J R Hailey

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Classification of proliferative hepatocellular lesions in harlan sprague-dawley rats chronically exposed to dioxin-like compounds
    James R Hailey
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:165-74. 2005
  2. ncbi request reprint Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies
    J R Hailey
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:602-11. 1998
  3. ncbi request reprint Inhalation toxicity and carcinogenicity studies of cobalt sulfate
    J R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 49:56-67. 1999
  4. ncbi request reprint Effects of glutaraldehyde in a 2-year inhalation study in rats and mice
    A P van Birgelen
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina Battelle Pacific Northwest, Richland, Washington
    Toxicol Sci 55:195-205. 2000
  5. ncbi request reprint Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in F344/N rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:267-78. 1999
  6. ncbi request reprint Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice
    N B Ress
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:287-96. 2003
  7. ncbi request reprint Two-year and lifetime toxicity and carcinogenicity studies of ozone in B6C3F1 mice
    R A Herbert
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:539-48. 1996
  8. ncbi request reprint Chronic nephropathy and renal carcinogenicity of o-benzyl-p-chlorophenol in F344/N rats and B6C3F1 mice
    D S Marsman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Fundam Appl Toxicol 27:252-62. 1995
  9. ncbi request reprint Body weight-tumor incidence correlations in long-term rodent carcinogenicity studies
    J K Haseman
    Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:256-63. 1997
  10. ncbi request reprint Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies
    R C Sills
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:589-99. 1999

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Classification of proliferative hepatocellular lesions in harlan sprague-dawley rats chronically exposed to dioxin-like compounds
    James R Hailey
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:165-74. 2005
    ..This paper describes the morphology of these lesions, as well as the diagnostic approach taken in this series of studies...
  2. ncbi request reprint Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies
    J R Hailey
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:602-11. 1998
    ..hepaticus and that hepatitis may be important in the pathogenesis. Therefore, interpretation of carcinogenic effects in the liver of B6C3F1 mice may be confounded if there is H. hepaticus-associated hepatitis...
  3. ncbi request reprint Inhalation toxicity and carcinogenicity studies of cobalt sulfate
    J R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 49:56-67. 1999
    ..Adrenal pheochromocytomas were increased in female rats, and possibly in male rats...
  4. ncbi request reprint Effects of glutaraldehyde in a 2-year inhalation study in rats and mice
    A P van Birgelen
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina Battelle Pacific Northwest, Richland, Washington
    Toxicol Sci 55:195-205. 2000
    ..However, exposure to glutaraldehyde resulted in considerable non-neoplastic lesions in the noses of rats and mice...
  5. ncbi request reprint Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in F344/N rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:267-78. 1999
    ..These data, when considered as a whole, are interpreted as indicating that chronic exposure to pure linearly polarized 60 Hz magnetic fields has little or no effect on cancer development in the F344/N rat...
  6. ncbi request reprint Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice
    N B Ress
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:287-96. 2003
    ..5 mg/m3 (dust) (National Institute for Occupational Safety and Health, NIOSH Pocket Guide to Chemical Hazards, U.S. Department of Health and Human Services, Washington, DC, 1997, p. 328)...
  7. ncbi request reprint Two-year and lifetime toxicity and carcinogenicity studies of ozone in B6C3F1 mice
    R A Herbert
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:539-48. 1996
    ..5 or 1.0 ppm of ozone for 2 yrs, which persist with continued exposure to 30 mo. It is uncertain whether or not the marginal increase (p > 0.05) of alveolar/bronchiolar neoplasms in male B6C3F1 mice resulted from exposure to ozone...
  8. ncbi request reprint Chronic nephropathy and renal carcinogenicity of o-benzyl-p-chlorophenol in F344/N rats and B6C3F1 mice
    D S Marsman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Fundam Appl Toxicol 27:252-62. 1995
    ....
  9. ncbi request reprint Body weight-tumor incidence correlations in long-term rodent carcinogenicity studies
    J K Haseman
    Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:256-63. 1997
    ..However, the high negative correlation between pituitary gland and testis tumors in male Fischer-344 rats cannot be dismissed so easily, does not reflect tumor lethality, and is currently being studied further...
  10. ncbi request reprint Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies
    R C Sills
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:589-99. 1999
    ....
  11. ncbi request reprint The association between severe nephropathy and pheochromocytoma in the male F344 rat -- the National Toxicology Program experience
    A Nyska
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:456-62. 1999
    ..The possible correlation between the severity of CPN and the incidence of pheochromocytoma may influence interpretation of carcinogenic effects observed at this site...
  12. ncbi request reprint The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenicity studies
    S L Eustis
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 22:457-72. 1994
    ..For these sex-species groups, there were only two instances, both involving male mice, in which the additional data confirmed an association with kidney neoplasia...
  13. ncbi request reprint Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:899-904. 1999
    ..This study does not support the hypothesis that magnetic field exposure can promote breast cancer in this rat model...
  14. ncbi request reprint Disseminated thrombosis and bone infarction in female rats following inhalation exposure to 2-butoxyethanol
    A Nyska
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:287-94. 1999
    ..In conclusion, exposure to 500 ppm BE vapors caused acute disseminated thrombosis and bone infarction in female rats. Possible pathogenic mechanisms are discussed...
  15. ncbi request reprint Alteration in cell kinetics in control B6C3F1 mice infected with Helicobacter hepaticus
    A Nyska
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:591-6. 1997
    ..Furthermore, the absence of enhanced cell proliferation in lungs and kidneys of male and females suggests that neoplastic effects at these sites are not exacerbated by H. hepaticus infection...
  16. ncbi request reprint An update of the National Toxicology Program database on nasal carcinogens
    J K Haseman
    Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mutat Res 380:3-11. 1997
    ....
  17. ncbi request reprint Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 56:4922-6. 1996
    ..One of the sites for neoplasm that is of particular concern is the ovary, and epidemiology studies are under way to identify any potential effects of phenolphthalein exposure at this site in humans...
  18. ncbi request reprint A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 rats
    T Suwa
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:467-78. 2001
    ..Inflammation was also present in the ampullary glands. We suggest an optimal embedment and trimming method in rat prostate and seminal vesicle to ensure adequate, consistent sampling...
  19. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated citral in rats and mice
    N B Ress
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 71:198-206. 2003
    ..However, the incidences were within the NTP historical control range and could not be clearly related to citral administration...
  20. ncbi request reprint Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update
    J K Haseman
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:428-41. 1998
    ..However, it is essential that the study being evaluated be comparable to those in the NTP database with respect to those factors that are known to influence tumor occurrence...
  21. pmc Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds"
    Nigel J Walker
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27705, USA
    Environ Health Perspect 113:43-8. 2005
    ..These data support the use of the TEF approach for dioxin cancer risk assessments...
  22. ncbi request reprint Inhalation toxicology and carcinogenesis studies of propylene glycol mono-t-butyl ether in rats and mice
    Adriana M Doi
    National Institute of Environmental Health Sciences, 79 Alexander Dr, Mail Drop EC 34, Research Triangle Park, NC 27709, USA
    Toxicology 199:1-22. 2004
    ..Exposure to PGMBE also produced increases in hepatic tumors in male and female mice...
  23. ncbi request reprint The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats
    John C Seely
    Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:681-6. 2002
    ..This marginal association suggests that the number of RTCNs that may develop secondary to chemically exacerbated nephropathy would be few...
  24. pmc alpha 2u-globulin nephropathy and renal tumors in national toxicology program studies
    Adriana M Doi
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:533-40. 2007
    ....
  25. ncbi request reprint Chemicals associated with decreases in the incidence of mononuclear cell leukemia in the Fischer rat
    M R Elwell
    Experimental Toxicology Program, National Institute of Environmental Health Sciences, USA
    Toxicol Pathol 24:238-45. 1996
    ....
  26. ncbi request reprint Topical application of representative multifunctional acrylates produced proliferative and inflammatory lesions in F344/N rats and B6C3F1 mice, and squamous cell neoplasms in Tg.AC mice
    Adriana M Doi
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:631-40. 2005
    ..Although chronic inflammation might have contributed to the development of the skin lesions, the dose-related nature of the induction of the skin papillomas in Tg.AC mice by TMPTA and PETA may reflect a potential for carcinogenicity...
  27. ncbi request reprint Association of adrenal pheochromocytoma and lung pathology in inhalation studies with particulate compounds in the male F344 rat--the National Toxicology Program experience
    Keisuke Ozaki
    Laboratory of Experimental Pathology National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:263-70. 2002
    ..Our investigation assessed the strength of these various associations and supports the possible roles of 2 chronic pulmonary lesions-fibrosis and inflammation-and hypoxemia in the induction of pheochromocytoma in the F344 male rat...
  28. ncbi request reprint Hepatoblastomas in mice in the US National Toxicology Program (NTP) studies
    Vladimir S Turusov
    NN Blokhin Cancer Research Centre, Moscow, Russian Federation
    Toxicol Pathol 30:580-91. 2002
    ..Therefore, it seems reasonable to combine the incidence of mice with hepatoblastomas and the incidence of mice with hepatocellular carcinomas in hazard identification studies...