Jack M Guralnik

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery
    J M Guralnik
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 55:M221-31. 2000
  2. ncbi request reprint The ratio of older women to men: historical perspectives and cross-national comparisons
    J M Guralnik
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA
    Aging (Milano) 12:65-76. 2000
  3. pmc Reduced midlife physical functioning among never married and childless men: evidence from the 1946 British birth cohort study
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Room 3C 309, Bethesda, MD 20892, USA
    Aging Clin Exp Res 21:174-81. 2009
  4. ncbi request reprint Robine and Michel's "Looking forward to a general theory on population aging": population aging across time and cultures: can we move from theory to evidence?
    Jack M Guralnik
    National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
    J Gerontol A Biol Sci Med Sci 59:M606-8; author reply M616-20. 2004
  5. ncbi request reprint Childhood socioeconomic status predicts physical functioning a half century later
    Jack M Guralnik
    Laboratory of Epidemiology, Demography aand Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 61:694-701. 2006
  6. ncbi request reprint Assessing the building blocks of function: utilizing measures of functional limitation
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    Am J Prev Med 25:112-21. 2003
  7. pmc Medical and long-term care costs when older persons become more dependent
    Jack M Guralnik
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Public Health 92:1244-5. 2002
  8. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
  9. pmc Proinflammatory state, hepcidin, and anemia in older persons
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Blood 115:3810-6. 2010
  10. ncbi request reprint Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery
    J M Guralnik
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 55:M221-31. 2000
    ....
  2. ncbi request reprint The ratio of older women to men: historical perspectives and cross-national comparisons
    J M Guralnik
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA
    Aging (Milano) 12:65-76. 2000
    ..Changes in survival probability in middle and late life, rather than childhood and young adulthood, have been responsible for the increased number of women compared to men in the older population...
  3. pmc Reduced midlife physical functioning among never married and childless men: evidence from the 1946 British birth cohort study
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Room 3C 309, Bethesda, MD 20892, USA
    Aging Clin Exp Res 21:174-81. 2009
    ..The goal of this study is to investigate the extent to which marital and parental role characteristics are associated with midlife physical function...
  4. ncbi request reprint Robine and Michel's "Looking forward to a general theory on population aging": population aging across time and cultures: can we move from theory to evidence?
    Jack M Guralnik
    National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
    J Gerontol A Biol Sci Med Sci 59:M606-8; author reply M616-20. 2004
  5. ncbi request reprint Childhood socioeconomic status predicts physical functioning a half century later
    Jack M Guralnik
    Laboratory of Epidemiology, Demography aand Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 61:694-701. 2006
    ..Relating childhood socioeconomic environment to midlife functional status provides a life course perspective on childhood factors associated with poor and good health status later in life...
  6. ncbi request reprint Assessing the building blocks of function: utilizing measures of functional limitation
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    Am J Prev Med 25:112-21. 2003
    ..Functional limitation measures add substantially to our knowledge about older populations, but further work is needed to promote their standardization and use in both clinical and research settings...
  7. pmc Medical and long-term care costs when older persons become more dependent
    Jack M Guralnik
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Public Health 92:1244-5. 2002
  8. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
    ..Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro-inflammatory markers and low lymphocyte counts...
  9. pmc Proinflammatory state, hepcidin, and anemia in older persons
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Blood 115:3810-6. 2010
    ..Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation...
  10. ncbi request reprint Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005
    ..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin...
  11. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
    ..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia...
  12. pmc The relationship between plasma carotenoids and depressive symptoms in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    World J Biol Psychiatry 13:588-98. 2012
    ..We examined the cross-sectional and longitudinal relationship between plasma carotenoids and depressive symptoms over a 6-year follow-up in older persons...
  13. ncbi request reprint Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:278-83. 2006
    ....
  14. pmc Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892 9205, USA
    Br J Haematol 145:514-23. 2009
    ..In conclusion, the haemoglobin threshold below which mortality rises significantly is a full g/dl lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans...
  15. pmc Association between hormones and metabolic syndrome in older Italian men
    Marcello Maggio
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:1832-8. 2006
    ....
  16. pmc Red cell distribution width and mortality in older adults: a meta-analysis
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:258-65. 2010
    ..Whether RDW is prognostic in more representative community-based populations is unclear...
  17. pmc Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study
    Marcello Maggio
    National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Arch Intern Med 167:2249-54. 2007
    ..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders...
  18. ncbi request reprint Frailty, hospitalization, and progression of disability in a cohort of disabled older women
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
    Am J Med 118:1225-31. 2005
    ..To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability...
  19. pmc Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study
    Sari Stenholm
    Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Clin Endocrinol (Oxf) 73:55-65. 2010
    ..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons...
  20. pmc Characteristics of 400-meter walk test performance and subsequent mortality in older adults
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    Rejuvenation Res 12:177-84. 2009
    ..We conclude that multiple aspects of performance in the 400-meter walk test provide complementary information on mortality prognosis in older persons...
  21. ncbi request reprint Incidence of loss of ability to walk 400 meters in a functionally limited older population
    Milan Chang
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 52:2094-8. 2004
    ..To assess the incidence of and factors related to nondisabled but functionally limited older adults aged 75 to 85 years losing the ability to walk 400 m...
  22. pmc Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine
    Sandra V Giannelli
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Am Geriatr Soc 55:816-23. 2007
    ....
  23. pmc Fatigue in a representative population of older persons and its association with functional impairment, functional limitation, and disability
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    J Gerontol A Biol Sci Med Sci 64:76-82. 2009
    ..The aim of the present study was to evaluate fatigue and its association with measures of physical function and disability in a representative sample of the older population...
  24. ncbi request reprint Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging Study
    Stefano Volpato
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Diabetes Care 26:70-5. 2003
    ..We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes...
  25. pmc Oxidative stress is associated with greater mortality in older women living in the community
    Richard D Semba
    Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1421-5. 2007
    ..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community...
  26. ncbi request reprint Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism
    Taina Rantanen
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Am Geriatr Soc 51:636-41. 2003
    ....
  27. pmc Mediterranean diet and mobility decline in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Exp Gerontol 46:303-8. 2011
    ..High adherence to a Mediterranean-style diet is associated with a slower decline of mobility over time in community-dwelling older persons. If replicated, this observation is highly relevant in terms of public health...
  28. pmc Midlife physical activity and mobility in older age: The InCHIANTI study
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Am J Prev Med 31:217-24. 2006
    ....
  29. ncbi request reprint Renal function, erythropoietin, and anemia of older persons: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Arch Intern Med 165:2222-7. 2005
    ..We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels...
  30. ncbi request reprint The origins of age-related proinflammatory state
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Longitudinal Studies Section, Clinical Research Branch, ASTRA Unit, Harbor Hospital 5th Floor, 3001 S Hanover St, Baltimore, MD, USA
    Blood 105:2294-9. 2005
    ..Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity...
  31. pmc Disparities in influenza vaccine coverage in the United States, 2008
    Shauna T Linn
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA
    J Am Geriatr Soc 58:1333-40. 2010
    ..To determine the distribution of influenza vaccine coverage in the United States in 2008...
  32. pmc Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study
    Sari Stenholm
    National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, Maryland 21225, USA
    Rejuvenation Res 13:3-11. 2010
    ..This study aims to examine whether high levels of multiple catabolic and low levels of multiple anabolic biomarkers predict accelerated decline of muscle strength...
  33. pmc Association of executive function and performance of dual-task physical tests among older adults: analyses from the InChianti study
    Antonia K Coppin
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Age Ageing 35:619-24. 2006
    ..previous studies have reported an association between cognitive function and physical performance, particularly among older adults...
  34. ncbi request reprint Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 91:439-46. 2006
    ..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established...
  35. ncbi request reprint Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study)
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 96:991-5. 2005
    ..In conclusion, these findings suggest that leptin may directly stimulate the production of CRP independent of fat-cell produced cytokines in older adults...
  36. ncbi request reprint Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  37. pmc Serum 25-hydroxyvitamin D and depressive symptoms in older women and men
    Yuri Milaneschi
    Longitudinal Studies Section, National Institute on Aging, Clinical Research Branch, Harbor Hospital Center, Room NM540, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 95:3225-33. 2010
    ..Hypovitaminosis D and depressive symptoms are common conditions in older adults...
  38. pmc Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort
    Kathryn R Martin
    Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20814, USA
    BMC Musculoskelet Disord 14:219. 2013
    ..We examined the associations of midlife kOA with body mass index (BMI) and activity exposure across adult life and their interaction...
  39. pmc Racial variation in the relationship of anemia with mortality and mobility disability among older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, Bethesda, MD 20892, USA
    Blood 109:4663-70. 2007
    ..Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse events, indicating that alternative criteria are warranted...
  40. pmc Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study
    Marcello Maggio
    National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 292:E353-8. 2007
    ..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS...
  41. ncbi request reprint Just get out the door! Importance of walking outside the home for maintaining mobility: findings from the women's health and aging study
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 53:198-203. 2005
    ..To determine the association between volitional walking behavior and change in walking ability and lower extremity function over 1 year in functionally limited older women...
  42. ncbi request reprint Patterns of functional decline at the end of life
    June R Lunney
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    JAMA 289:2387-92. 2003
    ..Clinicians have observed various patterns of functional decline at the end of life, but few empirical data have tested these patterns in large populations...
  43. pmc Associations between lower extremity ischemia, upper and lower extremity strength, and functional impairment with peripheral arterial disease
    Mary M McDermott
    Department of Medicine, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 56:724-9. 2008
    ..To determine whether poorer strength may mediate poorer lower extremity performance in persons with lower arterial brachial index (ABI) levels...
  44. pmc Interleukin-6 in aging and chronic disease: a magnificent pathway
    Marcello Maggio
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:575-84. 2006
    ....
  45. ncbi request reprint Low socioeconomic status and disability in old age: evidence from the InChianti study for the mediating role of physiological impairments
    Antonia K Coppin
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C 309, Bethesda, MD 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 61:86-91. 2006
    ..The purpose of this study was to determine if SES has an impact on mobility functioning and to explore which physiological impairments are also associated with SES and may explain its relationship with mobility...
  46. ncbi request reprint Relation of heart rate at rest and mortality in the Women's Health and Aging Study
    Milan Chang
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Cardiol 92:1294-9. 2003
    ..In patients with and without heart disease, further investigation of cardiovascular status may be warranted if their HR is >/=90 beats/min...
  47. pmc Red blood cell distribution width and the risk of death in middle-aged and older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Ste 3C309, Bethesda, MD 20814, USA
    Arch Intern Med 169:515-23. 2009
    ..In patients with symptomatic cardiovascular disease (CVD), RDW is associated with mortality. However, it has not been demonstrated that RDW is a predictor of mortality independent of nutritional deficiencies or in the general population...
  48. pmc Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
    Avner Shahar
    Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA
    Mov Disord 25:1909-15. 2010
    ..Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction...
  49. ncbi request reprint The frailty syndrome: a critical issue in geriatric oncology
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Crit Rev Oncol Hematol 46:127-37. 2003
    ..Improvements in the definition of the frailty syndrome may profit from the clinical experience of oncologists...
  50. ncbi request reprint A flame burning within
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD, USA
    Aging Clin Exp Res 16:240-3. 2004
    ..Given that the inflammatory response is a critical age-related process, understanding its regulatory action is essential in avoiding hazardous consequences in old age...
  51. ncbi request reprint Differential effects of premorbid physical and emotional health on recovery from acute events
    Glenn V Ostir
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Am Geriatr Soc 50:713-8. 2002
    ..The aim of this study is to determine whether premorbid emotional health is predictive of recovery in functional ability 1 year after reporting a stroke, heart attack, or hip fracture (event)...
  52. pmc Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 57:260-5. 2009
    ..To examine the association between stopping to rest during a 400-m usual-pace walk test (400-MWT) and incident mobility disability in older persons with functional limitations...
  53. pmc Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
    ..The ELOVL2 SNP was associated with docosapentanoic and DHA but not with EPA in GOLDN. These findings show that polymorphisms of genes encoding enzymes in the metabolism of PUFA contribute to plasma concentrations of fatty acids...
  54. ncbi request reprint Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological disease
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
    Am J Med 116:807-15. 2004
    ..To estimate the prevalence of neurological signs and their association with limitations in mobility and falls in a sample of older persons without known neurological disease...
  55. pmc Menopausal characteristics and physical functioning in older adulthood in the National Health and Nutrition Examination Survey III
    Sarah E Tom
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA
    Menopause 19:283-9. 2012
    ..We hypothesized that natural menopause would be related to better physical functioning compared with surgical menopause and that later age at menopause would be related to better physical functioning...
  56. ncbi request reprint Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia
    Jack M Guralnik
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
    Blood 104:2263-8. 2004
    ..The impact of anemia on quality of life, recovery from illness, and functional abilities must be further investigated in older persons...
  57. pmc Driving life expectancy of persons aged 70 years and older in the United States
    Daniel J Foley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Public Health 92:1284-9. 2002
    ..We estimated total life expectancy and driving life expectancy of US drivers aged 70 years and older...
  58. pmc Translating research to promote healthy aging: the complementary role of longitudinal studies and clinical trials
    Jack M Guralnik
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 58:S337-42. 2010
    ..Relevant issues are illustrated with examples of unsuccessful and successful trials, with a major emphasis on clinical trials of physical activity in older persons...
  59. pmc Epidemiology of aging
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, MD, USA
    Radiol Clin North Am 46:643-52, v. 2008
    ..We come to this enormous challenge unprepared...
  60. pmc Seat belt use among American Indians/Alaska Natives and non-Hispanic whites
    Andrea N Garcia
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    Am J Prev Med 33:200-6. 2007
    ..The purpose of this study was to examine geographic variation and the existence of a seat belt law on seat belt use among AI/AN and non-Hispanic whites (NHW)...
  61. ncbi request reprint Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life
    David Melzer
    Demography and Biometry Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    Aging Clin Exp Res 15:60-6. 2003
    ..in people aged 65 and over who died in the US in 1993, and to measure mobility outcomes during their last year of life...
  62. doi request reprint Weight loss and premature death: the 1946 british birth cohort study
    Emiliano Albanese
    Laboratory of Population Science, National Institute on Aging, Bethesda, Maryland, United States of America
    PLoS ONE 9:e86282. 2014
    ..We aimed to study the association between midlife weight change and mortality accounting for health and lifestyle characteristics, and also considering potential bias due to preexisting chronic diseases and smoking status...
  63. ncbi request reprint Comorbidities and impairments explaining the association between diabetes and lower extremity disability: The Women's Health and Aging Study
    Stefano Volpato
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
    Diabetes Care 25:678-83. 2002
    ....
  64. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  65. pmc Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
    ..This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PDE8B may thus provide a candidate target for the treatment of thyroid dysfunction...
  66. ncbi request reprint Does lower-extremity arterial disease predict future falling among older men and women?
    Adnan Arseven
    Department of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA
    Angiology 58:725-33. 2007
    ..Future study is needed to determine whether reduced levels of physical activity among patients with PAD account for the lower rate of falling observed here...
  67. ncbi request reprint Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
    J Am Geriatr Soc 55:1836-41. 2007
    ..To assess the association between physical activity and subsequent physical functioning in middle-aged adults across a range of body mass index (BMI) categories...
  68. pmc From chronic low back pain to disability, a multifactorial mediated pathway: the InCHIANTI study
    Angelo Di Iorio
    Department of Medicine and Sciences of Aging, Laboratory of Clinical Epidemiology, University G d Annunzio Chieti, Italy
    Spine (Phila Pa 1976) 32:E809-15. 2007
    ..Clinicoepidemiologic study in the Chianti area (Tuscany, Italy)...
  69. pmc Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Aging Clin Exp Res 19:259-64. 2007
    ..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality...
  70. pmc Corridor-based functional performance measures correlate better with physical activity during daily life than treadmill measures in persons with peripheral arterial disease
    Mary M McDermott
    Departments of Medicine and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Vasc Surg 48:1231-7, 1237.e1. 2008
    ..To compare associations of physical activity during daily life with treadmill walking performance and corridor-based functional performance measures in persons with lower extremity peripheral arterial disease (PAD)...
  71. ncbi request reprint Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    Anne R Cappola
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2019-25. 2003
    ..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
  72. ncbi request reprint Physical activity in prefrail older adults: confidence and satisfaction related to physical function
    W Jack Rejeski
    Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    J Gerontol B Psychol Sci Soc Sci 63:P19-26. 2008
    ..This is an important finding in light of the importance of these process variables in behavior change and quality of life...
  73. pmc Oxidative protein damage is associated with poor grip strength among older women living in the community
    Caitlin Howard
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Appl Physiol (1985) 103:17-20. 2007
    ..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults...
  74. ncbi request reprint Association between anemia and physical disability in older patients: role of comorbidity
    Cinzia Maraldi
    Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    Aging Clin Exp Res 18:485-92. 2006
    ..We evaluated the relationship between anemia and physical disability in a sample of older hospitalized patients, taking into account the role of comorbidity...
  75. ncbi request reprint Validation of the Late-Life Function and Disability Instrument
    Stephen P Sayers
    Human Physiology Laboratory, Department of Health Sciences, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:1554-9. 2004
    ..To assess the concurrent and predictive validity of the Late-Life Function and Disability Instrument (LLFDI)...
  76. ncbi request reprint Cognitive decline in high-functioning older persons is associated with an increased risk of hospitalization
    Joshua Chodosh
    VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    J Am Geriatr Soc 52:1456-62. 2004
    ..To examine hospital use for patients with evidence of cognitive decline indicative of early cognitive impairment...
  77. ncbi request reprint A pilot exercise intervention to improve lower extremity functioning in peripheral arterial disease unaccompanied by intermittent claudication
    Mary M McDermott
    Northwestern University s Feinberg School of Medicine, Chicago, Ill, USA
    J Cardiopulm Rehabil 24:187-96. 2004
    ..A pilot study was conducted to test the feasibility of supervised treadmill exercise training to improve functioning in study participants with peripheral arterial disease who did not have classical symptoms of intermittent claudication...
  78. ncbi request reprint The Israeli kibbutz as a venue for reduced disability in old age: lessons from the Cross-sectional and Longitudinal Aging Study (CALAS)
    Adrian Walter-Ginzburg
    Herczeg Institute on Aging, Tel Aviv University, Tel Aviv, Israel
    Soc Sci Med 59:389-403. 2004
    ....
  79. ncbi request reprint Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:719-24. 2004
    ..To examine the association between anemia and disability, physical performance, and muscle strength in older persons...
  80. ncbi request reprint Sexual satisfaction and risk of disability in older women
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, N C, USA
    J Clin Psychiatry 64:1177-82. 2003
    ....
  81. ncbi request reprint The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Age Ageing 32:619-25. 2003
    ..Evidence of the MOBLI 's responsiveness over time has been presented. Evidence of the predictive validity of the index is needed...
  82. ncbi request reprint Inflammation, hormones, and body composition at a crossroad
    Luigi Ferrucci
    Am J Med 115:501-2. 2003
  83. ncbi request reprint Anemia and decline in physical performance among older persons
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Med 115:104-10. 2003
    ..We examined whether anemia in older persons increases the risk of subsequent decline in physical function, as measured by objective performance-based tests...
  84. ncbi request reprint Mild cognitive deterioration with subcortical features: prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (The InCHIANTI Study)
    Cristina Geroldi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, Brescia, Italy
    J Am Geriatr Soc 51:1064-71. 2003
    ..To identify subjects with minimal or mild nonamnestic cognitive impairment with parkinsonian stance and gait and investigate vascular correlates of this condition...
  85. ncbi request reprint D-dimer, inflammatory markers, and lower extremity functioning in patients with and without peripheral arterial disease
    Mary Mcgrae McDermott
    Department of Medicine, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
    Circulation 107:3191-8. 2003
    ..We determined whether higher levels of D-dimer, C-reactive protein (CRP), fibrinogen, and serum amyloid A are associated independently with functional impairment in patients with and without peripheral arterial disease (PAD)...
  86. ncbi request reprint Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy
    Am J Physiol Endocrinol Metab 284:E481-7. 2003
    ..This mechanism may explain why IL-6 is a strong risk factor for disability...
  87. pmc Disabling symptoms: what do older women report?
    Suzanne G Leveille
    Hebrew Rehabilitation Center for Aged, Boston, Mass 02131 1097, USA
    J Gen Intern Med 17:766-73. 2002
    ..To answer the question, "What do older disabled women report as the main symptoms causing their disability?"..
  88. ncbi request reprint Geriatric Index of Comorbidity: validation and comparison with other measures of comorbidity
    Renzo Rozzini
    Medical Unit for the Acute Care of the Elderly Poliambulanza Hospital Brescia, and Geriatric Research Group, Brescia, Italy
    Age Ageing 31:277-85. 2002
    ..the debate about measures of chronic comorbidity in the elderly is mainly due to the lack of consensus on pathogenetic models...
  89. ncbi request reprint Environmental demands associated with community mobility in older adults with and without mobility disabilities
    Anne Shumway-Cook
    Department of Rehabilitation Medicine, University of Washington, Box 356490, Seattle, WA 98195, USA
    Phys Ther 82:670-81. 2002
    ..This was done in order to identify environmental factors that contribute to mobility disability...
  90. ncbi request reprint What constitutes normal hemoglobin concentration in community-dwelling disabled older women?
    Paulo H M Chaves
    Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
    J Am Geriatr Soc 52:1811-6. 2004
    ....
  91. ncbi request reprint Inflammatory and thrombotic blood markers and walking-related disability in men and women with and without peripheral arterial disease
    Mary M McDermott
    Feinberg School of Medicine, Northwestern University, 675 N St Clair, Chicago, IL 60611, USA
    J Am Geriatr Soc 52:1888-94. 2004
    ..To determine whether higher circulating levels of thrombotic and inflammatory markers are associated with greater disability...
  92. pmc Age-associated declines in complex walking task performance: the Walking InCHIANTI toolkit
    Anne Shumway-Cook
    Department of Rehabilitation Medicine, University of Washington, Seattle, WA 98195, USA
    J Am Geriatr Soc 55:58-65. 2007
    ..To describe a set of complex walking tasks (CWTs) that can be used to evaluate mobility and to characterize age- and sex-specific performance on these tests...
  93. pmc A randomized, controlled trial of disability prevention in frail older patients screened in primary care: the FRASI study. Design and baseline evaluation
    Stefania Bandinelli
    Geriatric Rehabilitation Unit, ASF, Tuscany Regional Health Agency, and Laboratory of Clinical Epidemiology, Italian National Institute of Research and Care of Aging, Firenze, Italy
    Aging Clin Exp Res 18:359-66. 2006
    ..We describe the enrollment and intervention phases of FRASI (FRAilty, Screening and Intervention), a randomized controlled trial aimed at preventing ADL disability in frail older persons screened in primary care...
  94. ncbi request reprint Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study
    Marco Pahor
    Department of Aging and Geriatric Research, College of Medicine, University of Florida, 1329 SW 16th St, Rm 5161, Gainesville, FL 32608, USA
    J Gerontol A Biol Sci Med Sci 61:1157-65. 2006
    ..Our objective was to assess the effect of a comprehensive physical activity (PA) intervention on the SPPB and other physical performance measures...
  95. pmc Low micronutrient levels as a predictor of incident disability in older women
    Benedetta Bartali
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 6301, USA
    Arch Intern Med 166:2335-40. 2006
    ..The role of nutritional status in the disablement process is still unclear. The objective of this study was to assess whether low concentrations of nutrients predict the development and course of disability...
  96. pmc Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study I
    Dae Hyun Kim
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Am Geriatr Soc 54:1751-7. 2006
    ..To examine the independent association between heart rate variability (HRV), a marker of cardiac autonomic function, and cognitive impairment...
  97. pmc Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey
    Elizabeth A Gardener
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Forvie Site, Cambridge, UK
    J Gen Intern Med 21:1091-6. 2006
    ..Lower limb mobility disabilities are well understood in older people, but the causes in middle age have attracted little attention...
  98. ncbi request reprint Anemia in old age is associated with increased mortality and hospitalization
    Brenda W J H Penninx
    EMGO Institute Department of Psychiatry, VU University School of Medicine, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:474-9. 2006
    ..To more fully understand the detrimental health effects of anemia, we examined the relationship of anemia with death and hospitalization outcomes in a large community-based sample of older persons...
  99. pmc Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32608, USA
    Am J Clin Nutr 83:1142-8. 2006
    ..Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes...
  100. ncbi request reprint Self-rated health showed a graded association with frequently used biomarkers in a large population sample
    Marja Jylha
    University of Tampere, School of Public Health, Medisiinarinkatu 3, Tampere, FIN 33014, Finland
    J Clin Epidemiol 59:465-71. 2006
    ..We investigated the association of frequently used biomarkers with self-rated health, and the role of these biomarkers in the association of self-rated health with mortality...
  101. ncbi request reprint D-dimer and inflammatory markers as predictors of functional decline in men and women with and without peripheral arterial disease
    Mary M McDermott
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Geriatr Soc 53:1688-96. 2005
    ..To determine whether higher circulating levels of inflammatory and thrombotic markers are associated with greater decline in lower extremity performance...