Affiliation: National Institutes of Health
- Heery C, O Sullivan Coyne G, Madan R, Cordes L, Rajan A, Rauckhorst M, et al. Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial. Lancet Oncol. 2017;18:587-598 pubmed publisher..Based on pharmacokinetics, target occupancy, and immunological analysis, we chose 10 mg/kg every 2 weeks as the dose for further development and phase 3 trials are ongoing. National Cancer Institute and Merck KGaA. ..
- Strauss J, Heery C, Schlom J, Madan R, Cao L, Kang Z, et al. Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFÎ², in Advanced Solid Tumors. Clin Cancer Res. 2018;24:1287-1295 pubmed publisher..Early signs of efficacy are encouraging, and multiple expansion cohorts are ongoing in a range of tumors. Clin Cancer Res; 24(6); 1287-95. Â©2018 AACR. ..
- Bilusic M, Madan R, Gulley J. Immunotherapy of Prostate Cancer: Facts and Hopes. Clin Cancer Res. 2017;23:6764-6770 pubmed publisher..With such concerted efforts, the future of immunotherapy in prostate cancer looks brighter than ever. Clin Cancer Res; 23(22); 6764-70. ©2017 AACR. ..
- Cordes L, Gulley J. Avelumab for the treatment of metastatic Merkel cell carcinoma. Drugs Today (Barc). 2017;53:377-383 pubmed publisher..Serious treatment-related adverse events were reported in 5 patients (6%), but no grade 4 adverse events or treatment-related deaths were reported. Preliminary data evaluating avelumab in chemotherapy-naive patients is also encouraging. ..
- Heery C, Palena C, McMahon S, Donahue R, Lepone L, Grenga I, et al. Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury. Clin Cancer Res. 2017;23:6833-6845 pubmed publisher..Further studies of this vaccine in combination therapies are warranted and planned. Clin Cancer Res; 23(22); 6833-45. ©2017 AACR. ..