Deanna K Greenstein

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:540-9. 2006
  2. ncbi request reprint Dynamic mapping of normal human hippocampal development
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
    Hippocampus 16:664-72. 2006
  3. pmc Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls
    Deanna Greenstein
    Child Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Bethesda MD, USA
    Front Psychiatry 3:53. 2012
  4. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Neuroinflammation 8:101. 2011
  5. pmc Cerebellar development in childhood onset schizophrenia and non-psychotic siblings
    Deanna Greenstein
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD, USA
    Psychiatry Res 193:131-7. 2011
  6. ncbi request reprint Childhood onset schizophrenia: cortical brain abnormalities as young adults
    Deanna Greenstein
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 47:1003-12. 2006
  7. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008
  8. pmc General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study
    Jennifer L Bakalar
    Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 115:12-6. 2009
  9. ncbi request reprint Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 44:925-33. 2005
  10. ncbi request reprint Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcome
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 46:1349-56. 2007

Detail Information

Publications44

  1. ncbi request reprint Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:540-9. 2006
    ..Data from a previous prospective study of lobar volumes in children with attention-deficit/hyperactivity disorder (ADHD) are reexamined using a measure of cortical thickness...
  2. ncbi request reprint Dynamic mapping of normal human hippocampal development
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, Maryland 20892, USA
    Hippocampus 16:664-72. 2006
    ..These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development...
  3. pmc Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls
    Deanna Greenstein
    Child Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Bethesda MD, USA
    Front Psychiatry 3:53. 2012
    ....
  4. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Neuroinflammation 8:101. 2011
    ..We recently reported upregulated brain AA metabolism in 7- to 9-month-old HIV-1 Tg rats. We hypothesized that these HIV-1 Tg rats also would show upregulated brain inflammatory and AA cascade markers and a deficit of synaptic proteins...
  5. pmc Cerebellar development in childhood onset schizophrenia and non-psychotic siblings
    Deanna Greenstein
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD, USA
    Psychiatry Res 193:131-7. 2011
    ..Sibling trajectories may represent a trait marker, although the effect size for volumetric differences in early adulthood may be small...
  6. ncbi request reprint Childhood onset schizophrenia: cortical brain abnormalities as young adults
    Deanna Greenstein
    Child Psychiatry Branch, NIMH NIH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 47:1003-12. 2006
    ....
  7. pmc Remission status and cortical thickness in childhood-onset schizophrenia
    Deanna K Greenstein
    Child Psychiatry Branch, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892 1600, USA
    J Am Acad Child Adolesc Psychiatry 47:1133-40. 2008
    ..We hypothesized that total, frontal, temporal, and parietal gray matter thickness would be greater in patients who subsequently remit...
  8. pmc General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study
    Jennifer L Bakalar
    Child Psychiatry Branch, NIMH, NIH, Rm 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 115:12-6. 2009
    ..Recent studies show dynamic changes in brain asymmetry during childhood and adolescence. We hypothesized that COS patients would show a lack of normal development of asymmetry and decreased overall asymmetry...
  9. ncbi request reprint Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 44:925-33. 2005
    ..In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment...
  10. ncbi request reprint Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcome
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 46:1349-56. 2007
    ..Here we evaluate these as well as other measures in an effort to find predictors of response to clozapine in our early-onset treatment-refractory population...
  11. ncbi request reprint Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?
    Alexandra L Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:989-94. 2004
    ..In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an independent risk factor for COS...
  12. ncbi request reprint Sleep disturbances in childhood-onset schizophrenia
    Anand A Mattai
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    Schizophr Res 86:123-9. 2006
    ..As there are numerous health implications of poor sleep, clinicians should have a low threshold for treating sleep disturbances in this population...
  13. pmc Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Bldg 10, Center Dr, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 166:58-63. 2009
    ..The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD) was associated with differences in the development of the cerebral cortex during adolescence...
  14. pmc Sexual dimorphism of brain developmental trajectories during childhood and adolescence
    Rhoshel K Lenroot
    Child Psychiatry Branch of the National Institute of Mental Health, NIMH CHP 10 Center Drive, Bethesda, MD 20814 9692, USA
    Neuroimage 36:1065-73. 2007
    ..These sexually dimorphic trajectories confirm the importance of longitudinal data in studies of brain development and underline the need to consider sex matching in studies of brain development...
  15. ncbi request reprint Stimulant drug treatment in childhood-onset schizophrenia with comorbid ADHD: an open-label case series
    Julia W Tossell
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Room 3N202, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 14:448-54. 2004
    ..Our results suggest that ADHD comorbid with COS may be safely treated with a stimulant, once the psychosis is stabilized. A systematic investigation of this question may be warranted...
  16. pmc Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study
    Henning Tiemeier
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neuroimage 49:63-70. 2010
    ....
  17. ncbi request reprint Progressive brain volume loss during adolescence in childhood-onset schizophrenia
    Alexandra L Sporn
    Child Psychiatry Branch, NIMH, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Am J Psychiatry 160:2181-9. 2003
    ..This study examined the rate of loss in cortical gray matter volume in relation to age and clinical status in adolescent patients over a follow-up period of 2-6 years...
  18. ncbi request reprint Dynamic mapping of hippocampal development in childhood onset schizophrenia
    Tom F Nugent
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Schizophr Res 90:62-70. 2007
    ....
  19. ncbi request reprint Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified
    Anjene M Addington
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1600, USA
    Biol Psychiatry 55:976-80. 2004
    ..Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder...
  20. ncbi request reprint Lack of evidence for elevated obstetric complications in childhood onset schizophrenia
    Anna E Ordoñez
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 58:10-5. 2005
    ..We hypothesized that by extrapolation, patients with childhood-onset schizophrenia (COS), with very early onset and very severe illness, would have had more numerous or more salient OC compared with their healthy siblings...
  21. ncbi request reprint Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorder
    Daniel P Dickstein
    National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 10 Center Drive MSC 1255, Building 10 Room 4N208, Bethesda MD 20892 1255, USA
    Biol Psychiatry 58:517-24. 2005
    ..To move beyond diagnosis toward unique pathophysiology, we evaluated both ADHD and BPD children for neurologic examination abnormalities (NEAs) in comparison with normal control (NC) children...
  22. pmc Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:15979-84. 2008
    ..Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth...
  23. doi request reprint Neurodevelopmental trajectories of the human cerebral cortex
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:3586-94. 2008
    ....
  24. pmc Development of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:888-96. 2009
    ..No study has examined the development of cortical asymmetry using longitudinal neuroanatomical data...
  25. ncbi request reprint Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:852-62. 2007
    ..We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset...
  26. pmc Cortical development in typically developing children with symptoms of hyperactivity and impulsivity: support for a dimensional view of attention deficit hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 168:143-51. 2011
    ....
  27. ncbi request reprint Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:772-80. 2007
    ..Nonpsychotic siblings of COS probands could help evaluate whether the cortical GM abnormalities are familial/trait markers...
  28. pmc Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophrenia
    Anand Mattai
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD, 20892 1600, United States
    Schizophr Res 116:44-8. 2010
    ..Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development...
  29. ncbi request reprint Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Lancet Neurol 6:494-500. 2007
    ....
  30. ncbi request reprint Childhood onset schizophrenia: familial neurocognitive measures
    Peter A Gochman
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3N202, Bethesda, MD 20892 1600, USA
    Schizophr Res 71:43-7. 2004
    ..Neurocognitive deficits which are seen in families of adult onset schizophrenic patients were examined in healthy family members of patients with childhood-onset schizophrenia (COS)...
  31. ncbi request reprint Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family members
    Alexandra Sporn
    Child Psychiatry Branch, National Institute of Mental Health, National Institute of Health, Bldg 10, Rm 3N202, Bethesda, MD 20892, USA
    Schizophr Res 73:243-52. 2005
    ..Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia...
  32. ncbi request reprint Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 1600, USA
    Arch Gen Psychiatry 61:17-22. 2004
    ..We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses...
  33. ncbi request reprint IQ stabilization in childhood-onset schizophrenia
    Peter A Gochman
    Child Psychiatry Branch, NIMH Bldg 10, Rm 3N202 Bethesda, MD 20892 1600, USA
    Schizophr Res 77:271-7. 2005
    ..To examine the long term IQ trajectory for childhood-onset schizophrenia (COS) in an expanded, prospective longitudinal study...
  34. pmc Dynamic mapping of human cortical development during childhood through early adulthood
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:8174-9. 2004
    ..Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism...
  35. ncbi request reprint Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison
    Philip Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
    Arch Gen Psychiatry 63:721-30. 2006
    ..The psychiatrist has a limited evidence base to guide treatment, particularly as there are no trials in children comparing atypical antipsychotics, the mainstay of current treatment...
  36. ncbi request reprint Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder
    Philip Shaw
    Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:921-31. 2007
    ..Attention-deficit/hyperactivity disorder (ADHD) is one of the most heritable neuropsychiatric disorders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated in its pathogenesis...
  37. ncbi request reprint Structural brain MRI abnormalities in healthy siblings of patients with childhood-onset schizophrenia
    Nitin Gogtay
    Child Psychiatry Branch, National Institute of Mental Health, NationalInstitutes of Health, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 160:569-71. 2003
    ....
  38. pmc Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited
    Judith Rapoport
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 48:10-8. 2009
    ..To highlight emerging evidence for clinical and biological links between autism/pervasive developmental disorder (PDD) and schizophrenia, with particular attention to childhood-onset schizophrenia (COS)...
  39. ncbi request reprint Multidimensionally impaired: the good news
    Catherine Stayer
    Child Psychiatry Branch at the National Institute of Mental Health, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 15:510-9. 2005
    ..Despite severe preadmission morbidity, some patients have successfully remained neuroleptic-free since discharge. Predictors of good versus poor outcome were sought...
  40. ncbi request reprint Support for association between ADHD and two candidate genes: NET1 and DRD1
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
    Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005
    ..Because family-based and case-control methods gave divergent results, both should be used in genetic studies of ADHD...
  41. ncbi request reprint Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder
    F Xavier Castellanos
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    JAMA 288:1740-8. 2002
    ..Various anatomic brain abnormalities have been reported for attention-deficit/hyperactivity disorder (ADHD), with varying methods, small samples, cross-sectional designs, and without accounting for stimulant drug exposure...
  42. ncbi request reprint Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder
    F Xavier Castellanos
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD, USA
    Am J Psychiatry 160:1693-6. 2003
    ..To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD...
  43. ncbi request reprint Chronic fluoxetine upregulates arachidonic acid incorporation into the brain of unanesthetized rats
    Ying Qu
    Brain Physiology and Metabolism Section, Building 9, Room 1S128, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Eur Neuropsychopharmacol 16:561-71. 2006
    ..Such upregulation may contribute to fluoxetine's efficacy against human depression...
  44. pmc Brain lipid concentrations in bipolar disorder
    Miki Igarashi
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Psychiatr Res 44:177-82. 2010
    ..Positron emission tomography might be used, however, to see if brain AA or DHA kinetics are disturbed in the disease...