Research Topics
Genomes and GenesSpecies | Shiv Is GrewalSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Heterochromatin and epigenetic control of gene expressionShiv I S Grewal
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Science 301:798-802. 2003..Finally, an unexpected role for noncoding RNAs and RNA interference in the formation of epigenetic chromatin domains has been uncovered...
RNAi-dependent formation of heterochromatin and its diverse functionsShiv Is Grewal
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Curr Opin Genet Dev 20:134-41. 2010..Recently, heterochromatin factors have been shown to suppress antisense RNAs at euchromatic loci. These findings define conserved pathways that probably have major impact on the epigenetic regulation of eukaryotic genomes...- Transcription and RNA interference in the formation of heterochromatinShiv I S Grewal
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 447:399-406. 2007..Silencing of chromatin might involve trans-acting sources of the crucial small RNAs that carry out RNA interference, but in some cases, transcription of the region to be silenced seems to be required--an apparent contradiction... - Heterochromatin revisitedShiv I S Grewal
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Genet 8:35-46. 2007.... - Regulation of heterochromatin by histone methylation and small RNAsShiv I S Grewal
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Opin Cell Biol 16:230-8. 2004..These new findings define a novel conserved mechanism of heterochromatin formation that is likely to have an impact on all eukaryotic silencing pathways... 
Cell cycle control of centromeric repeat transcription and heterochromatin assemblyEe Sin Chen
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 451:734-7. 2008..Together, these processes probably facilitate heterochromatin maintenance through successive cell divisions...- RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteinsSongtao Jia
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Science 304:1971-6. 2004..These analyses link ATF/CREB family proteins, involved in cellular response to environmental stresses, to nucleation of constitutive heterochromatin... - RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencingKen ichi Noma
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 36:1174-80. 2004..This tethering promotes the processing of transcripts and generation of additional siRNAs for heterochromatin maintenance... - The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeastTakatomi Yamada
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell 20:173-85. 2005.... - Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeatsMartin Zofall
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell 22:681-92. 2006..Our analyses suggest that Swi6/HP1 recruits opposing chromatin-modifying activities, the balancing of which is crucial for heterochromatin maintenance... - Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatinKe Zhang
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Struct Mol Biol 15:381-8. 2008..Our analyses delineate sequential steps for the assembly of heterochromatic domains and suggest that the ability of Clr4 to both 'write' and 'read' H3K9me facilitates heterochromatin maintenance through successive cell divisions... - HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeastMartin Zofall
Laboratory of Biochemistry and Molecular Biology, NCI, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 282:14065-72. 2007..These analyses implicate ubH2B in modulation of heterochromatin, which has important implications for dynamics and many functions associated with heterochromatic structures... - Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genomeHugh P Cam
Laboratory of Molecular Cell Biology, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
Nat Genet 37:809-19. 2005..Our analyses also uncover an important role for the RNAi machinery in maintaining genomic integrity... - RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA productionTomoyasu Sugiyama
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
Proc Natl Acad Sci U S A 102:152-7. 2005..These results not only implicate Rdp1 as an essential component of a self-enforcing RNAi loop but also ascribe a critical role for its RNA-dependent RNA polymerase activity in siRNA production necessary for heterochromatin formation... - Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombinationSongtao Jia
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 119:469-80. 2004..Our analyses implicate heterochromatin in long-range regulatory interactions and suggest that heterochromatin imposes at the mating-type region structural organization that is important for the donor-choice mechanism... - Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAsMartin Zofall
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health Bethesda, Maryland 20892, USA
Nature 461:419-22. 2009..These analyses suggest that as well as performing other functions, H2A.Z is a component of a genome indexing mechanism that cooperates with heterochromatin and RNAi factors to suppress read-through antisense transcripts... - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeastTamas Fischer
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:8998-9003. 2009.... - Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functionsEstelle Nicolas
Laboratory of Molecular Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:35983-8. 2006..Importantly, we show that SWIRM1 is not only required for optimum transcription of its target genes but also display a global role in regulation of antisense transcription... - Host genome surveillance for retrotransposons by transposon-derived proteinsHugh P Cam
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
Nature 451:431-6. 2008.... - SHREC, an effector complex for heterochromatic transcriptional silencingTomoyasu Sugiyama
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 128:491-504. 2007..Our analyses suggest that SHREC regulates nucleosome positioning to assemble higher-order chromatin structures critical for heterochromatin functions... - Transcriptional scaffolds for heterochromatin assemblyHugh P Cam
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 136:610-4. 2009.... - Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protectionEstelle Nicolas
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, US National Institutes of Health NIH, Bethesda, Maryland 20892, USA
Nat Struct Mol Biol 14:372-80. 2007.... - A role for TFIIIC transcription factor complex in genome organizationKen ichi Noma
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 125:859-72. 2006..Our analyses uncover a general genome organization mechanism involving conserved TFIIIC complex... - Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatinSongtao Jia
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Nat Cell Biol 7:1007-13. 2005..These analyses uncover a role for Cul4-based protein ubiquitination in regulating H3K9me and heterochromatin formation... - Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeastFrancisca E Reyes-Turcu
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Curr Opin Genet Dev 22:156-63. 2012..These findings have established that, in addition to coding for proteins, mRNAs also function as signaling molecules that modify chromatin structure by targeting heterochromatin assembly factors... - Retrotransposon Tf1 is targeted to Pol II promoters by transcription activatorsYoung Eun Leem
Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell 30:98-107. 2008..Surprisingly, we found Tf1 contained sequences that activated transcription, and these substituted for elements of the ade6 promoter disrupted by integration... - Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombeStephanie A Morris
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Eukaryot Cell 4:1446-54. 2005..These results, along with our finding that K36 methylation is highly conserved among eukaryotes, imply a conserved role for this modification in the transcription elongation process... - Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeastNobuhiro Nonaka
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113 0033, Japan
Nat Cell Biol 4:89-93. 2002..These data define a conserved function of Swi6/HP1 in recruitment of cohesin to heterochromatic regions, promoting the proper segregation of chromosomes... - Heterochromatin: new possibilities for the inheritance of structureShiv I S Grewal
Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA
Curr Opin Genet Dev 12:178-87. 2002.... - Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modificationsHiromi Nakagawa
Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
Genes Dev 16:1766-78. 2002..These results indicate that the CENP-B homologs act as site-specific nucleation factors for the formation of centromeric heterochromatin by heterochromatin-specific modifications of histone tails... - Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAiThomas A Volpe
Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA
Science 297:1833-7. 2002..We propose that double-stranded RNA arising from centromeric repeats targets formation and maintenance of heterochromatin through RNAi... - Establishment and maintenance of a heterochromatin domainIra M Hall
Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724, USA
Science 297:2232-7. 2002..This work defines sequential requirements for the initiation and propagation of regional heterochromatic domains... - Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeastKen ichi Noma
Cold Spring Harbor Laboratory, P O Box 100, NY 11724, USA
Proc Natl Acad Sci U S A 99:16438-45. 2002.... - Structure of the SET domain histone lysine methyltransferase Clr4Jinrong Min
W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Nat Struct Biol 9:828-32. 2002..The structure provides insights into the architecture of SET domain histone methyltransferases and establishes a paradigm for further characterization of the Clr4 family of epigenetic regulators... - Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrityJun Ichi Nakayama
Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY 11724, USA
EMBO J 22:2776-87. 2003..These results link the MRG family protein Alp13 to histone deacetylation, and suggest that Clr6 and its associated factors are essential for fundamental chromosomal events... - A novel jmjC domain protein modulates heterochromatization in fission yeastNabieh Ayoub
Department of Molecular Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel 91010
Mol Cell Biol 23:4356-70. 2003..Furthermore, overexpression of Epe1 elevates the rate of chromosome loss. We propose that Epe1 helps control chromatin organization by down-regulating the stability of epigenetic marks that govern heterochromatization... - Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeastGurumurthy D Shankaranarayana
Cold Spring Harbor Laboratory, P O Box 100, Cold Spring Harbor, NY 11724, USA
Curr Biol 13:1240-6. 2003..Our findings suggest that the NAD(+)-dependent deacetylase Sir2 plays an important and conserved role in heterochromatin assembly in eukaryotes... - Heterochromatin: silence is goldenSarah C R Elgin
Department of Biology, CB-1229, Washington University, One Brookings Drive, St. Louis, MO 63130, USA
Curr Biol 13:R895-8. 2003 - RNAi-mediated targeting of heterochromatin by the RITS complexAndre Verdel
Department of Cell Biology, Harvard Medical School, Boston, MA02115, USA
Science 303:672-6. 2004..The results suggest a mechanism for the role of the RNAi machinery and small RNAs in targeting of heterochromatin complexes and epigenetic gene silencing at specific chromosomal loci... - Biochemical interactions between proteins and mat1 cis-acting sequences required for imprinting in fission yeastBum Soo Lee
Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
Mol Cell Biol 24:9813-22. 2004..These results suggest that the stimulatory effect of swi1 and swi3 on switching and imprinting occurs through interaction of the Swi1p-Swi3p complex with the mat1 regions... - A discrete class of intergenic DNA dictates meiotic DNA break hotspots in fission yeastGareth A Cromie
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Genet 3:e141. 2007.... - RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeastIra M Hall
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, P.O. Box 100, NY 11724, USA
Proc Natl Acad Sci U S A 100:193-8. 2003..This study demonstrates that the fission yeast RNAi machinery is required for the proper regulation of chromosome architecture during mitosis and meiosis...