Teruo Hayashi

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders
    Teruo Hayashi
    Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21209, USA
    CNS Drugs 18:269-84. 2004
  2. pmc Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders
    Teruo Hayashi
    National Institute on Drug Abuse, National Institutes of Health Cellular Stress Signaling Unit, Integrative Neuroscience Branch, Baltimore, MD 21224, USA
    Expert Opin Ther Targets 15:557-77. 2011
  3. ncbi request reprint Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival
    Teruo Hayashi
    Cellular Pathobiology Unit, Plasticity and Development Section, Cellular Neurobiology Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, MD 21224, USA
    Cell 131:596-610. 2007
  4. pmc Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones
    Teruo Hayashi
    Cellular Stress Signaling Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    Histochem Cell Biol 135:627-37. 2011
  5. ncbi request reprint An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand
    Teruo Hayashi
    IRP, NIDA NIH, Cellular Pathobiology Unit, Development and Plasticity Section, Cellular Neurobiology Research Branch, Room 3418, Triad building, 333 Cassell Drive, Baltimore, MD 21224, USA
    Expert Opin Ther Targets 12:45-58. 2008
  6. pmc Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases
    Teruo Hayashi
    National Institute on Drug Abuse, Department of Health and Human Services, National Institutes of Health, Baltimore, MD 21224, USA
    Subcell Biochem 51:381-98. 2010
  7. pmc Regulation of sigma-1 receptors and endoplasmic reticulum chaperones in the brain of methamphetamine self-administering rats
    Teruo Hayashi
    Cellular Pathobiology Section, IRP, NIDA, NIH Triad Suite 3304, 333 Cassell Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 332:1054-63. 2010
  8. pmc Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway
    Shang Yi Tsai
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 333 Cassell Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 106:22468-73. 2009
  9. ncbi request reprint Protein kinase A activation down-regulates, whereas extracellular signal-regulated kinase activation up-regulates sigma-1 receptors in B-104 cells: Implication for neuroplasticity
    Gianfrancesco Cormaci
    Development and Plasticity Section Cellular Neurobiology Research Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 320:202-10. 2007
  10. pmc Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation
    Teruo Hayashi
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:14949-54. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders
    Teruo Hayashi
    Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21209, USA
    CNS Drugs 18:269-84. 2004
    ..This would allow clinical trials to be performed more efficiently, and the results may confirm a long-speculated possibility that sigma-1 receptor ligands represent a new class of therapeutic agents for neuropsychiatric disorders...
  2. pmc Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders
    Teruo Hayashi
    National Institute on Drug Abuse, National Institutes of Health Cellular Stress Signaling Unit, Integrative Neuroscience Branch, Baltimore, MD 21224, USA
    Expert Opin Ther Targets 15:557-77. 2011
    ..Drugs available for the treatment of neurodegenerative disorders are severely limited...
  3. ncbi request reprint Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival
    Teruo Hayashi
    Cellular Pathobiology Unit, Plasticity and Development Section, Cellular Neurobiology Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, MD 21224, USA
    Cell 131:596-610. 2007
    ..These results reveal that the orchestrated ER chaperone machinery at MAM, by sensing ER Ca(2+) concentrations, regulates ER-mitochondrial interorganellar Ca(2+) signaling and cell survival...
  4. pmc Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones
    Teruo Hayashi
    Cellular Stress Signaling Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    Histochem Cell Biol 135:627-37. 2011
    ..The improved ICC methodology using the urea AR at 80°C may improve ICC of ER molecules as well as visualization of ER structure and substructures...
  5. ncbi request reprint An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand
    Teruo Hayashi
    IRP, NIDA NIH, Cellular Pathobiology Unit, Development and Plasticity Section, Cellular Neurobiology Research Branch, Room 3418, Triad building, 333 Cassell Drive, Baltimore, MD 21224, USA
    Expert Opin Ther Targets 12:45-58. 2008
    ..Ligands for the sigma1 receptor may constitute a new class of therapeutic drugs targeting an endoplasmic reticular protein...
  6. pmc Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases
    Teruo Hayashi
    National Institute on Drug Abuse, Department of Health and Human Services, National Institutes of Health, Baltimore, MD 21224, USA
    Subcell Biochem 51:381-98. 2010
    ....
  7. pmc Regulation of sigma-1 receptors and endoplasmic reticulum chaperones in the brain of methamphetamine self-administering rats
    Teruo Hayashi
    Cellular Pathobiology Section, IRP, NIDA, NIH Triad Suite 3304, 333 Cassell Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 332:1054-63. 2010
    ....
  8. pmc Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway
    Shang Yi Tsai
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 333 Cassell Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 106:22468-73. 2009
    ..These results implicate Sig-1Rs as endogenous regulators of hippopcampal dendritic spine formation and suggest a free radical-sensitive ER-mitochondrion-Rac1.GTP pathway in the regulation of dendritic spine formation in the hippocampus...
  9. ncbi request reprint Protein kinase A activation down-regulates, whereas extracellular signal-regulated kinase activation up-regulates sigma-1 receptors in B-104 cells: Implication for neuroplasticity
    Gianfrancesco Cormaci
    Development and Plasticity Section Cellular Neurobiology Research Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 320:202-10. 2007
    ..Results also suggest that psychostimulants may manipulate the cAMP-PKA-Sig-1R and/or the cAMP-ERK-Sig-1R pathways to achieve a neuroplasticity that favors addictive behaviors...
  10. pmc Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation
    Teruo Hayashi
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:14949-54. 2004
    ..Our findings indicate that, in the brain, Sig-1Rs targeting GalCer-containing lipid microdomains are important for OL differentiation and that Sig-1Rs may play an important role in the pathogenesis of certain demyelinating diseases...
  11. pmc Sigma-1 receptor chaperones and diseases
    Shang Yi Tsai
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, IRP, NIDA, NIH, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA
    Cent Nerv Syst Agents Med Chem 9:184-9. 2009
    ..The sigma-1 receptor has been implicated in many diseases including addiction, pain, depression, stroke, and cancer. Whether the chaperone activity of the sigma-1 receptor attributes to those diseases awaits further investigation...
  12. pmc Delta opioid peptide DADLE and naltrexone cause cell cycle arrest and differentiation in a CNS neural progenitor cell line
    Shang Yi Tsai
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, Maryland 21224, USA
    Synapse 64:267-73. 2010
    ..Results also suggest some potential utilization of DADLE and/or naltrexone in stem cell research...
  13. pmc The sigma-1 receptor chaperone as an inter-organelle signaling modulator
    TSUNG PING SU
    Cellular Pathobiology Section, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Suite 3304, 333 Cassell Drive, Baltimore, MD 21224, USA
    Trends Pharmacol Sci 31:557-66. 2010
    ..Thus, the Sig-1R serves as an inter-organelle signaling modulator locally at the MAM and remotely at the plasmalemma/plasma membrane. Many pharmacological/physiological effects of Sig-1Rs might relate to this unique action of Sig-1Rs...
  14. pmc A mechanism for the inhibition of neural progenitor cell proliferation by cocaine
    Chun Ting Lee
    Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS Med 5:e117. 2008
    ..To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation...
  15. ncbi request reprint Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution
    Minoru Takebayashi
    Cellular Pathobiology Unit, Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health DHHS, Baltimore, Maryland, USA
    Synapse 53:90-103. 2004
    ..sigma-1R may thus play an important role in directing EGF signaling towards neuritogenesis, perhaps by shifting EGFR from the lipid raft into non-raft regions...
  16. pmc Compromising σ-1 receptors at the endoplasmic reticulum render cytotoxicity to physiologically relevant concentrations of dopamine in a nuclear factor-κB/Bcl-2-dependent mechanism: potential relevance to Parkinson's disease
    Tomohisa Mori
    Cellular Pathobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 341:663-71. 2012
    ..Thus, Sig-1Rs and associated ligands may represent new therapeutic targets for the treatment of parkinsonism...
  17. pmc Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction
    Teruo Hayashi
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Mol Pharmacol 77:517-28. 2010
    ..These findings suggest that the MAM, bearing cholesterol and ceramide-enriched microdomains at the ER, may use the microdomains to anchor Sig-1Rs to the location; thus, it serves to stage Sig-1R at ER-mitochondria junctions...
  18. pmc The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones
    Teruo Hayashi
    Cellular Stress Signaling Unit, Integrative Neuroscience Branch, Intramural Research Program, NIDA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 287:43156-69. 2012
    ..The GalCer synthesis may thus be influenced by sterols at the ER...
  19. doi request reprint Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor
    Michiko Fujimoto
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health Cellular Stress Signaling Unit and Cellular Pathobiology Section, Integrative Neuroscience Branch, Baltimore, Maryland 21224, USA
    Synapse 66:630-9. 2012
    ..This unique pharmacological profile may provide a novel therapeutic opportunity for the treatment of neuropsychiatric disorders...
  20. pmc Gene expression profiling reveals distinct cocaine-responsive genes in human fetal CNS cell types
    Chun Ting Lee
    Cellular Neurobiology Research Branch CTL, El, TH, RA, SYT, JC, JFS, WJF, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Department of Health and Human Services DHHS, Baltimore, MD the ScienCell Research Laboratories JS, San Diego, CA, and the Gene Expression and Genomics Unit KGB, IRP, National Institute on Aging NIA, NIH, DHHS, Baltimore, MD
    J Addict Med 3:218-26. 2009
    ..In the present study, cell type-specific responses to cocaine were further explored...
  21. pmc Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB
    Johann Meunier
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, IRP, NIDA, National Institutes of Health, DHHS, Triad Technology Building, Baltimore, MD, USA
    J Pharmacol Exp Ther 332:388-97. 2010
    ..Thus, these findings suggest that Sig-1Rs promote cell survival, at least in part, by transcriptionally regulating Bcl-2 expression via the ROS/NF-kappaB pathway...
  22. ncbi request reprint Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants
    Minoru Takebayashi
    Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 303:1227-37. 2002
    ..Thus, when taken together, our results indicate that Sig-1R play an important role in the NGF-induced neurite sprouting and that certain antidepressants may facilitate neuronal sprouting in the brain via Sig-1R...
  23. ncbi request reprint Picomolar concentrations of hibernation induction delta opioid peptide [D-Ala2,D-Leu5]enkephalin increase the nerve growth factor in NG-108 cells
    Shang Yi Tsai
    Cellular Pathobiology Unit DPS CNRB, IRP, National Institute on Drug Abuse, NIH DHHS, Triad Room 3304, 333 Cassell Drive, Baltimore, Maryland 21224, USA
    Synapse 57:179-81. 2005
    ....
  24. doi request reprint Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine
    Said Kourrich
    Cellular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Cell 152:236-47. 2013
    ..Functional consequences of Sig-1R binding to K(+) channels may have implications for other chronic diseases where maladaptive intrinsic plasticity and Sig-1Rs are engaged...
  25. pmc The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria
    Michiko Fujimoto
    Cellular Stress Signaling Unit, Integrative Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Biochem Biophys Res Commun 417:635-9. 2012
    ..Apparently, cholesterol depletion increased the PtSer transport from MAMs to mitochondria. Our findings suggest that cholesterol is an important substrate in regulating the association between MAMs of the ER and mitochondria...
  26. ncbi request reprint The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse
    Teruo Hayashi
    Cellular Pathobiology Unit, Development and Plasticity Section, Cellular Neurobiology Research Branch, IRP, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Life Sci 77:1612-24. 2005
    ....
  27. ncbi request reprint Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export
    Teruo Hayashi
    Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 306:718-25. 2003
    ..Thus, sigma-1 receptors are unique endoplasmic reticulum proteins that regulate the compartmentalization of lipids on the endoplasmic reticulum and their export from the endoplasmic reticulum to plasma membrane and c-LDs...
  28. pmc MAM: more than just a housekeeper
    Teruo Hayashi
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA
    Trends Cell Biol 19:81-8. 2009
    ..The MAM thus integrates signal transduction with metabolic pathways to regulate the communication and functional interactions between the ER and mitochondrion...
  29. ncbi request reprint Sigma1 receptor upregulation after chronic methamphetamine self-administration in rats: a study with yoked controls
    Roman Stefanski
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, NIDA IRP, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 175:68-75. 2004
    ..Involvement of Sig-1R in the self-administration of psychostimulants, however, has never been reported...
  30. ncbi request reprint Intracellular dynamics of sigma-1 receptors (sigma(1) binding sites) in NG108-15 cells
    Teruo Hayashi
    Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 306:726-33. 2003
    ....
  31. doi request reprint New insights into the role of mitochondria-associated endoplasmic reticulum membrane
    Michiko Fujimoto
    Cellular Stress Signaling Unit, Cellular Pathobiology Section, Integrative Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland, USA
    Int Rev Cell Mol Biol 292:73-117. 2011
    ..Thus, drug discovery aimed at regulating ER-to-mitochondria communication may open a new avenue in treatments of human diseases...
  32. pmc Hibernation-like state induced by an opioid peptide protects against experimental stroke
    Cesar V Borlongan
    National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular Neurobiology Branch, Baltimore, MD, USA
    BMC Biol 7:31. 2009
    ..In the present study, we investigated the protective effect of DADLE in the central nervous system...
  33. ncbi request reprint Chronic [D-Ala2, D-Leu5]enkephalin treatment increases the nerve growth factor in adult mouse brain
    Teruo Hayashi
    Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Pharmacol 464:237-9. 2003
    ..Glia-derived neurotrophic factor (GDNF) was not significantly affected. Thus, the neuroprotective action of DADLE may be mediated in part by NGF...
  34. ncbi request reprint Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction
    TSUNG PING SU
    Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, MD 21224, Baltimore, USA
    Curr Med Chem 10:2073-80. 2003
    ..Thus, it is hypothesized that sigma-1 receptors, at least in part, are intracellular amplifiers creating a supersensitized state for signal transduction in the biological system...
  35. pmc When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor
    TSUNG PING SU
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Sci Signal 2:pe12. 2009
    ..Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors...
  36. ncbi request reprint Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving
    Jeffrey W Grimm
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:742-7. 2003
    ..Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods...
  37. ncbi request reprint Antiapoptotic and cytotoxic properties of delta opioid peptide [D-Ala(2),D-Leu(5)]enkephalin in PC12 cells
    Teruo Hayashi
    Cellular Pathobiology Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Synapse 43:86-94. 2002
    ....
  38. ncbi request reprint Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release
    Yuki Yagasaki
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Tokyo 187 8502, Japan
    J Biol Chem 281:12941-9. 2006
    ..These results suggest that antidepressant pretreatment selectively enhance the BDNF signaling on the PLC-gamma/IP3/Ca2+ pathway via Sig-1R, and that Sig-1R plays an important role in BDNF signaling leading to glutamate release...