Colleen Hadigan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Increased prevalence of albuminuria in HIV-infected adults with diabetes
    Peter S Kim
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24610. 2011
  2. pmc A1C underestimates glycemia in HIV infection
    Peter S Kim
    Department of Infectious Diseases, Washington Hospital Center, Washington, DC, USA
    Diabetes Care 32:1591-3. 2009
  3. ncbi request reprint Magnetic resonance spectroscopy of hepatic lipid content and associated risk factors in HIV infection
    Colleen Hadigan
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:312-7. 2007
  4. pmc Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia
    Colleen Hadigan
    Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:4438-44. 2006
  5. doi request reprint Hepatitis C virus infection and coinfection with human immunodeficiency virus: challenges and advancements in management
    Colleen Hadigan
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 306:294-301. 2011
  6. ncbi request reprint Inhibition of lipolysis improves insulin sensitivity in protease inhibitor-treated HIV-infected men with fat redistribution
    Colleen Hadigan
    Neuroendocrine Unit and the Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Clin Nutr 77:490-4. 2003
  7. pmc Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhood
    David Dimock
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Metabolism 60:874-80. 2011
  8. ncbi request reprint Relation of body composition to body mass index in HIV-infected patients with metabolic abnormalities
    Tisha Joy
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 47:174-84. 2008
  9. ncbi request reprint Psoas muscle attenuation measurement with computed tomography indicates intramuscular fat accumulation in patients with the HIV-lipodystrophy syndrome
    Martin Torriani
    Division of Musculoskeletal Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Appl Physiol (1985) 95:1005-10. 2003
  10. ncbi request reprint Sustained benefits of metformin therapy on markers of cardiovascular risk in human immunodeficiency virus-infected patients with fat redistribution and insulin resistance
    Colleen Hadigan
    Neuroendocrine Unit and Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:4611-5. 2002

Collaborators

Detail Information

Publications39

  1. pmc Increased prevalence of albuminuria in HIV-infected adults with diabetes
    Peter S Kim
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24610. 2011
    ..HIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes...
  2. pmc A1C underestimates glycemia in HIV infection
    Peter S Kim
    Department of Infectious Diseases, Washington Hospital Center, Washington, DC, USA
    Diabetes Care 32:1591-3. 2009
    ..The objective of this study was to determine the relationship between A1C and glycemia in HIV infection...
  3. ncbi request reprint Magnetic resonance spectroscopy of hepatic lipid content and associated risk factors in HIV infection
    Colleen Hadigan
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:312-7. 2007
    ..Liver-related illness is increasingly recognized as a source of morbidity in HIV-infected patients. Fatty infiltration of the liver is potentially an important consequence of HIV and treatment with antiretroviral (ARV) therapy...
  4. pmc Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia
    Colleen Hadigan
    Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:4438-44. 2006
    ..Metabolic abnormalities such as hypertriglyceridemia remain a challenge for optimizing long-term health in HIV-infected patients...
  5. doi request reprint Hepatitis C virus infection and coinfection with human immunodeficiency virus: challenges and advancements in management
    Colleen Hadigan
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 306:294-301. 2011
    ..These advances may translate into more effective treatment and management of patients with chronic HCV and HIV coinfection in the years ahead...
  6. ncbi request reprint Inhibition of lipolysis improves insulin sensitivity in protease inhibitor-treated HIV-infected men with fat redistribution
    Colleen Hadigan
    Neuroendocrine Unit and the Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Clin Nutr 77:490-4. 2003
    ..Fatty acid concentrations are increased in patients with HIV and fat redistribution and may contribute to insulin resistance in this population...
  7. pmc Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhood
    David Dimock
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Metabolism 60:874-80. 2011
    ..002). Impaired glucose tolerance, insulin resistance, dyslipidemia, and microalbuminuria are common among young adults with HIV. Long-term exposure to therapy may translate into substantial persistent metabolic risk...
  8. ncbi request reprint Relation of body composition to body mass index in HIV-infected patients with metabolic abnormalities
    Tisha Joy
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 47:174-84. 2008
    ..To determine visceral adiposity (VAT), subcutaneous adiposity (SAT), and regional body adipose differences between HIV-infected and non-HIV-infected subjects in relation to body mass index (BMI) and World Health Organization BMI categories...
  9. ncbi request reprint Psoas muscle attenuation measurement with computed tomography indicates intramuscular fat accumulation in patients with the HIV-lipodystrophy syndrome
    Martin Torriani
    Division of Musculoskeletal Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Appl Physiol (1985) 95:1005-10. 2003
    ..Further studies are needed to assess the mechanisms and consequences of intramuscular lipid accumulation in HIV-infected patients...
  10. ncbi request reprint Sustained benefits of metformin therapy on markers of cardiovascular risk in human immunodeficiency virus-infected patients with fat redistribution and insulin resistance
    Colleen Hadigan
    Neuroendocrine Unit and Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:4611-5. 2002
    ..These data demonstrate a sustained benefit of metformin treatment to reduce hyperinsulinemia and certain markers of cardiovascular disease risk in patients with HIV infection and lipodystrophy...
  11. ncbi request reprint Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patients
    Susan D Driscoll
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:2171-8. 2004
    ..Reduction in muscle adiposity may be an important mechanism by which exercise improves hyperinsulinemia in this population...
  12. ncbi request reprint Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era
    Tisha Joy
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AIDS 21:1591-600. 2007
    ..To evaluate dietary intake and its relationship to lipid parameters in HIV-infected patients with metabolic abnormalities...
  13. ncbi request reprint Metabolic effects of rosiglitazone in HIV lipodystrophy: a randomized, controlled trial
    Colleen Hadigan
    Massachusetts General Hospital and Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
    Ann Intern Med 140:786-94. 2004
    ....
  14. ncbi request reprint Rosiglitazone increases small dense low-density lipoprotein concentration and decreases high-density lipoprotein particle size in HIV-infected patients
    Colleen Hadigan
    National Institute of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA
    AIDS 21:2543-6. 2007
    ..These data indicate the production of a more atherogenic lipid profile with rosiglitazone, a consideration when selecting treatment for the growing population of HIV-infected patients with type 2 diabetes and dyslipidemia...
  15. ncbi request reprint Increased rates of lipolysis among human immunodeficiency virus-infected men receiving highly active antiretroviral therapy
    Colleen Hadigan
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Metabolism 51:1143-7. 2002
    ..These data demonstrate increased rates of lipolysis and increased total FFA levels in HIV-infected subjects and suggest that increased lipolysis may contribute to insulin resistance in this patient population...
  16. ncbi request reprint Increased cardiovascular disease risk indices in HIV-infected women
    Sara E Dolan
    Program in Nutritional Metabolism, General Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 39:44-54. 2005
    ..HIV-infected women demonstrate significantly increased risk factors for cardiovascular disease in association with abnormal fat distribution...
  17. pmc Decreased respiratory quotient in relation to resting energy expenditure in HIV-infected and noninfected subjects
    Kathleen V Fitch
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, MA 02114, USA
    Metabolism 58:608-15. 2009
    ..Overall r(2) was equal to 0.825 and P was less than .0001 for the model. These data suggest that alterations in substrate metabolism may contribute to increased REE in HIV-infected patients compared with control subjects...
  18. doi request reprint Markers of endothelial dysfunction, coagulation and tissue fibrosis independently predict venous thromboembolism in HIV
    Laura W Musselwhite
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
    AIDS 25:787-95. 2011
    ..We investigated the relationship between venous thrombosis and HIV-related characteristics, traditional risk factors of hypercoagulability, and pre-event levels of biomarkers...
  19. pmc Pilot study of pioglitazone before HCV retreatment in HIV/HCV genotype 1-infected subjects with insulin resistance and previous nonresponse to peginterferon and ribavirin therapy: A5239
    Kristen M Marks
    Division of Infectious Diseases, Weill Cornell Medical College, New York, NY Harvard School of Public Health, Boston, MA Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD Division of Infectious Diseases, University of California San Francisco Medical School, San Francisco, CA Medical Service, Department of Veterans Affairs, San Francisco, CA and HIV AIDS Division, San Francisco General Hospital, University of California, San Francisco, CA
    J Acquir Immune Defic Syndr 65:345-9. 2014
    ..29, lower limit of the exact 1-sided 90% confidence interval 5.9%). Over the 24 weeks of PIO monotherapy, alanine aminotransferase and aspartate aminotransferase declined significantly and correlated with improved metabolic parameters. ..
  20. ncbi request reprint Body-composition measurements as predictors of glucose and insulin abnormalities in HIV-positive men
    Gary Meininger
    Neuroendocrine Unit, the Program in Nutritional Metabolism, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Am J Clin Nutr 76:460-5. 2002
    ..Fat redistribution and metabolic abnormalities are seen increasingly in HIV-positive patients. However, the degree to which abnormalities in fat distribution predict glucose and insulin concentrations in these patients remains unknown...
  21. pmc Microalbuminuria in HIV disease
    Colleen Hadigan
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Department of Critical Care Medicine, NIH, Bethesda, MD, USA
    Am J Nephrol 37:443-51. 2013
    ....
  22. ncbi request reprint Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone
    Daniel Kamin
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:3423-6. 2005
    ..Further investigation into the physiological role of this peroxisome proliferator-activated receptor-gamma-responsive adipocytokine in the metabolic abnormalities associated with HIV is warranted...
  23. pmc Abnormal cardiac strain in children and young adults with HIV acquired in early life
    Amy Sims
    Department of Cardiology, Children s National Medical Center, Washington, District of Columbia, USA
    J Am Soc Echocardiogr 25:741-8. 2012
    ..There is, however, evidence of myocardial abnormalities in adults with HIV. Cardiac strain analysis may detect impairment in cardiac function that may be missed by conventional measurements in this population...
  24. pmc Non-calcified coronary plaque volume inversely related to CD4(+) T-cell count in HIV infection
    Horacio Duarte
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 17:763-7. 2012
    ..Non-calcified coronary artery plaque (NCAP) might be an important predictor of cardiovascular events; however, few studies have directly measured NCAP in HIV-infected individuals...
  25. pmc Coronary artery abnormalities in Hyper-IgE syndrome
    Alexandra F Freeman
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, 10 Center Drive, Bethesda, MD 20892 1899, USA
    J Clin Immunol 31:338-45. 2011
    ..Coronary artery abnormalities have been reported infrequently. We aimed to determine the frequency and characteristics of coronary artery abnormalities...
  26. doi request reprint Cardiovascular complications in children with HIV infection
    Amy Sims
    Pediatric Cardiology, Children s National Medical Center, Washington, DC 20010, USA
    Curr HIV/AIDS Rep 8:209-14. 2011
    ..Recently, however, investigators are exploring new cardiovascular health challenges that face children living with HIV, and developing strategies to lower the cardiovascular disease risk for these children...
  27. pmc Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection
    Emily S Ford
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS 24:1509-17. 2010
    ..In this retrospective, case-control study of HIV-infected individuals, we investigated the association of traditional cardiac risk factors, HIV-related disease, and inflammation with CVD events...
  28. pmc Noninvasive coronary imaging for atherosclerosis in human immunodeficiency virus infection
    Ahmed M Gharib
    Biomedical and Metabolic Imaging Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
    Curr Probl Diagn Radiol 40:262-7. 2011
    ..Application of these techniques may prove very useful in the study of atherosclerosis in many diseases, such as HIV...
  29. ncbi request reprint Elevated concentrations of free fatty acids are associated with increased insulin response to standard glucose challenge in human immunodeficiency virus-infected subjects with fat redistribution
    Gary Meininger
    Department of Pathology, Massachusetts General Hospital and Children s Hospital, Boston, MA 02114, USA
    Metabolism 51:260-6. 2002
    ..Further studies are necessary to determine the mechanism of increased fatty acid concentrations and the role played by increased FFA in mediating insulin resistance in this population...
  30. ncbi request reprint Dietary habits and their association with metabolic abnormalities in human immunodeficiency virus-related lipodystrophy
    Colleen Hadigan
    Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Clin Infect Dis 37:S101-4. 2003
    ....
  31. pmc High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life
    Irene J Mikhail
    National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892 1662, USA
    Pediatr Infect Dis J 30:710-2. 2011
    ..More than 50% of participants (14/27) had evidence of CAA. Individuals had a high rate of CAA, suggesting possible early atherosclerosis...
  32. ncbi request reprint Hyperlipidemia in children with HIV infection: an emerging problem
    Daniel Kamin
    Massachusetts General Hospital, Boston 02114, USA
    Expert Rev Cardiovasc Ther 1:143-50. 2003
    ....
  33. ncbi request reprint Prediction of coronary heart disease risk in HIV-infected patients with fat redistribution
    Colleen Hadigan
    Program in Nutritional Metabolism, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Clin Infect Dis 36:909-16. 2003
    ..Therefore, although CHD risk is increased in HIV-infected patients with fat redistribution, the pattern of fat distribution and sex are potential important components in determining the risk in this population...
  34. pmc Gemfibrozil concentrations are significantly decreased in the presence of lopinavir-ritonavir
    Kristin H Busse
    Clinical Pharmacokinetics Research Laboratory, Pharmacy Department, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 52:235-9. 2009
    ..The objective of this study was to determine the influence of a 2-week course of lopinavir-ritonavir on the pharmacokinetics of the triglyceride-lowering agent, gemfibrozil...
  35. pmc Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease
    Virginia A Triant
    Massachusetts General Hospital Program in Nutritional Metabolism, Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:2506-12. 2007
    ..Metabolic changes and smoking are common among HIV patients and may confer increased cardiovascular risk...
  36. ncbi request reprint Alanine aminotransferase levels predict insulin resistance in HIV lipodystrophy
    Raymond T Chung
    J Acquir Immune Defic Syndr 34:534-6. 2003
  37. ncbi request reprint HIV Infection: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Dankwart Wittenberg
    J Pediatr Gastroenterol Nutr 39:S640-6. 2004
  38. ncbi request reprint Insulin resistance among HIV-infected patients: unraveling the mechanism
    Colleen Hadigan
    Clin Infect Dis 41:1341-2. 2005