Ahmad R Hariri

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Dextroamphetamine modulates the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 27:1036-40. 2002
  2. ncbi request reprint The amygdala response to emotional stimuli: a comparison of faces and scenes
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroimage 17:317-23. 2002
  3. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
  4. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
  5. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
  6. pmc Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social content
    Karen E Munoz
    Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Neuroimage 50:340-6. 2010
  7. ncbi request reprint A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
  8. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
  9. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
  10. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006

Detail Information

Publications38

  1. ncbi request reprint Dextroamphetamine modulates the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 27:1036-40. 2002
    ..Our results provide the first evidence of a specific neural substrate for the anxiogenic effects of amphetamine and are consistent with animal models of dopaminergic activation of the amygdala...
  2. ncbi request reprint The amygdala response to emotional stimuli: a comparison of faces and scenes
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroimage 17:317-23. 2002
    ..These results suggest that the human amygdala shows a stronger response to affective facial expressions than to scenes, a bias that should be considered in the design of experimental paradigms interested in probing amygdala function...
  3. ncbi request reprint Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation
    Emily M Drabant
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:1396-406. 2006
    ....
  4. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
    ..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...
  5. ncbi request reprint 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    ....
  6. pmc Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social content
    Karen E Munoz
    Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Neuroimage 50:340-6. 2010
    ..These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS...
  7. ncbi request reprint A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
    ....
  8. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    ....
  9. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
    ..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans...
  10. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
    ..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs...
  11. ncbi request reprint Functional changes in the activity of brain regions underlying emotion processing in the elderly
    Alessandro Tessitore
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Room 3C108, Bethesda, MD 20892 1384, USA
    Psychiatry Res 139:9-18. 2005
    ....
  12. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  13. pmc Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20982 1379, USA
    Proc Natl Acad Sci U S A 100:6186-91. 2003
    ..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine...
  14. ncbi request reprint Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
    Alessandro Tessitore
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1384, USA
    J Neurosci 22:9099-103. 2002
    ..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects...
  15. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...
  16. ncbi request reprint Neocortical modulation of the amygdala response to fearful stimuli
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:494-501. 2003
    ....
  17. ncbi request reprint Neural correlates of genetically abnormal social cognition in Williams syndrome
    Andreas Meyer-Lindenberg
    Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Neurosci 8:991-3. 2005
    ..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior...
  18. ncbi request reprint Serotonin transporter genetic variation and the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 297:400-3. 2002
    ....
  19. ncbi request reprint Imaging genomics
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Br Med Bull 65:259-70. 2003
    ....
  20. ncbi request reprint Zhou et al. reply
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 458:E7. 2009
    ..Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results...
  21. pmc Acute 5-HT reuptake blockade potentiates human amygdala reactivity
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
    Neuropsychopharmacology 33:3221-5. 2008
    ....
  22. ncbi request reprint Neuroimaging and human genetics
    Georg Winterer
    Genes, Cognition and Psychosis Program, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    Int Rev Neurobiol 67:325-83. 2005
  23. ncbi request reprint Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing
    Ahmad R Hariri
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2593, USA
    Biol Psychiatry 59:888-97. 2006
    ....
  24. ncbi request reprint Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder
    A Ting Wang
    Department of Psychology, UCLA, Los Angeles, CA, USA
    J Am Acad Child Adolesc Psychiatry 43:481-90. 2004
    ..To examine the neural basis of impairments in interpreting facial emotions in children and adolescents with autism spectrum disorders (ASD)...
  25. doi request reprint Neural bases of different cognitive strategies for facial affect processing in schizophrenia
    Eric Fakra
    CIC UPCET, Hopital de la Timone, UMR CNRS 6193 INCM, Marseille, France
    Schizophr Res 100:191-205. 2008
    ..To examine the neural basis and dynamics of facial affect processing in schizophrenic patients as compared to healthy controls...
  26. pmc Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Biol Psychiatry 63:852-7. 2008
    ..We evaluated the magnitude of the reported associations between amygdala activation and the serotonin transporter gene linked polymorphic region (5-HTTLPR) and the likely effect size of this relationship...
  27. ncbi request reprint Temporal stability of individual differences in amygdala reactivity
    Stephen B Manuck
    Am J Psychiatry 164:1613-4. 2007
  28. ncbi request reprint Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responses
    Jennifer S Lerner
    Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:743-50. 2005
    ..The present study hypothesized a new conception that disaggregates stress into emotion-specific, contrasting patterns of biological response...
  29. ncbi request reprint Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responses
    Jennifer S Lerner
    Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Biol Psychiatry 61:253-60. 2007
    ..Specifically, it hypothesized contrasting patterns for indignation (comprised of anger and disgust) versus fear. Moreover, it hypothesized that facial expressions of these emotions would signal corresponding biological stress responses...
  30. ncbi request reprint Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function
    Serina A Neumann
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23501
    Biol Psychiatry 60:1155-62. 2006
    ..Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism (SNP) in CHT1 on regional brain reactivity relevant to autonomic (cholinergic) function...
  31. ncbi request reprint Genetics of emotional regulation: the role of the serotonin transporter in neural function
    Ahmad R Hariri
    Department of Psychiatry and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Trends Cogn Sci 10:182-91. 2006
    ..The study of the 5-HTT provides a new foundation for understanding the neurobiological and genetic basis of emotional regulation and affective illness...
  32. ncbi request reprint Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and control
    Sarah M Brown
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Emotion 6:239-45. 2006
    ..Together, these findings suggest that dispositional impulsivity is influenced by the functional interplay of corticolimbic behavioral arousal and control circuits...
  33. ncbi request reprint Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behavior
    Sarah M Brown
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 729, Pittsburgh, PA 15213 2593, USA
    Cogn Affect Behav Neurosci 6:44-52. 2006
    ....
  34. ncbi request reprint Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults
    Sarah M Conklin
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, United States
    Neurosci Lett 421:209-12. 2007
    ..Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity...
  35. pmc Individual differences in stressor-evoked blood pressure reactivity vary with activation, volume, and functional connectivity of the amygdala
    Peter J Gianaros
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 28:990-9. 2008
    ....
  36. pmc Neuroimaging: technologies at the interface of genes, brain, and behavior
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 17:459-67, viii. 2007
    ....
  37. ncbi request reprint Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Germany
    Biol Psychiatry 61:1011-4. 2007
    ..However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers...
  38. ncbi request reprint Serotonin
    Ahmad R Hariri
    Am J Psychiatry 163:12. 2006