Research Topics
Genomes and GenesSpecies | Ahmad R HaririSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Dextroamphetamine modulates the response of the human amygdalaAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Neuropsychopharmacology 27:1036-40. 2002..Our results provide the first evidence of a specific neural substrate for the anxiogenic effects of amphetamine and are consistent with animal models of dopaminergic activation of the amygdala...- The amygdala response to emotional stimuli: a comparison of faces and scenesAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroimage 17:317-23. 2002..These results suggest that the human amygdala shows a stronger response to affective facial expressions than to scenes, a bias that should be considered in the design of experimental paradigms interested in probing amygdala function... - Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulationEmily M Drabant
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:1396-406. 2006.... 
Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic riskRoberta Rasetti
Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
Am J Psychiatry 166:216-25. 2009..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...- 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depressionLukas Pezawas
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
Nat Neurosci 8:828-34. 2005.... - Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social contentKaren E Munoz
Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
Neuroimage 50:340-6. 2010..These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS... - A susceptibility gene for affective disorders and the response of the human amygdalaAhmad R Hariri
Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Arch Gen Psychiatry 62:146-52. 2005.... - Variation in DISC1 affects hippocampal structure and function and increases risk for schizophreniaJoseph H Callicott
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:8627-32. 2005.... - Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performanceAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
J Neurosci 23:6690-4. 2003..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans... - Neurophysiological correlates of age-related changes in working memory capacityVenkata S Mattay
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neurosci Lett 392:32-7. 2006..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs... - Functional changes in the activity of brain regions underlying emotion processing in the elderlyAlessandro Tessitore
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Room 3C108, Bethesda, MD 20892-1384, USA
Psychiatry Res 139:9-18. 2005.... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... - Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamineVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4S-235, Bethesda, MD 20982-1379, USA
Proc Natl Acad Sci U S A 100:6186-91. 2003..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine... - Dopamine modulates the response of the human amygdala: a study in Parkinson's diseaseAlessandro Tessitore
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1384, USA
J Neurosci 22:9099-103. 2002..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects... - Genetic variation in human NPY expression affects stress response and emotionZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 452:997-1001. 2008..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases... - Neocortical modulation of the amygdala response to fearful stimuliAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 53:494-501. 2003.... - Neural correlates of genetically abnormal social cognition in Williams syndromeAndreas Meyer-Lindenberg
Section on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Neurosci 8:991-3. 2005..Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior... - Serotonin transporter genetic variation and the response of the human amygdalaAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Science 297:400-3. 2002.... - Imaging genomicsAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Br Med Bull 65:259-70. 2003.... - Zhou et al. replyZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 458:E7. 2009..Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results... - Acute 5-HT reuptake blockade potentiates human amygdala reactivityKristin L Bigos
Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
Neuropsychopharmacology 33:3221-5. 2008.... - Neuroimaging and human geneticsGeorg Winterer
Genes, Cognition and Psychosis Program, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
Int Rev Neurobiol 67:325-83. 2005 - Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processingAhmad R Hariri
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213-2593, USA
Biol Psychiatry 59:888-97. 2006.... - Neural correlates of facial affect processing in children and adolescents with autism spectrum disorderA Ting Wang
Department of Psychology, UCLA, Los Angeles, CA, USA
J Am Acad Child Adolesc Psychiatry 43:481-90. 2004..High-functioning individuals with ASD may be relatively unimpaired in the cognitive assessment of basic emotions, yet still show differences in the automatic processing of facial expressions... 
Neural bases of different cognitive strategies for facial affect processing in schizophreniaEric Fakra
CIC UPCET, Hopital de la Timone, UMR CNRS 6193 INCM, Marseille, France
Schizophr Res 100:191-205. 2008..To examine the neural basis and dynamics of facial affect processing in schizophrenic patients as compared to healthy controls...- Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysisMarcus R Munafo
Department of Experimental Psychology, University of Bristol, United Kingdom
Biol Psychiatry 63:852-7. 2008..We evaluated the magnitude of the reported associations between amygdala activation and the serotonin transporter gene linked polymorphic region (5-HTTLPR) and the likely effect size of this relationship... - Temporal stability of individual differences in amygdala reactivityStephen B Manuck
Am J Psychiatry 164:1613-4. 2007 - Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responsesJennifer S Lerner
Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 58:743-50. 2005..The present study hypothesized a new conception that disaggregates stress into emotion-specific, contrasting patterns of biological response... - Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responsesJennifer S Lerner
Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Biol Psychiatry 61:253-60. 2007..Specifically, it hypothesized contrasting patterns for indignation (comprised of anger and disgust) versus fear. Moreover, it hypothesized that facial expressions of these emotions would signal corresponding biological stress responses... - Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic functionSerina A Neumann
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23501
Biol Psychiatry 60:1155-62. 2006..Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism (SNP) in CHT1 on regional brain reactivity relevant to autonomic (cholinergic) function... - Genetics of emotional regulation: the role of the serotonin transporter in neural functionAhmad R Hariri
Department of Psychiatry and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Trends Cogn Sci 10:182-91. 2006..The study of the 5-HTT provides a new foundation for understanding the neurobiological and genetic basis of emotional regulation and affective illness... - Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and controlSarah M Brown
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Emotion 6:239-45. 2006..Together, these findings suggest that dispositional impulsivity is influenced by the functional interplay of corticolimbic behavioral arousal and control circuits... - Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behaviorSarah M Brown
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Room E-729, Pittsburgh, PA 15213-2593, USA
Cogn Affect Behav Neurosci 6:44-52. 2006.... - Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adultsSarah M Conklin
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, United States
Neurosci Lett 421:209-12. 2007..Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity... - Individual differences in stressor-evoked blood pressure reactivity vary with activation, volume, and functional connectivity of the amygdalaPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 28:990-9. 2008.... - Neuroimaging: technologies at the interface of genes, brain, and behaviorKristin L Bigos
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA
Neuroimaging Clin N Am 17:459-67, viii. 2007.... - Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activationAndreas Heinz
Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Germany
Biol Psychiatry 61:1011-4. 2007..However, a recent report suggested that this interaction is driven by amygdala deactivation during presentation of neutral stimuli in s carriers... - SerotoninAhmad R Hariri
Am J Psychiatry 163:12. 2006