Thomas Gray

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone
    T Gray
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem J 353:727-34. 2001
  2. ncbi request reprint Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium
    T Gray
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicology 160:35-46. 2001
  3. ncbi request reprint Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia
    Thomas Gray
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 286:L320-30. 2004
  4. ncbi request reprint Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling
    Thomas Gray
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 66:337-46. 2004
  5. pmc Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 101:4620-4. 2004
  6. pmc Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, Robert Koch Strasse 17, 35037 Marburg, Germany
    J Virol 78:12665-7. 2004

Collaborators

Detail Information

Publications6

  1. pmc Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone
    T Gray
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem J 353:727-34. 2001
    ..We propose that T(3) might inhibit retinoid-dependent MUC5AC expression by decreasing retinoid receptor levels and thereby decreasing the transcriptional activation of this gene for mucins...
  2. ncbi request reprint Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium
    T Gray
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicology 160:35-46. 2001
    ..These studies thus point to potentially important species differences in the mechanisms regulating mucous production, and they also confirm previous findings indicating differential regulation of MUC5AC and MUC5B gene expression...
  3. ncbi request reprint Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia
    Thomas Gray
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 286:L320-30. 2004
    ..The synchronous regulation of ASL mucin and liquid metabolism triggered by IL-1beta may be an important defense mechanism of the airway epithelium to enhance mucociliary clearance during airway inflammation...
  4. ncbi request reprint Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling
    Thomas Gray
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 66:337-46. 2004
    ..We conclude that the induction of MUC5AC by IL-1beta, TNF-alpha, PAF, and LPS involves COX-2- generated PGE(2), activation of EP2 and/or EP4 receptor(s), and cAMP-PKA-mediated signaling...
  5. pmc Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 101:4620-4. 2004
    ..Our data throw light on the mechanisms of generation of pandemic viruses from their avian progenitors and open avenues for cell level-oriented studies on the replication and pathogenicity of influenza virus in humans...
  6. pmc Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, Robert Koch Strasse 17, 35037 Marburg, Germany
    J Virol 78:12665-7. 2004
    ..These data demonstrate that viral NA plays a role early in infection, and they provide further rationale for the prophylactic use of NA inhibitors...