Yu Ying He

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 125:560-6. 2005
  2. ncbi request reprint Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance
    Y Y He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Oncogene 25:3680-8. 2006
  3. ncbi request reprint Role of reduced glutathione efflux in apoptosis of immortalized human keratinocytes induced by UVA
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:8058-64. 2003
  4. ncbi request reprint Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization
    Y Y He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institute of Health, Research Triangle Park, North Carolina 27709 2233, USA
    Oncogene 25:1521-31. 2006
  5. ncbi request reprint UVA-ketoprofen-induced hemoglobin radicals detected by immuno-spin trapping
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 77:585-91. 2003
  6. ncbi request reprint Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 278:42457-65. 2003
  7. ncbi request reprint Expression profiling of human keratinocyte response to ultraviolet A: implications in apoptosis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 122:533-43. 2004
  8. ncbi request reprint Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, FO 06, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:53867-74. 2004
  9. pmc Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 21:1056-63. 2008
  10. doi request reprint Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1215-23. 2008

Detail Information

Publications21

  1. ncbi request reprint Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 125:560-6. 2005
    ....
  2. ncbi request reprint Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance
    Y Y He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Oncogene 25:3680-8. 2006
    ..Further comparisons between the transformed ULTH and control cells should lead to a better understanding of the mechanism of UVA carcinogenesis and may help identify biomarkers for UVA-induced skin malignancies...
  3. ncbi request reprint Role of reduced glutathione efflux in apoptosis of immortalized human keratinocytes induced by UVA
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:8058-64. 2003
    ..These provide targets for macrophage recognition and phagocytosis and thus minimize the potential to invoke inflammation or neoplastic transformation...
  4. ncbi request reprint Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization
    Y Y He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institute of Health, Research Triangle Park, North Carolina 27709 2233, USA
    Oncogene 25:1521-31. 2006
    ..A cleavage-deficient EGFR mutant delayed apoptosis process. We conclude that the evolutionarily conserved C-terminus domain of EGFR is the target of caspases and subjected to degradation during apoptosis to shut down its signaling...
  5. ncbi request reprint UVA-ketoprofen-induced hemoglobin radicals detected by immuno-spin trapping
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 77:585-91. 2003
    ..The successful detection of protein radical formation caused by KP photosensitization could help further understand the photoallergic effect of this NSAID...
  6. ncbi request reprint Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 278:42457-65. 2003
    ....
  7. ncbi request reprint Expression profiling of human keratinocyte response to ultraviolet A: implications in apoptosis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 122:533-43. 2004
    ..This initial microarray analysis could advance our understanding of cellular responses to ultraviolet A exposure, and provide a platform from which to further study ultraviolet-A-induced apoptosis and carcinogenesis...
  8. ncbi request reprint Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, FO 06, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:53867-74. 2004
    ..The delayed and sustained ERK activation provides a survival signal to human HaCaT keratinocytes, which may serve as an important mechanism for cell transformation and potential skin carcinogenesis in vivo caused by UVA exposure...
  9. pmc Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 21:1056-63. 2008
    ..Our results clearly show that the phototoxicity induced by (gamma-CyD) 2/C 60 is mainly mediated by singlet oxygen with a minor contribution from superoxide, while C 60(OH) 24 phototoxicity is mainly due to superoxide...
  10. doi request reprint Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1215-23. 2008
    ..In vitro tests with HaCaT keratinocytes provided evidence that (gamma-CyD)(2)/C(60) phototoxicity is mainly mediated by (1)O(2) (Type II mechanism) with only a minor contribution from free radicals (Type I mechanism)...
  11. pmc Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 241:163-72. 2009
    ..We expect that modifying the surface of silicon nanoparticles encapsulating the photosensitizers with antibodies specific to melanoma cells will lead to even better early diagnosis and targeted treatment of melanoma in the future...
  12. pmc UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Cancer Res 68:3752-8. 2008
    ..Identification of these signaling pathways in UVA-induced cell proliferation will facilitate the development of efficient and safe chemopreventive and therapeutic strategies for skin cancer...
  13. ncbi request reprint Ultraviolet A sensitivity in Smith-Lemli-Opitz syndrome: Possible involvement of cholesta-5,7,9(11)-trien-3 beta-ol
    Colin F Chignell
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 41:339-46. 2006
    ..Finally, we have previously detected 9-DDHC in skin lipids from normal subjects, so this sterol may also be the skin chromophore responsible for skin photoaging and UV-induced skin cancer...
  14. pmc Spatial distribution of protein damage by singlet oxygen in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Photochem Photobiol 84:69-74. 2008
    ..The subcellular localization of the protein DMPO adducts was coincident with that of RB. This approach may provide information on the spatial distribution of singlet oxygen generated in cells...
  15. ncbi request reprint Phototoxicity in human lens epithelial cells promoted by St. John's Wort
    Yu Ying He
    Laboratory of Chemistry and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 10023, USA
    Photochem Photobiol 80:583-6. 2004
    ..Thus, ingested SJW is potentially phototoxic to the eye and could contribute to early cataractogenesis. Precautions should be taken to protect the eye from intense sunlight while taking SJW...
  16. ncbi request reprint Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 70:144-51. 2005
    ..Thus, the liver-selective NO donor, V-PYRRO/NO, was partially protective against ANIT-induced liver injury, without affecting ANIT-induced cholestasis and cholestasis-related gene expression...
  17. pmc Recent advances in the prevention and treatment of skin cancer using photodynamic therapy
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Expert Rev Anticancer Ther 10:1797-809. 2010
    ..This article summarizes the main principles of PDT and its current clinical use in the management of non-melanoma skin cancers, as well as recent developments and possible future research directions...
  18. pmc Difference in phototoxicity of cyclodextrin complexed fullerene [(gamma-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 22:660-7. 2009
    ..Our results also demonstrate that UVA-blocking sunglasses can limit the ocular phototoxicity of this nanomaterial, while nontoxic endogenous antioxidants like lutein or Trolox cannot provide adequate protection...
  19. ncbi request reprint Reactive oxygen species and UV-B: effect on cyanobacteria
    Yu Ying He
    Institut fur Botanik und Pharmazeutische Biologie, Friedrich Alexander Universitat, Staudtstr 5, D 91058 Erlangen, Germany
    Photochem Photobiol Sci 1:729-36. 2002
    ....
  20. ncbi request reprint UV-B-induced formation of reactive oxygen species and oxidative damage of the cyanobacterium Anabaena sp.: protective effects of ascorbic acid and N-acetyl-L-cysteine
    Yu Ying He
    Institut fur Botanik und Pharmazeutische Biologie, Friedrich Alexander Universitat, Staudtstrasse 5, D 91058 Erlangen, Germany
    J Photochem Photobiol B 66:115-24. 2002
    ....
  21. ncbi request reprint Adaptation of cyanobacteria to UV-B stress correlated with oxidative stress and oxidative damage
    Yu Ying He
    Institut fur Botanik und Pharmazeutische Biologie, Friedrich Alexander Universitat, Erlangen, German
    Photochem Photobiol 76:188-96. 2002
    ..to UV-B stress in our work. The adaptation of the cyanobacterium correlated with and could be caused by the oxidative stress and oxidative damage...