Research Topics
Species | M HallettSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The role of the dorsolateral prefrontal cortex in implicit procedural learningA Pascual-Leone
Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Exp Brain Res 107:479-85. 1996..Stimulation over the other areas did not interfere with learning. These results support the notion of a critical role of contralateral dorsolateral prefrontal structures in learning of motor sequences...
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPAVanessa L Cropley
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
Psychiatry Res 163:171-82. 2008..These results suggest that striatal dopamine denervation may contribute to some frontostriatal cognitive impairment in moderate stage PD...- The intrinsic and extrinsic aspects of freezing of gaitMark Hallett
Human Motor Control Section, NINDS, NIH, Bethesda, Maryland 20892 1428, USA
Mov Disord 23:S439-43. 2008..The sensory factors can both help or hinder freezing. Analogous to the problem with set-shifting, there is also some difficulty in regulation of internal versus external factors and in regulation of different external factors... 
Update on blepharospasm: report from the BEBRF International WorkshopMark Hallett
Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
Neurology 71:1275-82. 2008..Physiologic studies indicate increased plasticity and trigeminal sensitization. While botulinum neurotoxin injections are the mainstay of therapy, other therapies are on the horizon...- The timing of the conscious intention to moveMasao Matsuhashi
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Building 10 Room 5N226, Bethesda, MD 20892 1428, USA
Eur J Neurosci 28:2344-51. 2008..The difference between the conventional result and our result suggests that the perception of intention rises through multiple levels of awareness, starting just after the brain initiates movement... - A binary method for simple and accurate two-dimensional cursor control from EEG with minimal subject trainingTuran A Kayagil
National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
J Neuroeng Rehabil 6:14. 2009.... - Parkinson's disease tremor: pathophysiologyMark Hallett
Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892 1428, USA
Parkinsonism Relat Disord 18:S85-6. 2012..Analysis of cellular behavior in the thalamus shows that the thalamus is not the generator of tremor. New data suggest that the basal ganglia trigger a cerebellar circuit to produce the tremor... - Surround inhibitionMark Hallett
Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428, USA
Suppl Clin Neurophysiol 56:153-9. 2003 - Physiology of psychogenic movement disordersMark Hallett
Human Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Drive MSC 1428, Bethesda, Maryland 20892 1428, USA
J Clin Neurosci 17:959-65. 2010..Similar physiological abnormalities are seen in both groups. The question arises as to how a movement can be produced with voluntary mechanisms, but not be considered voluntary... - Functional reorganization after lesions of the human brain: studies with transcranial magnetic stimulationM Hallett
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
Rev Neurol (Paris) 157:822-6. 2001..The best recovery after stroke is due to reorganization of the lesioned hemisphere. Rehabilitative strategies might well be able to enhance rehabilitative efforts... - Plasticity of the human motor cortex and recovery from strokeM Hallett
Human Motor Control Section, NINDS, NIH, Medical Neurology Branch, Building 10, Room 5N226, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
Brain Res Brain Res Rev 36:169-74. 2001..Knowledge about the physiology of brain plasticity has led to the development of new techniques for rehabilitation... - Disordered plasticity in the primary somatosensory cortex in focal hand dystoniaYohei Tamura
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 7D37, 10 Center Drive, MSC 1428, Bethesda, MD 20892 1428, USA
Brain 132:749-55. 2009..In addition, intracortical inhibition in S1 was found to increase as well. This abnormal plasticity of the intracortical neurons in S1 may contribute to the pathophysiology of dystonia... - Cortical control of brainstem motor systemsMark Hallett
Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
Mov Disord 17:S23-6. 2002 - Blepharospasm: recent advancesMark Hallett
Human Motor Control Section, NINDS, NIH, Building 10, Room 5N226, 10 Center Dr, MSC 1428, Bethesda, MD 20892 1428, USA
Neurology 59:1306-12. 2002..The trigger could be repetitive use or local ocular disease. Although symptomatic therapy is available, better approaches are needed and will likely become available as the genetics and pathophysiology become well understood... - Treatment of focal dystonias with botulinum neurotoxinMark Hallett
Human Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
Toxicon 54:628-33. 2009..Disorders covered include cranial dystonia, cervical dystonia, spasmodic dysphonia, and focal hand dystonia. Considered are clinical aspects, alternative treatment strategies and principles of use of botulinum toxin injections... - Transcranial magnetic stimulation: a primerMark Hallett
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 55:187-99. 2007..TMS has some clinical utility, and, because it can influence brain function if delivered repetitively, it is being developed for various therapeutic purposes... - Neurophysiology of dystonia: The role of inhibitionMark Hallett
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Building 10, Room 7D37, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
Neurobiol Dis 42:177-84. 2011..This article is part of a Special Issue entitled "Advances in dystonia"... - Milestones in clinical neurophysiologyMark Hallett
Human Motor Control Section, NINDS, NIH, Bethesda, Maryland 20892 1428, USA
Mov Disord 26:958-67. 2011..Studies have been done looking at the use of noninvasive brain stimulation for therapy, but effects are generally small... - Corticobulbar tractsM Hallett
Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892-1428, USA
Suppl Clin Neurophysiol 58:3-9. 2006 - Recent advances in stroke rehabilitationMark Hallett
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1428, USA
Neurorehabil Neural Repair 16:211-7. 2002 - Psychogenic parkinsonismMark Hallett
Human Motor Control Section, NINDS, NIH, Bldg 10, Rm 7D37, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
J Neurol Sci 310:163-5. 2011..Patients may have both organic Parkinson's disease and psychogenic parkinsonism, and this might be considered a psychologically induced aggravation of the organic disorder... - Psychogenic movement disorders: a crisis for neurologyMark Hallett
Human Motor Control Section, NINDS NIH, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428, USA
Curr Neurol Neurosci Rep 6:269-71. 2006 - Volitional control of movement: the physiology of free willMark Hallett
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Building 10, Room 5N226, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
Clin Neurophysiol 118:1179-92. 2007.... - Pathophysiology of writer's crampMark Hallett
Human Motor Control Section, NINDS, NIH Building 10, Room 5N226 Bethesda, MD 20892 1428, USA
Hum Mov Sci 25:454-63. 2006..The fertile background, which is likely genetic, may be a decrease of inhibition, an increase of plasticity or an impairment in sensory function. Recent pathophysiological findings have implications for new therapies... - Psychogenic movement disordersMark Hallett
Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892 1428, USA
Parkinsonism Relat Disord 18:S155-7. 2012..With sequential movements, the sequence effect is typically lacking. Extreme slowness and grunting with great effort may be seen. Improvement in arm swing while running, a feature of organic parkinsonism, may not be seen... - Task-dependent changes of intracortical inhibitionJ Liepert
Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Exp Brain Res 118:421-6. 1998..Additionally, our data further supports the idea that ICI and ICF may be controlled independently... - Role of the human motor cortex in rapid motor learningW Muellbacher
Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
Exp Brain Res 136:431-8. 2001..Since the changes in MEP amplitude were observed only after TMS of M1 but not after direct stimulation of the corticospinal tract, these findings indicate task- and effector-specific involvement of human M1 in rapid motor learning... - Dissociation of the pathways mediating ipsilateral and contralateral motor-evoked potentials in human hand and arm musclesU Ziemann
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
J Physiol 518:895-906. 1999..Other pathways, such as branching of corticomotoneuronal axons, a transcallosal projection or a slow-conducting monosynaptic ipsilateral pathway are very unlikely or can be excluded... - Surround inhibition depends on the force exerted and is abnormal in focal hand dystoniaS Beck
Human Motor Control Section, NINDS, National Institutes of Health, Bldg 10 5N240, 10 Center Drive, Bethesda, MD 20892 1428, USA
J Appl Physiol 107:1513-8. 2009..The greater loss of SICI for the 10% F(max) level in patients with FHD than for the 20% F(max) level indicates that this inhibitory mechanism is more abnormal at lower levels of force... - Neural correlates of auditory-visual stimulus onset asynchrony detectionK O Bushara
National Institute of Neurological Disorders and Stroke, Human Motor Control Section, and Cognitive Neuroscience Section, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
J Neurosci 21:300-4. 2001.... - Inter-hemispheric inhibition is impaired in mirror dystoniaS Beck
Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD, USA
Eur J Neurosci 29:1634-40. 2009..We conclude that mirror dystonia may be due to impaired IHI towards neighboring muscles before movement onset. However, IHI does not seem to play a major role in the general pathophysiology of FHD... - Exploration of computational methods for classification of movement intention during human voluntary movement from single trial EEGOu Bai
Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders, NIH, Bethesda, MD 20892, USA
Clin Neurophysiol 118:2637-55. 2007..To explore effective combinations of computational methods for the prediction of movement intention preceding the production of self-paced right and left hand movements from single trial scalp electroencephalogram (EEG)... - Effect of volitional inhibition on cortical inhibitory mechanismsYoung H Sohn
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurophysiol 88:333-8. 2002..The present results demonstrate that volitional inhibition enhances SICI but reduces LICI nonselectively. These results suggest that these two inhibitory mechanisms act differently during execution and suppression of voluntary movements... - Analogous corticocortical inhibition and facilitation in ipsilateral and contralateral human motor cortex representations of the tongueW Muellbacher
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
J Clin Neurophysiol 18:550-8. 2001..0001). These findings indicate that the ipsilateral and contralateral representations of the tongue are under analogous inhibitory and facilitatory control, possibly by a common intracortical network... - Transcranial magnetic brain stimulation modulates blepharospasm: a randomized controlled studyG Kranz
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Neurology 75:1465-71. 2010..Benign essential blepharospasm (BEB) is a common form of focal dystonia. Besides pathology in the basal ganglia, accumulating evidence suggests pathologic changes in the anterior cingulate cortex (ACC)... - Surround inhibition is modulated by task difficultyS Beck
Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD 20892 1428, USA
Clin Neurophysiol 121:98-103. 2010..The aim of this study was to further characterize surround inhibition (SI) in the primary motor cortex (M1) by comparing its magnitude and time course during a simple reaction time task (SRT) and a choice reaction time task (CRT)... - Motor training as treatment in focal hand dystoniaKirsten E Zeuner
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
Mov Disord 20:335-41. 2005..Whereas this method of motor training for 4 weeks led to mild subjective improvement and some improvement in handwriting, it is not sufficient to reverse motor cortex abnormalities measured by TMS and EEG... - Accelerometry to distinguish psychogenic from essential or parkinsonian tremorK E Zeuner
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1428, USA
Neurology 61:548-50. 2003..Psychogenic tremors showed larger tremor frequency changes and higher intraindividual variability while tapping. Accelerometry may differentiate psychogenic from essential and parkinsonian tremor... - Event-related desynchronization in reaction time paradigms: a comparison with event-related potentials and corticospinal excitabilityL Leocani
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Drive MSC 1428, Bethesda, MD 20892-1428, USA
Clin Neurophysiol 112:923-30. 2001..CONCLUSIONS: These findings may suggest that ERD is compatible with both corticospinal activation and inhibition, ERS indicating the removal of either, resulting in cortical idling... - Blepharospasm and the modulation of cortical excitability in primary and secondary motor areasG Kranz
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Neurology 73:2031-6. 2009..Electrophysiologic and brain imaging studies suggest pathologic changes in excitability in the primary motor cortex (MC), anterior cingulate (AC), and secondary motor areas, such as premotor (PMC) and supplementary motor cortices (SMA)... - Parametric analysis of functional neuroimages: application to a variable-rate motor taskJ W VanMeter
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroimage 2:273-83. 1995..Habituation of responses was not observed... - Functional relevance of cross-modal plasticity in blind humansL G Cohen
Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
Nature 389:180-3. 1997..We propose that this cross-modal plasticity may account in part for the superior tactile perceptual abilities of blind subjects... - Task-dependent intracortical inhibition is impaired in focal hand dystoniaCathrin M Butefisch
Human Motor Control Section, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
Mov Disord 20:545-51. 2005..We found that performance of the selective but not the nonselective task resulted in increased SICI in the 4DIO of normal but not in dystonic subjects. We conclude that task-dependent SICI is disturbed in patients with dystonia... - Movement-related cortical potentials in primary lateral sclerosisOu Bai
Human Motor Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Ann Neurol 59:682-90. 2006..The loss of the MRCP may serve as a useful marker of upper motor neuron dysfunction. Preservation of event-related desynchronization suggests that the cells of origin differ from the large pyramidal cells that generate the MRCP... - Long-latency afferent inhibition during selective finger movementBernhard Voller
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Neurophysiol 94:1115-9. 2005..However, with finger stimulation added, there were almost no increased MEPs despite co-activation. These findings suggest that LAI increases during movement and can enhance SI... - Psychogenic palatal tremorSarah Pirio Richardson
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Mov Disord 21:274-6. 2006..We discuss the differential diagnosis of palatal tremor as well as the role of neurophysiological testing in the diagnosis of psychogenic movement disorders... - Contribution of the ipsilateral motor cortex to recovery after chronic strokeKonrad J Werhahn
Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Ann Neurol 54:464-72. 2003..These results are consistent with the idea that recovered motor function in the paretic hand of chronic stroke patients relies predominantly on reorganized activity within motor areas of the affected hemisphere... - Changes in short afferent inhibition during phasic movement in focal dystoniaSarah Pirio Richardson
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1428, Bldg 10, Bethesda, MD 20892 1428, USA
Muscle Nerve 37:358-63. 2008..Understanding the role of these inhibitory circuits in dystonia may lead to development of therapeutic agents aimed at restoring inhibition... - Modulation of motor cortex excitability by median nerve and digit stimulationR Chen
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Exp Brain Res 129:77-86. 1999..The time course for decreased motor cortex excitability following median nerve stimulation corresponds well to rebound of the 20-Hz cortical rhythm and supports the hypothesis that this increased power represents cortical deactivation... - Safety study of high-frequency transcranial magnetic stimulation in patients with chronic strokeM P Lomarev
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, NIH Building 10, Room 5N240, 10 Center Dr MSC 1428, Bethesda, MD 20892 1428, USA
Clin Neurophysiol 118:2072-5. 2007..Repetitive transcranial magnetic stimulation (rTMS) is a potential therapeutic tool to rehabilitate chronic stroke patients. In this study, the safety of high-frequency rTMS in stroke was investigated (Phase I)... - Cortical control of voluntary blinking: a transcranial magnetic stimulation studyY H Sohn
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10/Room 5N226, 10 Center Drive, Bethesda, MD 20892-1428, USA
Clin Neurophysiol 115:341-7. 2004..This result provides evidence that the cortical center for the upper facial movements, including blinking, is not principally located in the facial M1, but rather in the mesial frontal region... - Time course of determination of movement direction in the reaction time task in humansM Sommer
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892-1428, USA
J Neurophysiol 86:1195-201. 2001..We conclude that in concentric movements a change of the movement direction encoded in the primary motor cortex occurs in the 200 ms prior to movement onset, which is as early as increased excitability itself can be detected... - Left parietal activation related to planning, executing and suppressing praxis hand movementsLewis Wheaton
Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Clin Neurophysiol 120:980-6. 2009..We sought to investigate the activity of bilateral parietal and premotor areas during a Go/No Go paradigm involving praxis movements of the dominant hand... - Short-latency afferent inhibition during selective finger movementBernhard Voller
Human Motor Control Section, NINDS/NIH, Bldg. 10/5N226, 10 Center Dr, Bethesda, MD 20892, USA
Exp Brain Res 169:226-31. 2006..Heterotopic SAI found at rest disappeared with movement. We conclude that during movement, homotopic SAI on the muscle in the surround of the intended movement may contribute to SI... - Disturbed surround inhibition in focal hand dystoniaYoung H Sohn
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Ann Neurol 56:595-9. 2004..This result supports the idea that disturbed surround inhibition is a principal pathophysiological mechanism of dystonia... - Asymmetric spatiotemporal patterns of event-related desynchronization preceding voluntary sequential finger movements: a high-resolution EEG studyOu Bai
Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
Clin Neurophysiol 116:1213-21. 2005..SIGNIFICANCE: We provide further evidence for motor dominance of the left hemisphere in early period of motor preparation for complex sequential finger movements... - Synchronization of parietal and premotor areas during preparation and execution of praxis hand movementsLewis A Wheaton
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892-1428, USA
Clin Neurophysiol 116:1382-90. 2005..SIGNIFICANCE: This study adds to evidence that parietofrontal networks may be critical for integrating preparatory and motor-related activity for praxis movements... - Posterior parietal negativity preceding self-paced praxis movementsLewis A Wheaton
Human Motor Control Section, Medical Neurology Branch, NINDS, NIH, MSC 1428, Bethesda, MD 20892-1428, USA
Exp Brain Res 163:535-9. 2005..The posterior parietal negativity (PPN) suggests that early parietal activity is essential for tool-use movements and is not a part of preparing simple movements... - Generators of movement-related cortical potentials: fMRI-constrained EEG dipole source analysisKeiichiro Toma
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
Neuroimage 17:161-73. 2002..1 s after movement. Activation of the MFC shows timing similar to that of the bilateral precentral gyri These deduced patterns of activation are consis tent with previous studies of electrocorticography in humans... - Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndromeA Lerner
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2035, USA
Neurology 68:1979-87. 2007..To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline... - Discrete parieto-frontal functional connectivity related to graspingNoriaki Hattori
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Neurophysiol 101:1267-82. 2009..By contrast, the connection from the left ventral IPL might be related to motor imagination or enhanced external attention to the presented stimuli... - Finger and face representations in the ipsilateral precentral motor areas in humansTakashi Hanakawa
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892-1428, USA
J Neurophysiol 93:2950-8. 2005..These two systems may be differentially influenced by developmental or pathologic changes... - How self-initiated memorized movements become automatic: a functional MRI studyTao Wu
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
J Neurophysiol 91:1690-8. 2004..Our results do not provide evidence for any area to become more activated for automatic movements... - Task-related interaction between basal ganglia and cortical dopamine releaseGaetan Garraux
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:14434-41. 2007.... - Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystoniaYohei Tamura
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
Mov Disord 23:558-65. 2008.... - Paired associative stimulation induces change in presynaptic inhibition of Ia terminals in wrist flexors in humansJean Charles Lamy
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Neurophysiol 104:755-64. 2010..Postactivation depression was unaffected by PAS. It is argued that enhancement of segmental excitation by PAS relies on a selective effect of PAS on the interneurons controlling presynaptic inhibition of Ia terminals... - The representation of blinking movement in cingulate motor areas: a functional magnetic resonance imaging studyTakashi Hanakawa
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
Cereb Cortex 18:930-7. 2008..The CMAs may contribute to the sparing of upper facial muscles after a stroke involving the lateral precentral motor regions... - Surround inhibition in human motor systemYoung H Sohn
Human Motor Control Section, NINDS/NIH, Bldg. 10/5N226, 10 Center Dr, Bethesda, MD 20892, USA
Exp Brain Res 158:397-404. 2004..This result indicates that motor excitability related to little finger movement is suppressed at the supraspinal level during these movements, and supports the idea that SI is an organizational principle of the motor system... - Gesture subtype-dependent left lateralization of praxis planning: an event-related fMRI studyS Bohlhalter
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
Cereb Cortex 19:1256-62. 2009..In conclusion, the findings point to a left-hemispheric specialization for praxis planning, being more pronounced for intransitive gestures in PMC, possibly due to their communicative nature... - Role of cerebral cortex in human postural control: an EEG studyS Slobounov
Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892, USA
Clin Neurophysiol 116:315-23. 2005..It was our primary objective to provide evidence supporting the existence of neural detectors for postural instability that could trigger the compensatory adjustments to avoid falls... - Effect of levetiracetam on human corticospinal excitabilityY H Sohn
Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, MD 20892-1428, USA
Neurology 57:858-63. 2001..The lack of change in F-wave and CMAP suggests that this effect is mainly derived from the motor cortex... - Nervous system reorganization following injuryR Chen
Human Cortical Physiology Section and Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health Building 10, Bethesda, MD 20892-1428, USA
Neuroscience 111:761-73. 2002..An understanding of the mechanism of plasticity will help to develop treatment programs to improve functional outcome... - Comparison of auditory, somatosensory, and visually instructed and internally generated finger movements: a PET studyR A Weeks
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
Neuroimage 14:219-30. 2001..The data indicate that, on a regional level, modality-specific processing in a conditional motor task does not occur in frontal motor areas and is probably confined to sensory areas... - Limb positioning and magnitude of essential tremor and other pathological tremorsJ N Sanes
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
Mov Disord 5:304-9. 1990..These observations suggest a practical method for assistance with the clinical discrimination of essential tremor from other postural tremors... - Information flow from the sensorimotor cortex to muscle in humansT Mima
Human Motor Control Section, NINDS, National Institutes of Health, MSC1428, Bethesda, MD 20892-1428, USA
Clin Neurophysiol 112:122-6. 2001..The finding of the directional information flow from EEG to EMG within the gamma band indicates that 40 Hz EEG-EMG coherence is not specific to the muscle Piper rhythm which is seen only with strong contraction... - The neurophysiology of dystoniaM Hallett
Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
Arch Neurol 55:601-3. 1998..Curiously, the dystonia occurs at both peak and trough dopamine levels... - Classifying EEG signals preceding right hand, left hand, tongue, and right foot movements and motor imageriesValerie Morash
Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Clin Neurophysiol 119:2570-8. 2008..To use the neural signals preceding movement and motor imagery to predict which of the four movements/motor imageries is about to occur, and to access this utility for brain-computer interface (BCI) applications... - Improving hand function in chronic strokeWolf Muellbacher
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Room 5N226, Bethesda, MD 20892, USA
Arch Neurol 59:1278-82. 2002..CONCLUSION: This is a novel therapeutic strategy that may help improve hand function in patients with long-term weakness after stroke... - Changes in spinal excitability after PASSabine Meunier
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Neurophysiol 97:3131-5. 2007..Here, instead of F waves, we used H reflex recruitment curves to assess spinal excitability, and we demonstrate that PAS induces parallel changes in cortical and spinal excitability... - Effect of ethanol on the central oscillator in essential tremorKirsten E Zeuner
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
Mov Disord 18:1280-5. 2003..029) compared with diazepam. Our findings suggest that the improvement in tremor after ethanol ingestion was due, at least in part, to an effect on a central oscillator... - What is the Bereitschaftspotential?Hiroshi Shibasaki
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
Clin Neurophysiol 117:2341-56. 2006..Whether the late BP reflects conscious preparation for intended movement or not remains to be clarified... - CASL fMRI of subcortico-cortical perfusion changes during memory-guided finger sequencesGaetan Garraux
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Dr, MSC 1428, Bethesda, MD 20892 1428, USA
Neuroimage 25:122-32. 2005..These results demonstrate that perfusion-based fMRI using CASL with a separate labeling coil can now be used to characterize task-related flow changes in most of the brain volume with adequate accuracy and sensitivity... - A functional MRI study of automatic movements in patients with Parkinson's diseaseTao Wu
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Brain 128:2250-9. 2005..Our study is the first to demonstrate that patients with Parkinson's disease require more brain activity to compensate for basal ganglia dysfunction in order to perform automatic movements... - Associative plasticity in intracortical inhibitory circuits in human motor cortexHeike Russmann
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Clin Neurophysiol 120:1204-12. 2009..MEP size results from excitatory and inhibitory influences exerted on cortical pyramidal cells, but no robust effects on inhibitory networks have been demonstrated so far... - A high performance sensorimotor beta rhythm-based brain-computer interface associated with human natural motor behaviorOu Bai
Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders, National Institutes of Health, Bethesda, MD 20892, USA
J Neural Eng 5:24-35. 2008..Significance: The proposed new non-invasive BCI method highlights a practical BCI for clinical applications, where the user does not require extensive training... - Neural correlates of counting of sequential sensory and motor events in the human brainKenji Kansaku
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Drive MSC 1428, Bethesda, MD 20892-1428, USA
Neuroimage 31:649-60. 2006..These results suggest that overlapping but not identical networks of areas are involved in counting sequences of sensory stimuli and sequences of movements in the human brain... - Regional cerebral blood flow correlates of the severity of writer's cramp symptomsAlicja Lerner
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
Neuroimage 21:904-13. 2004..Writer's cramp may arise in part as a dysfunction of sensory circuits, which causes defective sensorimotor integration resulting in co-contractions of muscles and overflow phenomena... - Movement rate effect on activation and functional coupling of motor cortical areasKeiichiro Toma
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
J Neurophysiol 88:3377-85. 2002..In contrast, for fast repetitive movements (3-4 Hz), it appears that the rhythm is controlled and the motor cortices showed sustained EEG activation and continuous coupling... - Coherence between cortical and muscular activities after subcortical strokeT Mima
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Stroke 32:2597-601. 2001..The different effects of the lesion on the proximal and distal muscles appear to be associated with the strength of the corticospinal pathway... - Presynaptic inhibition compared with homosynaptic depression as an explanation for soleus H-reflex depression in humansA F Kohn
National Institutes of Health, NINDS, Human Motor Control Section, USA
Exp Brain Res 116:375-80. 1997..Homosynaptic depression localized at the presynaptic terminal seems to be the mechanism behind the H-reflex depression in humans... - Impairment of eyeblink classical conditioning in progressive supranuclear palsyM Sommer
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Mov Disord 16:240-51. 2001..We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PD and PSP patients... - Modulation of practice-dependent plasticity in human motor cortexU Ziemann
Clinic of Neurology, J W Goethe University, Schleusenweg 2 16, D 60590 Frankfurt am Main, Germany
Brain 124:1171-81. 2001..We propose that changes in GABA activity may be instrumented to modulate plasticity purposefully; for instance, to enhance plastic change and recovery of function after a lesion in neurological patients... - Placebo-controlled study of rTMS for the treatment of Parkinson's diseaseMikhail P Lomarev
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
Mov Disord 21:325-31. 2006..Although short-term benefit may be due to MC excitability enhancement, the mechanism of cumulative benefit must have another explanation... - Impulsive choice and response in dopamine agonist-related impulse control behaviorsValerie Voon
National Institutes of Health, 10 Center Drive, Bldg 10 Rm 7D37, Bethesda, MD 20892 1428, USA
Psychopharmacology (Berl) 207:645-59. 2010..Dopaminergic medication-related impulse control disorders (ICDs) such as pathological gambling and compulsive shopping have been reported in Parkinson's disease (PD)... - Identifying true brain interaction from EEG data using the imaginary part of coherencyGuido Nolte
Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bldg 10, Room 5N226, Bethesda, MD 20892 1428, USA
Clin Neurophysiol 115:2292-307. 2004..Here, we present an approach which is insensitive to false connectivity arising from volume conduction... - Shared brain areas but not functional connections controlling movement timing and orderGaetan Garraux
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
J Neurosci 25:5290-7. 2005.... - The role of inhibition from the left dorsal premotor cortex in right-sided focal hand dystoniaSandra Beck
Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
Brain Stimul 2:208-14. 2009..The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD)... - Short intracortical and surround inhibition are selectively reduced during movement initiation in focal hand dystoniaSandra Beck
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
J Neurosci 28:10363-9. 2008..SICI may contribute to its generation, because in patients with FHD, the lack of depression of APB MEP size is accompanied by a reduction in SICI... - Double-blind, placebo-controlled, pilot trial of botulinum toxin A in restless legs syndromeFatta B Nahab
Human Motor Control Section, NINDS/NIH, 10 Center Drive, Bldg 10, Room 5N226, Bethesda, MD 20892-1428, USA
Neurology 71:950-1. 2008 - Involvement of insula and cingulate cortices in control and suppression of natural urgesAlicja Lerner
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Cereb Cortex 19:218-23. 2009..These results suggest a central role for the insula possibly together with ACC in suppression of blinking... - Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological studyKristina Simonyan
Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Room 5D38, Bethesda, MD 20892 1416, USA
Brain 131:447-59. 2008..509, P = 0.037). These brain abnormalities may alter the central control of voluntary voice production and, therefore, may underlie the pathophysiology of this disorder...