M Hallett

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The role of the dorsolateral prefrontal cortex in implicit procedural learning
    A Pascual-Leone
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Exp Brain Res 107:479-85. 1996
  2. ncbi request reprint Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
    Psychiatry Res 163:171-82. 2008
  3. ncbi request reprint The intrinsic and extrinsic aspects of freezing of gait
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, Maryland 20892 1428, USA
    Mov Disord 23:S439-43. 2008
  4. pmc Update on blepharospasm: report from the BEBRF International Workshop
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 71:1275-82. 2008
  5. ncbi request reprint The timing of the conscious intention to move
    Masao Matsuhashi
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Building 10 Room 5N226, Bethesda, MD 20892 1428, USA
    Eur J Neurosci 28:2344-51. 2008
  6. ncbi request reprint Tremor: pathophysiology
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, MD, USA Electronic address
    Parkinsonism Relat Disord 20:S118-22. 2014
  7. pmc Anatomical correlates of blepharospasm
    Silvina G Horovitz
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Bdg10 7D37, Bethesda, MD, USA
    Transl Neurodegener 1:12. 2012
  8. pmc A binary method for simple and accurate two-dimensional cursor control from EEG with minimal subject training
    Turan A Kayagil
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    J Neuroeng Rehabil 6:14. 2009
  9. pmc Physiology of psychogenic movement disorders
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Drive MSC 1428, Bethesda, Maryland 20892 1428, USA
    J Clin Neurosci 17:959-65. 2010
  10. ncbi request reprint Cortical control of brainstem motor systems
    Mark Hallett
    Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mov Disord 17:S23-6. 2002

Collaborators

Detail Information

Publications136 found, 100 shown here

  1. ncbi request reprint The role of the dorsolateral prefrontal cortex in implicit procedural learning
    A Pascual-Leone
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Exp Brain Res 107:479-85. 1996
    ..Stimulation over the other areas did not interfere with learning. These results support the notion of a critical role of contralateral dorsolateral prefrontal structures in learning of motor sequences...
  2. ncbi request reprint Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
    Psychiatry Res 163:171-82. 2008
    ..These results suggest that striatal dopamine denervation may contribute to some frontostriatal cognitive impairment in moderate stage PD...
  3. ncbi request reprint The intrinsic and extrinsic aspects of freezing of gait
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, Maryland 20892 1428, USA
    Mov Disord 23:S439-43. 2008
    ..The sensory factors can both help or hinder freezing. Analogous to the problem with set-shifting, there is also some difficulty in regulation of internal versus external factors and in regulation of different external factors...
  4. pmc Update on blepharospasm: report from the BEBRF International Workshop
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 71:1275-82. 2008
    ..Physiologic studies indicate increased plasticity and trigeminal sensitization. While botulinum neurotoxin injections are the mainstay of therapy, other therapies are on the horizon...
  5. ncbi request reprint The timing of the conscious intention to move
    Masao Matsuhashi
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Building 10 Room 5N226, Bethesda, MD 20892 1428, USA
    Eur J Neurosci 28:2344-51. 2008
    ..The difference between the conventional result and our result suggests that the perception of intention rises through multiple levels of awareness, starting just after the brain initiates movement...
  6. ncbi request reprint Tremor: pathophysiology
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, MD, USA Electronic address
    Parkinsonism Relat Disord 20:S118-22. 2014
    ..This is a tremor of action, and the associated ataxia suggests that delays in motor control processing may set up the oscillation. ..
  7. pmc Anatomical correlates of blepharospasm
    Silvina G Horovitz
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Bdg10 7D37, Bethesda, MD, USA
    Transl Neurodegener 1:12. 2012
    ..abstract:..
  8. pmc A binary method for simple and accurate two-dimensional cursor control from EEG with minimal subject training
    Turan A Kayagil
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    J Neuroeng Rehabil 6:14. 2009
    ....
  9. pmc Physiology of psychogenic movement disorders
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Drive MSC 1428, Bethesda, Maryland 20892 1428, USA
    J Clin Neurosci 17:959-65. 2010
    ..Similar physiological abnormalities are seen in both groups. The question arises as to how a movement can be produced with voluntary mechanisms, but not be considered voluntary...
  10. ncbi request reprint Cortical control of brainstem motor systems
    Mark Hallett
    Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mov Disord 17:S23-6. 2002
  11. pmc Neurophysiology of dystonia: The role of inhibition
    Mark Hallett
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Building 10, Room 7D37, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
    Neurobiol Dis 42:177-84. 2011
    ..This article is part of a Special Issue entitled "Advances in dystonia"...
  12. ncbi request reprint Plasticity of the human motor cortex and recovery from stroke
    M Hallett
    Human Motor Control Section, NINDS, NIH, Medical Neurology Branch, Building 10, Room 5N226, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Brain Res Brain Res Rev 36:169-74. 2001
    ..Knowledge about the physiology of brain plasticity has led to the development of new techniques for rehabilitation...
  13. ncbi request reprint Functional reorganization after lesions of the human brain: studies with transcranial magnetic stimulation
    M Hallett
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Rev Neurol (Paris) 157:822-6. 2001
    ..The best recovery after stroke is due to reorganization of the lesioned hemisphere. Rehabilitative strategies might well be able to enhance rehabilitative efforts...
  14. ncbi request reprint Transcranial magnetic stimulation: a primer
    Mark Hallett
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 55:187-99. 2007
    ..TMS has some clinical utility, and, because it can influence brain function if delivered repetitively, it is being developed for various therapeutic purposes...
  15. ncbi request reprint Blepharospasm: recent advances
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Dr, MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 59:1306-12. 2002
    ..The trigger could be repetitive use or local ocular disease. Although symptomatic therapy is available, better approaches are needed and will likely become available as the genetics and pathophysiology become well understood...
  16. ncbi request reprint Corticobulbar tracts
    M Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892 1428, USA
    Suppl Clin Neurophysiol 58:3-9. 2006
  17. ncbi request reprint Surround inhibition
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892 1428, USA
    Suppl Clin Neurophysiol 56:153-9. 2003
  18. pmc Disordered plasticity in the primary somatosensory cortex in focal hand dystonia
    Yohei Tamura
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 7D37, 10 Center Drive, MSC 1428, Bethesda, MD 20892 1428, USA
    Brain 132:749-55. 2009
    ..In addition, intracortical inhibition in S1 was found to increase as well. This abnormal plasticity of the intracortical neurons in S1 may contribute to the pathophysiology of dystonia...
  19. ncbi request reprint Recent advances in stroke rehabilitation
    Mark Hallett
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1428, USA
    Neurorehabil Neural Repair 16:211-7. 2002
  20. ncbi request reprint Treatment of focal dystonias with botulinum neurotoxin
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
    Toxicon 54:628-33. 2009
    ..Disorders covered include cranial dystonia, cervical dystonia, spasmodic dysphonia, and focal hand dystonia. Considered are clinical aspects, alternative treatment strategies and principles of use of botulinum toxin injections...
  21. pmc Psychogenic parkinsonism
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bldg 10, Rm 7D37, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
    J Neurol Sci 310:163-5. 2011
    ..Patients may have both organic Parkinson's disease and psychogenic parkinsonism, and this might be considered a psychologically induced aggravation of the organic disorder...
  22. pmc Volitional control of movement: the physiology of free will
    Mark Hallett
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Building 10, Room 5N226, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 118:1179-92. 2007
    ....
  23. ncbi request reprint Psychogenic movement disorders: a crisis for neurology
    Mark Hallett
    Human Motor Control Section, NINDS NIH, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892 1428, USA
    Curr Neurol Neurosci Rep 6:269-71. 2006
  24. ncbi request reprint Pathophysiology of writer's cramp
    Mark Hallett
    Human Motor Control Section, NINDS, NIH Building 10, Room 5N226 Bethesda, MD 20892 1428, USA
    Hum Mov Sci 25:454-63. 2006
    ..The fertile background, which is likely genetic, may be a decrease of inhibition, an increase of plasticity or an impairment in sensory function. Recent pathophysiological findings have implications for new therapies...
  25. doi request reprint Parkinson's disease tremor: pathophysiology
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892 1428, USA
    Parkinsonism Relat Disord 18:S85-6. 2012
    ..Analysis of cellular behavior in the thalamus shows that the thalamus is not the generator of tremor. New data suggest that the basal ganglia trigger a cerebellar circuit to produce the tremor...
  26. pmc Milestones in clinical neurophysiology
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, Maryland 20892 1428, USA
    Mov Disord 26:958-67. 2011
    ..Studies have been done looking at the use of noninvasive brain stimulation for therapy, but effects are generally small...
  27. doi request reprint Psychogenic movement disorders
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892 1428, USA
    Parkinsonism Relat Disord 18:S155-7. 2012
    ..With sequential movements, the sequence effect is typically lacking. Extreme slowness and grunting with great effort may be seen. Improvement in arm swing while running, a feature of organic parkinsonism, may not be seen...
  28. pmc Dissociation of the pathways mediating ipsilateral and contralateral motor-evoked potentials in human hand and arm muscles
    U Ziemann
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    J Physiol 518:895-906. 1999
    ..Other pathways, such as branching of corticomotoneuronal axons, a transcallosal projection or a slow-conducting monosynaptic ipsilateral pathway are very unlikely or can be excluded...
  29. pmc Surround inhibition depends on the force exerted and is abnormal in focal hand dystonia
    S Beck
    Human Motor Control Section, NINDS, National Institutes of Health, Bldg 10 5N240, 10 Center Drive, Bethesda, MD 20892 1428, USA
    J Appl Physiol (1985) 107:1513-8. 2009
    ..The greater loss of SICI for the 10% F(max) level in patients with FHD than for the 20% F(max) level indicates that this inhibitory mechanism is more abnormal at lower levels of force...
  30. ncbi request reprint Neural correlates of auditory-visual stimulus onset asynchrony detection
    K O Bushara
    National Institute of Neurological Disorders and Stroke, Human Motor Control Section, and Cognitive Neuroscience Section, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
    J Neurosci 21:300-4. 2001
    ....
  31. ncbi request reprint Task-dependent changes of intracortical inhibition
    J Liepert
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Exp Brain Res 118:421-6. 1998
    ..Additionally, our data further supports the idea that ICI and ICF may be controlled independently...
  32. ncbi request reprint Role of the human motor cortex in rapid motor learning
    W Muellbacher
    Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
    Exp Brain Res 136:431-8. 2001
    ..Since the changes in MEP amplitude were observed only after TMS of M1 but not after direct stimulation of the corticospinal tract, these findings indicate task- and effector-specific involvement of human M1 in rapid motor learning...
  33. pmc Inter-hemispheric inhibition is impaired in mirror dystonia
    S Beck
    Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA
    Eur J Neurosci 29:1634-40. 2009
    ..We conclude that mirror dystonia may be due to impaired IHI towards neighboring muscles before movement onset. However, IHI does not seem to play a major role in the general pathophysiology of FHD...
  34. ncbi request reprint Effect of volitional inhibition on cortical inhibitory mechanisms
    Young H Sohn
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurophysiol 88:333-8. 2002
    ..The present results demonstrate that volitional inhibition enhances SICI but reduces LICI nonselectively. These results suggest that these two inhibitory mechanisms act differently during execution and suppression of voluntary movements...
  35. pmc Exploration of computational methods for classification of movement intention during human voluntary movement from single trial EEG
    Ou Bai
    Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders, NIH, Bethesda, MD 20892, USA
    Clin Neurophysiol 118:2637-55. 2007
    ..To explore effective combinations of computational methods for the prediction of movement intention preceding the production of self-paced right and left hand movements from single trial scalp electroencephalogram (EEG)...
  36. ncbi request reprint Analogous corticocortical inhibition and facilitation in ipsilateral and contralateral human motor cortex representations of the tongue
    W Muellbacher
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
    J Clin Neurophysiol 18:550-8. 2001
    ..0001). These findings indicate that the ipsilateral and contralateral representations of the tongue are under analogous inhibitory and facilitatory control, possibly by a common intracortical network...
  37. pmc Surround inhibition is modulated by task difficulty
    S Beck
    Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 121:98-103. 2010
    ..The aim of this study was to further characterize surround inhibition (SI) in the primary motor cortex (M1) by comparing its magnitude and time course during a simple reaction time task (SRT) and a choice reaction time task (CRT)...
  38. pmc Transcranial magnetic brain stimulation modulates blepharospasm: a randomized controlled study
    G Kranz
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neurology 75:1465-71. 2010
    ..Benign essential blepharospasm (BEB) is a common form of focal dystonia. Besides pathology in the basal ganglia, accumulating evidence suggests pathologic changes in the anterior cingulate cortex (ACC)...
  39. ncbi request reprint Motor training as treatment in focal hand dystonia
    Kirsten E Zeuner
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Mov Disord 20:335-41. 2005
    ..Whereas this method of motor training for 4 weeks led to mild subjective improvement and some improvement in handwriting, it is not sufficient to reverse motor cortex abnormalities measured by TMS and EEG...
  40. ncbi request reprint Accelerometry to distinguish psychogenic from essential or parkinsonian tremor
    K E Zeuner
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1428, USA
    Neurology 61:548-50. 2003
    ..Psychogenic tremors showed larger tremor frequency changes and higher intraindividual variability while tapping. Accelerometry may differentiate psychogenic from essential and parkinsonian tremor...
  41. ncbi request reprint Functional relevance of cross-modal plasticity in blind humans
    L G Cohen
    Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Nature 389:180-3. 1997
    ..We propose that this cross-modal plasticity may account in part for the superior tactile perceptual abilities of blind subjects...
  42. ncbi request reprint Parametric analysis of functional neuroimages: application to a variable-rate motor task
    J W VanMeter
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroimage 2:273-83. 1995
    ..Habituation of responses was not observed...
  43. pmc Blepharospasm and the modulation of cortical excitability in primary and secondary motor areas
    G Kranz
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neurology 73:2031-6. 2009
    ..Electrophysiologic and brain imaging studies suggest pathologic changes in excitability in the primary motor cortex (MC), anterior cingulate (AC), and secondary motor areas, such as premotor (PMC) and supplementary motor cortices (SMA)...
  44. ncbi request reprint Event-related desynchronization in reaction time paradigms: a comparison with event-related potentials and corticospinal excitability
    L Leocani
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Drive MSC 1428, Bethesda, MD 20892-1428, USA
    Clin Neurophysiol 112:923-30. 2001
    ..CONCLUSIONS: These findings may suggest that ERD is compatible with both corticospinal activation and inhibition, ERS indicating the removal of either, resulting in cortical idling...
  45. ncbi request reprint Changes in short afferent inhibition during phasic movement in focal dystonia
    Sarah Pirio Richardson
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1428, Bldg 10, Bethesda, MD 20892 1428, USA
    Muscle Nerve 37:358-63. 2008
    ..Understanding the role of these inhibitory circuits in dystonia may lead to development of therapeutic agents aimed at restoring inhibition...
  46. ncbi request reprint Movement-related cortical potentials in primary lateral sclerosis
    Ou Bai
    Human Motor Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 59:682-90. 2006
    ....
  47. ncbi request reprint Long-latency afferent inhibition during selective finger movement
    Bernhard Voller
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurophysiol 94:1115-9. 2005
    ..However, with finger stimulation added, there were almost no increased MEPs despite co-activation. These findings suggest that LAI increases during movement and can enhance SI...
  48. ncbi request reprint Psychogenic palatal tremor
    Sarah Pirio Richardson
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mov Disord 21:274-6. 2006
    ..We discuss the differential diagnosis of palatal tremor as well as the role of neurophysiological testing in the diagnosis of psychogenic movement disorders...
  49. pmc Task-dependent intracortical inhibition is impaired in focal hand dystonia
    Cathrin M Butefisch
    Human Motor Control Section, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Mov Disord 20:545-51. 2005
    ..We found that performance of the selective but not the nonselective task resulted in increased SICI in the 4DIO of normal but not in dystonic subjects. We conclude that task-dependent SICI is disturbed in patients with dystonia...
  50. ncbi request reprint Contribution of the ipsilateral motor cortex to recovery after chronic stroke
    Konrad J Werhahn
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 54:464-72. 2003
    ..These results are consistent with the idea that recovered motor function in the paretic hand of chronic stroke patients relies predominantly on reorganized activity within motor areas of the affected hemisphere...
  51. ncbi request reprint Cortical control of voluntary blinking: a transcranial magnetic stimulation study
    Y H Sohn
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10 Room 5N226, 10 Center Drive, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 115:341-7. 2004
    ..To investigate cortical regions related to voluntary blinking...
  52. ncbi request reprint Modulation of motor cortex excitability by median nerve and digit stimulation
    R Chen
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Exp Brain Res 129:77-86. 1999
    ..The time course for decreased motor cortex excitability following median nerve stimulation corresponds well to rebound of the 20-Hz cortical rhythm and supports the hypothesis that this increased power represents cortical deactivation...
  53. ncbi request reprint Time course of determination of movement direction in the reaction time task in humans
    M Sommer
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892-1428, USA
    J Neurophysiol 86:1195-201. 2001
    ..We conclude that in concentric movements a change of the movement direction encoded in the primary motor cortex occurs in the 200 ms prior to movement onset, which is as early as increased excitability itself can be detected...
  54. ncbi request reprint Safety study of high-frequency transcranial magnetic stimulation in patients with chronic stroke
    M P Lomarev
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, NIH Building 10, Room 5N240, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 118:2072-5. 2007
    ..Repetitive transcranial magnetic stimulation (rTMS) is a potential therapeutic tool to rehabilitate chronic stroke patients. In this study, the safety of high-frequency rTMS in stroke was investigated (Phase I)...
  55. ncbi request reprint Asymmetric spatiotemporal patterns of event-related desynchronization preceding voluntary sequential finger movements: a high-resolution EEG study
    Ou Bai
    Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 116:1213-21. 2005
    ..To study spatiotemporal patterns of event-related desynchronization (ERD) preceding voluntary sequential finger movements performed with dominant right hand and nondominant left hand...
  56. ncbi request reprint Posterior parietal negativity preceding self-paced praxis movements
    Lewis A Wheaton
    Human Motor Control Section, Medical Neurology Branch, NINDS, NIH, MSC 1428, Bethesda, MD 20892 1428, USA
    Exp Brain Res 163:535-9. 2005
    ..The posterior parietal negativity (PPN) suggests that early parietal activity is essential for tool-use movements and is not a part of preparing simple movements...
  57. ncbi request reprint Short-latency afferent inhibition during selective finger movement
    Bernhard Voller
    Human Motor Control Section, NINDS NIH, Bldg 10 5N226, 10 Center Dr, Bethesda, MD 20892, USA
    Exp Brain Res 169:226-31. 2006
    ..Heterotopic SAI found at rest disappeared with movement. We conclude that during movement, homotopic SAI on the muscle in the surround of the intended movement may contribute to SI...
  58. ncbi request reprint Generators of movement-related cortical potentials: fMRI-constrained EEG dipole source analysis
    Keiichiro Toma
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Neuroimage 17:161-73. 2002
    ..1 s after movement. Activation of the MFC shows timing similar to that of the bilateral precentral gyri These deduced patterns of activation are consis tent with previous studies of electrocorticography in humans...
  59. ncbi request reprint Synchronization of parietal and premotor areas during preparation and execution of praxis hand movements
    Lewis A Wheaton
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 116:1382-90. 2005
    ..We sought to determine temporal patterns of functional connectivity between the parietal, premotor, and motor cortices during preparation and execution of praxis hand movements...
  60. ncbi request reprint Disturbed surround inhibition in focal hand dystonia
    Young H Sohn
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 56:595-9. 2004
    ..This result supports the idea that disturbed surround inhibition is a principal pathophysiological mechanism of dystonia...
  61. pmc Left parietal activation related to planning, executing and suppressing praxis hand movements
    Lewis Wheaton
    Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Clin Neurophysiol 120:980-6. 2009
    ..We sought to investigate the activity of bilateral parietal and premotor areas during a Go/No Go paradigm involving praxis movements of the dominant hand...
  62. ncbi request reprint Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome
    A Lerner
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2035, USA
    Neurology 68:1979-87. 2007
    ..To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline...
  63. ncbi request reprint How self-initiated memorized movements become automatic: a functional MRI study
    Tao Wu
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    J Neurophysiol 91:1690-8. 2004
    ..Our results do not provide evidence for any area to become more activated for automatic movements...
  64. ncbi request reprint Surround inhibition in human motor system
    Young H Sohn
    Human Motor Control Section, NINDS NIH, Bldg 10 5N226, 10 Center Dr, Bethesda, MD 20892, USA
    Exp Brain Res 158:397-404. 2004
    ..This result indicates that motor excitability related to little finger movement is suppressed at the supraspinal level during these movements, and supports the idea that SI is an organizational principle of the motor system...
  65. ncbi request reprint The representation of blinking movement in cingulate motor areas: a functional magnetic resonance imaging study
    Takashi Hanakawa
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Cereb Cortex 18:930-7. 2008
    ..The CMAs may contribute to the sparing of upper facial muscles after a stroke involving the lateral precentral motor regions...
  66. pmc Discrete parieto-frontal functional connectivity related to grasping
    Noriaki Hattori
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Neurophysiol 101:1267-82. 2009
    ..By contrast, the connection from the left ventral IPL might be related to motor imagination or enhanced external attention to the presented stimuli...
  67. pmc Paired associative stimulation induces change in presynaptic inhibition of Ia terminals in wrist flexors in humans
    Jean Charles Lamy
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Neurophysiol 104:755-64. 2010
    ..Postactivation depression was unaffected by PAS. It is argued that enhancement of segmental excitation by PAS relies on a selective effect of PAS on the interneurons controlling presynaptic inhibition of Ia terminals...
  68. ncbi request reprint Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia
    Yohei Tamura
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Mov Disord 23:558-65. 2008
    ....
  69. ncbi request reprint Task-related interaction between basal ganglia and cortical dopamine release
    Gaetan Garraux
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:14434-41. 2007
    ....
  70. pmc Finger and face representations in the ipsilateral precentral motor areas in humans
    Takashi Hanakawa
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892 1428, USA
    J Neurophysiol 93:2950-8. 2005
    ..These two systems may be differentially influenced by developmental or pathologic changes...
  71. ncbi request reprint Nervous system reorganization following injury
    R Chen
    Human Cortical Physiology Section and Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health Building 10, Bethesda, MD 20892 1428, USA
    Neuroscience 111:761-73. 2002
    ..An understanding of the mechanism of plasticity will help to develop treatment programs to improve functional outcome...
  72. ncbi request reprint The neurophysiology of dystonia
    M Hallett
    Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Arch Neurol 55:601-3. 1998
    ..Curiously, the dystonia occurs at both peak and trough dopamine levels...
  73. ncbi request reprint Information flow from the sensorimotor cortex to muscle in humans
    T Mima
    Human Motor Control Section, NINDS, National Institutes of Health, MSC1428, Bethesda, MD 20892-1428, USA
    Clin Neurophysiol 112:122-6. 2001
    ..The finding of the directional information flow from EEG to EMG within the gamma band indicates that 40 Hz EEG-EMG coherence is not specific to the muscle Piper rhythm which is seen only with strong contraction...
  74. ncbi request reprint Comparison of auditory, somatosensory, and visually instructed and internally generated finger movements: a PET study
    R A Weeks
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
    Neuroimage 14:219-30. 2001
    ..The data indicate that, on a regional level, modality-specific processing in a conditional motor task does not occur in frontal motor areas and is probably confined to sensory areas...
  75. pmc Gesture subtype-dependent left lateralization of praxis planning: an event-related fMRI study
    S Bohlhalter
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Cereb Cortex 19:1256-62. 2009
    ..In conclusion, the findings point to a left-hemispheric specialization for praxis planning, being more pronounced for intransitive gestures in PMC, possibly due to their communicative nature...
  76. ncbi request reprint Limb positioning and magnitude of essential tremor and other pathological tremors
    J N Sanes
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
    Mov Disord 5:304-9. 1990
    ..These observations suggest a practical method for assistance with the clinical discrimination of essential tremor from other postural tremors...
  77. ncbi request reprint Role of cerebral cortex in human postural control: an EEG study
    S Slobounov
    Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892, USA
    Clin Neurophysiol 116:315-23. 2005
    ..It was our primary objective to provide evidence supporting the existence of neural detectors for postural instability that could trigger the compensatory adjustments to avoid falls...
  78. ncbi request reprint Effect of levetiracetam on human corticospinal excitability
    Y H Sohn
    Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD 20892-1428, USA
    Neurology 57:858-63. 2001
    ..The lack of change in F-wave and CMAP suggests that this effect is mainly derived from the motor cortex...
  79. pmc Classifying EEG signals preceding right hand, left hand, tongue, and right foot movements and motor imageries
    Valerie Morash
    Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Clin Neurophysiol 119:2570-8. 2008
    ..To use the neural signals preceding movement and motor imagery to predict which of the four movements/motor imageries is about to occur, and to access this utility for brain-computer interface (BCI) applications...
  80. ncbi request reprint Changes in spinal excitability after PAS
    Sabine Meunier
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Neurophysiol 97:3131-5. 2007
    ..Here, instead of F waves, we used H reflex recruitment curves to assess spinal excitability, and we demonstrate that PAS induces parallel changes in cortical and spinal excitability...
  81. ncbi request reprint A high performance sensorimotor beta rhythm-based brain-computer interface associated with human natural motor behavior
    Ou Bai
    Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    J Neural Eng 5:24-35. 2008
    ..The sensorimotor beta rhythm of EEG associated with human natural motor behavior can be used for a reliable and high performance BCI for both healthy subjects and patients with neurological disorders...
  82. pmc Associative plasticity in intracortical inhibitory circuits in human motor cortex
    Heike Russmann
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Clin Neurophysiol 120:1204-12. 2009
    ..MEP size results from excitatory and inhibitory influences exerted on cortical pyramidal cells, but no robust effects on inhibitory networks have been demonstrated so far...
  83. ncbi request reprint A functional MRI study of automatic movements in patients with Parkinson's disease
    Tao Wu
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Brain 128:2250-9. 2005
    ..Our study is the first to demonstrate that patients with Parkinson's disease require more brain activity to compensate for basal ganglia dysfunction in order to perform automatic movements...
  84. ncbi request reprint Regional cerebral blood flow correlates of the severity of writer's cramp symptoms
    Alicja Lerner
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Neuroimage 21:904-13. 2004
    ..Recent studies provide evidence that one element might be a sensory processing defect. We performed a PET study with O(15) H(2)O to find out in which brain areas activity correlates with the severity of writer's cramp symptoms...
  85. ncbi request reprint What is the Bereitschaftspotential?
    Hiroshi Shibasaki
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 117:2341-56. 2006
    ..Whether the late BP reflects conscious preparation for intended movement or not remains to be clarified...
  86. ncbi request reprint CASL fMRI of subcortico-cortical perfusion changes during memory-guided finger sequences
    Gaetan Garraux
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Dr, MSC 1428, Bethesda, MD 20892 1428, USA
    Neuroimage 25:122-32. 2005
    ..These results demonstrate that perfusion-based fMRI using CASL with a separate labeling coil can now be used to characterize task-related flow changes in most of the brain volume with adequate accuracy and sensitivity...
  87. ncbi request reprint Improving hand function in chronic stroke
    Wolf Muellbacher
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Room 5N226, Bethesda, MD 20892, USA
    Arch Neurol 59:1278-82. 2002
    ..Deafferentation of a body part in a healthy brain enhances cortical representations of adjacent body parts, and this effect is markedly increased by voluntary activity of the adjacent part...
  88. ncbi request reprint Movement rate effect on activation and functional coupling of motor cortical areas
    Keiichiro Toma
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    J Neurophysiol 88:3377-85. 2002
    ..In contrast, for fast repetitive movements (3-4 Hz), it appears that the rhythm is controlled and the motor cortices showed sustained EEG activation and continuous coupling...
  89. ncbi request reprint Effect of ethanol on the central oscillator in essential tremor
    Kirsten E Zeuner
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Mov Disord 18:1280-5. 2003
    ..029) compared with diazepam. Our findings suggest that the improvement in tremor after ethanol ingestion was due, at least in part, to an effect on a central oscillator...
  90. ncbi request reprint Neural correlates of counting of sequential sensory and motor events in the human brain
    Kenji Kansaku
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neuroimage 31:649-60. 2006
    ..These results suggest that overlapping but not identical networks of areas are involved in counting sequences of sensory stimuli and sequences of movements in the human brain...
  91. ncbi request reprint Impairment of eyeblink classical conditioning in progressive supranuclear palsy
    M Sommer
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mov Disord 16:240-51. 2001
    ..We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients...
  92. ncbi request reprint Presynaptic inhibition compared with homosynaptic depression as an explanation for soleus H-reflex depression in humans
    A F Kohn
    National Institutes of Health, NINDS, Human Motor Control Section, USA
    Exp Brain Res 116:375-80. 1997
    ..Homosynaptic depression localized at the presynaptic terminal seems to be the mechanism behind the H-reflex depression in humans...
  93. ncbi request reprint Coherence between cortical and muscular activities after subcortical stroke
    T Mima
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Stroke 32:2597-601. 2001
    ..The different effects of the lesion on the proximal and distal muscles appear to be associated with the strength of the corticospinal pathway...
  94. ncbi request reprint Modulation of practice-dependent plasticity in human motor cortex
    U Ziemann
    Clinic of Neurology, J W Goethe University, Schleusenweg 2 16, D 60590 Frankfurt am Main, Germany
    Brain 124:1171-81. 2001
    ..We propose that changes in GABA activity may be instrumented to modulate plasticity purposefully; for instance, to enhance plastic change and recovery of function after a lesion in neurological patients...
  95. pmc The role of inhibition from the left dorsal premotor cortex in right-sided focal hand dystonia
    Sandra Beck
    Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Brain Stimul 2:208-14. 2009
    ..The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD)...
  96. doi request reprint Short intracortical and surround inhibition are selectively reduced during movement initiation in focal hand dystonia
    Sandra Beck
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    J Neurosci 28:10363-9. 2008
    ..SICI may contribute to its generation, because in patients with FHD, the lack of depression of APB MEP size is accompanied by a reduction in SICI...
  97. ncbi request reprint Placebo-controlled study of rTMS for the treatment of Parkinson's disease
    Mikhail P Lomarev
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    Mov Disord 21:325-31. 2006
    ..Although short-term benefit may be due to MC excitability enhancement, the mechanism of cumulative benefit must have another explanation...
  98. pmc Double-blind, placebo-controlled, pilot trial of botulinum toxin A in restless legs syndrome
    Fatta B Nahab
    Human Motor Control Section, NINDS NIH, 10 Center Drive, Bldg 10, Room 5N226, Bethesda, MD 20892 1428, USA
    Neurology 71:950-1. 2008
  99. pmc Impulsive choice and response in dopamine agonist-related impulse control behaviors
    Valerie Voon
    National Institutes of Health, 10 Center Drive, Bldg 10 Rm 7D37, Bethesda, MD 20892 1428, USA
    Psychopharmacology (Berl) 207:645-59. 2010
    ..Dopaminergic medication-related impulse control disorders (ICDs) such as pathological gambling and compulsive shopping have been reported in Parkinson's disease (PD)...
  100. ncbi request reprint Exercise-induced dystonia as a preceding symptom of familial Parkinson's disease
    Michiko K Bruno
    Parkinson s Unit, Division of Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 19:228-30. 2004
    ..Further genotype-phenotype studies in this and similar families may give clues to pre-symptomatic symptoms in PD and may reflect a particular phenotype of interest for genetics studies in the future...
  101. pmc Involvement of insula and cingulate cortices in control and suppression of natural urges
    Alicja Lerner
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Cereb Cortex 19:218-23. 2009
    ..These results suggest a central role for the insula possibly together with ACC in suppression of blinking...