Zvi Grossman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Pathogenesis of HIV infection: what the virus spares is as important as what it destroys
    Zvi Grossman
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:289-95. 2006
  2. pmc Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells
    Souheil Antoine Younes
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 9:e1001171. 2011
  3. pmc Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number
    Juan Quiel
    Laboratories of Immunology and Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:3312-7. 2011
  4. ncbi request reprint HIV preferentially infects HIV-specific CD4+ T cells
    Daniel C Douek
    Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
    Nature 417:95-8. 2002
  5. ncbi request reprint Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model
    Avinash Bhandoola
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 17:425-36. 2002
  6. pmc Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    Afam Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 204:2171-85. 2007
  7. ncbi request reprint The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells
    Souheil Antoine Younes
    Laboratoire d Immunologie, Departement de Microbiologie et Immunologie, Universite de Montreal, Montreal, Quebec, Canada
    J Immunol 178:788-97. 2007
  8. ncbi request reprint HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation
    Marie Lise Dion
    Laboratoire d Immunologie, Centre de Recherches du CHUM, Hotel Dieu, Montreal, Quebec H2X 1P1, Canada
    Immunity 21:757-68. 2004
  9. ncbi request reprint Concomitant regulation of T-cell activation and homeostasis
    Zvi Grossman
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Nat Rev Immunol 4:387-95. 2004
  10. ncbi request reprint Immunologic and virologic evolution during periods of intermittent and persistent low-level viremia
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    AIDS 18:981-9. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Pathogenesis of HIV infection: what the virus spares is as important as what it destroys
    Zvi Grossman
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:289-95. 2006
    ....
  2. pmc Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells
    Souheil Antoine Younes
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 9:e1001171. 2011
    ....
  3. pmc Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number
    Juan Quiel
    Laboratories of Immunology and Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:3312-7. 2011
    ....
  4. ncbi request reprint HIV preferentially infects HIV-specific CD4+ T cells
    Daniel C Douek
    Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
    Nature 417:95-8. 2002
    ..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption...
  5. ncbi request reprint Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model
    Avinash Bhandoola
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 17:425-36. 2002
    ....
  6. pmc Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    Afam Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 204:2171-85. 2007
    ....
  7. ncbi request reprint The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells
    Souheil Antoine Younes
    Laboratoire d Immunologie, Departement de Microbiologie et Immunologie, Universite de Montreal, Montreal, Quebec, Canada
    J Immunol 178:788-97. 2007
    ....
  8. ncbi request reprint HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation
    Marie Lise Dion
    Laboratoire d Immunologie, Centre de Recherches du CHUM, Hotel Dieu, Montreal, Quebec H2X 1P1, Canada
    Immunity 21:757-68. 2004
    ..Our findings reveal a substantial reduction in intrathymic proliferation. The analysis also indicates the existence of a compensatory mechanism acting to sustain the numbers of recent thymic emigrants (RTEs) in the periphery...
  9. ncbi request reprint Concomitant regulation of T-cell activation and homeostasis
    Zvi Grossman
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Nat Rev Immunol 4:387-95. 2004
  10. ncbi request reprint Immunologic and virologic evolution during periods of intermittent and persistent low-level viremia
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    AIDS 18:981-9. 2004
    ..The interaction of these factors is not well understood, particularly in the setting of antiretroviral therapy...
  11. pmc HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity
    Souheil Antoine Younes
    Departement de Microbiologie et Immunologie, Universite de Montreal, 2900 Edouard Montpetit Boulevard, Montreal H3T 1J4, Canada
    J Exp Med 198:1909-22. 2003
    ..Our data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-gamma only-producing cells that lack self-renewal capacity...
  12. ncbi request reprint CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load
    Ana E Sousa
    Clinical Immunology Unit Institute of Molecular Medicine, Faculty of Medicine of Lisbon, Lisbon, Portugal
    J Immunol 169:3400-6. 2002
    ....
  13. ncbi request reprint CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?
    Zvi Grossman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nat Med 8:319-23. 2002
  14. ncbi request reprint Immune reconstitution in HIV infection: how to measure thymic function?
    Zvi Grossman
    Clin Immunol 115:115-7. 2005
  15. ncbi request reprint Mathematical modeling of thymopoiesis in HIV infection: real data, virtual data, and data interpretation
    Zvi Grossman
    Clin Immunol 107:137-9. 2003