Research Topics
| K D HallSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
The dynamics of human body weight changeCarson C Chow
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Comput Biol 4:e1000045. 2008..Nevertheless, this distinction has important implications for the efficacy of clinical interventions that alter body composition and mass...- Estimating the continuous-time dynamics of energy and fat metabolism in miceJuen Guo
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
PLoS Comput Biol 5:e1000511. 2009..We also discovered a time-invariant curve relating body fat and fat-free masses in male C57BL/6 mice, and the shape of this curve determines how diet, fuel selection, and body composition are interrelated... 
Metabolism of mice and men: mathematical modeling of body weight dynamicsKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Curr Opin Clin Nutr Metab Care 15:418-23. 2012..This review describes how mathematical models offer a quantitative framework for integrating dynamic physiological and behavioral data underlying body weight dynamics in both humans and mice...- Modeling metabolic adaptations and energy regulation in humansKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Nutr 32:35-54. 2012.... - Metabolic slowing with massive weight loss despite preservation of fat-free massDarcy L Johannsen
Skeletal Muscle Physiology Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 12a South Drive, Room 4007, Bethesda, Maryland 20892, USA ke
J Clin Endocrinol Metab 97:2489-96. 2012..An important goal during weight loss is to maximize fat loss while preserving metabolically active fat-free mass (FFM). Massive weight loss typically results in substantial loss of FFM potentially slowing metabolic rate... - Predicting metabolic adaptation, body weight change, and energy intake in humansKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 5621, USA
Am J Physiol Endocrinol Metab 298:E449-66. 2010..The validated model was used to estimate free-living energy intake during a long-term weight loss intervention, a variable that has never previously been measured accurately... - The progressive increase of food waste in America and its environmental impactKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States of America
PLoS ONE 4:e7940. 2009..Food waste now accounts for more than one quarter of the total freshwater consumption and approximately 300 million barrels of oil per year... - Mathematical modelling of energy expenditure during tissue depositionKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
Br J Nutr 104:4-7. 2010..The proposed mathematical framework has implications for interpreting studies of animal nutrition as well as providing a roadmap for future modelling efforts... - Mechanisms of metabolic fuel selection: modeling human metabolism and body-weight changeKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 12a South Drive, Room 4007, Bethesda, MD 20892 5621, USA
IEEE Eng Med Biol Mag 29:36-41. 2010.... - Estimating changes in free-living energy intake and its confidence intervalKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
Am J Clin Nutr 94:66-74. 2011..Free-living energy intake in humans is notoriously difficult to measure but is required to properly assess outpatient weight-control interventions... - Quantification of the effect of energy imbalance on bodyweightKevin D Hall
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Lancet 378:826-37. 2011..The average increase of energy intake needed to sustain the increased weight (the maintenance energy gap) has amounted to about 0ยท9 MJ per day and quantifies the public health challenge to reverse the obesity epidemic... - Computational model of in vivo human energy metabolism during semistarvation and refeedingKevin D Hall
NIDDK NIH, 12 South Drive, Rm 4007, Bethesda, MD 20892 5621, USA
Am J Physiol Endocrinol Metab 291:E23-37. 2006..The predicted changes in body weight, fat mass, resting metabolic rate, and nitrogen balance matched the experimental measurements, thereby providing support for the validity of the model... - How adaptations of substrate utilization regulate body compositionK D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Int J Obes (Lond) 31:1378-83. 2007..To elucidate the mathematical relationship between longitudinal changes of body composition and the adaptations of substrate utilization required to produce those changes... - Modeling weight-loss maintenance to help prevent body weight regainKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
Am J Clin Nutr 88:1495-503. 2008..Such a tool would be helpful for goal-setting, because obese patients and their physicians could assess at the outset of an intervention whether long-term adherence to the calculated lifestyle change is realistic... - Computational modeling of cancer cachexiaKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 5621, USA
Curr Opin Clin Nutr Metab Care 11:214-21. 2008..Thus, models of cancer-associated weight loss are an important tool for helping to understand this debilitating condition... - Body fat and fat-free mass inter-relationships: Forbes's theory revisitedKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Br J Nutr 97:1059-63. 2007..The new equation that accounts for the magnitude of the weight loss provides better predictions of body composition changes in such patients... - What is the required energy deficit per unit weight loss?K D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
Int J Obes (Lond) 32:573-6. 2008..International Journal of Obesity (2008) 32, 573-576; doi:10.1038/sj.ijo.0803720; published online 11 September 2007... - Dynamic coordination of macronutrient balance during infant growth: insights from a mathematical modelPeter N Jordan
Laboratory of Biological Modeling, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
Am J Clin Nutr 87:692-703. 2008..Although previous investigators have focused on energy requirements for normal growth, little is known about the dynamic coordination of macronutrient balance... - Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic dietsJuen Guo
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 4:e5370. 2009.... - Models use leptin and calculus to count caloriesKevin D Hall
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
Cell Metab 9:3-4. 2009..Work in this issue of Cell Metabolism (Tam et al., 2009) applies similar modeling strategies to explore the control of murine energy and body weight homeostasis by leptin...