Gaylia Jean Harry

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment
    Gaylia Jean Harry
    National Institute of Environmental Health Sciences, National Institutes of Health, Neurotoxicology Group, Laboratory of Neurobiology, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Expert Opin Drug Metab Toxicol 4:1265-77. 2008
  2. pmc Microglia during development and aging
    G Jean Harry
    National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, MD C1 04, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Pharmacol Ther 139:313-26. 2013
  3. doi request reprint Neuroinflammation: a need to understand microglia as resident cells of the developing brain
    G Jean Harry
    National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, PO Box 12233, MD C1 04, Research Triangle Park, NC 27709, USA
    Neurotoxicology 33:558-9. 2012
  4. pmc Microglia in the developing brain: a potential target with lifetime effects
    G Jean Harry
    National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Neurotoxicology 33:191-206. 2012
  5. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Neuroinflammation 8:101. 2011
  6. doi request reprint Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons
    G Jean Harry
    Department of Health and Human Services, Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 106:281-98. 2008
  7. pmc The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation
    G Jean Harry
    Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Brain Res 1194:8-20. 2008
  8. ncbi request reprint Evaluation of neurotoxic potential by use of in vitro systems
    Gaylia Jean Harry
    National Institutes of Health, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Expert Opin Drug Metab Toxicol 1:701-13. 2005
  9. pmc Maternal infection and white matter toxicity
    G Jean Harry
    Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, NC 27709, USA
    Neurotoxicology 27:658-70. 2006
  10. ncbi request reprint Emerging technologies in neurotoxicology: Session III summary and research needs
    G Jean Harry
    Neurotoxicology Group, National Institute of Environmental Health Sciences NIEHS, MD C1 04, P O Box 12233, Research Triangle Park, NC 27709, USA
    Neurotoxicology 25:503-6. 2004

Collaborators

Detail Information

Publications29

  1. pmc Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment
    Gaylia Jean Harry
    National Institute of Environmental Health Sciences, National Institutes of Health, Neurotoxicology Group, Laboratory of Neurobiology, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Expert Opin Drug Metab Toxicol 4:1265-77. 2008
    ....
  2. pmc Microglia during development and aging
    G Jean Harry
    National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, MD C1 04, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Pharmacol Ther 139:313-26. 2013
    ....
  3. doi request reprint Neuroinflammation: a need to understand microglia as resident cells of the developing brain
    G Jean Harry
    National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, PO Box 12233, MD C1 04, Research Triangle Park, NC 27709, USA
    Neurotoxicology 33:558-9. 2012
    ..A number of these point are now being raised for consideration...
  4. pmc Microglia in the developing brain: a potential target with lifetime effects
    G Jean Harry
    National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Neurotoxicology 33:191-206. 2012
    ..g., vascularization, synaptogenesis, and myelination) and have a long term impact on the functional vulnerability of the nervous system to a subsequent insult, whether environmental, physical, age-related, or disease-related...
  5. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Neuroinflammation 8:101. 2011
    ..We recently reported upregulated brain AA metabolism in 7- to 9-month-old HIV-1 Tg rats. We hypothesized that these HIV-1 Tg rats also would show upregulated brain inflammatory and AA cascade markers and a deficit of synaptic proteins...
  6. doi request reprint Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons
    G Jean Harry
    Department of Health and Human Services, Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 106:281-98. 2008
    ..The data demonstrate TNFR-mediated apoptotic death of dentate granule neurons utilizing both TNFRs and suggest a TNFp75R-mediated apoptosis in the absence of normal TNFp55R activity...
  7. pmc The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation
    G Jean Harry
    Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Brain Res 1194:8-20. 2008
    ....
  8. ncbi request reprint Evaluation of neurotoxic potential by use of in vitro systems
    Gaylia Jean Harry
    National Institutes of Health, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Expert Opin Drug Metab Toxicol 1:701-13. 2005
    ....
  9. pmc Maternal infection and white matter toxicity
    G Jean Harry
    Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, NC 27709, USA
    Neurotoxicology 27:658-70. 2006
    ..The intent is to draw attention to the impact of altered immune status during pregnancy on the offspring for the consideration of such contributing factors to the general assessment of developmental neurotoxicology...
  10. ncbi request reprint Emerging technologies in neurotoxicology: Session III summary and research needs
    G Jean Harry
    Neurotoxicology Group, National Institute of Environmental Health Sciences NIEHS, MD C1 04, P O Box 12233, Research Triangle Park, NC 27709, USA
    Neurotoxicology 25:503-6. 2004
  11. pmc In vitro techniques for the assessment of neurotoxicity
    G J Harry
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 106:131-58. 1998
    ..Therefore, in vitro tests have their greatest potential in providing information on basic mechanistic processes in order to refine specific experimental questions to be addressed in the whole animal...
  12. ncbi request reprint Dentate gyrus: alterations that occur with hippocampal injury
    G Jean Harry
    Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, 27709, Research Triangle Park, NC, USA
    Neurotoxicology 24:343-56. 2003
    ..Examination of the responses between these distinct cell populations offers the potential for understanding factors that are critical in neuronal death and survival...
  13. ncbi request reprint Morphological alterations and elevations in tumor necrosis factor-alpha, interleukin (IL)-1alpha, and IL-6 in mixed glia cultures following exposure to trimethyltin: modulation by proinflammatory cytokine recombinant proteins and neutralizing antibodies
    G Jean Harry
    National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 180:205-18. 2002
    ..These data suggest a relationship between microglia activation, proinflammatory cytokine release, and glia morphological responses, the significance of which remains to be determined, as well as, the impact on neuronal degeneration...
  14. pmc Trimethyltin-induced neurogenesis in the murine hippocampus
    G Jean Harry
    Neurotoxicology Group, Laboratory of Molecular Toxicology, Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, MD C1 04, Research Triangle Park, NC 27709, USA
    Neurotox Res 5:623-7. 2004
    ..The TMT-induced injury offers a model system for further examination of the process of neurogenesis, neural adaptation, and the influence of inflammatory factors and glia interactions...
  15. ncbi request reprint Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies
    G Jean Harry
    Neurotoxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Neurosci Res 73:526-36. 2003
    ..Data suggests a role for TNFalpha in the pathogenesis of hippocampal injury induced by TMT...
  16. ncbi request reprint Molecular profiles of mRNA levels in laser capture microdissected murine hippocampal regions differentially responsive to TMT-induced cell death
    Christian Lefebvre d'Hellencourt
    Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 93:206-20. 2005
    ..In the CA, a differential level of elevation was seen in CD86 antigen, zinc finger protein 38 and DNA damage inducible transcript 3. A significant number of genes was decreased at these early time points in both hippocampal regions...
  17. doi request reprint IGF-1 and pAKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells
    Robert N Wine
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD C1 04, Research Triangle Park, NC 27709, USA
    Neurotox Res 16:280-92. 2009
    ....
  18. ncbi request reprint Alterations in cyclin A, B, and D1 in mouse dentate gyrus following TMT-induced hippocampal damage
    Christopher A McPherson
    Neurotoxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Neurotox Res 5:339-54. 2003
    ..These data suggest an integrated role for cell cycle regulation of neural cells in the manifestation of hippocampal pathophysiology...
  19. pmc Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival
    Andrew D Kraft
    Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC 27709, United States
    Neurotoxicology 30:785-93. 2009
    ....
  20. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Schizophr Res 147:24-31. 2013
    ..Drugs that downregulate these changes might be considered for new therapies in SZ...
  21. pmc Isolation of rafts from mouse brain tissue by a detergent-free method
    Dixie Ann Persaud-Sawin
    Laboratory of Molecular Toxicology Neurotoxicology Group, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    J Lipid Res 50:759-67. 2009
    ..We demonstrate that clean raft fractions with minimal myelin contamination can be reproducibly obtained in the top three low-density fractions along a sucrose step gradient...
  22. ncbi request reprint Carbon monoxide neurotoxicity: transient inhibition of avoidance response and delayed microglia reaction in the absence of neuronal death
    Susan H Brunssen
    Laboratory of Molecular Toxicology, NIEHS, 111 TW Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicology 194:51-63. 2003
    ..This regional and focal response of microglia suggests the need for further study regarding such subtle cellular changes and their relationship with COHb levels...
  23. ncbi request reprint Mercury concentrations in brain and kidney following ethylmercury, methylmercury and Thimerosal administration to neonatal mice
    G Jean Harry
    Laboratory of Neurobiology, Neurotoxicology Group, National Institute of Environmental Health Sciences, P O Box 12233, MD C1 04, Research Triangle Park, NC 27709, USA
    Toxicol Lett 154:183-9. 2004
    ..Comparisons of tissue distribution following IM administration suggest that an oral route of administration for mercury is not comparable to an IM delivery and that MeHg does not appear to be a good model for EtHg-containing compounds...
  24. ncbi request reprint Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide
    Thad A Rosenberger
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 1582, USA
    J Neurochem 88:1168-78. 2004
    ..These observations suggest that selective alterations in brain arachidonic acid metabolism involving cytosolic and secretory PLA2 contribute to early pathology in neuroinflammation...
  25. ncbi request reprint Interdisciplinary neurotoxicity inhalation studies: carbon disulfide and carbonyl sulfide research in F344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, 111 Alexander Drive, South Campus, MD B3 08, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 207:245-50. 2005
    ..A decrease in cytochrome oxidase activity was considered to be a contributing factor to the pathogenesis of carbonyl sulfide neurotoxicity...
  26. ncbi request reprint Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Daniel L Morgan
    Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 200:131-45. 2004
    ..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure...
  27. pmc Raft aggregation with specific receptor recruitment is required for microglial phagocytosis of Abeta42
    Dixie Ann Persaud-Sawin
    Laboratory of Neurobiology, Neurotoxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Glia 57:320-35. 2009
    ..Thus, we propose that maintaining raft integrity is crucial for determining microglial phagocytic outcomes and disease progression...
  28. pmc G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator
    Donghui Zhang
    Laboratories of Respiratory Biology and Neurobiology, Office of Clinical Research, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 283:8580-90. 2008
    ..Based on these data, we conclude that GPS2 interacts with RFX4_v3 to modulate transactivation of genes involved in brain morphogenesis, including Cx3Cl1...
  29. ncbi request reprint Neurobehavioral assessment of mice after developmental AZT exposure
    Edward D Levin
    Department of Psychiatry, Duke University Medical Center, Box 3412, Durham, NC, USA
    Neurotoxicol Teratol 26:65-71. 2004
    ....