Genomes and Genes
C R Haft
Affiliation: National Institutes of Health
- Characterization of Drosophila insulin receptor substrateR M Poltilove
Diabetes Branch, NIDDKD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:23346-54. 2000..Taken together with published genetic studies, these biochemical data support the hypothesis that dIRS functions directly downstream from the insulin receptor in Drosophila...
- Identification of a family of sorting nexin molecules and characterization of their association with receptorsC R Haft
Diabetes Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 18:7278-87. 1998..Our demonstration of a large conserved family of sorting nexins that interact with a variety of receptor types suggests that these proteins may be involved in several stages of intracellular trafficking in mammalian cells...
- Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexesC R Haft
Diabetes Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
Mol Biol Cell 11:4105-16. 2000..In the absence of hVps35, neither hVps26 nor hVps29 is found in the large complex. These data provide the first insights into the binding interactions among subunits of a putative mammalian retromer complex...
- Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein traffickingV A Barr
Diabetes Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Traffic 1:904-16. 2000..Both the morphological and biochemical data indicate that SNX15 plays a crucial role in trafficking through the endocytic pathway. This is the first demonstration that a mammalian SNX protein is involved in protein trafficking...
- Identification and characterization of SNX15, a novel sorting nexin involved in protein traffickingS A Phillips
Diabetes Branch, NIDDK National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 276:5074-84. 2001....
- Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulinN Perrotti
Diabetes Branch, Division of Intramural Research, NIDDK, Bethesda, Maryland 20892, USA
J Biol Chem 276:9406-12. 2001..Cross-talk among these signaling pathways may play an important role in the pathogenesis of the hypertension associated with hyperinsulinemia, obesity, and insulin resistance...