Research Topics
Genomes and Genes
Species | P HartgeSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Breast cancer epidemiology according to recognized breast cancer risk factors in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial CohortJames V Lacey
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
BMC Cancer 9:84. 2009..We therefore evaluated known risk factors for breast cancer in a cancer screening trial that does not have breast cancer as a study endpoint but is large enough to provide numerous analytic opportunities for breast cancer...
Estimating the burden of disease and the benefits of preventionPatricia Hartge
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Epidemiology 17:498-9. 2006
Participation in population studiesPatricia Hartge
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Executive Plaza South, Rm. 8093, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Epidemiology 17:252-4. 2006
Epidemiologic tools for today and tomorrowP Hartge
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7246, USA
Ann N Y Acad Sci 954:295-300; discussion 301-10. 2001..The paradigms of each discipline still offer important insights into the problems of both disciplines, so cross-training would be a simple step to begin enlarging the tool box for population science...
Ultraviolet radiation, dietary vitamin D, and risk of non-Hodgkin lymphoma (United States)Patricia Hartge
Division of Cancer Epidemiology and Genetics, National Cancer Institue, Rockville, MD 20852, USA
Cancer Causes Control 17:1045-52. 2006....
Genetics of reproductive lifespanPatricia Hartge
Patricia Hartge is at the Division of Cancer Epidemiology and Genetics, in the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 41:637-8. 2009..The list of new genetic associations identified for these two traits should shed light on the mechanisms of ovarian aging, as well as breast cancer and other diseases associated with reproductive lifespan...
Residential herbicide use and risk of non-Hodgkin lymphomaPatricia Hartge
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland
Cancer Epidemiol Biomarkers Prev 14:934-7. 2005..Environmental exposure to herbicides has been hypothesized to contribute to the long-term increase in non-Hodgkin lymphoma (NHL)...
Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanomaPhuong L Mai
Clinical Genetic Branch, National Cancer Institute, Rockville, Maryland, United States of America
PLoS ONE 4:e4812. 2009..Further, possible effect of BRCA mutations on non-cancer mortality risk has not been examined...
Gynecologic surgeries and risk of ovarian cancer in women with BRCA1 and BRCA2 Ashkenazi founder mutations: an Israeli population-based case-control studyJoni L Rutter
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7246, USA
J Natl Cancer Inst 95:1072-8. 2003..We assessed the level and persistence of reduction of ovarian (including peritoneal) cancer risk after gynecologic surgeries for women who carry BRCA1/2 mutations but were not selected from high-risk clinics...
The prevalence of common BRCA1 and BRCA2 mutations among Ashkenazi JewsP Hartge
Division of Cancer Epidemiology and Statistics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7374, USA
Am J Hum Genet 64:963-70. 1999..Even with accurate estimates of the likelihood of carrying a mutation and the likelihood of developing cancer if a mutation is detected, the most vexing clinical problems remain...
Degreasing and risk of non-Hodgkin lymphomaM P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, 6120 Executive Blvd, Bethesda, MD 20892, USA
Occup Environ Med 66:557-60. 2009..To investigate the relationship between selected solvent-related workplace tasks (degreasing, painting, gluing, stripping paint, staining) and risk of non-Hodgkin lymphoma (NHL)...
Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanomaM A Tucker
Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892 7372, USA
JAMA 277:1439-44. 1997..To investigate the relationship of number and type of nevi to the development of melanoma...
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studiesMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Br J Haematol 151:239-44. 2010..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL...
Dietary flavonoid intake and non-Hodgkin lymphoma riskCara L Frankenfeld
Division of Cancer, Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Am J Clin Nutr 87:1439-45. 2008..Dietary flavonoids are polyphenolic compounds proposed to be anticarcinogenic. Flavonoids are well-characterized antioxidants and metal chelators, and certain flavonoids exhibit antiproliferative and antiestrogenic effects...
Determinants of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in house dust samples from four areas of the United StatesN C Deziel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, United States
Sci Total Environ 433:516-22. 2012..Further study of the contribution of these sources and other facility types to total PCDD/F exposure in a larger number of homes is warranted...
Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer CancersMark P Purdue
National Cancer Institute, Bethesda, Maryland, USA
Am J Epidemiol 172:58-69. 2010..Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects...
Joint effect of genes and environment distorted by selection biases: implications for hospital-based case-control studiesSholom Wacholder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892-7244, USA
Cancer Epidemiol Biomarkers Prev 11:885-9. 2002..This formulation extends to the general problem of distortion of joint effects from selection biases or confounding...
Positional accuracy of two methods of geocodingMary H Ward
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7240, USA
Epidemiology 16:542-7. 2005..Using a commercial firm did not improve accuracy compared with our in-house method. The effect of geocoding errors on exposure classification will depend on the spatial variation of the exposure being studied...
Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohortsLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 21:1305-14. 2010..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes...
Antibiotic use and risk of non-Hodgkin's lymphoma: a population-based case-control studyL A Anderson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Br J Cancer 98:161-4. 2008..7, 95% confidence interval=0.5-1.2), nor antibiotic use by site, was associated with total NHL, or NHL subtypes. There were no trends with frequency or age at first use (P trend=0.23 and 0.26, respectively)...
Recent trends in cutaneous melanoma incidence among whites in the United StatesA Jemal
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Cancer Inst 93:678-83. 2001....
Risk of non-Hodgkin lymphoma and nitrate and nitrite from drinking water and dietMary H Ward
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892, USA
Epidemiology 17:375-82. 2006..Nitrate and nitrite are precursors in the in vivo formation of N-nitroso compounds, potent animal carcinogens...
A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Carcinogenesis 30:275-81. 2009..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL...
Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphomaJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
Blood 113:1899-905. 2009..This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL...
Proximity to crops and residential exposure to agricultural herbicides in iowaMary H Ward
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Environ Health Perspect 114:893-7. 2006..Our results indicate that crop maps may be a useful method for estimating levels of herbicides in homes from nearby crop fields...
Identifying individuals at high risk of melanoma: a practical predictor of absolute riskThomas R Fears
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Clin Oncol 24:3590-6. 2006..We developed a model to estimate the 5-year absolute risk of melanoma to efficiently identify individuals at increased risk of melanoma for potential interventions...
Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trialShih Chen Chang
Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Executive Plaza South, Suite 320, MSC7232, Bethesda, Maryland 20892 7232, USA
Cancer Epidemiol Biomarkers Prev 15:334-41. 2006..In addition, these three aspects of energy balance may act jointly in determining breast cancer risk...
Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma riskUnhee Lim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Am J Epidemiol 166:697-708. 2007..19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology...
Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphomaSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Carcinogenesis 27:1828-34. 2006....
Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphomaLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Pharmacogenet Genomics 16:537-45. 2006..15-5.20, P = 0.02). Our data provide evidence that NAT1 and NAT2 genotypes are associated with NHL risk and support a contributory role for carcinogenic aromatic and/or heterocyclic amines in the multi-factorial etiology of NHL...
Cellular telephones and non-Hodgkin lymphomaMartha S Linet
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
Int J Cancer 119:2382-8. 2006..These findings must be interpreted in the context of less than 5% of the population reporting duration of use of 6 or more years or lifetime cumulative use of 200 or more hours...
Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factorsSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
Cancer Res 67:5042-54. 2007....
Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health studyShih Chen Chang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 320, Executive Plaza South, MSC7232, Bethesda, MD 20892 7232, USA
Cancer Epidemiol Biomarkers Prev 16:723-30. 2007..We conclude that both current adiposity and adult weight gain are associated with substantial increases in the risk of endometrial cancer, with relations particularly evident among never users of menopausal hormone therapy...
Vitamin D and cancer: current dilemmas and future needsCindy D Davis
Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892, USA
Nutr Rev 65:S71-4. 2007
Effect of changing breast cancer incidence rates on the calibration of the Gail modelSara J Schonfeld
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Bethesda, MD 20892, USA
J Clin Oncol 28:2411-7. 2010..Motivated by changes in breast cancer incidence during the 1990s, we evaluated the model's calibration in two recent cohorts...
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control studyUnhee Lim
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Rockville, MD 20852, USA
Blood 109:3050-9. 2007..13; 95% CI = 0.04-0.39), and MTRR Ex5+136T>CTT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis...
Ovarian cancer screening in women with a family history of breast or ovarian cancerJames V Lacey
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Obstet Gynecol 108:1176-84. 2006..To evaluate positive predictive values of CA 125 or transvaginal ultrasonography screening for ovarian cancer according to family history of breast or ovarian cancer...
Menopausal hormone therapy and ovarian cancer risk in the National Institutes of Health-AARP Diet and Health Study CohortJames V Lacey
Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MDUSA
J Natl Cancer Inst 98:1397-405. 2006....
Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphomaSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
Cancer Res 66:9771-80. 2006..Our results require replication but potentially provide important clues for investigating common genetic variants as susceptibility factors and in disease outcomes, treatment responses, and immunotherapy targets...
Hobbies with solvent exposure and risk of non-Hodgkin lymphomaJoanne S Colt
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 18:385-90. 2007..We conclude that participation in hobbies involving exposure to organic solvents is unlikely to increase NHL risk...
Ovarian volume: determinants and associations with cancer among postmenopausal womenMark E Sherman
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 15:1550-4. 2006..Confirmation of these findings in future studies, including analyses of serum hormone levels and tissues, may provide insights into hormonal carcinogenesis among older women...
Cigarette smoking and cancer risk: modeling total exposure and intensityJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 166:479-89. 2007..The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites...
Residential insecticide use and risk of non-Hodgkin's lymphomaJoanne S Colt
Occupational and Environmental Epidemiology Branch, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
Cancer Epidemiol Biomarkers Prev 15:251-7. 2006..We concluded that chlordane treatment of homes for termites may increase residents' NHL risk...
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph ConsortiumNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Lancet Oncol 7:27-38. 2006..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
BRCA1 and sex ratioJeffery P Struewing
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5060, USA
Eur J Hum Genet 12:663-7. 2004..Nonetheless, these observations do not support the idea that BRCA1 mutation carriers have a lower ratio of male offspring than BRCA2 mutation carriers...
Survival among women with borderline ovarian tumors and ovarian carcinoma: a population-based analysisMark E Sherman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Cancer 100:1045-52. 2004..Comparison of the survival for women with LMP tumors staged as distant with women who have carcinoma may have important implications for diagnostic terminology and clinical management...
Comparison of pesticide levels in carpet dust and self-reported pest treatment practices in four US sitesJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Room 8112, Rockville, MD 20852, USA
J Expo Anal Environ Epidemiol 14:74-83. 2004..Dust sampling provides an objective measure of specific compounds to which a person may have been exposed through personal use of a pesticide or by drift-in or track-in from outside, and avoids recall bias...
Adjustment for competing risk in kin-cohort estimationNilanjan Chatterjee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
Genet Epidemiol 25:303-13. 2003..We also evaluate the performance of the proposed estimation method, based on simulated data that were generated following the setup of the Washington Ashkenazi Study...
Medication use and risk of ovarian carcinoma: a prospective studyJames V Lacey
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852 7234, USA
Int J Cancer 108:281-6. 2004..5) appeared to increase risk. In our study, neither anti-inflammatory medications nor anti-psychotic medications were associated with ovarian cancer. Potential associations with histamine-receptor antagonists may warrant further study...
Apportioning causes, targeting populations and predicting risks: population attributable fractionsNilanjan Chatterjee
Biostatistics Branch, Epidemiology and Biostatistics Program, National Cancer Institute, NIH, DHHS, USA
Eur J Epidemiol 18:933-5. 2003
Performance of common genetic variants in breast-cancer risk modelsSholom Wacholder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
N Engl J Med 362:986-93. 2010..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)Sophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Blood 109:3479-88. 2007..0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology...
Menopausal hormone replacement therapy and risk of ovarian cancerJames V Lacey
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7234, Rockville, MD 20852, USA
JAMA 288:334-41. 2002..The association between menopausal hormone replacement therapy and ovarian cancer is unclear...
Breast cancer risk in Ashkenazi BRCA1/2 mutation carriers: effects of reproductive historyPatricia Hartge
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7246, USA
Epidemiology 13:255-61. 2002..Younger age at first birth and greater parity generally reduce the risk of developing breast cancer, but whether this reduced risk holds in women with a mutation in the BRCA1 or BRCA2 gene is unknown...
Body-mass index and mortality among 1.46 million white adultsAmy Berrington de Gonzalez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
N Engl J Med 363:2211-9. 2010....
Diet and melanoma in a case-control studyAmy E Millen
Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7344, USA
Cancer Epidemiol Biomarkers Prev 13:1042-51. 2004..Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable risk factors. This study investigates risk related to dietary factors, which are potentially modifiable...
Hepatitis C virus infection and non-Hodgkin lymphoma: results of the NCI-SEER multi-center case-control studyEric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Int J Cancer 111:76-80. 2004..Our study demonstrates an association between HCV infection and NHL in the United States. HCV infection may be a cause of NHL...
Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortiumShannon M Lynch
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
Am J Epidemiol 170:403-13. 2009..This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis...
Reporting participation in epidemiologic studies: a survey of practiceLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Am J Epidemiol 163:197-203. 2006..The authors conclude that epidemiologists need to address declining participation and to report participation consistently, including for biologic specimen collection...
Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma riskSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
PLoS ONE 4:e5360. 2009..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk...
Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphomaAllison H Gathany
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
Cancer Causes Control 20:1291-302. 2009..We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other...
Hormone replacement therapy, reproductive history, and colorectal adenomas: data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (United States)Mark P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, MSC 7240, Executive Plaza South 8121, Rockville, MD 20892, USA
Cancer Causes Control 16:965-73. 2005....
Meat and meat-mutagen intake and risk of non-Hodgkin lymphoma: results from a NCI-SEER case-control studyAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
Carcinogenesis 27:293-7. 2006..39 (0.22-0.70); P trend = 0.004]. Overall, our study suggests that consumption of meat, whether or not it is well-done, does not increase the risk of NHL. Furthermore, neither HCAs nor B[a]P from meat increase the risk of NHL...
Antibodies to JC and BK viruses among persons with non-Hodgkin lymphomaEric A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20892, USA
Int J Cancer 117:1013-9. 2005..Additional research is needed to determine whether JCV replication is decreased in individuals with NHL and whether these findings are consistent with an etiologic role for JCV in NHL...
Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studiesQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Blood 114:264-7. 2009..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis...
Cancer risk prediction models: a workshop on development, evaluation, and applicationAndrew N Freedman
Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
J Natl Cancer Inst 97:715-23. 2005....
Cigarette smoking and risk of non-Hodgkin lymphoma: a pooled analysis from the International Lymphoma Epidemiology Consortium (interlymph)Lindsay M Morton
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conneticut, USA
Cancer Epidemiol Biomarkers Prev 14:925-33. 2005....
Antibody responses to simian virus 40 T antigen: a case-control study of non-Hodgkin lymphomaEric A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8010, Rockville, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:521-4. 2005..We found no association between the presence of T antibody and NHL, arguing against SV40 as a cause of NHL. Infrequent and low-level T antibody responses among humans could represent cross-reactivity to BK virus T antigen...
Case-control study of simian virus 40 and non-Hodgkin lymphoma in the United StatesEric A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Blvd, EPS 8010, Rockville, MD 20892, USA
J Natl Cancer Inst 96:1368-74. 2004..S. non-Hodgkin lymphoma (NHL) patients. SV40 accidentally contaminated U.S. poliovirus vaccines that were widely administered from 1955 through 1962. However, epidemiologic data linking SV40 with NHL are lacking...
Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte developmentLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009..Replication of our findings and further study to identify functional SNPs are warranted...
Ovarian volumes among women with endometrial carcinoma: associations with risk factors and serum hormonesMark E Sherman
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
Gynecol Oncol 107:431-5. 2007..Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case-control study...
Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8009, Rockville, MD 20892, USA
Cancer Causes Control 18:989-99. 2007....
Immune-related conditions and immune-modulating medications as risk factors for non-Hodgkin's lymphoma: a case-control studyEric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
Am J Epidemiol 162:1153-61. 2005..02), but dermatomyositis was absent in cases themselves. Family history of remaining conditions was unrelated to NHL. Results suggest that disordered immunity in some immune-related conditions can lead to NHL...
Organochlorines in carpet dust and non-Hodgkin lymphomaJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Epidemiology 16:516-25. 2005..The incidence of non-Hodgkin lymphoma (NHL) has risen over the past several decades. Reasons for this increase are largely unexplained...
Genetic variation and willingness to participate in epidemiologic research: data from three studiesParveen Bhatti
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7091, MSC 7238, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 14:2449-53. 2005..To the extent possible, investigators should evaluate their own genetic data for bias in response categories...
Average midrange ultraviolet radiation flux and time outdoors predict melanoma riskThomas R Fears
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 62:3992-6. 2002..4%). The association between melanoma risk and average annual UVB flux was strong and consistent for men and for women. The association with total adult hours outdoors was notable for men of all skin types and women who develop a suntan...
Cyclin D1 splice variant and risk for non-Hodgkin lymphomaSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS MSC 7234, Bethesda, Rockville, MD 20892 7234, USA
Hum Genet 120:297-300. 2006..4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival...
Inferring past pesticide exposures: a matrix of individual active ingredients in home and garden pesticides used in past decadesJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Environ Health Perspect 115:248-54. 2007..However, if the goal of the study is to assess disease risk from specific chemicals, the investigator must be able to link the pest type treated with specific chemicals or products...
Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphomaLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Carcinogenesis 28:1759-64. 2007..Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed...
Blood levels of organochlorines before and after chemotherapy among non-Hodgkin's lymphoma patientsD Baris
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 9:193-7. 2000..There was no association between the length of time between blood draws and changes in chemical levels. Our data raise the possibility that lymphoma treatment depresses serum organochlorine levels...
The APCI1307K allele and cancer risk in a community-based study of Ashkenazi JewsT Woodage
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 20:62-5. 1998..Risk of developing colorectal, breast and other cancers were compared between genotyped I1307K carriers and non-carriers and their first-degree relatives...
Dietary determinants of one-carbon metabolism and the risk of non-Hodgkin's lymphoma: NCI-SEER case-control study, 1998-2000U Lim
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Am J Epidemiol 162:953-64. 2005..Findings suggest that one-carbon nutrients, particularly vitamin B6 and methionine, may be protective against NHL...
Cancer surveillance series: changing patterns of cutaneous malignant melanoma mortality rates among whites in the United StatesA Jemal
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Cancer Inst 92:811-8. 2000..In this study, we describe the changing patterns of melanoma mortality rates among whites by demographic factors and geography and further assess the relationship between the geographic patterns and the UV radiation (UV-B) level...
Association and aggregation analysis using kin-cohort designs with applications to genotype and family history data from the Washington Ashkenazi StudyN Chatterjee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
Genet Epidemiol 21:123-38. 2001..We find that positive history of a single first-degree relative significantly increases risk of the non-carriers (RR = 2.0, 95% CI = 1.6-2.6) but has little or no effect on the carriers...
Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States)E E Hatch
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Causes Control 12:837-45. 2001..The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES...
Ovarian cancer, ovulation and side of originP Hartge
Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892
Br J Cancer 71:642-3. 1995..Ovarian cancer occurred equally often in the left and right ovaries in this large series of incident cases...
Breast cancer risks for BRCA1/2 carriersSholom Wacholder
Science 306:2187-91; author reply 2187-91. 2004
Genes, hormones, and pathways to breast cancerPatricia Hartge
N Engl J Med 348:2352-4. 2003
Personal sun exposure and risk of non Hodgkin lymphoma: a pooled analysis from the Interlymph ConsortiumAnne Kricker
School of Public Health, University of Sydney, Sydney, New South Wales, Australia
Int J Cancer 122:144-54. 2008..Increased recreational sun exposure may protect against NHL...
Asthma history, occupational exposure to pesticides and the risk of non-Hodgkin's lymphomaWon Jin Lee
Department of Preventive Medicine, College of Medicine, Korea University, Seoul
Int J Cancer 118:3174-6. 2006..2-29.0) or daily medication for asthma (OR = infinite) than those among asthmatics who did not have such histories. Our results support the previous finding that the risk of NHL from pesticide exposure may be greater among asthmatics...
Prognostic significance of host immune gene polymorphisms in follicular lymphoma survivalJames R Cerhan
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Blood 109:5439-46. 2007..Common variation in host immune genes warrants further evaluation as a promising class of prognostic factors in follicular lymphoma...
Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma riskLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA
Cancer Causes Control 19:491-503. 2008..Although most associations have not been examined previously with NHL, our results suggest the examined polymorphisms are not modifiers of the association between vegetable and zinc intakes and NHL risk...
Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology ConsortiumSilvia de Sanjose
Unit of Infections and Cancer, Catalan Institute of Oncology, Institut d Investigacio Biomedica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain
Clin Gastroenterol Hepatol 6:451-8. 2008..We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection...
Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphomaYawei Zhang
Environmental Science Division, School of Public Health, Yale University, New Haven, CT, USA
Am J Epidemiol 167:1321-31. 2008..1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded...
Reproductive risk factors for cutaneous melanoma in women: a case-control studyC Suzanne Lea
Statistics and Epidemiology Program, Research Triangle Institute International, Research Triangle Park, NC, USA
Am J Epidemiol 165:505-13. 2007..9, 95% confidence interval: 1.1, 8.1). Oral contraceptive use and hormone replacement therapy were not associated with melanoma risk...
Blood transfusion, anesthesia, surgery and risk of non-Hodgkin lymphoma in a population-based case-control studyJames R Cerhan
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 5905, USA
Int J Cancer 123:888-94. 2008..Multiple surgical procedures and/or repeated administration of anesthesia have not been previously reported to be associated with risk of NHL and these exposures warrant further evaluation...
Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab eraThomas M Habermann
Mayo Clinic College of Medicine, Rochester, MN, USA
Blood 112:2694-702. 2008..These data support a role for germ line variation in immune genes, particularly genes associated with a proinflammatory state, as predictors of late survival in DLBCL...
Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006..These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms...
Vegetables, fruit, and antioxidant-related nutrients and risk of non-Hodgkin lymphoma: a National Cancer Institute-Surveillance, Epidemiology, and End Results population-based case-control studyLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Am J Clin Nutr 83:1401-10. 2006..91; P for trend = 0.02). An effect modification by exercise and NHL subtype was observed with some food groups and nutrients. CONCLUSION: Higher intakes of vegetables, lutein and zeaxanthin, and zinc are associated with a lower NHL risk...
A pooled analysis of bladder cancer case-control studies evaluating smoking in men and womenDiana Puente
Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research (IMIM, 80 Dr Aiguader Rd, Barcelona, 08003, Spain
Cancer Causes Control 17:71-9. 2006..CONCLUSION: These results do not support the hypothesis that women have a higher relative risk of smoking-related bladder cancer than men...
Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph ConsortiumEleanor V Willett
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Heslington, York YO10 5DD, United Kingdom
Int J Cancer 122:2062-70. 2008....
