Research Topics
Species | Jack M GuralnikSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance batteryJ M Guralnik
Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
J Gerontol A Biol Sci Med Sci 55:M221-31. 2000....- Robine and Michel's "Looking forward to a general theory on population aging": population aging across time and cultures: can we move from theory to evidence?Jack M Guralnik
National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
J Gerontol A Biol Sci Med Sci 59:M606-8; author reply M616-20. 2004 - Childhood socioeconomic status predicts physical functioning a half century laterJack M Guralnik
Laboratory of Epidemiology, Demography aand Biometry, National Institute on Aging, Bethesda, MD 20892, USA
J Gerontol A Biol Sci Med Sci 61:694-701. 2006..Relating childhood socioeconomic environment to midlife functional status provides a life course perspective on childhood factors associated with poor and good health status later in life... - Assessing the building blocks of function: utilizing measures of functional limitationJack M Guralnik
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
Am J Prev Med 25:112-21. 2003..Functional limitation measures add substantially to our knowledge about older populations, but further work is needed to promote their standardization and use in both clinical and research settings... 
Reduced midlife physical functioning among never married and childless men: evidence from the 1946 British birth cohort studyJack M Guralnik
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Room 3C 309, Bethesda, MD 20892, USA
Aging Clin Exp Res 21:174-81. 2009..The goal of this study is to investigate the extent to which marital and parental role characteristics are associated with midlife physical function...- Medical and long-term care costs when older persons become more dependentJack M Guralnik
Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
Am J Public Health 92:1244-5. 2002 - The ratio of older women to men: historical perspectives and cross-national comparisonsJ M Guralnik
Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA
Aging (Milano) 12:65-76. 2000..Changes in survival probability in middle and late life, rather than childhood and young adulthood, have been responsible for the increased number of women compared to men in the older population... - Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markersLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
Br J Haematol 136:849-55. 2007..Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro-inflammatory markers and low lymphocyte counts... - Proinflammatory state, hepcidin, and anemia in older personsLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
Blood 115:3810-6. 2010..Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation... - Proinflammatory state and circulating erythropoietin in persons with and without anemiaLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
Am J Med 118:1288. 2005..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin... - Low testosterone levels and the risk of anemia in older men and womenLuigi Ferrucci
Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
Arch Intern Med 166:1380-8. 2006..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia... - Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI studyAlessandro Ble
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
J Gerontol A Biol Sci Med Sci 61:278-83. 2006..30; 95% confidence interval, 0.10-0.91). CONCLUSIONS: Our findings show an association between low circulating levels of one of the most important components of the human antioxidant system and the presence of frailty... - Association between hormones and metabolic syndrome in older Italian menMarcello Maggio
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 54:1832-8. 2006.... - Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-upKushang V Patel
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892 9205, USA
Br J Haematol 145:514-23. 2009..In conclusion, the haemoglobin threshold below which mortality rises significantly is a full g/dl lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans... - Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) studyMarcello Maggio
National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
Arch Intern Med 167:2249-54. 2007..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders... - Red cell distribution width and mortality in older adults: a meta-analysisKushang V Patel
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
J Gerontol A Biol Sci Med Sci 65:258-65. 2010..Whether RDW is prognostic in more representative community-based populations is unclear... - Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI studySari Stenholm
Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
Clin Endocrinol (Oxf) 73:55-65. 2010..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons... - Characteristics of 400-meter walk test performance and subsequent mortality in older adultsSonja Vestergaard
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
Rejuvenation Res 12:177-84. 2009..We conclude that multiple aspects of performance in the 400-meter walk test provide complementary information on mortality prognosis in older persons... - Frailty, hospitalization, and progression of disability in a cohort of disabled older womenCynthia M Boyd
Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
Am J Med 118:1225-31. 2005..To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability... - Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinineSandra V Giannelli
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
J Am Geriatr Soc 55:816-23. 2007.... - Incidence of loss of ability to walk 400 meters in a functionally limited older populationMilan Chang
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
J Am Geriatr Soc 52:2094-8. 2004..To assess the incidence of and factors related to nondisabled but functionally limited older adults aged 75 to 85 years losing the ability to walk 400 m... - Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging StudyStefano Volpato
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, USA
Diabetes Care 26:70-5. 2003..We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes... - Fatigue in a representative population of older persons and its association with functional impairment, functional limitation, and disabilitySonja Vestergaard
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
J Gerontol A Biol Sci Med Sci 64:76-82. 2009..The aim of the present study was to evaluate fatigue and its association with measures of physical function and disability in a representative sample of the older population... - Renal function, erythropoietin, and anemia of older persons: the InCHIANTI studyAlessandro Ble
Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
Arch Intern Med 165:2222-7. 2005..Whether moderate kidney impairment in older persons is associated with a progressively increasing risk of anemia remains to be determined... - Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI studySari Stenholm
National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, Maryland 21225, USA
Rejuvenation Res 13:3-11. 2010..This study aims to examine whether high levels of multiple catabolic and low levels of multiple anabolic biomarkers predict accelerated decline of muscle strength... - The origins of age-related proinflammatory stateLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Longitudinal Studies Section, Clinical Research Branch, ASTRA Unit, Harbor Hospital 5th Floor, 3001 S Hanover St, Baltimore, MD, USA
Blood 105:2294-9. 2005..Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity... - Midlife physical activity and mobility in older age: The InCHIANTI studyKushang V Patel
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
Am J Prev Med 31:217-24. 2006.... - Mediterranean diet and mobility decline in older personsYuri Milaneschi
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
Exp Gerontol 46:303-8. 2011..High adherence to a Mediterranean-style diet is associated with a slower decline of mobility over time in community-dwelling older persons. If replicated, this observation is highly relevant in terms of public health... - Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanismTaina Rantanen
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
J Am Geriatr Soc 51:636-41. 2003.... - Disparities in influenza vaccine coverage in the United States, 2008Shauna T Linn
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, MD, USA
J Am Geriatr Soc 58:1333-40. 2010..To determine the distribution of influenza vaccine coverage in the United States in 2008... - Oxidative stress is associated with greater mortality in older women living in the communityRichard D Semba
Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
J Am Geriatr Soc 55:1421-5. 2007..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community... - Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study)Alessandro Ble
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Am J Cardiol 96:991-5. 2005..In conclusion, these findings suggest that leptin may directly stimulate the production of CRP independent of fat-cell produced cytokines in older adults... - Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markersLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
J Clin Endocrinol Metab 91:439-46. 2006..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established... - Serum 25-hydroxyvitamin D and depressive symptoms in older women and menYuri Milaneschi
Longitudinal Studies Section, National Institute on Aging, Clinical Research Branch, Harbor Hospital Center, Room NM540, 3001 South Hanover Street, Baltimore, MD 21225, USA
J Clin Endocrinol Metab 95:3225-33. 2010..Hypovitaminosis D and depressive symptoms are common conditions in older adults... - Association of executive function and performance of dual-task physical tests among older adults: analyses from the InChianti studyAntonia K Coppin
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Age Ageing 35:619-24. 2006..Further research is needed to determine whether improvement in executive function abilities translates to better performance on selected complex walking tasks... - Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus reportLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Am Geriatr Soc 52:625-34. 2004.... - The relationship between plasma carotenoids and depressive symptoms in older personsYuri Milaneschi
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
World J Biol Psychiatry 13:588-98. 2012..We examined the cross-sectional and longitudinal relationship between plasma carotenoids and depressive symptoms over a 6-year follow-up in older persons... - Racial variation in the relationship of anemia with mortality and mobility disability among older adultsKushang V Patel
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, Bethesda, MD 20892, USA
Blood 109:4663-70. 2007..Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse events, indicating that alternative criteria are warranted... - Just get out the door! Importance of walking outside the home for maintaining mobility: findings from the women's health and aging studyEleanor M Simonsick
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 53:198-203. 2005..To determine the association between volitional walking behavior and change in walking ability and lower extremity function over 1 year in functionally limited older women... - Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI studyMarcello Maggio
National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
Am J Physiol Endocrinol Metab 292:E353-8. 2007..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS... - Interleukin-6 in aging and chronic disease: a magnificent pathwayMarcello Maggio
Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
J Gerontol A Biol Sci Med Sci 61:575-84. 2006.... - Patterns of functional decline at the end of lifeJune R Lunney
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
JAMA 289:2387-92. 2003..Clinicians have observed various patterns of functional decline at the end of life, but few empirical data have tested these patterns in large populations... - Associations between lower extremity ischemia, upper and lower extremity strength, and functional impairment with peripheral arterial diseaseMary M McDermott
Department of Medicine, National Institute on Aging, Bethesda, Maryland, USA
J Am Geriatr Soc 56:724-9. 2008..To determine whether poorer strength may mediate poorer lower extremity performance in persons with lower arterial brachial index (ABI) levels... - Low socioeconomic status and disability in old age: evidence from the InChianti study for the mediating role of physiological impairmentsAntonia K Coppin
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C 309, Bethesda, MD 20892 9205, USA
J Gerontol A Biol Sci Med Sci 61:86-91. 2006..The purpose of this study was to determine if SES has an impact on mobility functioning and to explore which physiological impairments are also associated with SES and may explain its relationship with mobility... - Relation of heart rate at rest and mortality in the Women's Health and Aging StudyMilan Chang
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Cardiol 92:1294-9. 2003..In patients with and without heart disease, further investigation of cardiovascular status may be warranted if their HR is >/=90 beats/min... - Red blood cell distribution width and the risk of death in middle-aged and older adultsKushang V Patel
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Ste 3C309, Bethesda, MD 20814, USA
Arch Intern Med 169:515-23. 2009..In patients with symptomatic cardiovascular disease (CVD), RDW is associated with mortality. However, it has not been demonstrated that RDW is a predictor of mortality independent of nutritional deficiencies or in the general population... - Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speedAvner Shahar
Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA
Mov Disord 25:1909-15. 2010..Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction... - Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitationsSonja Vestergaard
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
J Am Geriatr Soc 57:260-5. 2009..To examine the association between stopping to rest during a 400-m usual-pace walk test (400-MWT) and incident mobility disability in older persons with functional limitations... - A flame burning withinLuigi Ferrucci
Intramural Research Program, National Institute on Aging, Baltimore, MD, USA
Aging Clin Exp Res 16:240-3. 2004..Given that the inflammatory response is a critical age-related process, understanding its regulatory action is essential in avoiding hazardous consequences in old age... - Differential effects of premorbid physical and emotional health on recovery from acute eventsGlenn V Ostir
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
J Am Geriatr Soc 50:713-8. 2002..The aim of this study is to determine whether premorbid emotional health is predictive of recovery in functional ability 1 year after reporting a stroke, heart attack, or hip fracture (event)... - The frailty syndrome: a critical issue in geriatric oncologyLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Crit Rev Oncol Hematol 46:127-37. 2003..Improvements in the definition of the frailty syndrome may profit from the clinical experience of oncologists... - Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI StudyToshiko Tanaka
MedStar Research Institute, Baltimore, MD, USA
PLoS Genet 5:e1000338. 2009..The ELOVL2 SNP was associated with docosapentanoic and DHA but not with EPA in GOLDN. These findings show that polymorphisms of genes encoding enzymes in the metabolism of PUFA contribute to plasma concentrations of fatty acids... - Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological diseaseLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
Am J Med 116:807-15. 2004..To estimate the prevalence of neurological signs and their association with limitations in mobility and falls in a sample of older persons without known neurological disease... - Menopausal characteristics and physical functioning in older adulthood in the National Health and Nutrition Examination Survey IIISarah E Tom
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA
Menopause 19:283-9. 2012..We hypothesized that natural menopause would be related to better physical functioning compared with surgical menopause and that later age at menopause would be related to better physical functioning... - Epidemiology of agingLuigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, MD, USA
Radiol Clin North Am 46:643-52, v. 2008..We come to this enormous challenge unprepared... - Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of lifeDavid Melzer
Demography and Biometry Laboratory, National Institute on Aging, Bethesda, Maryland, USA
Aging Clin Exp Res 15:60-6. 2003..in people aged 65 and over who died in the US in 1993, and to measure mobility outcomes during their last year of life... - Seat belt use among American Indians/Alaska Natives and non-Hispanic whitesAndrea N Garcia
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
Am J Prev Med 33:200-6. 2007..The purpose of this study was to examine geographic variation and the existence of a seat belt law on seat belt use among AI/AN and non-Hispanic whites (NHW)... - Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemiaJack M Guralnik
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Rm 3C-309, Bethesda, MD 20815, USA
Blood 104:2263-8. 2004..The impact of anemia on quality of life, recovery from illness, and functional abilities must be further investigated in older persons... - Translating research to promote healthy aging: the complementary role of longitudinal studies and clinical trialsJack M Guralnik
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
J Am Geriatr Soc 58:S337-42. 2010..Relevant issues are illustrated with examples of unsuccessful and successful trials, with a major emphasis on clinical trials of physical activity in older persons... - Driving life expectancy of persons aged 70 years and older in the United StatesDaniel J Foley
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
Am J Public Health 92:1284-9. 2002..Because of differences in life expectancy, women require more years of support for transportation, on average, than men after age 70... - Multiple loci influence erythrocyte phenotypes in the CHARGE ConsortiumSanthi K Ganesh
National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
Nat Genet 41:1191-8. 2009..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures... - Comorbidities and impairments explaining the association between diabetes and lower extremity disability: The Women's Health and Aging StudyStefano Volpato
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
Diabetes Care 25:678-83. 2002.... - Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid functionLisette Arnaud-Lopez
Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
Am J Hum Genet 82:1270-80. 2008..This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PDE8B may thus provide a candidate target for the treatment of thyroid dysfunction... - Environmental demands associated with community mobility in older adults with and without mobility disabilitiesAnne Shumway-Cook
Department of Rehabilitation Medicine, University of Washington, Box 356490, Seattle, WA 98195, USA
Phys Ther 82:670-81. 2002..This was done in order to identify environmental factors that contribute to mobility disability... - Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weightIain A Lang
Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom
J Am Geriatr Soc 55:1836-41. 2007..To assess the association between physical activity and subsequent physical functioning in middle-aged adults across a range of body mass index (BMI) categories... - D-dimer, inflammatory markers, and lower extremity functioning in patients with and without peripheral arterial diseaseMary Mcgrae McDermott
Department of Medicine, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
Circulation 107:3191-8. 2003..We determined whether higher levels of D-dimer, C-reactive protein (CRP), fibrinogen, and serum amyloid A are associated independently with functional impairment in patients with and without peripheral arterial disease (PAD)... - Does lower-extremity arterial disease predict future falling among older men and women?Adnan Arseven
Department of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA
Angiology 58:725-33. 2007..Future study is needed to determine whether reduced levels of physical activity among patients with PAD account for the lower rate of falling observed here... - From chronic low back pain to disability, a multifactorial mediated pathway: the InCHIANTI studyAngelo Di Iorio
Department of Medicine and Sciences of Aging, Laboratory of Clinical Epidemiology, University G d Annunzio Chieti, Italy
Spine (Phila Pa 1976) 32:E809-15. 2007..Clinicoepidemiologic study in the Chianti area (Tuscany, Italy)... - Chronic inflammation and the effect of IGF-I on muscle strength and power in older personsMichelangela Barbieri
Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy
Am J Physiol Endocrinol Metab 284:E481-7. 2003..This mechanism may explain why IL-6 is a strong risk factor for disability... - Physical activity in prefrail older adults: confidence and satisfaction related to physical functionW Jack Rejeski
Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
J Gerontol B Psychol Sci Soc Sci 63:P19-26. 2008..This is an important finding in light of the importance of these process variables in behavior change and quality of life... - Musculoskeletal pain and risk for falls in older disabled women living in the communitySuzanne G Leveille
Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 02131, USA
J Am Geriatr Soc 50:671-8. 2002..To determine whether musculoskeletal pain increased risk for falls in older women with disabilities... - Disabling symptoms: what do older women report?Suzanne G Leveille
Hebrew Rehabilitation Center for Aged, Boston, Mass 02131 1097, USA
J Gen Intern Med 17:766-73. 2002..To answer the question, "What do older disabled women report as the main symptoms causing their disability?".. - Corridor-based functional performance measures correlate better with physical activity during daily life than treadmill measures in persons with peripheral arterial diseaseMary M McDermott
Departments of Medicine and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Vasc Surg 48:1231-7, 1237.e1. 2008..To compare associations of physical activity during daily life with treadmill walking performance and corridor-based functional performance measures in persons with lower extremity peripheral arterial disease (PAD)... - Geriatric Index of Comorbidity: validation and comparison with other measures of comorbidityRenzo Rozzini
Medical Unit for the Acute Care of the Elderly Poliambulanza Hospital Brescia, and Geriatric Research Group, Brescia, Italy
Age Ageing 31:277-85. 2002..the debate about measures of chronic comorbidity in the elderly is mainly due to the lack of consensus on pathogenetic models... - Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older womenAnne R Cappola
Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 88:2019-25. 2003..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging... - Mild cognitive deterioration with subcortical features: prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (The InCHIANTI Study)Cristina Geroldi
Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, Brescia, Italy
J Am Geriatr Soc 51:1064-71. 2003..001). LCP with subcortical features was significantly associated with cerebrovascular risk factors (P =.001). CONCLUSION: Gait disturbance and nonamnestic cognitive symptoms might be the consequence of subcortical vascular damage... - Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study IRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Aging Clin Exp Res 19:259-64. 2007..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality... - Executive function correlates with walking speed in older persons: the InCHIANTI studyAlesandro Ble
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
J Am Geriatr Soc 53:410-5. 2005..CONCLUSION: In nondemented older persons, executive function is independently associated with tasks of lower extremity function that require high attentional demand... - Anemia in old age is associated with increased mortality and hospitalizationBrenda W J H Penninx
EMGO Institute Department of Psychiatry, VU University School of Medicine, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
J Gerontol A Biol Sci Med Sci 61:474-9. 2006..To more fully understand the detrimental health effects of anemia, we examined the relationship of anemia with death and hospitalization outcomes in a large community-based sample of older persons... - Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti studyMatteo Cesari
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32608, USA
Am J Clin Nutr 83:1142-8. 2006..Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes... - Self-rated health showed a graded association with frequently used biomarkers in a large population sampleMarja Jylha
University of Tampere, School of Public Health, Medisiinarinkatu 3, Tampere, FIN 33014, Finland
J Clin Epidemiol 59:465-71. 2006..We investigated the association of frequently used biomarkers with self-rated health, and the role of these biomarkers in the association of self-rated health with mortality... - Cognitive decline in high-functioning older persons is associated with an increased risk of hospitalizationJoshua Chodosh
VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
J Am Geriatr Soc 52:1456-62. 2004..To examine hospital use for patients with evidence of cognitive decline indicative of early cognitive impairment... - Validation of the Late-Life Function and Disability InstrumentStephen P Sayers
Human Physiology Laboratory, Department of Health Sciences, Boston University, Boston, Massachusetts, USA
J Am Geriatr Soc 52:1554-9. 2004..To assess the concurrent and predictive validity of the Late-Life Function and Disability Instrument (LLFDI)... - What constitutes normal hemoglobin concentration in community-dwelling disabled older women?Paulo H M Chaves
Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
J Am Geriatr Soc 52:1811-6. 2004.... - Inflammatory and thrombotic blood markers and walking-related disability in men and women with and without peripheral arterial diseaseMary M McDermott
Feinberg School of Medicine, Northwestern University, 675 N St Clair, Chicago, IL 60611, USA
J Am Geriatr Soc 52:1888-94. 2004..To determine whether higher circulating levels of thrombotic and inflammatory markers are associated with greater disability... - D-dimer and inflammatory markers as predictors of functional decline in men and women with and without peripheral arterial diseaseMary M McDermott
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Am Geriatr Soc 53:1688-96. 2005..To determine whether higher circulating levels of inflammatory and thrombotic markers are associated with greater decline in lower extremity performance... - Predictors of combined cognitive and physical declineHal H Atkinson
Roena Kulynych Center for Memory and Cognition Research, Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Am Geriatr Soc 53:1197-202. 2005..To determine the incidence and correlates of combined declines in cognitive and physical performance... - Patterns of inflammation associated with peripheral arterial disease: the InCHIANTI studyMary Mcgrae McDermott
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Am Heart J 150:276-81. 2005..To determine whether peripheral arterial disease is associated with high circulating levels of pro-inflammatory cytokines, independent of confounders... - Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: the Women's Health and Aging Study ICynthia M Boyd
Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 60:888-93. 2005..The objective of this study was to determine whether hospitalization predicts long-term Activities of Daily Living (ADL) dependence in previously ADL independent, although disabled, older women... - A pilot exercise intervention to improve lower extremity functioning in peripheral arterial disease unaccompanied by intermittent claudicationMary M McDermott
Northwestern University's Feinberg School of Medicine, Chicago, Ill, USA
J Cardiopulm Rehabil 24:187-96. 2004..Further study is needed with a larger sample to identify optimal exercise methods that improve lower extremity functioning in men and women with peripheral arterial disease who do not have intermittent claudication... - The Israeli kibbutz as a venue for reduced disability in old age: lessons from the Cross-sectional and Longitudinal Aging Study (CALAS)Adrian Walter-Ginzburg
Herczeg Institute on Aging, Tel Aviv University, Tel Aviv, Israel
Soc Sci Med 59:389-403. 2004.... - Anemia is associated with disability and decreased physical performance and muscle strength in the elderlyBrenda W J H Penninx
Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Am Geriatr Soc 52:719-24. 2004..To examine the association between anemia and disability, physical performance, and muscle strength in older persons... - Anemia and decline in physical performance among older personsBrenda W J H Penninx
Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Am J Med 115:104-10. 2003..We examined whether anemia in older persons increases the risk of subsequent decline in physical function, as measured by objective performance-based tests... - Oxidative protein damage is associated with poor grip strength among older women living in the communityCaitlin Howard
Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Appl Physiol 103:17-20. 2007..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults... - Inflammation, hormones, and body composition at a crossroadLuigi Ferrucci
Am J Med 115:501-2. 2003 - The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE studyDavid Melzer
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Age Ageing 32:619-25. 2003..Evidence of the MOBLI 's responsiveness over time has been presented. Evidence of the predictive validity of the index is needed... - Association between anemia and physical disability in older patients: role of comorbidityCinzia Maraldi
Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
Aging Clin Exp Res 18:485-92. 2006..The disablement process associated with anemia may be partially explained by nutritional and disease-related factors. However, anemia appears to have an independent effect, particularly in subjects with low comorbidity... - Age-associated declines in complex walking task performance: the Walking InCHIANTI toolkitAnne Shumway-Cook
Department of Rehabilitation Medicine, University of Washington, Seattle, WA 98195, USA
J Am Geriatr Soc 55:58-65. 2007..To describe a set of complex walking tasks (CWTs) that can be used to evaluate mobility and to characterize age- and sex-specific performance on these tests... - A randomized, controlled trial of disability prevention in frail older patients screened in primary care: the FRASI study. Design and baseline evaluationStefania Bandinelli
Geriatric Rehabilitation Unit, ASF, Tuscany Regional Health Agency, and Laboratory of Clinical Epidemiology, Italian National Institute of Research and Care of Aging, Firenze, Italy
Aging Clin Exp Res 18:359-66. 2006..Whether such an intervention effectively prevents new disability remains to be confirmed... - Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) studyMarco Pahor
Department of Aging and Geriatric Research, College of Medicine, University of Florida, 1329 SW 16th St, Rm 5161, Gainesville, FL 32608, USA
J Gerontol A Biol Sci Med Sci 61:1157-65. 2006..Our objective was to assess the effect of a comprehensive physical activity (PA) intervention on the SPPB and other physical performance measures... - Low micronutrient levels as a predictor of incident disability in older womenBenedetta Bartali
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 6301, USA
Arch Intern Med 166:2335-40. 2006..The role of nutritional status in the disablement process is still unclear. The objective of this study was to assess whether low concentrations of nutrients predict the development and course of disability...