K J Hasenkrug

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells
    Christoph G Ammann
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    PLoS ONE 4:e6105. 2009
  2. pmc In vitro and in vivo analyses of regulatory T cell suppression of CD8+ T cells
    Kim J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Methods Mol Biol 707:45-54. 2011
  3. ncbi request reprint The role of CD4 and CD8 T cells in recovery and protection from retroviral infection: lessons from the Friend virus model
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, Montana, 59840, USA
    Virology 272:244-9. 2000
  4. ncbi request reprint The leptin connection: regulatory T cells and autoimmunity
    Kim J Hasenkrug
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Immunity 26:143-5. 2007
  5. pmc Lymphocyte deficiencies increase susceptibility to friend virus-induced erythroleukemia in Fv-2 genetically resistant mice
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 73:6468-73. 1999
  6. pmc Critical role for CD4(+) T cells in controlling retrovirus replication and spread in persistently infected mice
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 72:6559-64. 1998
  7. pmc Immunity to retroviral infection: the Friend virus model
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 94:7811-6. 1997
  8. pmc Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 72:6554-8. 1998
  9. pmc Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 75:654-60. 2001
  10. pmc Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia
    K E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 74:5363-7. 2000

Collaborators

  • B Chesebro
  • U Dittmer
  • J L Portis
  • V A Letts
  • K D Sarge
  • W N Frankel
  • Leonard H Evans
  • Karin E Peterson
  • Robert S Mittler
  • S Sakaguchi
  • Ronald J Messer
  • Shelly J Robertson
  • Christoph G Ammann
  • Aaron B Carmody
  • Justin M Greene
  • Mario L Santiago
  • Anke R M Kraft
  • Gennadiy Zelinskyy
  • Hong He
  • Ingunn M Stromnes
  • M Iwashiro
  • DAVID H O'CONNOR
  • Robert Benitez
  • Nicole Gerlach
  • Lara Myers
  • Jung Joo Hong
  • Roger W Wiseman
  • H J Super
  • Benjamin J Burwitz
  • Christopher Burlak
  • Warner C Greene
  • Teresa L Mattila
  • Pamela J Skinner
  • Wes Yonemoto
  • William A Cafruny
  • Alex J Blasky
  • Savita Nair
  • Eva G Rakasz
  • Mauricio Montano
  • Shelby L O'Connor
  • Simone Schimmer
  • Tanja Arndt
  • Guojun Yang
  • S J Robertson
  • Brent Race
  • Koen Schepers
  • Ton N M Schumacher
  • I M Stromnes
  • R J Messer
  • T Sugie
  • N G Copeland
  • R Konzek
  • S Simmons
  • N A Jenkins
  • D M Brooks
  • R I Morimoto
  • D J Gilbert

Detail Information

Publications29

  1. pmc Lactate dehydrogenase-elevating virus induces systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells
    Christoph G Ammann
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    PLoS ONE 4:e6105. 2009
    ..The mechanism of this activation has not been fully described and is the focus of the current studies...
  2. pmc In vitro and in vivo analyses of regulatory T cell suppression of CD8+ T cells
    Kim J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
    Methods Mol Biol 707:45-54. 2011
    ..Interestingly, while virus-induced Tregs suppress CD8(+) T cell function in vitro and in vivo, they do not suppress proliferation unless they are further activated in vitro...
  3. ncbi request reprint The role of CD4 and CD8 T cells in recovery and protection from retroviral infection: lessons from the Friend virus model
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, Montana, 59840, USA
    Virology 272:244-9. 2000
  4. ncbi request reprint The leptin connection: regulatory T cells and autoimmunity
    Kim J Hasenkrug
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Immunity 26:143-5. 2007
    ..In this issue of Immunity, De Rosa et al. (2007) elucidate an important new role for leptin in the anergy and hyporesponsiveness of regulatory T cells...
  5. pmc Lymphocyte deficiencies increase susceptibility to friend virus-induced erythroleukemia in Fv-2 genetically resistant mice
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 73:6468-73. 1999
    ..Thus, Fv-2 resistance does not independently prevent FV-induced erythroleukemia but works in concert with the immune system by limiting early infection long enough to allow virus-specific immunity time to develop and facilitate recovery...
  6. pmc Critical role for CD4(+) T cells in controlling retrovirus replication and spread in persistently infected mice
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 72:6559-64. 1998
    ....
  7. pmc Immunity to retroviral infection: the Friend virus model
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 94:7811-6. 1997
    ..In vivo depletion experiments demonstrate different requirements for CD8(+) T cells depending on the vaccine used. The implications of these studies for human retroviral diseases are discussed...
  8. pmc Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 72:6554-8. 1998
    ..The results indicated that immune mechanisms rather than viral interference mediated protection...
  9. pmc Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 75:654-60. 2001
    ..The results indicate that IFN-gamma plays an important role during primary immune responses against Friend virus but is dispensable during vaccine-primed secondary responses...
  10. pmc Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia
    K E Peterson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 74:5363-7. 2000
    ..Furthermore, the influence of MHC class I genotype on the generation of both IFN-gamma-producing CD4(+) and CD8(+) T cells helps explain the major impact of the H-2D gene on recovery from FV disease...
  11. pmc Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15
    H J Super
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 73:7848-52. 1999
    ..This localization of Rfv3 to a region of less than 1 cM now makes it feasible to attempt the cloning of Rfv3 by physical methods...
  12. pmc Neurologic disease induced by polytropic murine retroviruses: neurovirulence determined by efficiency of spread to microglial cells
    S J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 71:5287-94. 1997
    ....
  13. pmc Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection
    M Iwashiro
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 98:9226-30. 2001
    ..These results suggest a possible explanation for HIV- and human T cell leukemia virus-I-induced immunosuppression in the absence of T cell depletion...
  14. pmc Two separate envelope regions influence induction of brain disease by a polytropic murine retrovirus (FMCF98)
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA Kim
    J Virol 70:4825-8. 1996
    ....
  15. pmc Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus
    K J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 69:2617-20. 1995
    ..Potential candidate genes for Rfv3 are several genes expressed in cells of the immune system and previously mapped to the same region, including a T-cell antigen gene, Ly6, and three cytokine receptor genes, IL2rb, IL3rb1, and IL3rb2...
  16. ncbi request reprint Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection
    Ulf Dittmer
    Institut für Virologie des Universitätsklinikums, 45122 Essen, Germany
    Immunity 20:293-303. 2004
    ..The results indicate that CD4(+) regulatory T cells contribute to viral persistence and demonstrate an immunotherapy for treating chronic retroviral infections...
  17. pmc Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection
    Mario L Santiago
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Science 321:1343-6. 2008
    ..The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections...
  18. pmc CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells
    Shelly J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 180:5267-74. 2008
    ..However, the results demonstrate a potent strategy to potentiate the function of CD8(+) T cells in the context of immunosuppressive Treg cells...
  19. pmc Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus
    Shelly J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Virol 82:408-18. 2008
    ..Coinfection of mice with LDV and FV provides a well-defined, natural host model for such studies...
  20. pmc Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice
    Ingunn M Stromnes
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases NIH, Hamilton, Montana 59840, USA
    J Virol 76:2225-32. 2002
    ..Eventually, all of the IFN-gamma-deficient mice failed to keep persistent virus in check and developed fatal FV-induced erythroleukemia...
  21. ncbi request reprint Immune control and prevention of chronic Friend retrovirus infection
    Kim J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Front Biosci 12:1544-51. 2007
    ..Also summarized are findings from vaccine studies demonstrating the immunological requirements for the prevention of chronic retroviral infection. The implications of these findings for chronic infections in humans are discussed...
  22. ncbi request reprint In vitro suppression of CD8+ T cell function by Friend virus-induced regulatory T cells
    Shelly J Robertson
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S Fourth Street, Hamilton, MT 59840, USA
    J Immunol 176:3342-9. 2006
    ..Such activity may also have adverse consequences by allowing viruses to establish and maintain chronic infections if suppression of antiviral immune responses occurs before virus eradication...
  23. ncbi request reprint Effective treatment of retrovirus-induced suppression of antibody responses with CpG oligodeoxynucleotides
    Anke R M Kraft
    Institut für Virologie des Universitätsklinikums Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Gen Virol 86:3365-8. 2005
    ..Protection also required IFN-gamma, as neutralization of this cytokine abolished the therapeutic effect of CpG-ODN. These findings may have implications for the treatment of immunosuppressive virus infections...
  24. pmc Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection
    Ronald J Messer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:12260-5. 2004
    ..These results emphasize the importance of inducing both T cell responses and virus-neutralizing antibody responses for effective retroviral vaccine protection...
  25. pmc CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection
    Gennadiy Zelinskyy
    Institut fuer Virologie, Universitaetsklinikum Essen, 45122 Essen, Germany
    J Virol 79:10619-26. 2005
    ..These results demonstrate a broad impairment of cytotoxic CD8+ T-cell effector function during chronic retroviral infection and explain the inability of virus-specific CD8+ T cells to eliminate persistent virus...
  26. pmc Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection
    Hong He
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Virol 78:11641-7. 2004
    ..DTA-1 therapy produced faster Th1 immune responses, significant reductions in both acute virus loads and pathology and, most importantly, long-term improvement of CD8(+) T-cell-mediated antitumor responses...
  27. pmc Allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques
    Justin M Greene
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 3:e2384. 2008
    ..Previous adoptive transfers in primates have failed as transferred cells are typically cleared within hours after transfer...
  28. pmc Essential roles for CD8+ T cells and gamma interferon in protection of mice against retrovirus-induced immunosuppression
    Ulf Dittmer
    Institut für Virologie der Universität Würzburg, Wurzburg, Germany
    J Virol 76:450-4. 2002
    ..Thus, FV-induced immunosuppression of antibody responses involves complex mechanisms controlled at least in part by CD8+ T cells...
  29. ncbi request reprint CD4+ regulatory T cells in chronic viral infection
    Kim J Hasenkrug
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Novartis Found Symp 252:194-9; discussion 199-210. 2003
    ..Thus findings from the Friend virus mouse model may provide insights into new therapies or preventive strategies against persistent pathogens...