Tamara B Harris

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics
    Tamara B Harris
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892 9205, USA
    Am J Epidemiol 165:1076-87. 2007
  2. pmc Inflammation and race and gender differences in computerized tomography-measured adipose depots
    Lydia E Beasley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 17:1062-9. 2009
  3. pmc Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults?
    Annemarie Koster
    National Institute on Aging, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 66:888-95. 2011
  4. pmc Association between fitness and changes in body composition and muscle strength
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C309, Bethesda, MD 20892, USA
    J Am Geriatr Soc 58:219-26. 2010
  5. pmc Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Ann Neurol 65:569-76. 2009
  6. pmc Drug burden index score and functional decline in older people
    Sarah N Hilmer
    Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Am J Med 122:1142-1149.e1-2. 2009
  7. pmc Candidate gene association study of BMI-related loci, weight, and adiposity in old age
    Rachel A Murphy
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 68:661-6. 2013
  8. pmc The combined relations of adiposity and smoking on mortality
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Clin Nutr 88:1206-12. 2008
  9. pmc Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study
    Jean Sébastien Vidal
    National Institutes of Health, NIA LEDB, 7201 Wisconsin Ave, Gateway Building, Suite 3C309, Bethesda, MD 20892 9205, USA
    Stroke 41:891-7. 2010
  10. pmc Body fat distribution and inflammation among obese older adults with and without metabolic syndrome
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 18:2354-61. 2010

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. pmc Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics
    Tamara B Harris
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892 9205, USA
    Am J Epidemiol 165:1076-87. 2007
    ..This approach should facilitate identification of genetic factors that contribute to healthy aging as well as the chronic conditions common in old age...
  2. pmc Inflammation and race and gender differences in computerized tomography-measured adipose depots
    Lydia E Beasley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 17:1062-9. 2009
    ..Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined...
  3. pmc Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults?
    Annemarie Koster
    National Institute on Aging, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 66:888-95. 2011
    ..We therefore examined the association of baseline total body fat with changes in leg lean mass, muscle strength, and muscle quality over 7 years of follow-up and whether this link was explained by adipocytokines and insulin resistance...
  4. pmc Association between fitness and changes in body composition and muscle strength
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C309, Bethesda, MD 20892, USA
    J Am Geriatr Soc 58:219-26. 2010
    ..To examine the association between physical fitness, assessed according to ability and time to complete a 400-m walk, on changes in body composition and muscle strength over a 7-year period...
  5. pmc Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Ann Neurol 65:569-76. 2009
    ..To investigate whether the severity and location of cerebral white matter hyperintensities (WMHs) and brain infarcts are correlated with the signs of retinal microvascular abnormalities in the elderly...
  6. pmc Drug burden index score and functional decline in older people
    Sarah N Hilmer
    Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Am J Med 122:1142-1149.e1-2. 2009
    ..Here we evaluate the association between DBI and functional outcomes in Health, Aging and Body Composition study participants over 5 years...
  7. pmc Candidate gene association study of BMI-related loci, weight, and adiposity in old age
    Rachel A Murphy
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 68:661-6. 2013
    ..In African Americans, a SNP near SEC16B was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity...
  8. pmc The combined relations of adiposity and smoking on mortality
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Clin Nutr 88:1206-12. 2008
    ..Smoking cessation is associated with increased body weight and a substantial increase in waist circumference. How this affects mortality risk is unknown...
  9. pmc Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study
    Jean Sébastien Vidal
    National Institutes of Health, NIA LEDB, 7201 Wisconsin Ave, Gateway Building, Suite 3C309, Bethesda, MD 20892 9205, USA
    Stroke 41:891-7. 2010
    ..Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function...
  10. pmc Body fat distribution and inflammation among obese older adults with and without metabolic syndrome
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 18:2354-61. 2010
    ....
  11. ncbi request reprint Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition study
    Nathalie de Rekeneire
    Laboratory of Epidemiology, National Institute on Aging, Bethesda, MD 20892 9205, USA
    Diabetes Care 29:1902-8. 2006
    ..The objective of this study was to assess the association of inflammation with hyperglycemia (impaired fasting glucose [IFG]/impaired glucose tolerance [IGT]) and diabetes in older individuals...
  12. pmc Pulmonary function impairment may be an early risk factor for late-life cognitive impairment
    Jean Sébastien Vidal
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 61:79-83. 2013
    ..To determine the association between change in pulmonary function (PF) and mid- and late-life cognitive function...
  13. pmc Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women--results from the Health, Aging, and Body Composition Study
    Sari Stenholm
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 65:84-92. 2010
    ..Although both obesity and the metabolic syndrome (MetS) are known risk factors for decline in physical function, the joint association of obesity and metabolic alterations with risk of incident mobility limitation is unknown...
  14. pmc Associations of visceral and liver fat with the metabolic syndrome across the spectrum of obesity: the AGES-Reykjavik study
    Lauren J Kim
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 19:1265-71. 2011
    ..Importantly, fatty liver may be a novel metabolic risk factor in overweight and obese individuals...
  15. pmc Cerebral microbleeds and age-related macular degeneration: the AGES-Reykjavik Study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 33:2935-7. 2012
    ..85 (0.89-3.87, p = 0.100) for nonlobar CMB. This study provides no evidence that amyloid deposits in the brain and AMD are correlated. However, the suggestive association of geographic atrophy with CMB warrants further investigation...
  16. pmc Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study
    Sari Stenholm
    Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Clin Endocrinol (Oxf) 73:55-65. 2010
    ..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons...
  17. doi request reprint Employment and physical activity in the U.S
    Dane R Van Domelen
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    Am J Prev Med 41:136-45. 2011
    ..S. and worldwide. Time at work represents a major portion of the day for employed people...
  18. pmc The effect of midlife physical activity on cognitive function among older adults: AGES--Reykjavik Study
    Milan Chang
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:1369-74. 2010
    ..There are few studies on the long-term associations of physical activity (PA) to cognition. Here, we examine the association of midlife PA to late-life cognitive function and dementia...
  19. ncbi request reprint [Trends in body weight and diabetes in forty years in Iceland]
    Bolli Thorsson
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA
    Laeknabladid 95:259-66. 2009
    ..Obesity and diabetes are increasing problems worldwide. Therefore, new data on these issues are of importance. Here, we publish data on body mass index (BMI) and prevalence of diabetes of type 2 in Iceland...
  20. pmc Migraine, depression, and brain volume: the AGES-Reykjavik Study
    Larus S Gudmundsson
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, National Institute on Aging, Bethesda, MD, USA
    Neurology 80:2138-44. 2013
    ..To examine the joint association of migraine headache and major depressive disorder on brain volume in older persons without dementia...
  21. pmc Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
    Kristen M Beavers
    Department of Internal Medicine, National Institute on Aging, Baltimore, MD, USA
    Am J Clin Nutr 97:552-60. 2013
    ..In older adults, every 0.1-m/s slower gait speed is associated with a 12% higher mortality. However, little research has identified risk factors for gait-speed decline...
  22. pmc Correlation of echocardiographic findings with cerebral infarction in elderly adults: the AGES-Reykjavik study
    Dorothea McAreavey
    NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Stroke 41:2223-8. 2010
    ..In this cross-sectional analysis of elderly subjects, we investigated the relationship of a comprehensive set of echocardiographic measures with cerebral infarction detected by MRI...
  23. doi request reprint Joint effects of adiposity and physical activity on incident mobility limitation in older adults
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 56:636-43. 2008
    ..To examine joint associations of physical activity and adiposity measures (body mass index (BMI), waist circumference, percentage body fat) with incident mobility limitation...
  24. ncbi request reprint Cross-sectional associations between trunk muscle composition, back pain, and physical function in the health, aging and body composition study
    Gregory E Hicks
    Clinical Research Branch, National Institute on Aging, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 60:882-7. 2005
    ..We hypothesized that lower trunk muscle area and attenuation (higher fat infiltration) are associated with decreased functional capacity...
  25. ncbi request reprint The association of regional fat depots with hypertension in older persons of white and African American ethnicity
    Jingzhong Ding
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hypertens 17:971-6. 2004
    ..Fat distribution has been shown to be a strong correlate of hypertension, independent of general obesity. However, population-based studies are lacking on the association of regional fat depots with hypertension...
  26. pmc Association of sedentary time with mortality independent of moderate to vigorous physical activity
    Annemarie Koster
    National Institute on Aging, Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, Bethesda, Maryland, United States of America
    PLoS ONE 7:e37696. 2012
    ..The objective our study was to examine the association between objectively measured sedentary time and all-cause mortality...
  27. doi request reprint Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults
    Erik B Schelbert
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 308:890-6. 2012
    ..Unrecognized myocardial infarction (MI) is prognostically important. Electrocardiography (ECG) has limited sensitivity for detecting unrecognized MI (UMI)...
  28. pmc Subclinical hypothyroidism and functional mobility in older adults
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 S Hanover St, Fifth Floor, Baltimore, MD 21225, USA
    Arch Intern Med 169:2011-7. 2009
    ..4 to <4.5 mIU/L), mild subclinical hypothyroid (>or=4.5 to <7.0 mIU/L), or moderate subclinical hypothyroid (>or=7.0 to <or=20.0 mIU/L with a normal free thyroxine level) cross-sectionally and over 2 years...
  29. ncbi request reprint Mobility limitation in self-described well-functioning older adults: importance of endurance walk testing
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Harbor Hospital NIA ASTRA Unit, 3001 S Hanover St Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 63:841-7. 2008
    ..This study evaluates standardized administration of an endurance walk test for identifying unrecognized and impending mobility limitation in community elders...
  30. pmc Sarcopenic obesity: definition, cause and consequences
    Sari Stenholm
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225 1233, USA
    Curr Opin Clin Nutr Metab Care 11:693-700. 2008
    ..Tantamount to this discussion is whether low muscle mass or, rather, muscle weakness should be used for the definition...
  31. doi request reprint Abnormal T-wave axis is associated with coronary artery calcification in older adults
    Matthew L Scherer
    National Institute on Aging, Laboratory of Epidemiology, Demography, and Biometry, NIH, Bethesda, MD, USA
    Scand Cardiovasc J 43:240-8. 2009
    ..To determine whether T-wave axis on the resting electrocardiogram (ECG) is associated with coronary artery calcification (CAC) score, a measurement of coronary atherosclerosis, in older adults...
  32. pmc Joint associations of adiposity and physical activity with mortality: the National Institutes of Health-AARP Diet and Health Study
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    Am J Epidemiol 169:1344-51. 2009
    ..High physical activity attenuated but did not eliminate the increased mortality risk associated with obesity. Preventing weight gain and promoting physical activity in older persons may lower mortality risk...
  33. pmc Racial variation in the relationship of anemia with mortality and mobility disability among older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, Bethesda, MD 20892, USA
    Blood 109:4663-70. 2007
    ..Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse events, indicating that alternative criteria are warranted...
  34. doi request reprint Waist circumference and mortality
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Epidemiol 167:1465-75. 2008
    ..36). The finding that persons with a normal BMI but a large waist circumference had a higher mortality risk in this study suggests that increased waist circumference should be considered a risk factor for mortality, in addition to BMI...
  35. ncbi request reprint Lower extremity physical performance and hip bone mineral density in elderly black and white men and women: cross-sectional associations in the Health ABC Study
    Dennis R Taaffe
    The Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 58:M934-42. 2003
    ..However, it is unclear if these factors coexist or are independent in elderly people, and if a relationship does exist, whether it varies by sex and/or race...
  36. ncbi request reprint Diabetes is associated with subclinical functional limitation in nondisabled older individuals: the Health, Aging, and Body Composition study
    Nathalie de Rekeneire
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Diabetes Care 26:3257-63. 2003
    ....
  37. doi request reprint Lack of association between the MTHFR C677T variant and migraine with aura in an older population: could selective survival play a role?
    Ann I Scher
    Department of Preventive Medicine and Biometrics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cephalalgia 33:308-15. 2013
    ..Here, we consider whether this variant is associated with MA risk in an older non-clinical population (AGES-Reykjavik cohort)...
  38. doi request reprint Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
    Sonja I Berndt
    1 US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Genet 45:501-12. 2013
    ..Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups...
  39. pmc Late-life depressed mood and weight change contribute to the risk of each other
    Annemarie Koster
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Geriatr Psychiatry 18:236-44. 2010
    ....
  40. ncbi request reprint Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    Lisa H Colbert
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 52:1098-104. 2004
    ..To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use...
  41. pmc Multiple loci are associated with white blood cell phenotypes
    Michael A Nalls
    Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 7:e1002113. 2011
    ....
  42. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  43. doi request reprint Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Diabetes 57:1645-50. 2008
    ..We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes...
  44. pmc Genetic variation in antioxidant enzymes and lung function
    Amy R Bentley
    Center for Research in Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:1577-83. 2012
    ....
  45. ncbi request reprint Racial differences in glycemic control in a well-functioning older diabetic population: findings from the Health, Aging and Body Composition Study
    Nathalie de Rekeneire
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 9205, USA
    Diabetes Care 26:1986-92. 2003
    ..We further hypothesized that the association of race with poorer glycemic control would be limited to those with lower education or lower income...
  46. pmc Red cell distribution width and mortality in older adults: a meta-analysis
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:258-65. 2010
    ..Whether RDW is prognostic in more representative community-based populations is unclear...
  47. pmc Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study
    Qian Xiao
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    JAMA Intern Med 173:639-46. 2013
    ..Calcium intake has been promoted because of its proposed benefit on bone health, particularly among the older population. However, concerns have been raised about the potential adverse effect of high calcium intake on cardiovascular health...
  48. pmc Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study
    Mikaela B von Bonsdorff
    Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA
    Age (Dordr) 35:1401-9. 2013
    ..93; 95 % CI, 2.14-11.37). Excessive weight gain in adulthood might be particularly detrimental to the health of old individuals with low birth weight...
  49. ncbi request reprint Daily activity energy expenditure and mortality among older adults
    Todd M Manini
    National Institute on Aging, Laboratory of Epidemiology, Demography and Biometry, Bethesda, MD 20892, USA
    JAMA 296:171-9. 2006
    ..Exercise is associated with mortality benefits but simply expending energy through any activity in an individual's free-living environment may confer survival advantages...
  50. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  51. doi request reprint Lifestyle factors and incident mobility limitation in obese and non-obese older adults
    Annemarie Koster
    Department of Health Care Studies, Medical Sociology Section, Universiteit Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:3122-32. 2007
    ..This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults...
  52. ncbi request reprint Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old
    Kenneth F Adams
    Nutritional Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 355:763-78. 2006
    ..0 or more, is associated with an increased risk of death, but the relation between overweight (a BMI of 25.0 to 29.9) and the risk of death has been questioned...
  53. pmc Sedentary activity associated with metabolic syndrome independent of physical activity
    Andrea Bankoski
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Diabetes Care 34:497-503. 2011
    ..This study examined the association between objectively measured sedentary activity and metabolic syndrome among older adults...
  54. ncbi request reprint Is a fall just a fall: correlates of falling in healthy older persons. The Health, Aging and Body Composition Study
    Nathalie de Rekeneire
    Laboratory of Epidemiology, Demography and Biometry and Gerontology Research Center, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 51:841-6. 2003
    ..To identify factors associated with falling in well-functioning older people...
  55. ncbi request reprint A drug burden index to define the functional burden of medications in older people
    Sarah N Hilmer
    Laboratory of Clinical Investigation and Clinical Research Branch, Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA
    Arch Intern Med 167:781-7. 2007
    ..We developed an index to determine drug burden based on pharmacologic principles. We evaluated the relationship of this index to physical and cognitive performance apart from disease indication...
  56. pmc Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort
    Kathryn R Martin
    Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20814, USA
    BMC Musculoskelet Disord 14:219. 2013
    ..We examined the associations of midlife kOA with body mass index (BMI) and activity exposure across adult life and their interaction...
  57. ncbi request reprint Invited commentary: body composition in studies of aging: new opportunities to better understand health risks associated with weight
    Tamara B Harris
    Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    Am J Epidemiol 156:122-4; discussion 125-6. 2002
    ....
  58. pmc Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies
    Michael A Nalls
    Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Hum Genet 82:81-7. 2008
    ..Additional studies are needed to determine the biological mechanism for this effect and its clinical implications...
  59. pmc Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics
    Michael A Nalls
    Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
    PLoS Genet 5:e1000415. 2009
    ..Autozygosity has declined, and it seems it will continue doing so...
  60. ncbi request reprint Aging well and aging poorly: primary and secondary low blood pressure
    Tamara B Harris
    Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 208792 9205, USA
    J Gerontol A Biol Sci Med Sci 58:662-4; discussion 669-70. 2003
  61. ncbi request reprint Poor correlation of mid-femoral measurements by CT and hip measurements by DXA in the elderly
    Dennis R Taaffe
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
    Aging Clin Exp Res 15:131-5. 2003
    ..Therefore, we examined if it was possible to predict hip bone density using mid-femoral bone density...
  62. pmc Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study
    Jane S Saczynski
    Division of Geriatric Medicine, University of Massachusetts Medical School, Biotech Four, Suite 315, 377 Plantation Street, Worcester, MA 01605, USA
    Am J Epidemiol 168:1132-9. 2008
    ..01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance...
  63. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
    ..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown...
  64. doi request reprint The association of pericardial fat with calcified coronary plaque
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 16:1914-9. 2008
    ..Pericardial fat has a higher secretion of inflammatory cytokines than subcutaneous fat. Cytokines released from pericardial fat around coronary arteries may act locally on the adjacent cells...
  65. ncbi request reprint Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) study
    Jingzhong Ding
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room 6009, Baltimore, MD 21205, USA
    Stroke 35:16-21. 2004
    ..We examined the associations of alcohol intake with MRI-defined cerebral abnormalities in a middle-aged, population-based cohort...
  66. pmc Association between non-subcutaneous adiposity and calcified coronary plaque: a substudy of the Multi-Ethnic Study of Atherosclerosis
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 88:645-50. 2008
    ..Excessive non-subcutaneous fat deposition may impair the functions of surrounding tissues and organs through the release of inflammatory cytokines and free fatty acids...
  67. pmc The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults: the Health, Aging, and Body Composition (Health ABC) study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 31:1767-72. 2008
    ..Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance...
  68. ncbi request reprint Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons
    David B Reuben
    Multicampus Program in Geriatric Medicine and Gerontology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Am Geriatr Soc 50:638-44. 2002
    ..The objective of this study was to determine the prognostic value of combining four peripheral blood measures of inflammation in healthy older persons...
  69. ncbi request reprint Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Epidemiol 160:741-9. 2004
    ..79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women...
  70. pmc Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    Am J Hum Genet 76:463-77. 2005
    ..Complementary methods that identify discrete subgroups on the basis of genetic similarity may help to further characterize the complex biodemographic structure of human populations...
  71. ncbi request reprint Diabetes and bone loss at the hip in older black and white adults
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:596-603. 2005
    ....
  72. pmc Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue
    Dympna Gallagher
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Am J Clin Nutr 81:903-10. 2005
    ..The manner in which fat depot volumes and distributions, particularly the adipose tissue (AT) between the muscles, vary by race is unknown...
  73. ncbi request reprint Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:777-83. 2005
    ..We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults...
  74. ncbi request reprint Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:324-33. 2005
    ..This study aims to investigate whether low muscle mass, low muscle strength, and greater fat infiltration into the muscle predict incident mobility limitation...
  75. ncbi request reprint Is there a biomedical explanation for socioeconomic differences in incident mobility limitation?
    Annemarie Koster
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:1022-7. 2005
    ..This study examines the association between socioeconomic status and incident mobility limitation in well-functioning older adults, and seeks to determine whether this link could be explained by biomedical factors...
  76. ncbi request reprint Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adults
    Nadine R Sahyoun
    Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
    Am J Clin Nutr 82:547-52. 2005
    ..Recent evidence suggests that the rate of carbohydrate digestion and absorption may influence the development of type 2 diabetes...
  77. ncbi request reprint Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 82:872-8; quiz 915-6. 2005
    ..Weight loss may contribute to the loss of lean mass with age...
  78. ncbi request reprint Association between physical and cognitive function in healthy elderly: the health, aging and body composition study
    Caterina Rosano
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroepidemiology 24:8-14. 2005
    ..Longitudinal studies are needed to determine the direction of causality in this relationship...
  79. ncbi request reprint Serum leptin concentrations and body adipose measures in older black and white adults
    Constance E Ruhl
    Social and Scientific Systems, Inc, 8758 Georgia Avenue, Silver Spring, MD 20910, USA
    Am J Clin Nutr 80:576-83. 2004
    ..Among US adults, serum leptin concentrations are higher in women than in men and are higher in blacks than in whites independent of anthropometric measures of body fatness...
  80. ncbi request reprint Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study
    Marjolein Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Am Geriatr Soc 50:897-904. 2002
    ..Our aim was to determine whether low leg muscle mass and greater fat infiltration in the muscle were associated with poor lower extremity performance (LEP)...
  81. ncbi request reprint Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels
    Luigi Ferrucci
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
    J Am Geriatr Soc 50:1947-54. 2002
    ..To test whether accelerated sarcopenia in older persons with high interleukin (IL)-6 serum levels plays a role in the prospective association between inflammation and disability found in many studies...
  82. ncbi request reprint Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Diabetes Care 26:372-9. 2003
    ....
  83. ncbi request reprint One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women
    Marjolein Visser
    Institute for Research in Extramural Medicine, Vrije University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Appl Physiol 94:2368-74. 2003
    ..Loss of ALST was greater in men compared with women, and greater in blacks compared with whites, suggesting that men and blacks may be more prone to muscle loss...
  84. ncbi request reprint Neck and shoulder pain in 70- to 79-year-old men and women: findings from the Health, Aging and Body Composition Study
    Molly T Vogt
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Spine J 3:435-41. 2003
    ..Musculoskeletal pain in the cervicobrachial region is considered a major health problem among adults of working age, but little is known about the impact of this pain in the elderly...
  85. ncbi request reprint Edentulism and nutritional status in a biracial sample of well-functioning, community-dwelling elderly: the health, aging, and body composition study
    Jung Sun Lee
    Division of Geriatric Medicine, University of Pittsburgh, PA 15213, USA
    Am J Clin Nutr 79:295-302. 2004
    ..Edentulism may affect dietary intake in older adults, but the relation between edentulism and nutritional status is not completely understood...
  86. ncbi request reprint Energy requirements in the eighth decade of life
    Stephane Blanc
    University of Wisconsin Madison, WI 53706, USA
    Am J Clin Nutr 79:303-10. 2004
    ..Knowledge of energy requirements among relatively healthy elderly is limited...
  87. ncbi request reprint Cholesterol and health in old age: risk factor or risk marker?
    Tamara B Harris
    J Am Geriatr Soc 52:639-40. 2004
  88. ncbi request reprint Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition Study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 19:1084-91. 2004
    ..Diabetes predicted higher hip, whole body, and volumetric spine BMD, and lower spine bone volume, independent of body composition and fasting insulin...
  89. ncbi request reprint Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
    Arch Intern Med 165:2148-54. 2005
    ..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...
  90. ncbi request reprint Cystatin C and mortality risk in the elderly: the health, aging, and body composition study
    Michael G Shlipak
    University of San Francisco, General Internal Medicine Section, VA Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 17:254-61. 2006
    ..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine...
  91. ncbi request reprint Multitasking: association between poorer performance and a history of recurrent falls
    Kimberly A Faulkner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:570-6. 2007
    ..To examine the association between poorer performance on concurrent walking and reaction time and recurrent falls...
  92. ncbi request reprint Body mass index and serum leptin concentration independently estimate percentage body fat in older adults
    Constance E Ruhl
    Social and Scientific Systems Inc, Silver Spring, MD, USA
    Am J Clin Nutr 85:1121-6. 2007
    ....
  93. ncbi request reprint Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 22:1088-95. 2007
    ..We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study. Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture...
  94. ncbi request reprint Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study
    Nicole Vogelzangs
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:563-9. 2007
    ..This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons...
  95. ncbi request reprint Factors associated with impaired appetite in well-functioning community-dwelling older adults
    Jung Sun Lee
    Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA
    J Nutr Elder 26:27-43. 2006
    ..5 (1.6- 4.1)), poor self-reported health (2.4 (1.7-3.2)), current smoking, chewing problems, reported visual impairment, weight loss since age 50, and log (TNF-alpha) were significantly related to impaired appetite...
  96. ncbi request reprint Kidney function as a predictor of loss of lean mass in older adults: health, aging and body composition study
    Linda F Fried
    Renal Section, Veterans Affairs Pittsburgh Healthcare System Pittsburgh, Pennsylvania 15240, USA
    J Am Geriatr Soc 55:1578-84. 2007
    ..To assess the association between kidney function and change in body composition in older individuals...
  97. pmc Diabetes-related complications, glycemic control, and falls in older adults
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107 1762, USA
    Diabetes Care 31:391-6. 2008
    ..We determined whether diabetes-related complications or treatments are associated with risk of falls in older diabetic adults...
  98. ncbi request reprint Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study
    Rajat Deo
    Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 155:62-8. 2008
    ..We evaluated whether impaired kidney function predicted risk of fatal cardiovascular disease independent of prevalent and incident cardiovascular events...
  99. pmc Dietary glycemic index and glycemic load and the risk of type 2 diabetes in older adults
    Nadine R Sahyoun
    Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
    Am J Clin Nutr 87:126-31. 2008
    ..It is unclear whether immediate dietary effects on blood glucose influence the risk of developing type 2 diabetes...
  100. ncbi request reprint Reduced peripheral nerve function is related to lower hip BMD and calcaneal QUS in older white and black adults: the Health, Aging, and Body Composition Study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 21:1803-10. 2006
    ..Poor peripheral nerve function may directly affect bone...
  101. ncbi request reprint Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study
    M Kathleen Figaro
    Department of Medicine, Vanderbilt University Medical Center GRECC, 1310 24th Ave South, Room 4B111, Nashville, TN 37212, USA
    Diabetes Care 29:2039-45. 2006
    ..We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes...