Karen Hayton

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Osmiophilic bodies and the odd organelles of alveolates
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Mol Microbiol 67:236-40. 2008
  2. doi request reprint Drug resistance and genetic mapping in Plasmodium falciparum
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Genet 54:223-39. 2008
  3. pmc The impact of malaria parasitism: from corpuscles to communities
    Thomas E Wellems
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 8132, USA
    J Clin Invest 119:2496-505. 2009
  4. pmc Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biochem Parasitol 187:103-10. 2013
  5. pmc Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum
    Jing Yuan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Nat Chem Biol 5:765-71. 2009
  6. pmc High recombination rates and hotspots in a Plasmodium falciparum genetic cross
    Hongying Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Genome Biol 12:R33. 2011
  7. pmc Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
    Juliana Martha Sá
    Laboratory of Malaria and Vector Research and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:18883-9. 2009
  8. ncbi request reprint Genetic linkage and association analyses for trait mapping in Plasmodium falciparum
    Xinzhuan Su
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland 20892 8132, USA
    Nat Rev Genet 8:497-506. 2007
  9. pmc Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8132, USA
    Cell Host Microbe 4:40-51. 2008
  10. pmc Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis
    Tetsuya Furuya
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Proc Natl Acad Sci U S A 102:16813-8. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Osmiophilic bodies and the odd organelles of alveolates
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Mol Microbiol 67:236-40. 2008
    ..These findings suggest that targeting PFG377 may be a strategy to block parasite transmission...
  2. doi request reprint Drug resistance and genetic mapping in Plasmodium falciparum
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Genet 54:223-39. 2008
    ..Here we discuss strategies and issues related to mapping genes contributing to drug resistance in the human malaria parasite Plasmodium falciparum...
  3. pmc The impact of malaria parasitism: from corpuscles to communities
    Thomas E Wellems
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 8132, USA
    J Clin Invest 119:2496-505. 2009
    ..Advances in genetics and genomics are providing fresh insights into the nature of these evolutionary adaptations, processes of parasite transmission and infection, and the difficult challenges of malaria control...
  4. pmc Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biochem Parasitol 187:103-10. 2013
    ..These studies offer insights into the PfRH5 receptor-binding domain and interactions that support the invasion of various primate and rodent erythrocytes by P. falciparum...
  5. pmc Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum
    Jing Yuan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Nat Chem Biol 5:765-71. 2009
    ..This study identifies new leads for antimalarial drugs and demonstrates the utility of a high-throughput chemical genomic strategy for studying malaria traits...
  6. pmc High recombination rates and hotspots in a Plasmodium falciparum genetic cross
    Hongying Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Genome Biol 12:R33. 2011
    ..A better understanding of these mechanisms may provide important information for studying parasite evolution, immune evasion and drug resistance...
  7. pmc Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
    Juliana Martha Sá
    Laboratory of Malaria and Vector Research and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:18883-9. 2009
    ..Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America...
  8. ncbi request reprint Genetic linkage and association analyses for trait mapping in Plasmodium falciparum
    Xinzhuan Su
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland 20892 8132, USA
    Nat Rev Genet 8:497-506. 2007
    ..Rapidly increasing genetic and genomic information on Plasmodium parasites, mosquitoes and humans will combine as a rich resource for new advances in our understanding of malaria, its transmission and its manifestations of disease...
  9. pmc Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8132, USA
    Cell Host Microbe 4:40-51. 2008
    ..nancymaae erythrocytes. Our results also suggest that PfRH5 is a parasite ligand for human infection, and that amino acid substitutions can cause its binding domain to recognize different human erythrocyte surface receptors...
  10. pmc Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis
    Tetsuya Furuya
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Proc Natl Acad Sci U S A 102:16813-8. 2005
    ..Mosquito infectivity of the knockout parasites was also greatly reduced but not completely lost. The results suggest that pfmdv-1 plays a key role in gametocyte membrane formation and integrity...
  11. pmc A blasticidin S-resistant Plasmodium falciparum mutant with a defective plasmodial surface anion channel
    David A Hill
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Proc Natl Acad Sci U S A 104:1063-8. 2007
    ..These findings provide solid evidence for the uptake of diverse solutes via PSAC and implicate one or more parasite genes in expression of this channel...
  12. ncbi request reprint Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 435:1117-21. 2005
    ..Haemoglobin C might protect against malaria by reducing PfEMP-1-mediated adherence of parasitized erythrocytes, thereby mitigating the effects of their sequestration in the microvasculature...
  13. ncbi request reprint Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:3309-15. 2003
    ....
  14. pmc A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquito
    Gabriele Pradel
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Exp Med 199:1533-44. 2004
    ..Our results describe members of a conserved apicomplexan protein family expressed in sexual stage Plasmodium parasites that may represent candidates for subunits of a transmission-blocking vaccine...
  15. pmc Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum
    Petra Rohrbach
    Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    EMBO J 25:3000-11. 2006
    ..On the basis of our data, we propose that Pgh-1 imports solutes, including certain antimalarial drugs, into the parasite's food vacuole. The implications of our findings for drug resistance mechanisms and testing are discussed...