Markus Heilig

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi A key role for corticotropin-releasing factor in alcohol dependence
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, NIH, 10 Center Dr, 1 5334, Bethesda, MD 20892, USA
    Trends Neurosci 30:399-406. 2007
  2. ncbi Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
    Neurosci Biobehav Rev 35:334-44. 2010
  3. ncbi Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms
    Markus Heilig
    National Institute on Alcohol Abuse and Alcoholism NIH DHHS, 10 Center Drive, 10 1E 5334 Bethesda, MD 20892 1610, United States
    Pharmacol Ther 111:855-76. 2006
  4. ncbi Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
    Markus Heilig
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Addict Biol 15:169-84. 2010
  5. ncbi Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:823-30. 2010
  6. ncbi Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Alcohol 44:67-80. 2010
  7. ncbi Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
  8. ncbi Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors
    Camilla Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 102:400-6. 2012
  9. ncbi Gene-environment interactions and response to social intrusion in male and female rhesus macaques
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Poolesville, Maryland, USA
    Biol Psychiatry 67:323-30. 2010
  10. ncbi Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health NIH National Institute on Alcohol Abuse and Alcoholism NIAAA, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:78-80. 2010

Detail Information

Publications96

  1. ncbi A key role for corticotropin-releasing factor in alcohol dependence
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, NIH, 10 Center Dr, 1 5334, Bethesda, MD 20892, USA
    Trends Neurosci 30:399-406. 2007
    ..Therefore, the CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment...
  2. ncbi Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
    Neurosci Biobehav Rev 35:334-44. 2010
    ....
  3. ncbi Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms
    Markus Heilig
    National Institute on Alcohol Abuse and Alcoholism NIH DHHS, 10 Center Drive, 10 1E 5334 Bethesda, MD 20892 1610, United States
    Pharmacol Ther 111:855-76. 2006
    ..Once novel treatments are developed, the field faces a major challenge to assure their delivery to patients...
  4. ncbi Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
    Markus Heilig
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Addict Biol 15:169-84. 2010
    ..due to heritable factors, similar to what animal models have indicated for susceptibility to physical aspects of withdrawal?; and (3) to what extent is susceptibility to negative affect that persists into protracted abstinence heritable?..
  5. ncbi Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:823-30. 2010
    ..Here, we examined whether the group II metabotropic glutamate receptor agonist LY379268 prevents neuronal death and learning deficits in a rat model of binge-like exposure to alcohol...
  6. ncbi Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Alcohol 44:67-80. 2010
    ....
  7. ncbi Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
    ..In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence...
  8. ncbi Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors
    Camilla Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 102:400-6. 2012
    ..Here, we examined whether the MCH system plays a role both in caloric and motivational aspects of sugar intake...
  9. ncbi Gene-environment interactions and response to social intrusion in male and female rhesus macaques
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Poolesville, Maryland, USA
    Biol Psychiatry 67:323-30. 2010
    ..In this study, we investigated the possibility of sex-specific gene-environment interactions in a nonhuman primate model of response to social threat...
  10. ncbi Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health NIH National Institute on Alcohol Abuse and Alcoholism NIAAA, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:78-80. 2010
    ..A functionally equivalent OPRM1 C77G polymorphism in rhesus macaques allows this to be addressed under controlled experimental conditions...
  11. ncbi Functional CRH variation increases stress-induced alcohol consumption in primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institutes on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:14593-8. 2009
    ..Our data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals...
  12. ncbi The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Addict Biol 17:634-47. 2012
    ..Our results provide additional evidence for the involvement of KOR in regulation of alcohol-related behaviors and provide support for KOR antagonists, including JDTic, to be evaluated as medications for alcoholism...
  13. ncbi Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD 20892 1108, USA
    Pharmacol Biochem Behav 100:522-9. 2012
    ..The aim of the present study was to evaluate whether the CRH system is also recruited when non-dependent Wistar rats escalate to high alcohol intake in the intermittent (alternate days) model of drinking...
  14. ncbi Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:417-26. 2010
    ..Here, we examined whether neuropeptide Y (NPY), an endogenous anti-stress mediator, blocks reinstatement of alcohol-seeking induced by the pharmacological stressor yohimbine...
  15. ncbi Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate
    John C Umhau
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 1108, USA
    Neuropsychopharmacology 36:1178-86. 2011
    ..Under the experimental conditions used, alcohol cravings induced by these two stimuli are not sensitive to acamprosate at clinically used doses...
  16. ncbi Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 10 Room 1E 5330, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1578-89. 2009
    ..These findings demonstrate that gene deletion of GLAST produces select phenotypic abnormalities related to the negative and cognitive symptoms of schizophrenia...
  17. ncbi Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm
    Simona Spinelli
    National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, P O Box 529, Poolesville, MD 20837, USA
    Dev Psychopathol 19:977-87. 2007
    ....
  18. ncbi Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers
    David Ted George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, 10 CRC Hatfield Center, Rm 1 5330, MSC 1108, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:37-44. 2010
    ..There is an extensive literature showing that the CB(1) cannabinoid receptor antagonist rimonabant (SR141716) decreases alcohol consumption in animals, but little is known about its effects in human alcohol drinkers...
  19. ncbi The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Alcohol 45:567-76. 2011
    ....
  20. ncbi Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies LCTS, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH Bethesda, MD 20892, USA
    Neurobiol Learn Mem 94:538-46. 2010
    ....
  21. ncbi Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
    Karl Björk
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Addict Biol 15:299-303. 2010
    ..One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs...
  22. ncbi Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcoholism and Alcohol Abuse, NIH, 10 Center Drive, 1 5330, Bethesda, MD 20892 1108, USA
    Neuropharmacology 63:181-9. 2012
    ..Endocannabinoid signaling appears to be down-regulated upstream of the CB1 receptor as a result of the GLAST deletion, and is a candidate mechanism behind the reduction of alcohol reward observed...
  23. ncbi OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Bethesda, MD 20892, USA
    Psychoneuroendocrinology 36:1303-11. 2011
    ..Our results also suggest that OPRM1 variation may influence coping style, as well as alcohol-induced and postpartum levels of HPA axis activity and, as such, may modify vulnerability to alcohol use disorders and postpartum depression...
  24. ncbi Neuroplasticity in brain reward circuitry following a history of ethanol dependence
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Eur J Neurosci 27:1912-22. 2008
    ..These two neuroadaptations could act in concert to facilitate progression into ethanol dependence...
  25. ncbi Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:5277-81. 2008
    ..These findings suggest a role for OPRM1 variation in the expression of attachment behavior in human subjects, especially as a function of separation from the caregiver...
  26. ncbi Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Bethesda, MD, USA
    Int J Neuropsychopharmacol 13:583-93. 2010
    ..While suppression of hippocampal neurogenesis by alcohol dependence is transient, the suppression in the forebrain SVZ appears long-lasting...
  27. ncbi Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Building 10 CRC, Room 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 218:111-9. 2011
    ..The role of the NK1 system for relapse-like behavior has not previously been examined...
  28. ncbi Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex
    Olga Neznanova
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 12:275-80. 2009
    ..Together, these results identify candidate pathways for mediating high ethanol preference and emphasize the importance of the mPFC in controlling this behaviour...
  29. ncbi Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center Poolesville, Maryland 20837 0529, USA
    Alcohol Clin Exp Res 32:1217-28. 2008
    ....
  30. ncbi Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr, 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 211:367-75. 2010
    ..Melanin-concentrating hormone (MCH) is involved in regulation of appetitive behaviors as well as emotional reactivity and reward, behavioral domains relevant to alcohol addiction...
  31. ncbi Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography
    Simona Spinelli
    National Institute on Alcohol Abuse and Alcoholism, Poolesville, MD, USA
    Biol Psychiatry 67:1146-53. 2010
    ..Low serotonin(1A) receptor (5-HT(1A)R) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders...
  32. ncbi Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice
    Annika Thorsell
    The Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, 10 CRC 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 209:103-11. 2010
    ..It remains unknown whether this reflects developmental effects or direct regulation of alcohol consumption by NK1R:s, and whether the reduced consumption reflects motivational effects...
  33. ncbi Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study
    John C Umhau
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Arch Gen Psychiatry 67:1069-77. 2010
    ..Human translation of these findings is lacking...
  34. ncbi Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, USA
    Hum Mutat 31:E1594-608. 2010
    ..Our results show the importance of rs16147:T>C for regulation of NPY gene expression and brain function...
  35. ncbi Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland 20892 1108, USA
    Alcohol Clin Exp Res 31:1302-7. 2007
    ....
  36. ncbi Relationship between liver function and brain shrinkage in patients with alcohol dependence
    Chun Hsin Chen
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 36:625-32. 2012
    ..The aim of this study was to assess the correlations between liver function and brain volume (BV) measurements in patients with alcohol dependence...
  37. ncbi Neurokinin 1 receptor antagonism as a possible therapy for alcoholism
    David T George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Science 319:1536-9. 2008
    ..Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism...
  38. ncbi Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist
    Rose Marie Karlsson
    Laboratory for Clinical and Translational Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:810-4. 2008
    ....
  39. ncbi Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism
    Biol Psychiatry 73:774-81. 2013
    ..Genetic deletion or antagonism of the neurokinin 1 receptor (NK1R) decreases alcohol intake, alcohol reward, and stress-induced alcohol relapse in rodents, while TACR1 variation is associated with alcoholism in humans...
  40. ncbi Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients
    Ming Chyi Huang
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 36:1099-107. 2012
    ..The relationships between various types of CTE and lifetime psychiatric comorbidities and suicide attempts were also explored...
  41. ncbi Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    J Psychopharmacol 25:1378-87. 2011
    ..These results indicate that the tropic hypothesis of depression has limitations and emphasize the need for validated disease models of depression to assess potential treatment targets...
  42. ncbi Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 64:369-76. 2007
    ..In humans, a variant of the mu-opioid receptor gene (OPRM1A118G) increases receptor affinity, alcohol-induced euphoria, and risk for alcohol use disorders...
  43. ncbi Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Addict Biol 12:30-4. 2007
    ....
  44. ncbi The biometric measurement of alcohol consumption
    Lawrence D Snell
    Lohocla Research Corporation, Aurora, Colorado, USA
    Alcohol Clin Exp Res 36:332-41. 2012
    ..Biological (biometric) diagnostic tests that provide information on current and past quantity and frequency of alcohol consumption by an individual, prior to onset of organ damage, continue to be sought...
  45. ncbi Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence
    Marcus W Meinhardt
    Institute of Psychopharmacology at Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany
    J Neurosci 33:2794-806. 2013
    ..Normalization of mGluR(2) function within this brain circuit may be of therapeutic value...
  46. ncbi The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, NIH, National Institute of Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 1 15330, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 195:547-57. 2008
    ..Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors...
  47. ncbi CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
    ..As such, CRH gene variation may influence risk for alcohol use and dependence...
  48. ncbi The NPY system in stress, anxiety and depression
    Markus Heilig
    Division of Psychiatry, Neurotec Department, Karolinska Institute, Huddinge University Hospital M57, Stockholm 141 86, Sweden Laboratory of Clinical Science, NIAAA NIH, Bethesda, MD, USA
    Neuropeptides 38:213-24. 2004
    ..Development of Y2 antagonists presently appears to offer the most promising strategy for developing these clinical treatments...
  49. ncbi Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders
    Andrew Holmes
    Section on Behavioral Science and Genetics, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 24:580-8. 2003
    ....
  50. ncbi Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice
    Rose Marie Karlsson
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm Laboratory of Clinical Science, NIAAA, NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 80:427-36. 2005
    ..These findings provide a basis for future studies of mice with targeted gene mutations, directed at delineating the anatomical regions and receptor subtypes mediating the effects of NPY and GAL on emotion...
  51. ncbi Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data
    Mark Reimers
    Laboratory of Molecular Pharmacology, NCI, National Institutes of Health, Bethesda, USA
    Methods 37:219-28. 2005
    ..We also describe in detail the pre-processing methods we have found useful for Affymetrix data. Finally, we summarize the statistical literature and describe some pitfalls in the post-processing analysis...
  52. ncbi Low vitamin d status and suicide: a case-control study of active duty military service members
    John C Umhau
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e51543. 2013
    ....
  53. ncbi Pharmacogenetic approaches to the treatment of alcohol addiction
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA nih gov
    Nat Rev Neurosci 12:670-84. 2011
    ....
  54. ncbi Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism
    Markus Heilig
    The National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1108, USA
    Addiction 106:1052-60. 2011
    ....
  55. ncbi Stress-related neuropeptides and addictive behaviors: beyond the usual suspects
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 76:192-208. 2012
    ..Here, we review this emerging literature, discussing to what extent the properties of these neuromodulators are shared or distinct and considering their potential as drug targets...
  56. ncbi Medications development to treat alcohol dependence: a vision for the next decade
    Raye Z Litten
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Addict Biol 17:513-27. 2012
    ..Successful implementation of these objectives will result in the development of more efficacious and safe medications, provide a greater selection of therapy options and ultimately lessen the impact of this devastating disorder...
  57. ncbi The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus
    Smitha Sreedharan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    FEBS J 278:4881-94. 2011
    ..This report provides the first detailed characterization of the evolution, expression and primary functional properties of the Gpr153 gene...
  58. ncbi Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Neuropsychopharmacology 32:117-26. 2007
    ..These results show for the first time that impaired FAAH function may confer a phenotype of high voluntary alcohol intake, and point to a FAAH both as a potential susceptibility factor and a therapeutic target...
  59. ncbi D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimage 50:1402-7. 2010
    ..In addition, this study demonstrates the utility of small animal PET to study receptor trafficking in vivo in genetically modified mice...
  60. ncbi Imagen: implications for addiction science and science policy
    Markus Heilig
    NIAAA, 10 Center Drive, 10/1-5334, Bethesda, MD 20892-1108, USA
    Addiction 102:1699-700. 2007
  61. ncbi Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats
    Andrea Cippitelli
    , Avenida Carlos Haya 82, 7 Planta, , 29010 Malaga, Spain
    Eur J Neurosci 21:2243-51. 2005
    ..In addition, current pharmacological and neuroanatomical data suggest that an altered function of the CB1 receptor system exists between genetically selected alcohol-preferring msP rats and a heterogeneous animal population...
  62. ncbi Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence
    Subhash C Pandey
    Department of Psychiatry, Psychiatric Institute, University of Illinois, IL 60612, USA
    Alcohol Clin Exp Res 27:149-54. 2003
    ..Pandey; (4) Involvement of NPY in alcohol dependence: from animal models to human genetics, by Markus Heilig; and (5) Association of neuropeptide Y polymorphism with the occurrence of type 1 and type 2 alcoholism, by ..
  63. ncbi Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino MC, Italy
    Biol Psychiatry 64:211-8. 2008
    ....
  64. ncbi NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations
    Guanshan Zhu
    Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, USA
    Alcohol Clin Exp Res 27:19-24. 2003
    ..Recently, this polymorphism was also reported to be associated with an actual diagnosis of alcohol dependence...
  65. ncbi Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence
    Jia Huang
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, Jupiter, FL 33458, USA
    Addict Biol 13:88-94. 2008
    ..These findings suggest that genetic variants of the OPRL1 gene play a role in alcohol dependence in the Scandinavian population, warranting further investigation at the OPRL1 locus...
  66. ncbi A temporal threshold for induction of persistent alcohol preference: behavioral evidence in a rat model of intermittent intoxication
    Roberto Rimondini
    Division of Psychiatry, Neurotec Department, Karolinska Institute, M57 Huddinge University Hospital, S141 86 Stockholm, Sweden
    J Stud Alcohol 64:445-9. 2003
    ..CONCLUSIONS: These observations support the existence of a temporal threshold for induction of long-lasting changes in voluntary alcohol consumption. The search for underlying molecular processes should be carried out in this context...
  67. ncbi Brain neuropeptide Y (NPY) in stress and alcohol dependence
    Markus Heilig
    Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Rev Neurosci 13:85-94. 2002
    ..Recent data additionally point to a role of NPY in the regulation of alcohol intake, and alcohol dependence emerges as a novel potential indication for compounds targeting the NPY system...
  68. ncbi Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test
    Christian Möller
    Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Prog Neuropsychopharmacol Biol Psychiatry 26:119-22. 2002
    ..GLP-1 may participate in the control of fear-induced suppression of behavior, probably via action in the amygdala...
  69. ncbi Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors
    Salim Mottagui-Tabar
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Alcohol Alcohol 39:380-5. 2004
    ..To examine whether polymorphic variants of the HTR2C gene are associated with diagnosis of alcohol dependence...
  70. ncbi Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence
    Johan Kakko
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 63:172-7. 2008
    ..Maintenance treatment with methadone normalizes HPA axis activity. Here, we examined HPA axis activity under maintenance treatment with the increasingly utilized partial opiate agonist buprenorphine...
  71. ncbi Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
    Roberto Rimondini
    Neurotec, Karolinska Institutet, Stockholm, Sweden
    FASEB J 16:27-35. 2002
    ..These observations may have important implications for how alcoholism is managed clinically. Novel clinically effective treatments may be possible to develop by targeting the products of genes found to be regulated in our model...
  72. ncbi Long-lasting tolerance to alcohol following a history of dependence
    Roberto Rimondini
    Department of Pharmacology, University of Bologna, Italy
    Addict Biol 13:26-30. 2008
    ..In conclusion, a history of alcohol dependence induces long-lasting hypnotic tolerance. This process may play an important role in maintaining the dependent state...
  73. ncbi 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
    Donald R Gehlert
    Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 27:2718-26. 2007
    ..Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence...
  74. ncbi Persistent behavioral and autonomic supersensitivity to stress following prenatal stress exposure in rats
    Roberto Rimondini
    Neurotec, Karolinska Institute, M 57, Huddinge University Hospital, 14186 Stockholm, Sweden
    Behav Brain Res 140:75-80. 2003
    ..In summary, PS induces a persistent phenotype of increased behavioral and autonomic sensitivity to stress. This paradigm might serve as an attractive screening model for anti-anxiety compounds...
  75. ncbi Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 30:417-22. 2005
    ..1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased attributable risk for alcohol dependence...
  76. ncbi High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroimage 23:382-91. 2004
    ..In the context of an anxiety-inhibiting role of the dmPFC, we propose that failure to sufficiently activate this region in stressful situations may contribute to high trait anxiety...
  77. ncbi Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence
    Markus Heilig
    Division of Psychiatry, Neurotec Department, Karolinska Institutet, M57 Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Neurotox Res 6:363-72. 2004
    ..For this purpose, we have applied differential display and more recently Affymetrix oligonucleotide gene arrays to models of genetic susceptibility and alcohol-induced neuroadaptation...
  78. ncbi Addiction and its brain science
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Addiction 100:1813-22. 2005
    ..To illustrate how modern neurobiological approaches will help to identify the neurocircuits and genes involved in addictive behavior...
  79. ncbi Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism
    Markus Heilig
    Karolinska Institutet, Neurotec Department, Division of Psychiatry, Huddinge University Hospital, M57, SE 141 86, Stockholm, Sweden
    J Psychiatr Res 38:113-21. 2004
    ..Our present findings are in line with an extensive animal literature, and further support the notion that impaired NPY function could contribute to depressive illness...
  80. ncbi Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence
    Roberto Rimondini
    Neurotec, Karolinska Institutet, M57, Huddinge University Hospital, SE 14186 Huddinge, Sweden
    Neurosci Lett 375:129-33. 2005
    ..This may render the NPY system, and Y2 receptors in particular, an attractive target for treatment of alcohol dependence...
  81. ncbi A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence
    Salim Mottagui-Tabar
    Karolinska Institute, Center for Genomics and Bioinformatics, Stockholm, Sweden
    Alcohol Clin Exp Res 29:702-7. 2005
    ..The aim of this study was to examine whether polymorphic variants of the NPY gene are associated with the diagnosis of alcohol dependence...
  82. ncbi Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Psychopharmacology (Berl) 172:170-8. 2004
    ....
  83. ncbi Fetus at risk: prevalence of alcohol consumption during pregnancy estimated with a simple screening method in Swedish antenatal clinics
    Mona Göransson
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm, Sweden
    Addiction 98:1513-20. 2003
    ..The aim of this study was to examine the prevalence of hazardous or harmful alcohol consumption during pregnancy in a consecutive series of Swedish pregnant females...
  84. ncbi Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Biol Psychiatry 61:4-12. 2007
    ..Here we evaluated whether buprenorphine, a partial agonist at micro-opioid and NOP receptors, would reduce ethanol consumption in msP rats via activation of NOP receptors...
  85. ncbi Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?
    Laura Caberlotto
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neuropsychopharmacology 29:15-22. 2004
    ..The expression of CRH-R1, CRH-R2alpha, NPY, and its Y1 receptor mRNA was analyzed in search of neural substrates for the allostatic shift observed, but did not seem to contribute to the dysregulated state...
  86. ncbi Unexpectedly high prevalence of alcohol use among pregnant Swedish women: failed detection by antenatal care and simple tools that improve detection
    Asa Magnusson
    Division of Psychiatry, Neurotec, Karolinska Institute, 14186 Stockholm, Sweden
    J Stud Alcohol 66:157-64. 2005
    ..Elevated laboratory markers likely indicated somatic illness rather than harmful drinking...
  87. ncbi [Surprising conclusion by the SBU concerning the benefits of naltrexone in the treatment of heroin dependence]
    Markus Heilig
    Lakartidningen 99:200-4. 2002
  88. ncbi Hazardous alcohol users during pregnancy: psychiatric health and personality traits
    Asa Magnusson
    Department of Clinical Neuroscience, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Drug Alcohol Depend 89:275-81. 2007
    ..We examined alcohol use disorders, psychiatric symptoms and personality traits in women reporting alcohol use during pregnancy...
  89. ncbi Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties
    Johanna Kela
    Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius vag 35, SE 171 77 Stockholm, Sweden
    Regul Pept 114:109-14. 2003
    ..Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH...
  90. ncbi [Documented effect of methadone, but not naltrexone]
    Markus Heilig
    Huddinge Universitetssjukhus
    Lakartidningen 99:551-2. 2002
  91. ncbi Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depression
    Ingrid Rydmark
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 60:867-73. 2006
    ..This is opposite to what has been described in major depression. It remains to be established whether this impairment is the end result of prolonged stress exposure, or a pre-existing susceptibility factor...
  92. ncbi Beliefs and reality: detection and prevention of high alcohol consumption in Swedish antenatal clinics
    Mona Göransson
    Division of Psychiatry, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 83:796-800. 2004
    ..Available statistics indicate, however, that this system is ineffective in dealing with psychosocial health problems, such as hazardous drug and alcohol use. Factors underlying this failure have not been explored...
  93. ncbi Identifying hazardous alcohol consumption during pregnancy: implementing a research-based model in real life
    Mona Göransson
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm, Sweden
    Acta Obstet Gynecol Scand 85:657-62. 2006
    ....
  94. ncbi The dual-diagnosis concept used by Swedish social workers: limited validity upon examination using a structured diagnostic approach
    Markus Heilig
    Neurotec, Division of Psychiatry, Karolinska Institute, Sweden
    Eur Psychiatry 17:363-5. 2002
    ..A systematic individual evaluation in an alcohol- and drug-free state of sufficient duration is necessary to obtain a basis for an adequate individual treatment plan...
  95. ncbi [Ecstasy is a dangerous drug the society chooses to ignore]
    Markus Heilig
    Huddinge Universitetssjukhus, Stockholm
    Lakartidningen 100:688-90. 2003
  96. ncbi [The brain behind stress and fatigue depression]
    Markus Heilig
    Huddinge Universitetssjukhus
    Lakartidningen 99:2515-8. 2002