Mark H Greene

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  3. pmc Factors associated with testicular self-examination among unaffected men from multiple-case testicular cancer families
    Susan T Vadaparampil
    Division of Population Sciences, Moffitt Cancer Center, Tampa, Flordia, USA
    Hered Cancer Clin Pract 7:11. 2009
  4. pmc Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype
    Mark H Greene
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Endocr Relat Cancer 17:R109-21. 2010
  5. pmc A prospective study of risk-reducing salpingo-oophorectomy and longitudinal CA-125 screening among women at increased genetic risk of ovarian cancer: design and baseline characteristics: a Gynecologic Oncology Group study
    Mark H Greene
    Clinical Genetics Branch, National Cancer Institute, 6120 Executive Boulevard, Room EPS 7032, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 17:594-604. 2008
  6. pmc Confirmation of family cancer history reported in a population-based survey
    Phuong L Mai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7022, Rockville Pike, Bethesda, MD 20852, USA
    J Natl Cancer Inst 103:788-97. 2011
  7. pmc The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies
    Lutecia H Mateus Pereira
    Laboratory of Population Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Genet 8:68. 2007
  8. pmc BRCA mutation-negative women from hereditary breast and ovarian cancer families: a qualitative study of the BRCA-negative experience
    Alexis D Bakos
    Department of Health and Human Services, National Institute of Nursing Research, NIH, Rockville, MD, USA
    Health Expect 11:220-31. 2008
  9. pmc Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study
    Blanche P Alter
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7231, USA
    Br J Haematol 150:179-88. 2010
  10. pmc Tolerability of breast ductal lavage in women from families at high genetic risk of breast cancer
    Jennifer T Loud
    Clinical Genetics Branch, National Cancer Institute, NIH, Rockville, MD, USA
    BMC Womens Health 9:20. 2009

Detail Information

Publications61

  1. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
    ..2)...
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  3. pmc Factors associated with testicular self-examination among unaffected men from multiple-case testicular cancer families
    Susan T Vadaparampil
    Division of Population Sciences, Moffitt Cancer Center, Tampa, Flordia, USA
    Hered Cancer Clin Pract 7:11. 2009
    ..Our data provide a basis for further exploring psychosocial issues that are specific to men with a family history of TC, and formulating intervention strategies aimed at improving adherence to TSE guidelines...
  4. pmc Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype
    Mark H Greene
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Endocr Relat Cancer 17:R109-21. 2010
    ..All five loci are involved in normal testicular development and/or male infertility. These genetic data provide a novel insight into the genetic basis of FTGCT, and an invaluable guide to future TGCT research...
  5. pmc A prospective study of risk-reducing salpingo-oophorectomy and longitudinal CA-125 screening among women at increased genetic risk of ovarian cancer: design and baseline characteristics: a Gynecologic Oncology Group study
    Mark H Greene
    Clinical Genetics Branch, National Cancer Institute, 6120 Executive Boulevard, Room EPS 7032, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 17:594-604. 2008
    ..We developed a collaboration among the Clinical Genetics Branch (National Cancer Institute's Intramural Research Program), the Gynecologic Oncology Group (GOG), and the Cancer Genetics Network to address these issues...
  6. pmc Confirmation of family cancer history reported in a population-based survey
    Phuong L Mai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7022, Rockville Pike, Bethesda, MD 20852, USA
    J Natl Cancer Inst 103:788-97. 2011
    ..However, it is not clear if reported family cancer history is sufficiently accurate for this purpose...
  7. pmc The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies
    Lutecia H Mateus Pereira
    Laboratory of Population Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Genet 8:68. 2007
    ..We evaluated LD using pairwise and haplotype-based methods, and assessed correlation of SNPs with the founder mutations using Pearson's correlation coefficient...
  8. pmc BRCA mutation-negative women from hereditary breast and ovarian cancer families: a qualitative study of the BRCA-negative experience
    Alexis D Bakos
    Department of Health and Human Services, National Institute of Nursing Research, NIH, Rockville, MD, USA
    Health Expect 11:220-31. 2008
    ..This study was designed to explore cancer risk perception and the experience of being a mutation-negative woman within a known BRCA1/2 mutation-positive family...
  9. pmc Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study
    Blanche P Alter
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7231, USA
    Br J Haematol 150:179-88. 2010
    ..The findings demonstrate that both FA and DC are major cancer susceptibility syndromes. The IBMFS, historically considered paediatric disorders, have important management implications for physicians treating adult patients...
  10. pmc Tolerability of breast ductal lavage in women from families at high genetic risk of breast cancer
    Jennifer T Loud
    Clinical Genetics Branch, National Cancer Institute, NIH, Rockville, MD, USA
    BMC Womens Health 9:20. 2009
    ..We report DL tolerability in BRCA1/2 mutation-positive and -negative women from an IRB-approved research study...
  11. pmc Sisters in hereditary breast and ovarian cancer families: communal coping, social integration, and psychological well-being
    Laura M Koehly
    Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Psychooncology 17:812-21. 2008
    ..We investigated the association between psychological distress and indices of social integration and communal coping among sisters from hereditary breast and ovarian cancer (HBOC) families...
  12. pmc Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls
    Victoria M Chia
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 124:952-7. 2009
    ..69, 95% CI: 0.51-0.94). Thus, this study suggests that there may be aggregation of cancer among families of men diagnosed with TGCT...
  13. pmc Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers
    Kate M Im
    Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute, Frederick, MD, USA
    Hum Genet 130:685-99. 2011
    ....
  14. ncbi request reprint Prophylactic oophorectomy reduces breast cancer penetrance during prospective, long-term follow-up of BRCA1 mutation carriers
    Joan L Kramer
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Room 7016, MSC 7231, Rockville, MD 20852, USA
    J Clin Oncol 23:8629-35. 2005
    ..Because prophylactic oophorectomy reduces breast cancer risk by approximately 50%, we hypothesized that population differences in oophorectomy prevalence might significantly influence breast cancer penetrance estimates...
  15. pmc Complementary and alternative medicine use among women at increased genetic risk of breast and ovarian cancer
    Christine M Mueller
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    BMC Complement Altern Med 8:17. 2008
    ..Complementary and alternative medicine (CAM) use is well documented among breast cancer patients and survivors, but little evidence is available to describe rates and patterns of use among women at increased genetic risk of breast cancer...
  16. ncbi request reprint Breast-cancer risk in BRCA-mutation-negative women from BRCA-mutation-positive families
    Hormuzd A Katki
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Lancet Oncol 8:1042-3. 2007
  17. pmc Characteristics of health information gatherers, disseminators, and blockers within families at risk of hereditary cancer: implications for family health communication interventions
    Laura M Koehly
    Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, Building 31, Room B1B37D, 31 Center Drive MSC 2073, Bethesda, MD 20892, USA
    Am J Public Health 99:2203-9. 2009
    ..Given the importance of the dissemination of accurate family history to assess disease risk, we characterized the gatherers, disseminators, and blockers of health information within families at high genetic risk of cancer...
  18. pmc A mini-review of familial ovarian germ cell tumors: an additional manifestation of the familial testicular germ cell tumor syndrome
    Claudia Giambartolomei
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol 33:31-6. 2009
    ..In this paper, we investigate the familial occurrence of testicular and ovarian germ cell tumors...
  19. pmc Cancer risk among patients with myotonic muscular dystrophy
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20892, USA
    JAMA 306:2480-6. 2011
    ..Case reports have suggested that MMD patients may be at increased risk of malignancy, putative risks that have never been quantified...
  20. pmc Ductal lavage in women from BRCA1/2 families: is there a future for ductal lavage in women at increased genetic risk of breast cancer?
    Jennifer T Loud
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1243-51. 2009
    ..Little is known about patient characteristics associated with obtaining nipple aspirate fluid (NAF) and adequate cell counts (> or =10 cells) in ductal lavage specimens from BRCA mutation carriers...
  21. pmc Testicular cancer and genetics knowledge among familial testicular cancer family members
    June A Peters
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS 7026, Rockville, MD 20852, USA
    J Genet Couns 17:351-64. 2008
    ..It was our aim to determine baseline levels of testicular cancer and genetics knowledge among members of families with Familial Testicular Cancer (FTC)...
  22. pmc Meta-analysis identifies four new loci associated with testicular germ cell tumor
    Charles C Chung
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 45:680-5. 2013
    ..These new TGCT susceptibility loci contain biologically plausible genes encoding proteins important for male germ cell development, chromosomal segregation and the DNA damage response...
  23. pmc Potential usefulness of single nucleotide polymorphisms to identify persons at high cancer risk: an evaluation of seven common cancers
    Ju Hyun Park
    National Cancer Institute, Rockville, MD 20852 7244, USA
    J Clin Oncol 30:2157-62. 2012
    ..To estimate the likely number and predictive strength of cancer-associated single nucleotide polymorphisms (SNPs) that are yet to be discovered for seven common cancers...
  24. pmc Mammographic density does not differ between unaffected BRCA1/2 mutation carriers and women at low-to-average risk of breast cancer
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 123:245-55. 2010
    ..Taking these factors into account did not significantly alter the results of the age/body mass index-adjusted analysis. Our results do not provide support for an independent effect of BRCA1/2 mutation status on mammographic density...
  25. ncbi request reprint Ovarian cancer screening in women with a family history of breast or ovarian cancer
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Obstet Gynecol 108:1176-84. 2006
    ..To evaluate positive predictive values of CA 125 or transvaginal ultrasonography screening for ovarian cancer according to family history of breast or ovarian cancer...
  26. pmc Competing risks analysis of correlated failure time data
    Bingshu E Chen
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Biometrics 64:172-9. 2008
    ..For women with BRCA1 mutations, we estimate the cumulative incidence of breast cancer in the presence of competing mortality from ovarian cancer, accounting for significant within-family correlation...
  27. pmc Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour
    Christian P Kratz
    Division of CancerEpidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Med Genet 48:473-6. 2011
    ..Familial testicular germ cell tumours (TGCTs) and bilateral TGCTs comprise 1-2% and 5% of all TGCTs, respectively, but their genetic basis remains largely unknown...
  28. pmc Unpacking the blockers: understanding perceptions and social constraints of health communication in hereditary breast ovarian cancer (HBOC) susceptibility families
    June A Peters
    Clinical Genetics Branch CGB, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Rockville, MD 20852, USA
    J Genet Couns 20:450-64. 2011
    ..Blocking often seemed to involve bi-directional feedback loops, in keeping with Lepore's Social Constraints and Modulation Theory. Privacy and protectiveness predominated as explanations for long-term blocking...
  29. pmc Constitutional cytogenetic analysis in men with hereditary testicular germ cell tumor: no evidence of disease-related abnormalities
    Christine M Mueller
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7101, Rockville, MD 20852 7231, USA
    Cancer Epidemiol Biomarkers Prev 16:2791-4. 2007
  30. pmc The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred
    Phuong L Mai
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Urol Oncol 28:492-9. 2010
    ..Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population...
  31. ncbi request reprint Evolution of the colored eco-genetic relationship map (CEGRM) for assessing social functioning in women in hereditary breast-ovarian (HBOC) families
    June A Peters
    Clinical Genetics Branch CGB, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Rockville, MD 20852, USA
    J Genet Couns 15:477-89. 2006
    ....
  32. pmc Quantifying cancer absolute risk and cancer mortality in the presence of competing events after a myotonic dystrophy diagnosis
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e79851. 2013
    ..It is important to apply population-appropriate, validated cancer screening strategies in DM patients. ..
  33. doi request reprint Toward a new understanding of risk perception among young female BRCA1/2 "previvors"
    Lindsey M Hoskins
    National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Fam Syst Health 30:32-46. 2012
    ..Here we present data from our qualitative research to aid in this effort...
  34. pmc LINE-1 methylation is inherited in familial testicular cancer kindreds
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    BMC Med Genet 11:77. 2010
    ..Global DNA hypomethylation has been associated with the risk of cancers of the bladder and head/neck...
  35. ncbi request reprint Familial testicular cancer: interest in genetic testing among high-risk family members
    June A Peters
    Clinical Genetics Branch CGB, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute NCI, National Institutes of Health NIH, DHHS, Rockville, Maryland 20852, USA
    Genet Med 8:760-70. 2006
    ..The current report targets interest in clinical genetic testing for susceptibility to FTC...
  36. ncbi request reprint Family history of breast cancer as a risk factor for ovarian cancer in a prospective study
    Neely Kazerouni
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852 7234, USA
    Cancer 107:1075-83. 2006
    ....
  37. ncbi request reprint BRCA1 and sex ratio
    Jeffery P Struewing
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5060, USA
    Eur J Hum Genet 12:663-7. 2004
    ..Nonetheless, these observations do not support the idea that BRCA1 mutation carriers have a lower ratio of male offspring than BRCA2 mutation carriers...
  38. ncbi request reprint Exploratory study of the feasibility and utility of the colored eco-genetic relationship map (CEGRM) in women at high genetic risk of developing breast cancer
    June A Peters
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Am J Med Genet A 130:258-64. 2004
    ..In this clinical research context, the participants felt free to share poignant stories about their friends and families. Further studies are planned to refine the CEGRM and to examine its utility in cancer genetics research...
  39. pmc Younger age-at-diagnosis for familial malignant testicular germ cell tumor
    Phuong L Mai
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MA 20852, USA
    Fam Cancer 8:451-6. 2009
    ..The younger age at diagnosis might be suggestive of a genetic basis for familial TGCT...
  40. pmc Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition
    Monalisa F Azevedo
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:E1393-400. 2013
    ....
  41. pmc A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report
    Phuong L Mai
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Med Case Reports 1:9. 2007
    ..Familial testicular cancer in the presence of other findings in affected and unaffected family members might indicate a previously-unidentified hereditary cancer syndrome...
  42. pmc Coherence and completeness of population-based family cancer reports
    Louise Wideroff
    National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 19:799-810. 2010
    ..Given its widespread use in cancer screening and surveillance, better information is needed about the clarity and accuracy of family history information reported in the general population...
  43. ncbi request reprint Deliberate deceit of family members: a challenge to providers of clinical genetics services
    Jennifer T Loud
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Food and Drug Administration, Rockville, MD 20853 7231, USA
    J Clin Oncol 24:1643-6. 2006
  44. doi request reprint Anticipatory loss and early mastectomy for young female BRCA1/2 mutation carriers
    Lindsey M Hoskins
    National Institutes of Health, Rockville, Maryland, USA
    Qual Health Res 22:1633-46. 2012
    ....
  45. pmc Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium
    Phuong L Mai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Cancer Genet 205:479-87. 2012
    ..This workshop also led to the creation of the Li-Fraumeni Exploration (LiFE) Research Consortium...
  46. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  47. pmc Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma
    Ying Gao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Int J Cancer 131:E105-13. 2012
    ..Our analysis showed a significant positive association between circulating IGF1 levels and risk of advanced colorectal adenoma, suggesting that IGF1 is associated with the pivotal precursor to colorectal cancer...
  48. ncbi request reprint Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals
    Joni L Rutter
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    Hum Mutat 22:121-8. 2003
    ..Further analysis in unselected cases will be required to know whether the identified variants play a role in genetic predisposition to breast cancer in the general population. Hum Mutat 22:121-128, 2003. Published 2003 Wiley-Liss, Inc...
  49. pmc Familial testicular germ cell tumours
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Best Pract Res Clin Endocrinol Metab 24:503-13. 2010
    ..Notably, all five loci are involved in the biology of primordial germ cells, representing the cell of origin of TGCT, suggesting that the tumours arise as a result of disturbed testicular development...
  50. pmc Does bilateral salpingectomy with ovarian retention warrant consideration as a temporary bridge to risk-reducing bilateral oophorectomy in BRCA1/2 mutation carriers?
    Mark H Greene
    Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Rockville, MD, USA
    Am J Obstet Gynecol 204:19.e1-6. 2011
    ....
  51. pmc Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors
    Anelia Horvath
    Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 10 Center Drive, CRC, Room 1 3330, Bethesda, MD 20892, USA
    Cancer Res 69:5301-6. 2009
    ..In conclusion, we report that PDE11A-inactivating sequence variants may modify the risk of familial and bilateral TGCT...
  52. pmc Familial and genetic risk of transitional cell carcinoma of the urinary tract
    Christine M Mueller
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, Rockville, MD 20852, USA
    Urol Oncol 26:451-64. 2008
    ....
  53. pmc Promoter methylation of candidate genes associated with familial testicular cancer
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA
    Int J Mol Epidemiol Genet 3:213-27. 2012
    ..Our results suggest that familial TGCT susceptibility may be associated with promoter methylation of previously-identified TGCT risk-modifying genes. Larger studies are warranted...
  54. pmc Close ties: an exploratory Colored Eco-Genetic Relationship Map (CEGRM) study of social connections of men in Familial Testicular Cancer (FTC) families
    June A Peters
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, 6120 Executive Blvd, Rockville, MD, 20852 USA
    Hered Cancer Clin Pract 10:2. 2012
    ..abstract:..
  55. pmc Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer
    Kelly L Bolton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    JAMA 307:382-90. 2012
    ..A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear...
  56. pmc Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
    Suhwan Chang
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Nat Med 17:1275-82. 2011
    ..Our findings demonstrate a new mode of tumor suppression by BRCA1 and suggest that miR-155 is a potential therapeutic target for BRCA1-deficient tumors...
  57. ncbi request reprint Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:15-25. 2006
    ..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer...
  58. pmc Challenges related to developing serum-based biomarkers for early ovarian cancer detection
    Phuong L Mai
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 4:303-6. 2011
    ....
  59. ncbi request reprint Cancer incidence in persons with Fanconi anemia
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Blood 101:822-6. 2003
    ..The risk of a solid tumor may become even higher as death from aplastic anemia is reduced and as patients survive longer after BMT...
  60. pmc Hypothesis: neoplasms in myotonic dystrophy
    Christine M Mueller
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, EPS 7101, Rockville, MD 20852 7231, USA
    Cancer Causes Control 20:2009-20. 2009
    ..We hope to stimulate further study into the potential role of DM genes in tumorigenesis, and help define DM pathogenesis, and facilitate developing novel treatment modalities...
  61. pmc Dyskeratosis congenita: the first NIH clinical research workshop
    Sharon A Savage
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA
    Pediatr Blood Cancer 53:520-3. 2009
    ..dcoutreach.com/). Ongoing, open collaboration between the clinical, scientific, and family communities is required for continued improvement in our understanding of DC and the clinical consequences of telomeric defects...