Research Topics
| G L HagerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Dynamics of gene targeting and chromatin remodelling by nuclear receptorsG L Hager
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
Biochem Soc Trans 28:405-10. 2000..The results both in vitro and in vivo are consistent with a dynamic model ('hit and run') in which GR first binds to chromatin after ligand activation, recruits a remodelling activity and is then lost from the template...- Protein dynamics in the nuclear compartmentGordon L Hager
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
Curr Opin Genet Dev 12:137-41. 2002..Two countervailing views of factor/regulatory site interactions emerge from the current literature... - Chromatin dynamics and the evolution of alternate promoter statesGordon L Hager
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Building 41, Room B602, Bethesda, MD 20892 5055, USA
Chromosome Res 14:107-16. 2006..Potential mechanisms involved in the unexpectedly rapid flux of factor/template interactions are discussed in the context of a "return-to-template" model for transcription factor function... 
Large-scale chromatin decondensation and recondensation regulated by transcription from a natural promoterW G Muller
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, 41 Library Dr, Bethesda, MD 20892, USA
J Cell Biol 154:33-48. 2001..They also support fiber-packing models of higher order structure and suggest that transcription from a natural promoter may occur at much higher DNA-packing densities than reported previously...- The glucocorticoid receptor: rapid exchange with regulatory sites in living cellsJ G McNally
Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, Bethesda, MD 20892 5055, USA
Science 287:1262-5. 2000..Thus, the interaction of regulatory proteins with target sites in chromatin is a more dynamic process than previously believed... - Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimerasC S Lim
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
Mol Endocrinol 13:366-75. 1999..The causes for and implications of this differential localization of the A and B forms of the human PR are discussed... - Intranuclear trafficking and gene targeting by members of the steroid/nuclear receptor superfamilyG L Hager
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892 5055, USA
J Steroid Biochem Mol Biol 65:125-32. 1998.... - Nuclear cytoplasmic shuttling by thyroid hormone receptors. multiple protein interactions are required for nuclear retentionC T Baumann
Laboratory of Receptor Biology and Gene Expression, NCI and Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, NIDDKD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:11237-45. 2001.... - The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasomeC T Baumann
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health Bethesda, Maryland 20892-5055, USA
Mol Endocrinol 15:485-500. 2001..These findings suggest the intriguing possibility that degradation of GRIP1 by the 26S proteasome may be a key component of its regulation... - A glucocorticoid/retinoic acid receptor chimera that displays cytoplasmic/nuclear translocation in response to retinoic acid. A real time sensing assay for nuclear receptor ligandsS Mackem
Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:45501-4. 2001.... - Characterization of transiently and constitutively expressed progesterone receptors: evidence for two functional statesC L Smith
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Endocrinol 14:956-71. 2000.... - Differential activity of progesterone and glucocorticoid receptors on mouse mammary tumor virus templates differing in chromatin structureC L Smith
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
J Biol Chem 272:14227-35. 1997..These differences may provide a mechanism for establishing target gene specificity in vivo for steroid receptors that recognize and bind to identical DNA sequences... - Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laserT S Karpova
CCR Core Fluorescence Imaging Facility, Laboratory of Receptor Biology and Gene Expression, NCI, National Institutes of Health, Bethesda, MD 20892, USA
J Microsc 209:56-70. 2003..In summary, we extensively characterize a simple approach to FRET that should be adaptable to most laser-scanning confocal microscopes, and demonstrate its feasibility for detecting FRET between several CFP/YFP partners... - Selective intranuclear redistribution of PPAR isoforms by RXR alphaTaro E Akiyama
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Endocrinol 16:707-21. 2002..These results implicate RXR alpha in the nuclear reorganization of PPAR gamma and suggest that PPAR gamma colocalizes with RXR alpha at specific locations within the nucleus independent of added ligand... - Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitroGeetha V Rayasam
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, National Cancer Institute, National Institutes of Health, 41 Library Dr, Bethesda, MD 20892 5055, USA
Mol Cell Biol 25:2406-18. 2005.... - Molecular chaperones function as steroid receptor nuclear mobility factorsCem Elbi
Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
Proc Natl Acad Sci U S A 101:2876-81. 2004..Thus, our results provide a description of soluble nuclear mobility factors and furthermore demonstrate a previously unrecognized role for molecular chaperones in the regulation of steroid receptor function within the nucleus... - A novel in situ assay for the identification and characterization of soluble nuclear mobility factorsCem Elbi
Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, Bethesda, MD 20892-5055, USA
Sci STKE 2004:pl10. 2004..This assay can readily be adapted to identify and characterize other nuclear mobility factors... - Hormone-induced translocation of thyroid hormone receptors in living cells visualized using a receptor green fluorescent protein chimeraX G Zhu
Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 273:27058-63. 1998..Furthermore, the inability of the mutant TR to translocate to the nucleus correlated with the loss of most of its transcriptional activity. These results suggest that TR functions may, in part, be regulated by T3-induced nuclear entry... - Characterization of an NF-1/CTF family member as a functional activator of the mouse mammary tumor virus long terminal repeat 5' enhancerP Kusk
Laboratory of Receptor Biology and Gene Expression, NCI, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
J Biol Chem 271:31269-76. 1996..We conclude that the F3 activity represents a new member of the NF-1/CTF family... 
Visualizing chromatin dynamics in intact cellsTy C Voss
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, National Cancer Institute, NIH Bethesda, MD 20892 5055, USA
Biochim Biophys Acta 1783:2044-51. 2008..In this review we discuss how dynamic interactions allow transcriptional regulatory proteins find their targets within the nucleus, alter target chromatin structure, and modulate physiological gene expression...- Interaction of the glucocorticoid receptor with the chromatin landscapeSam John
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
Mol Cell 29:611-24. 2008..Furthermore, the widespread requirement for chromatin remodeling supports the recent hypothesis that the rapid exchange of receptor proteins occurs during nucleosome reorganization... - Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneityTy C Voss
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
J Cell Sci 122:345-56. 2009.... - Dynamic access of the glucocorticoid receptor to response elements in chromatinAnuja A George
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
Int J Biochem Cell Biol 41:214-24. 2009..In this review we discuss the dynamics of a nuclear receptor, and its transcriptional response in the chromatin context... - UV laser cross-linking: a real-time assay to study dynamic protein/DNA interactions during chromatin remodelingAkhilesh K Nagaich
Laboratory of Receptor Biology and Gene Expression, Bldg 41 Room B602, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-5055, USA
Sci STKE 2004:pl13. 2004.... - Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cellsMyong Hee Sung
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Room B602, Bldg 41, 41 Library Dr, Bethesda, MD 20892, USA
Mol Pharmacol 74:1215-22. 2008.... - Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoterThomas A Johnson
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
Mol Biol Cell 19:3308-22. 2008..Our data provide a kinetic and mechanistic basis for the BRG1 and BRM chromatin-remodeling complexes in regulating gene expression at a steroid hormone inducible promoter... - Dynamics of nuclear receptor movement and transcriptionGordon L Hager
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Building 41, Room B602, 41 Library Dr MSC 5055, Bethesda, MD 20892 5055, USA
Biochim Biophys Acta 1677:46-51. 2004..Several processes are implicated in rapid nuclear dynamics, including potential roles for molecular chaperones, the proteasome degradation machinery and chromatin remodeling complexes... - Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profilesMyong Hee Sung
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 4:e7163. 2009..We propose that negative feedback loops do not simply terminate signaling, but rather promote oscillations of NF-kappaB in the nucleus, and these oscillations are functionally advantageous... - Dynamic shuttling and intranuclear mobility of nuclear hormone receptorsPadma Maruvada
Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:12425-32. 2003..They also show that ligand-binding and protein-protein interactions can affect the intracellular mobility of some NRs and thereby may contribute to their biological activity... - Transcription dynamicsGordon L Hager
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell 35:741-53. 2009..Its dynamic nature is not only a fundamental property of the transcription machinery, but it is emerging as an important modulator of physiological processes, particularly in differentiation and development... - Characterization of the human glucocorticoid receptor promoterY Nobukuni
Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biochemistry 34:8207-14. 1995..Our studies demonstrate that several transcription factors are involved in regulating GR expression and that AP2 could function as an important positive regulator of GR promoter activity... - ATP-dependent mobilization of the glucocorticoid receptor during chromatin remodelingTerace M Fletcher
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
Mol Cell Biol 22:3255-63. 2002.... - Subnuclear trafficking and gene targeting by steroid receptorsAkhilesh K Nagaich
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA
Ann N Y Acad Sci 1024:213-20. 2004..We also find that receptor mobility in the nucleoplasm is strongly enhanced by molecular chaperones. These observations indicate that multiple mechanisms are involved in transient receptor interactions with nucleoplasmic targets... - Recruitment of dioxin receptor to active transcription sitesCem Elbi
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
Mol Biol Cell 13:2001-15. 2002..These results indicate that AhR/ARNT complexes are recruited to specific subnuclear compartments in a ligand-dependent manner and that these foci represent the sites of AhR target genes... - Development of assays for nuclear receptor modulators using fluorescently tagged proteinsElisabeth D Martinez
Laboratory of Receptor Biology and Gene Expression, Hormone Action and Oncogenesis Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Methods Enzymol 414:37-50. 2006..This approach has been validated for both the estrogen receptor and the retinoic acid receptor and should be applicable to any member of the superfamily, facilitating the identification of new ligands and selective receptor modulators... - Rapid periodic binding and displacement of the glucocorticoid receptor during chromatin remodelingAkhilesh K Nagaich
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell 14:163-74. 2004..These results indicate that enhancement of hSWI/SNF-mediated factor accessibility, a hallmark of chromatin remodeling, is in some cases transient, reversible, and periodic... - Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcriptionDiana A Stavreva
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
Nat Cell Biol 11:1093-102. 2009..The GR signalling pathway has been optimized for a prompt and timely response to fluctuations in hormone levels, indicating that biologically accurate regulation of gene targets by GR requires an ultradian mode of hormone stimulation... - Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomesDiana A Stavreva
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute Light Imaging Facility, National Institute for Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
Mol Cell Biol 24:2682-97. 2004..Moreover, our results reveal that longer GR residence times are consistently associated with greater transcriptional output, suggesting a new paradigm in which the rate of rapid exchange provides a means to tune transcriptional levels... - High-yield purification of functionally active glucocorticoid receptorT M Fletcher
Laboratory of Receptor Biology and Gene Expression, NCI, NIH, Bethesda, MD, USA
Methods Mol Biol 176:55-65. 2001 - Glucocorticoid receptor dynamics and gene regulationSimon C Biddie
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
Stress 12:193-205. 2009..This finding has led to a paradigm shift in our understanding of receptor function throughout the genome. The mechanisms involved in these rapid exchange events, as well as the implications for receptor function, are discussed... - Genome-wide mechanisms of nuclear receptor actionSimon C Biddie
Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, 41 Library Dr, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
Trends Endocrinol Metab 21:3-9. 2010..These mechanisms contribute importantly to the action of nuclear receptors in health and disease... - Kinetic complexity of the global response to glucocorticoid receptor actionSam John
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
Endocrinology 150:1766-74. 2009..Thus, the cellular response to GR stimulation involves a highly orchestrated series of regulatory actions and not simply a binary response to hormone... - Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactionsOfir Hakim
Laboratory of Receptor Biology and Gene Expression, NCI, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
J Biol Chem 284:6048-52. 2009..The strong correlation between gene expression and loop structure in different cell lines suggests that high order interactions play a role in determining tissue-specific gene regulation... - 3D shortcuts to gene regulationOfir Hakim
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Curr Opin Cell Biol 22:305-13. 2010..Thus the spatial architecture of the genome has attracted a lot of interest and has intensified its significance in modern cell biology. Here we discuss current methods, concepts, and controversies in this rapidly evolving field... - Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitroAndrea K Robertson
Epigenetic Gene Regulation and Cancer Section, LRBGE NCI NIH, Bldg 41, Rm C306, 41 Library Dr, Bethesda, MD 20892, USA
Biochem Biophys Res Commun 322:110-8. 2004..These findings raise interesting implications about the interactions of mammalian DNA methyltransferases with chromatin and provide the first evidence that a chromatin remodeling enzyme can alter the biological properties of a DNMT... - An estrogen receptor chimera senses ligands by nuclear translocationElisabeth D Martinez
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health (NIH, Bethesda, MD 20892-5055, USA
J Steroid Biochem Mol Biol 97:307-21. 2005..The translocation properties of this chimera can be utilized in high content screens for novel estrogen receptor modulators... - HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcriptionYi Qiu
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Building 41, B602, Bethesda, Maryland 20892, USA
Mol Cell 22:669-79. 2006..These findings indicate that HDAC1 is required for the induction of some genes by the GR, and this activator function is dynamically modulated by acetylation... - Expanding horizons for nuclear receptorsMalgorzata Wiench
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
EMBO Rep 11:569-71. 2010..The meeting covered all aspects of regulation by nuclear receptors and provided a good orientation for investigators new to the area, as well as a timely update for those with long tenure in the field... - High-content fluorescence-based screening for epigenetic modulatorsElisabeth D Martinez
Laboratory of Receptor Biology and Gene Expression, Hormone Action and Oncogenesis Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Methods Enzymol 414:21-36. 2006..Furthermore, options for evaluating the mechanism of action of these compounds are presented and principles to govern the choice of hit compounds for the development of leads are discussed... - Differential in vivo binding dynamics of somatic and oocyte-specific linker histones in oocytes and during ES cell nuclear transferMatthias Becker
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biol Cell 16:3887-95. 2005..These results provide the first mechanistic insights into the crucial step of linker histone replacement as it occurs during fertilization and somatic cell nuclear transfer... - Single-cell analysis of glucocorticoid receptor action reveals that stochastic post-chromatin association mechanisms regulate ligand-specific transcriptionTy C Voss
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-5055, USA
Mol Endocrinol 20:2641-55. 2006.... - NSD1 is essential for early post-implantation development and has a catalytically active SET domainGeetha Vani Rayasam
Laboratory of Receptor Biology and Gene Expression, National Institutes of Health, Bethesda, MD 20892, USA
EMBO J 22:3153-63. 2003..We have also examined the enzymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase activity with specificity for Lys36 of histone H3 (H3-K36) and Lys20 of histone H4 (H4-K20)... - Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damageKathleen M Dohoney
Basic Research Laboratory, Virus Tumor Biology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Oncogene 23:49-57. 2004..Furthermore, in vitro phosphatase assays show that PP2A dephosphorylates p53 at S37. These results suggest that dephosphorylation of p53 at S37 plays a role in the transcriptional regulation of the p53 protein in response to DNA damage... - Dynamic behavior of transcription factors on a natural promoter in living cellsMatthias Becker
Laboratory of Receptor Biology and Gene Expression, Building 41 Room B602, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5055, USA
EMBO Rep 3:1188-94. 2002..Our results indicate that GR and GRIP-1 as components of the activating complex are in a dynamic equilibrium with the promoter, and must return to the template many times during the course of transcriptional activation... - 2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant miceJung im Huh
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 41, 41 Medlars Drive, Bethesda, MD 20892, USA
Endocrinology 148:1266-77. 2007..These data demonstrate that 2ME(2) can induce a partial differentiation of the mammary gland through mechanisms that differ from those normally used during pregnancy... - Ligand-specific dynamics of the androgen receptor at its response element in living cellsTove I Klokk
Department of Molecular Biosciences, University of Oslo, Postboks 1041 Blindern, 0316 Oslo, Norway
Mol Cell Biol 27:1823-43. 2007..These data provide a kinetic and mechanistic basis for regulation of gene expression by androgens and antiandrogens in living cells... - Imaging in situ protein-DNA interactions in the cell nucleus using FRET-FLIMFrédéric G E Cremazy
Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Kruislaan 318, 1098 SM Amsterdam, The Netherlands
Exp Cell Res 309:390-6. 2005..The method was successfully applied to the DNA-binding proteins histone H2B and the glucocorticoid receptor and to the heterochromatin-associated proteins HP1alpha and HP1beta... - Formation of higher-order secondary and tertiary chromatin structures by genomic mouse mammary tumor virus promotersPhilippe T Georgel
Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
Genes Dev 17:1617-29. 2003..These results suggest that transcriptionally active eukaryotic promoters may function in a locally folded chromatin environment in vivo... - Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancerKemal S Korkmaz
Department of Biology and the Biotechnology Centre of Oslo, University of Oslo, Postboks 1050 Blindern, 0316 Oslo, Norway
J Biol Chem 277:36689-96. 2002..Taken together, these data suggest that STAMP1 may have an important role in the normal prostate cell as well as in prostate cancer progression... - Glucocorticoid receptor domain requirements for chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter in different nucleoprotein contextsErika Krasnickas Keeton
Department of Genetics, George Washington University, Washington, DC, USA
J Biol Chem 277:28247-55. 2002..Within a particular cellular environment the GR appears to possess a significant degree of versatility in the mechanism by which it activates a target promoter... - Glutaraldehyde modified mica: a new surface for atomic force microscopy of chromatinHongda Wang
Department of Physics and Astronomy, Arizona State University, Tempe, AZ 85287, USA
Biophys J 83:3619-25. 2002..We foresee many important applications for this surface in future atomic force microscopy studies of chromatin... - Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubinsMarie Knockaert
C.N.R.S, Cell Cycle Group and UPS-2682, Station Biologique, BP 74, 29682 Roscoff Cedex, Bretagne, France
Oncogene 23:4400-12. 2004..In contrast, kinase inhibition, rather than AhR activation, represents the main mechanism underlying the cytotoxic properties of this class of promising antitumor molecules... - Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancerCeren G Korkmaz
Department of Molecular Biosciences, University of Oslo, Postboks 1050 Blindern, 0316 Oslo, Norway
Oncogene 24:4934-45. 2005..Taken together, these data suggest that STAMP2 may contribute to the normal biology of the prostate cell, as well as prostate cancer progression... - Actin-dependent intranuclear repositioning of an active gene locus in vivoMiroslav Dundr
Department of Cell Biology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
J Cell Biol 179:1095-103. 2007..In the presence of a dominant-negative mutant of beta-actin, the repositioning of activated U2 genes is markedly inhibited. This supports a model in which nuclear actin is required for these rapid, long-range chromosomal movements... - The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand releaseSebastiaan H Meijsing
Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, Room GH S574, San Francisco, CA 94107 2280, USA
Mol Cell Biol 27:2442-51. 2007..Overall, these studies showed that activities impinging on the LBD regulate GR exchange with GREs but that the dissociation of GR from GREs is independent from ligand dissociation...