K D Hall

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The dynamics of human body weight change
    Carson C Chow
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Comput Biol 4:e1000045. 2008
  2. pmc Estimating the continuous-time dynamics of energy and fat metabolism in mice
    Juen Guo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    PLoS Comput Biol 5:e1000511. 2009
  3. pmc Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice
    Juen Guo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 6:e15961. 2011
  4. pmc Diet versus exercise in "the biggest loser" weight loss competition
    Kevin D Hall
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Obesity (Silver Spring) 21:957-9. 2013
  5. doi Metabolism of mice and men: mathematical modeling of body weight dynamics
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Clin Nutr Metab Care 15:418-23. 2012
  6. doi Modeling metabolic adaptations and energy regulation in humans
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Nutr 32:35-54. 2012
  7. pmc Metabolic slowing with massive weight loss despite preservation of fat-free mass
    Darcy L Johannsen
    Skeletal Muscle Physiology Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 12a South Drive, Room 4007, Bethesda, Maryland 20892, USA ke
    J Clin Endocrinol Metab 97:2489-96. 2012
  8. pmc The progressive increase of food waste in America and its environmental impact
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7940. 2009
  9. doi Mathematical modelling of energy expenditure during tissue deposition
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Br J Nutr 104:4-7. 2010
  10. doi Mechanisms of metabolic fuel selection: modeling human metabolism and body-weight change
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 12a South Drive, Room 4007, Bethesda, MD 20892 5621, USA
    IEEE Eng Med Biol Mag 29:36-41. 2010

Detail Information

Publications22

  1. pmc The dynamics of human body weight change
    Carson C Chow
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Comput Biol 4:e1000045. 2008
    ..Nevertheless, this distinction has important implications for the efficacy of clinical interventions that alter body composition and mass...
  2. pmc Estimating the continuous-time dynamics of energy and fat metabolism in mice
    Juen Guo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    PLoS Comput Biol 5:e1000511. 2009
    ..We also discovered a time-invariant curve relating body fat and fat-free masses in male C57BL/6 mice, and the shape of this curve determines how diet, fuel selection, and body composition are interrelated...
  3. pmc Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice
    Juen Guo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 6:e15961. 2011
    ..This is the first validated mathematical model of mouse energy metabolism and it provides a quantitative framework for investigating energy balance relationships in mouse models of obesity and diabetes...
  4. pmc Diet versus exercise in "the biggest loser" weight loss competition
    Kevin D Hall
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Obesity (Silver Spring) 21:957-9. 2013
    ..However, the magnitude of the diet and exercise intervention has not been previously quantified...
  5. doi Metabolism of mice and men: mathematical modeling of body weight dynamics
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Clin Nutr Metab Care 15:418-23. 2012
    ..This review describes how mathematical models offer a quantitative framework for integrating dynamic physiological and behavioral data underlying body weight dynamics in both humans and mice...
  6. doi Modeling metabolic adaptations and energy regulation in humans
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Nutr 32:35-54. 2012
    ....
  7. pmc Metabolic slowing with massive weight loss despite preservation of fat-free mass
    Darcy L Johannsen
    Skeletal Muscle Physiology Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 12a South Drive, Room 4007, Bethesda, Maryland 20892, USA ke
    J Clin Endocrinol Metab 97:2489-96. 2012
    ..An important goal during weight loss is to maximize fat loss while preserving metabolically active fat-free mass (FFM). Massive weight loss typically results in substantial loss of FFM potentially slowing metabolic rate...
  8. pmc The progressive increase of food waste in America and its environmental impact
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7940. 2009
    ..Food waste now accounts for more than one quarter of the total freshwater consumption and approximately 300 million barrels of oil per year...
  9. doi Mathematical modelling of energy expenditure during tissue deposition
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Br J Nutr 104:4-7. 2010
    ..The proposed mathematical framework has implications for interpreting studies of animal nutrition as well as providing a roadmap for future modelling efforts...
  10. doi Mechanisms of metabolic fuel selection: modeling human metabolism and body-weight change
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 12a South Drive, Room 4007, Bethesda, MD 20892 5621, USA
    IEEE Eng Med Biol Mag 29:36-41. 2010
    ....
  11. pmc Estimating changes in free-living energy intake and its confidence interval
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Am J Clin Nutr 94:66-74. 2011
    ..Free-living energy intake in humans is notoriously difficult to measure but is required to properly assess outpatient weight-control interventions...
  12. pmc Quantification of the effect of energy imbalance on bodyweight
    Kevin D Hall
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet 378:826-37. 2011
    ..The average increase of energy intake needed to sustain the increased weight (the maintenance energy gap) has amounted to about 0ยท9 MJ per day and quantifies the public health challenge to reverse the obesity epidemic...
  13. pmc Predicting metabolic adaptation, body weight change, and energy intake in humans
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 5621, USA
    Am J Physiol Endocrinol Metab 298:E449-66. 2010
    ..The validated model was used to estimate free-living energy intake during a long-term weight loss intervention, a variable that has never previously been measured accurately...
  14. pmc Computational model of in vivo human energy metabolism during semistarvation and refeeding
    Kevin D Hall
    NIDDK NIH, 12 South Drive, Rm 4007, Bethesda, MD 20892 5621, USA
    Am J Physiol Endocrinol Metab 291:E23-37. 2006
    ..The predicted changes in body weight, fat mass, resting metabolic rate, and nitrogen balance matched the experimental measurements, thereby providing support for the validity of the model...
  15. pmc How adaptations of substrate utilization regulate body composition
    K D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Int J Obes (Lond) 31:1378-83. 2007
    ..To elucidate the mathematical relationship between longitudinal changes of body composition and the adaptations of substrate utilization required to produce those changes...
  16. pmc Body fat and fat-free mass inter-relationships: Forbes's theory revisited
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Nutr 97:1059-63. 2007
    ..The new equation that accounts for the magnitude of the weight loss provides better predictions of body composition changes in such patients...
  17. doi Modeling weight-loss maintenance to help prevent body weight regain
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
    Am J Clin Nutr 88:1495-503. 2008
    ..Such a tool would be helpful for goal-setting, because obese patients and their physicians could assess at the outset of an intervention whether long-term adherence to the calculated lifestyle change is realistic...
  18. pmc Computational modeling of cancer cachexia
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 5621, USA
    Curr Opin Clin Nutr Metab Care 11:214-21. 2008
    ..Thus, models of cancer-associated weight loss are an important tool for helping to understand this debilitating condition...
  19. pmc What is the required energy deficit per unit weight loss?
    K D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
    Int J Obes (Lond) 32:573-6. 2008
    ..International Journal of Obesity (2008) 32, 573-576; doi:10.1038/sj.ijo.0803720; published online 11 September 2007...
  20. pmc Dynamic coordination of macronutrient balance during infant growth: insights from a mathematical model
    Peter N Jordan
    Laboratory of Biological Modeling, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
    Am J Clin Nutr 87:692-703. 2008
    ..Although previous investigators have focused on energy requirements for normal growth, little is known about the dynamic coordination of macronutrient balance...
  21. pmc Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets
    Juen Guo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5370. 2009
    ....
  22. doi Models use leptin and calculus to count calories
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 5621, USA
    Cell Metab 9:3-4. 2009
    ..Work in this issue of Cell Metabolism (Tam et al., 2009) applies similar modeling strategies to explore the control of murine energy and body weight homeostasis by leptin...