Research Topics
Genomes and GenesSpecies | M HauptmannSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The use of sliding time windows for the exploratory analysis of temporal effects of smoking histories on lung cancer riskM Hauptmann
GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
Stat Med 19:2185-94. 2000..Among different smoking profiles that result in the same lifelong cumulative number of cigarettes smoked, those with a concentration of smoked cigarettes within 20 years before interview bear substantially larger risk than others...- Analysis of exposure-time-response relationships using a spline weight functionM Hauptmann
GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
Biometrics 56:1105-8. 2000..The method is evaluated in a simulation study and is applied to data on smoking histories and lung cancer from a recent case-control study in Germany... - The exposure-time-response relationship between occupational asbestos exposure and lung cancer in two German case-control studiesMichael Hauptmann
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7244, USA
Am J Ind Med 41:89-97. 2002..Numerous studies have been carried out to evaluate the association between lung cancer and occupational asbestos exposure. However, the effects of timing of exposure have not been analyzed thoroughly... - Mortality from lymphohematopoietic malignancies among workers in formaldehyde industriesMichael Hauptmann
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Natl Cancer Inst 95:1615-23. 2003..We extended follow-up of a cohort of industrial workers to evaluate the association between formaldehyde exposure and lymphohematopoietic cancers... - Mortality from solid cancers among workers in formaldehyde industriesMichael Hauptmann
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Epidemiol 159:1117-30. 2004..In this cohort of formaldehyde-industry workers, some evidence was found of an exposure-response relation with mortality from nasopharyngeal cancer (based on small numbers) but not for cancers of the pancreas, brain, lung, or prostate... - Retrospective biodosimetry among United States radiologic technologistsParveen Bhatti
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Radiat Res 167:727-34. 2007..S. radiologic technologists... - Cancer and other causes of mortality among radiologic technologists in the United StatesAparna K Mohan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7244, USA
Int J Cancer 103:259-67. 2003.... - Interventional radiography and mortality risks in U.S. radiologic technologistsMartha S Linet
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7238, USA
Pediatr Radiol 36:113-20. 2006..The present study cannot rule out increased risks of cerebrovascular disease, specific cancers, and diseases with low case-fatality rates or a long latency period preceding death... - Risk of cataract after exposure to low doses of ionizing radiation: a 20-year prospective cohort study among US radiologic technologistsGabriel Chodick
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7238, USA
Am J Epidemiol 168:620-31. 2008.... - Using splines to analyse latency in the Colorado Plateau uranium miners cohortM Hauptmann
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892-7244, USA
J Epidemiol Biostat 6:417-24. 2001..CONCLUSIONS: The proposed spline model is a flexible tool for latency analyses, and extends previously used methods... - Occupation and adult-onset asthma among Chinese women in a population-based cohortSrmena Krstev
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA
Am J Ind Med 50:265-73. 2007..We examined the associations between occupation and asthma among women in a case-control study nested in the population-based Shanghai Women's Health Study cohort in China... - Lung cancer risk among US radiologic technologists, 1983-1998Preetha Rajaraman
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892 7238, USA
Int J Cancer 119:2481-6. 2006..Overall, we find very limited evidence that chronic low-to-moderate dose occupational exposure increased lung cancer risk in the US Radiologic Technologist cohort... - Smoking cigarettes before first childbirth and risk of breast cancerMina Ha
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Epidemiol 166:55-61. 2007.... - Cigarette smoking and cancer risk: modeling total exposure and intensityJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 166:479-89. 2007..The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites... - Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologistsParveen Bhatti
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
Int J Cancer 122:177-82. 2008..The suggestive evidence found for modification of radiation-related breast cancer risk for 5 of the 55 SNPs evaluated requires confirmation in larger studies of women with quantified radiation breast doses in the low-to-moderate range... - Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic TechnologistsAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 16:2000-7. 2007..For this reason, potential modification of the relationship between ionizing radiation exposure and breast cancer risk by polymorphic apoptosis gene variants have not been investigated among radiation-exposed women... - Occupation and breast cancer risk among Shanghai women in a population-based cohort studyBu Tian Ji
National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
Am J Ind Med 51:100-10. 2008..A total of 74,942 female subjects were recruited in a population-based cohort study in Shanghai, China between 1997 and 2000. We examined the relationship between occupation and breast cancer risk... - Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute CohortLaura E Beane Freeman
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
J Natl Cancer Inst 101:751-61. 2009.... - Estimating historical radiation doses to a cohort of U.S. radiologic technologistsSteven L Simon
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health, Bethesda, Maryland, USA
Radiat Res 166:174-92. 2006..The models and predictions presented here, while continuing to be modified and improved, represent one of the most comprehensive dose reconstructions undertaken to date for a large cohort of medical radiation workers... - Cancer incidence in the US radiologic technologists health study, 1983-1998Alice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer 97:3080-9. 2003..The observed excesses of melanoma and thyroid cancers may reflect, at least in part, earlier detection among medical workers with easy access to health care... - Risk of melanoma among radiologic technologists in the United StatesD Michal Freedman
Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Room 7087, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Int J Cancer 103:556-62. 2003.... - Site-specific cancer incidence and mortality after cerebral angiography with radioactive thorotrastLois B Travis
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA
Radiat Res 160:691-706. 2003..Nonetheless, the substantial risks associated with liver cancer and leukemia indicate that unique and prolonged exposure to alpha-particle-emitting Thorotrast increased carcinogenic risks... - Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genesAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, Maryland, 20892 7238, USA
BMC Cancer 4:9. 2004..Thus, 19 single nucleotide polymorphisms (SNPs) in eight genes involved in base excision repair (XRCC1, APEX, POLD1), BRCA1 protein interaction (BRIP1, ZNF350, BRCA2), and growth regulation (TGFss1, IGFBP3) were evaluated... - Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologistsShinji Yoshinaga
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Int J Cancer 115:828-34. 2005..013 and 0.027, respectively). This study provides some evidence that chronic occupational exposure to IR at low to moderate levels can increase the risk of BCC, and that this risk may be modified by pigmentation characteristics... - DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individualsAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
Mutat Res 586:173-88. 2005..Measuring this DNA damage phenotype may contribute to the identification of susceptible sub-groups. Our observations require replication in a prospective study with a large number of pre-diagnostic samples... - Breast cancer incidence in U.S. radiologic technologistsMichele Morin Doody
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
Cancer 106:2707-15. 2006.... - Mortality from diseases of the circulatory system in radiologic technologists in the United StatesMichael Hauptmann
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 157:239-48. 2003..007 and < 0.001, respectively). The data suggest increased mortality from diseases of the circulatory system with occupational radiation exposure before 1950 when radiation doses were likely high... - Incidence of haematopoietic malignancies in US radiologic technologistsM S Linet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Occup Environ Med 62:861-7. 2005..There are limited data on risks of haematopoietic malignancies associated with protracted low-to-moderate dose radiation... - Breast cancer mortality among female radiologic technologists in the United StatesAparna K Mohan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7244, USA
J Natl Cancer Inst 94:943-8. 2002..The high risks of breast cancer mortality for women exposed to occupational radiation prior to 1950 and the subsequent decline in risk are consistent with the dramatic reduction in recommended radiation exposure limits over time... - Low level alcohol intake, cigarette smoking and risk of breast cancer in Asian-American womenLinda Morris Brown
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Breast Cancer Res Treat 120:203-10. 2010.... - International study of factors affecting human chromosome translocationsAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Mutat Res 652:112-21. 2008..Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes... - A case-control study of dietary phytoestrogens and testicular cancer riskFarzana L Walcott
Department of Epidemiology, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA
Nutr Cancer 44:44-51. 2002..This hypothesis-generating study does not support the premise that dietary phytoestrogens increase or decrease testicular cancer risk in young men... - Re: Population-based, case-control study of HER2 genetic polymorphism and breast cancer riskMichael Hauptmann
J Natl Cancer Inst 95:1251-2. 2003 - Treatment-related risk factors for premature menopause following Hodgkin lymphomaMarie L De Bruin
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam
Blood 111:101-8. 2008..As long as alkylating agents will be used for curing HL, premature menopause will remain a frequent adverse treatment effect, with various clinical implications... - A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerKatrien Berns
Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Cancer Cell 12:395-402. 2007..Thus, assessment of PI3K pathway activation may provide a biomarker to identify patients unlikely to respond to trastuzumab-based therapy... - Relationship between clinical factors and the incidence of toxicity after intra-arterial chemoradiation for head and neck cancerGuido B van den Broek
Department of Head and Neck Oncology and Surgery, Academic Medical Centre, Amsterdam, The Netherlands
Radiother Oncol 81:143-50. 2006..This study was set up to determine the relationship between patient-, tumour- and treatment-related factors and acute/late toxicity after concomitant chemoradiation... - Thyroid cancer and employment as a radiologic technologistErik W Zabel
Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
Int J Cancer 119:1940-5. 2006..04, 95% CI = 1.01-10.78). These data provide modest evidence of an association between employment as a radiologic technologist and thyroid cancer risk; however, the findings require confirmation with more accurate exposure models...