Research Topics
| David A GorelickSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Bromocriptine treatment for cocaine addiction: association with plasma prolactin levelsDavid A Gorelick
Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Department of Health and Human Services DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 81:189-95. 2006..These data do not support the efficacy of bromocriptine treatment nor a role for prolactin concentration in predicting treatment response...- Agents in development for the management of cocaine abuseDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drugs 64:1547-73. 2004..A recent phase I trial of a "cocaine vaccine" found it to be well tolerated and producing detectable levels of anti-cocaine antibodies for up to 9 months after immunisation... 
CB1 - cannabinoid receptor antagonist effects on cortisol in cannabis-dependent menRobert S Goodwin
Chemistry and Drug Metabolism Section, Intramural Research Program, National Institutes of Health, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Am J Drug Alcohol Abuse 38:114-9. 2012..The endocannabinoid system modulates the hypothalamic-pituitary-adrenal (HPA) axis, but the effect of cannabinoid type 1 (CB1) receptor antagonism following chronic CB1 receptor stimulation in humans is unknown...- Sociodemographic characteristics associated with substance use status in a trauma inpatient populationSilvia S Martins
Department of Mental Health, John Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Addict Dis 26:53-62. 2007..1%) were also more likely male, unmarried, and older. These findings highlight the need for screening for substance use disorders in trauma settings and referral of patients to substance abuse treatment programs... 
Sociodemographic characteristics of cannabis smokers and the experience of cannabis withdrawalMarc L Copersino
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Am J Drug Alcohol Abuse 36:311-9. 2010..Cannabis withdrawal can be a negative reinforcer for relapse, but little is known about its association with demographic characteristics...- Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis usersMarilyn A Huestis
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 194:505-15. 2007..A single 90-mg dose of the cannabinoid CB1 receptor antagonist rimonabant attenuates effects of smoked cannabis in humans... - Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinenceDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Psychopharmacology (Berl) 200:475-86. 2008..Cocaine users have increased regional brain mu-opioid receptor (mOR) binding which correlates with cocaine craving. The relationship of mOR binding to relapse is unknown... - Antagonist-elicited cannabis withdrawal in humansDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
J Clin Psychopharmacol 31:603-12. 2011..In summary, prespecified criteria for antagonist-elicited cannabis withdrawal were not observed at the 20- or 40-mg rimonabant doses. These data do not preclude antagonist-elicited withdrawal at higher rimonabant doses... - Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance useMarc L Copersino
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
Am J Addict 15:297-302. 2006..These findings suggest areas for further research on spontaneous recovery from marijuana use... - Influence of psychotherapy attendance on buprenorphine treatment outcomeIvan D Montoya
Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
J Subst Abuse Treat 28:247-54. 2005..02). These results suggest that psychotherapy can improve the outcome of buprenorphine maintenance treatment for patients with dual (cocaine and opioid) dependence... - Predictive model accuracy in estimating last Δ9-tetrahydrocannabinol (THC) intake from plasma and whole blood cannabinoid concentrations in chronic, daily cannabis smokers administered subchronic oral THCErin L Karschner
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Drug Alcohol Depend 125:313-9. 2012..5 whole blood-to-plasma (WB/P) ratio. No studies previously evaluated predictive models utilizing empirically-derived WB/P ratios, or whole blood cannabinoid pharmacokinetics after subchronic THC dosing... - Differentiating new cannabis use from residual urinary cannabinoid excretion in chronic, daily cannabis usersEugene W Schwilke
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21146, USA
Addiction 106:499-506. 2011..To develop and validate empirically a mathematical model for identifying new cannabis use in chronic, daily cannabis smokers... - On-site test for cannabinoids in oral fluidNathalie A Desrosiers
Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Clin Chem 58:1418-25. 2012..On-site tests must accurately identify cannabis exposure because this drug accounts for the highest prevalence in workplace drug testing and driving under the influence of drugs (DUID) programs... - Diagnostic criteria for cannabis withdrawal syndromeDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Drug Alcohol Depend 123:141-7. 2012..Cannabis withdrawal occurs in frequent users who quit, but there are no accepted diagnostic criteria for a cannabis withdrawal syndrome (CWS). This study evaluated diagnostic criteria for CWS proposed in DSM-V and two earlier proposals... - Cannabinoid disposition in oral fluid after controlled smoked cannabisDayong Lee
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
Clin Chem 58:748-56. 2012.... - Cannabis withdrawal symptoms in non-treatment-seeking adult cannabis smokersKenneth H Levin
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Drug Alcohol Depend 111:120-7. 2010..Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance... - Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administrationGarry Milman
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
Clin Chem 56:1261-9. 2010..Cannabinoid distribution into oral fluid is complex and incompletely characterized due to the lack of controlled drug administration studies... - Physiological and subjective responses to controlled oral 3,4-methylenedioxymethamphetamine administrationErin A Kolbrich
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
J Clin Psychopharmacol 28:432-40. 2008.... - Oral fluid and plasma cannabinoid ratios after around-the-clock controlled oral Δ(9)-tetrahydrocannabinol administrationGarry Milman
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Clin Chem 57:1597-606. 2011..There is interest in predicting plasma or whole-blood concentrations from OF concentrations; however, the relationship between these matrices is incompletely characterized because of few controlled drug-administration studies... - Cannabinoids and metabolites in expectorated oral fluid after 8 days of controlled around-the-clock oral THC administrationGarry Milman
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224, USA
Anal Bioanal Chem 401:599-607. 2011..Measurement of THCCOOH may improve the detection and interpretation of OF cannabinoid tests and minimize the possibility of OF contamination from passive inhalation of cannabis smoke... - Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatientsUdi E Ghitza
Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
Biol Psychiatry 68:697-703. 2010..In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown... - Tolerance to effects of high-dose oral δ9-tetrahydrocannabinol and plasma cannabinoid concentrations in male daily cannabis smokersDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
J Anal Toxicol 37:11-6. 2013..Plasma THC and 11-OH-THC concentrations increased significantly over the first five days of dosing. Six days of around-the-clock, oral THC produced tolerance to subjective intoxication, but not to cardiovascular effects... - Cannabinoid stability in authentic oral fluid after controlled cannabis smokingDayong Lee
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
Clin Chem 58:1101-9. 2012..There are few published OF stability data, and of those available, all employed fortified synthetic OF solutions or elution buffers; none included authentic OF following controlled cannabis smoking... - Psychomotor performance, subjective and physiological effects and whole blood Δ⁹-tetrahydrocannabinol concentrations in heavy, chronic cannabis smokers following acute smoked cannabisDavid M Schwope
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd, Suite 200, Baltimore, Maryland 21224, USA
J Anal Toxicol 36:405-12. 2012..These data inform our understanding of impairment and subjective effects following acute smoked cannabis and interpretation of whole blood cannabinoid concentrations in forensic investigations... - Signal-averaged electrocardiogram in physically healthy, chronic 3,4-methylenedioxymethamphetamine (MDMA) usersPraveen Kanneganti
Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Am J Drug Alcohol Abuse 34:712-20. 2008..Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG... - Interest in marijuana treatment programs among teenage smokers and nonsmokersAmy J Sheer
National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
J Subst Abuse Treat 37:421-5. 2009..These findings suggest that most adolescent marijuana smokers endorse the need for and are willing to attend marijuana treatment programs... - Exercise stress testing in recently abstinent chronic cocaine abusersPraveen Kanneganti
Department of Health and Human Services, Office of the Science Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224 2816, USA
Am J Drug Alcohol Abuse 34:489-98. 2008..EST may cause more cardiac work (indicated by heart rate and blood pressure) than intravenous cocaine (at the doses in this study)... - The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokersDavid A Gorelick
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Am Heart J 151:754.e1-754.e5. 2006..In human studies, activation of CB1 receptors by cannabis or its active ingredient, Delta9-tetrahydrocannabinol (THC), has modest and inconsistent effects on BP... - Identification of recent cannabis use: whole-blood and plasma free and glucuronidated cannabinoid pharmacokinetics following controlled smoked cannabis administrationDavid M Schwope
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Biomedical Research Center, Baltimore, MD 21224, USA
Clin Chem 57:1406-14. 2011..Furthermore, there are no studies directly examining whole-blood cannabinoid pharmacokinetics, although this matrix is often the only available specimen... - Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administrationErin A Kolbrich
Chemistry and Drug Metabolism, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Anal Toxicol 30:501-10. 2006..7 ng/mL). These data improve our knowledge of the pharmacokinetics of cocaine and its major and minor metabolites in plasma following controlled subcutaneous cocaine administration... - Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adultsErin A Kolbrich
Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Ther Drug Monit 30:320-32. 2008.... - Oral fluid and plasma 3,4-methylenedioxymethamphetamine (MDMA) and metabolite correlation after controlled oral MDMA administrationNathalie A Desrosiers
Chemistry and Drug Metabolism Section, Clinical Pharmacology and Therapeutic Research Branch, NIDA IRP, 251 Bayview Boulevard, Suite 200 Room 05A 721, Baltimore, MD, 21224, USA
Anal Bioanal Chem 405:4067-76. 2013..The MDMA and MDA concentrations were higher in OF than in plasma. OF and plasma concentrations were correlated, but large inter-subject variability precludes the estimation of plasma concentrations from OF... - Cannabinoids and metabolites in expectorated oral fluid following controlled smoked cannabisGarry Milman
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Clin Chim Acta 413:765-70. 2012..9)-Tetrahydrocannabinol (THC) in oral fluid (OF) implies cannabis intake, but eliminating passive exposure and improving interpretation of test results requires additional research... - Longitudinal ECG changes in cocaine users during extended abstinenceKenneth H Levin
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 95:160-3. 2008..Cocaine lengthens electrocardiographic QTc, QRS and PR intervals through blockade of sodium and potassium channels, but changes during withdrawal have not been well studied... - Cocaine craving and use during daily lifeKenzie L Preston
Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 207:291-301. 2009..Craving is often assumed to cause ongoing drug use and relapse and is a major focus of addiction research. However, its relationship to drug use has not been adequately documented... - Delta9-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC plasma pharmacokinetics during and after continuous high-dose oral THCEugene W Schwilke
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Biomedical Research Center, Baltimore, MD 21224, USA
Clin Chem 55:2180-9. 2009..Delta(9)-tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. No plasma pharmacokinetic data after repeated oral THC administration are available... - Urinary MDMA, MDA, HMMA, and HMA excretion following controlled MDMA administration to humansTsadik T Abraham
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
J Anal Toxicol 33:439-46. 2009..Measurement of urinary HMMA provides the longest detection of MDMA exposure yet is not included in routine monitoring procedures... - Cannabis withdrawal in chronic cannabis users with schizophreniaDouglas L Boggs
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
J Psychiatr Res 47:240-5. 2013..Chronic users of cannabis often report withdrawal symptoms after abstinence from use, but little is known about cannabis withdrawal in people with schizophrenia... - Signal-averaged electrocardiogram in physically healthy, recently abstinent chronic cocaine usersPraveen Kanneganti
From the Department of Health and Human Services PK, MLC, RAN, SJB, DAG, Office of the Scientific Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health and Division of Cardiology RCZ, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
J Addict Med 3:128-33. 2009..Markers of ventricular late potentials, which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG) but not by standard ECG... - Reliability and validity of a short form of the Marijuana Craving QuestionnaireStephen J Heishman
Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Blvd, Baltimore, MD 21224, USA
Drug Alcohol Depend 102:35-40. 2009..For use in research and clinical settings, we constructed a 12-item version of the MCQ by selecting three items from each of the four factors that exhibited the greatest within-factor internal consistency (Cronbach's alpha coefficient)... - Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependenceIvan D Montoya
Division of Treatment Research and Development and Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Clin Pharmacol Ther 75:34-48. 2004..CONCLUSIONS: A sublingual buprenorphine solution at 16 mg daily is well tolerated and effective in reducing concomitant opiate and cocaine use. The therapeutic effect on cocaine use appears independent of that on opiate use... - Conditional substance abuse and dependence by diagnosis of mood or anxiety disorder or schizophrenia in the U.S. populationSilvia S Martins
Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, MD 21205 1900, USA
Drug Alcohol Depend 119:28-36. 2011..Little is known about the association of various psychiatric disorders with the risk of developing dependence or abuse among users of various psychoactive substances (conditional dependence, CD; conditional abuse, CA)... - MDMA and metabolite disposition in expectorated oral fluid after controlled oral MDMA administrationAllan J Barnes
Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Ther Drug Monit 33:602-8. 2011..Oral fluid is an important alternative matrix for drug testing, but little is known about MDMA detection windows in oral fluid... - EEG and cerebral blood flow velocity abnormalities in chronic cocaine usersMarc L Copersino
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
Clin EEG Neurosci 40:39-42. 2009..EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence... - Effects of the cannabinoid-1 receptor antagonist rimonabant on psychiatric symptoms in overweight people with schizophrenia: a randomized, double-blind, pilot studyDeanna L Kelly
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
J Clin Psychopharmacol 31:86-91. 2011..The endocannabinoid system remains a promising target for pharmacotherapy of schizophrenia and obesity... - Serotonergic responsiveness in human cocaine usersUdi E Ghitza
Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Drug Alcohol Depend 86:207-13. 2007..Studies of human cocaine users given a serotonergic challenge have produced inconsistent results... - Disposition of MDMA and metabolites in human sweat following controlled MDMA administrationAllan J Barnes
Chemistry and Drug Metabolism and Office of Scientific Director, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore MD 21224, USA
Clin Chem 55:454-62. 2009..Understanding the excretion of 3,4-methylenedioxymethamphetamine (MDMA) and metabolites in sweat is vital for interpretation of sweat tests in drug treatment, criminal justice, and workplace programs... - EEG absolute power during extended cocaine abstinenceKenneth H Levin
From the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD
J Addict Med 1:139-44. 2007..The findings suggest that chronic cocaine use is associated with EEG changes that may reflect persisting brain electrophysiological abnormalities during cocaine abstinence... - Effect of rate of administration on subjective and physiological effects of intravenous cocaine in humansRichard A Nelson
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Drug Alcohol Depend 82:19-24. 2006..These findings provide support for the rate hypothesis as it applies to both subjective and cardiovascular effects of IV cocaine administration in humans... - A factor analysis of the Fagerström Test for Nicotine Dependence (FTND)Aleksandras Radzius
Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224, USA
Nicotine Tob Res 5:255-40. 2003..These two dimensions may provide indirect assessment of a smoker's daily nicotine intake. Testing this hypothesis requires correlation of biomarkers and responses to specific items of the FTND... - The Fagerstrom Test for Nicotine Dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?Eric T Moolchan
Clinical Pharmacology and Therapeutics Research Branch, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore MD, 21224, USA
Addict Behav 27:101-13. 2002..Disagreements between the FTND and the DSM are likely to become greater with the changes in the DSM-IV... - Use of a 'microecological technique' to study crime incidents around methadone maintenance treatment centersSusan J Boyd
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
Addiction 107:1632-8. 2012..Methadone maintenance reduces crime among those treated, but the relationship between MTCs and neighborhood crime is unknown. We evaluated crime around MTCs... - Differential response to IV carfentanil in chronic cocaine users and healthy controlsCarolynne P Minkowski
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA
Addict Biol 17:149-55. 2012..These findings suggest that cocaine users are less responsive than healthy controls to mOR agonist adverse effects despite having increased regional brain mOR binding potential... - Cannabis withdrawal among non-treatment-seeking adult cannabis usersMarc L Copersino
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224-6823, USA
Am J Addict 15:8-14. 2006.... - Open-label pilot study of bupropion plus bromocriptine for treatment of cocaine dependenceIvan D Montoya
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Am J Drug Alcohol Abuse 28:189-96. 2002..There were no significant differences in outcome between groups. These results suggest that the combination of bupropion and bromocriptine is safe in cocaine addicts, but provide ambiguous evidence of its efficacy... - Risk of psychoactive substance dependence among substance users in a trauma inpatient populationSilvia S Martins
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Addict Dis 26:71-7. 2007.... - Calorie restriction increases cigarette use in adult smokersLawrence J Cheskin
Department of Health and Human Services, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 179:430-6. 2005..These findings suggest that dieting may increase smoking behavior and could impede smoking-cessation attempts... - Imaging brain mu-opioid receptors in abstinent cocaine users: time course and relation to cocaine cravingDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
Biol Psychiatry 57:1573-82. 2005..Human data regarding this phenomenon are limited. We previously used positron emission tomography (PET) with [11C]-carfentanil to show increased mOR binding in brain regions of 10 cocaine-dependent men after 1 and 28 days of abstinence... - Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in ratsGilberto N Carmona
Intramural Research Programs, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Eur J Pharmacol 517:186-90. 2005..These findings suggest that butyrylcholinesterase treatment may have benefits in enhancing cocaine metabolism and in increasing levels of ecgonine methylester, which may have a protective action against cocaine... - Methods for clinical research involving cannabis administrationDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Methods Mol Med 123:235-53. 2006..Subjects should not be discharged from research participation until reevaluation has shown that they have returned to baseline status... - Strategies for quitting among non-treatment-seeking marijuana smokersSusan J Boyd
Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
Am J Addict 14:35-42. 2005..Clinicians are likely to see marijuana users in their practice and should be proactive in offering assistance, incorporating the strategies reported here into treatment plans for their marijuana-using patients... - Counseling plus buprenorphine-naloxone for opioid dependenceDavid A Gorelick
N Engl J Med 355:1736; author reply 1736-7. 2006 - Spending of remuneration by subjects in non-treatment drug abuse research studiesJacob E Kurlander
Columbia University, New York, New York, USA
Am J Drug Alcohol Abuse 32:527-40. 2006..CONCLUSION: Residential drug abuse research participants prefer cash to in-kind research remuneration, and their choices reflected drug use and economic status... - Regarding "Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system"David A Gorelick
Biol Psychiatry 62:702; author reply 702. 2007 - Management of alcohol withdrawal delirium. An evidence-based practice guidelineMichael F Mayo-Smith
Primary Care Service, Veterans Administration Medical Center, Manchester, NH 03104, USA
Arch Intern Med 164:1405-12. 2004..Alcohol withdrawal delirium is the most serious manifestation of alcohol withdrawal. Evidence suggests that appropriate care improves mortality, but systematic reviews are unavailable... - The Lexington narcotic farmThomas R Kosten
Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Am J Psychiatry 159:22. 2002 - World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: AlcoholismMichael Soyka
Psychiatric Hospital Meiringen, Meiringen, Switzerland
World J Biol Psychiatry 9:6-23. 2008..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...