflammatory diseases...
  55. ncbi request reprint The matrix degrades, neutrophils invade
    Peter M Henson
    Nat Med 12:280-1. 2006
  56. pmc Hemophagocytic macrophages harbor Salmonella enterica during persistent infection
    Rebecca N Nix
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America
    PLoS Pathog 3:e193. 2007
    ..These data suggest that during persistent infection hemophagocytic macrophages may provide S. Typhimurium with a survival niche...
  57. pmc ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages
    Andreas W Jehle
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Biol 174:547-56. 2006
    ..These studies reveal a major role of ABCA7 and not -A1 in the clearance of apoptotic cells and therefore suggest that ABCA7 is an authentic orthologue of CED-7...
  58. pmc Immunological consequences of apoptotic cell phagocytosis
    Lars Peter Erwig
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Am J Pathol 171:2-8. 2007
    ..Here, we will outline the consequences of apoptotic cell phagocytosis and illustrate how apoptotic cells could be used to manipulate the immune response for therapeutic gain...
  59. ncbi request reprint Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
    Benjamin T Suratt
    University of Vermont College of Medicine, 149 Beaumont Ave, Burlington, VT 05405, USA
    Blood 104:565-71. 2004
    ....
  60. ncbi request reprint Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages
    Celio G Freire-de-Lima
    Instituto de Biofisica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro RJ 21944 970, Brazil
    J Biol Chem 281:38376-84. 2006
    ..These results strongly suggest that the apoptotic cell inhibition of pro-inflammatory mediator production is pleiotropic and significantly dependent on the stimulation of TGF-beta production...
  61. ncbi request reprint Apoptosis and emphysema: the missing link
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 28:551-4. 2003
  62. ncbi request reprint Il-4-induced lipid mediators class switching in human normal mononuclear phagocytes
    Angelo Sala
    Dipartimento di Scienze Famacologiche and Center for Cardiopulmonary Pharmacology, Universita di Milano, Milan, Italy
    Adv Exp Med Biol 525:15-8. 2003
  63. pmc The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function
    Mojca Skoberne
    New York University School of Medicine, 550 First Ave, MSB 507, New York, NY 10016, USA
    Blood 108:947-55. 2006
    ..This immunomodulatory role, however, is countered by a significant inflammatory stimulus such as bacterial infection. Overall, our data suggest that under steady-state conditions, signaling via CRs predominates to render DCs tolerogenic...
  64. ncbi request reprint Leukotriene B4 production in human mononuclear phagocytes is modulated by interleukin-4-induced 15-lipoxygenase
    Mirella Profita
    Istituto di Fisiopatologia Respiratoria, Consiglio Nazionale delle Ricerche, Palermo, Italy
    J Pharmacol Exp Ther 300:868-75. 2002
    ..Whereas this effect did not reflect changes in 5-LO and FLAP mRNA expression, synthetic 15(S)-HETE was able to significantly inhibit the synthesis of LTB4, without affecting AA release...
  65. ncbi request reprint Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)
    Hua Poo Su
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11772-9. 2002
    ..These studies suggest a physical link between CED-1 or CD91/LRP and the adapter protein CED-6/GULP during engulfment of apoptotic cells and further elucidate the pathway suggested by the genetic studies...