David A Gorelick

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Bromocriptine treatment for cocaine addiction: association with plasma prolactin levels
    David A Gorelick
    Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Department of Health and Human Services DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 81:189-95. 2006
  2. ncbi request reprint Agents in development for the management of cocaine abuse
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drugs 64:1547-73. 2004
  3. pmc CB1 - cannabinoid receptor antagonist effects on cortisol in cannabis-dependent men
    Robert S Goodwin
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institutes of Health, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Am J Drug Alcohol Abuse 38:114-9. 2012
  4. ncbi request reprint Sociodemographic characteristics associated with substance use status in a trauma inpatient population
    Silvia S Martins
    Department of Mental Health, John Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Addict Dis 26:53-62. 2007
  5. pmc In vitro stability of free and glucuronidated cannabinoids in blood and plasma following controlled smoked cannabis
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 59:1108-17. 2013
  6. pmc Tolerance to effects of high-dose oral δ9-tetrahydrocannabinol and plasma cannabinoid concentrations in male daily cannabis smokers
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    J Anal Toxicol 37:11-6. 2013
  7. pmc Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users
    Marilyn A Huestis
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 194:505-15. 2007
  8. pmc Sociodemographic characteristics of cannabis smokers and the experience of cannabis withdrawal
    Marc L Copersino
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Am J Drug Alcohol Abuse 36:311-9. 2010
  9. pmc Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Psychopharmacology (Berl) 200:475-86. 2008
  10. ncbi request reprint Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance use
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Am J Addict 15:297-302. 2006

Detail Information

Publications73

  1. ncbi request reprint Bromocriptine treatment for cocaine addiction: association with plasma prolactin levels
    David A Gorelick
    Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Department of Health and Human Services DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 81:189-95. 2006
    ..These data do not support the efficacy of bromocriptine treatment nor a role for prolactin concentration in predicting treatment response...
  2. ncbi request reprint Agents in development for the management of cocaine abuse
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drugs 64:1547-73. 2004
    ..A recent phase I trial of a "cocaine vaccine" found it to be well tolerated and producing detectable levels of anti-cocaine antibodies for up to 9 months after immunisation...
  3. pmc CB1 - cannabinoid receptor antagonist effects on cortisol in cannabis-dependent men
    Robert S Goodwin
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institutes of Health, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Am J Drug Alcohol Abuse 38:114-9. 2012
    ..The endocannabinoid system modulates the hypothalamic-pituitary-adrenal (HPA) axis, but the effect of cannabinoid type 1 (CB1) receptor antagonism following chronic CB1 receptor stimulation in humans is unknown...
  4. ncbi request reprint Sociodemographic characteristics associated with substance use status in a trauma inpatient population
    Silvia S Martins
    Department of Mental Health, John Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Addict Dis 26:53-62. 2007
    ..1%) were also more likely male, unmarried, and older. These findings highlight the need for screening for substance use disorders in trauma settings and referral of patients to substance abuse treatment programs...
  5. pmc In vitro stability of free and glucuronidated cannabinoids in blood and plasma following controlled smoked cannabis
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 59:1108-17. 2013
    ..Blood and plasma cannabinoid stability is important for test interpretation and is best studied in authentic rather than fortified samples...
  6. pmc Tolerance to effects of high-dose oral δ9-tetrahydrocannabinol and plasma cannabinoid concentrations in male daily cannabis smokers
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    J Anal Toxicol 37:11-6. 2013
    ..Plasma THC and 11-OH-THC concentrations increased significantly over the first five days of dosing. Six days of around-the-clock, oral THC produced tolerance to subjective intoxication, but not to cardiovascular effects...
  7. pmc Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users
    Marilyn A Huestis
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 194:505-15. 2007
    ..A single 90-mg dose of the cannabinoid CB1 receptor antagonist rimonabant attenuates effects of smoked cannabis in humans...
  8. pmc Sociodemographic characteristics of cannabis smokers and the experience of cannabis withdrawal
    Marc L Copersino
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Am J Drug Alcohol Abuse 36:311-9. 2010
    ..Cannabis withdrawal can be a negative reinforcer for relapse, but little is known about its association with demographic characteristics...
  9. pmc Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Psychopharmacology (Berl) 200:475-86. 2008
    ..Cocaine users have increased regional brain mu-opioid receptor (mOR) binding which correlates with cocaine craving. The relationship of mOR binding to relapse is unknown...
  10. ncbi request reprint Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance use
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Am J Addict 15:297-302. 2006
    ..These findings suggest areas for further research on spontaneous recovery from marijuana use...
  11. pmc Antagonist-elicited cannabis withdrawal in humans
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Clin Psychopharmacol 31:603-12. 2011
    ..In summary, prespecified criteria for antagonist-elicited cannabis withdrawal were not observed at the 20- or 40-mg rimonabant doses. These data do not preclude antagonist-elicited withdrawal at higher rimonabant doses...
  12. pmc Influence of psychotherapy attendance on buprenorphine treatment outcome
    Ivan D Montoya
    Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    J Subst Abuse Treat 28:247-54. 2005
    ..02). These results suggest that psychotherapy can improve the outcome of buprenorphine maintenance treatment for patients with dual (cocaine and opioid) dependence...
  13. pmc Predictive model accuracy in estimating last Δ9-tetrahydrocannabinol (THC) intake from plasma and whole blood cannabinoid concentrations in chronic, daily cannabis smokers administered subchronic oral THC
    Erin L Karschner
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Drug Alcohol Depend 125:313-9. 2012
    ..5 whole blood-to-plasma (WB/P) ratio. No studies previously evaluated predictive models utilizing empirically-derived WB/P ratios, or whole blood cannabinoid pharmacokinetics after subchronic THC dosing...
  14. pmc Differentiating new cannabis use from residual urinary cannabinoid excretion in chronic, daily cannabis users
    Eugene W Schwilke
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21146, USA
    Addiction 106:499-506. 2011
    ..To develop and validate empirically a mathematical model for identifying new cannabis use in chronic, daily cannabis smokers...
  15. pmc On-site test for cannabinoids in oral fluid
    Nathalie A Desrosiers
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Clin Chem 58:1418-25. 2012
    ..On-site tests must accurately identify cannabis exposure because this drug accounts for the highest prevalence in workplace drug testing and driving under the influence of drugs (DUID) programs...
  16. pmc Diagnostic criteria for cannabis withdrawal syndrome
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Drug Alcohol Depend 123:141-7. 2012
    ..Cannabis withdrawal occurs in frequent users who quit, but there are no accepted diagnostic criteria for a cannabis withdrawal syndrome (CWS). This study evaluated diagnostic criteria for CWS proposed in DSM-V and two earlier proposals...
  17. pmc Cannabinoid disposition in oral fluid after controlled smoked cannabis
    Dayong Lee
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 58:748-56. 2012
    ....
  18. pmc Cannabis withdrawal symptoms in non-treatment-seeking adult cannabis smokers
    Kenneth H Levin
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Drug Alcohol Depend 111:120-7. 2010
    ..Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance...
  19. pmc Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administration
    Garry Milman
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 56:1261-9. 2010
    ..Cannabinoid distribution into oral fluid is complex and incompletely characterized due to the lack of controlled drug administration studies...
  20. pmc Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients
    Udi E Ghitza
    Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Biol Psychiatry 68:697-703. 2010
    ..In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown...
  21. pmc Physiological and subjective responses to controlled oral 3,4-methylenedioxymethamphetamine administration
    Erin A Kolbrich
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Clin Psychopharmacol 28:432-40. 2008
    ....
  22. pmc Cannabinoids and metabolites in expectorated oral fluid after 8 days of controlled around-the-clock oral THC administration
    Garry Milman
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224, USA
    Anal Bioanal Chem 401:599-607. 2011
    ..Measurement of THCCOOH may improve the detection and interpretation of OF cannabinoid tests and minimize the possibility of OF contamination from passive inhalation of cannabis smoke...
  23. pmc Oral fluid and plasma cannabinoid ratios after around-the-clock controlled oral Δ(9)-tetrahydrocannabinol administration
    Garry Milman
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Clin Chem 57:1597-606. 2011
    ..There is interest in predicting plasma or whole-blood concentrations from OF concentrations; however, the relationship between these matrices is incompletely characterized because of few controlled drug-administration studies...
  24. pmc Cannabis withdrawal in chronic cannabis users with schizophrenia
    Douglas L Boggs
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    J Psychiatr Res 47:240-5. 2013
    ..Chronic users of cannabis often report withdrawal symptoms after abstinence from use, but little is known about cannabis withdrawal in people with schizophrenia...
  25. pmc Psychomotor performance, subjective and physiological effects and whole blood Δ⁹-tetrahydrocannabinol concentrations in heavy, chronic cannabis smokers following acute smoked cannabis
    David M Schwope
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd, Suite 200, Baltimore, Maryland 21224, USA
    J Anal Toxicol 36:405-12. 2012
    ..These data inform our understanding of impairment and subjective effects following acute smoked cannabis and interpretation of whole blood cannabinoid concentrations in forensic investigations...
  26. pmc Cannabinoid stability in authentic oral fluid after controlled cannabis smoking
    Dayong Lee
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 58:1101-9. 2012
    ..There are few published OF stability data, and of those available, all employed fortified synthetic OF solutions or elution buffers; none included authentic OF following controlled cannabis smoking...
  27. pmc Signal-averaged electrocardiogram in physically healthy, chronic 3,4-methylenedioxymethamphetamine (MDMA) users
    Praveen Kanneganti
    Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Am J Drug Alcohol Abuse 34:712-20. 2008
    ..Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG...
  28. pmc Oral fluid and plasma 3,4-methylenedioxymethamphetamine (MDMA) and metabolite correlation after controlled oral MDMA administration
    Nathalie A Desrosiers
    Chemistry and Drug Metabolism Section, Clinical Pharmacology and Therapeutic Research Branch, NIDA IRP, Baltimore, MD 21224, USA
    Anal Bioanal Chem 405:4067-76. 2013
    ..The MDMA and MDA concentrations were higher in OF than in plasma. OF and plasma concentrations were correlated, but large inter-subject variability precludes the estimation of plasma concentrations from OF...
  29. doi request reprint Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers
    David A Gorelick
    Chemistry and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Am J Addict 22:510-4. 2013
    ..Human laboratory studies of oral THC have not shown consistent effects on sleep. We prospectively evaluated self-reported sleep parameters during controlled oral THC administration to research volunteers...
  30. pmc Identification of recent cannabis use: whole-blood and plasma free and glucuronidated cannabinoid pharmacokinetics following controlled smoked cannabis administration
    David M Schwope
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Biomedical Research Center, Baltimore, MD 21224, USA
    Clin Chem 57:1406-14. 2011
    ..Furthermore, there are no studies directly examining whole-blood cannabinoid pharmacokinetics, although this matrix is often the only available specimen...
  31. pmc Interest in marijuana treatment programs among teenage smokers and nonsmokers
    Amy J Sheer
    National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    J Subst Abuse Treat 37:421-5. 2009
    ..These findings suggest that most adolescent marijuana smokers endorse the need for and are willing to attend marijuana treatment programs...
  32. pmc Exercise stress testing in recently abstinent chronic cocaine abusers
    Praveen Kanneganti
    Department of Health and Human Services, Office of the Science Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224 2816, USA
    Am J Drug Alcohol Abuse 34:489-98. 2008
    ..EST may cause more cardiac work (indicated by heart rate and blood pressure) than intravenous cocaine (at the doses in this study)...
  33. ncbi request reprint The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokers
    David A Gorelick
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Am Heart J 151:754.e1-754.e5. 2006
    ..In human studies, activation of CB1 receptors by cannabis or its active ingredient, Delta9-tetrahydrocannabinol (THC), has modest and inconsistent effects on BP...
  34. pmc Motivations to quit cannabis use in an adult non-treatment sample: are they related to relapse?
    Emeline Chauchard
    Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Addict Behav 38:2422-7. 2013
    ..The majority of cannabis smokers who quit do so without formal treatment, suggesting that motivations to quit are an important part of cessation process. However, little is known about how motivations relate to successful quitting...
  35. ncbi request reprint Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration
    Erin A Kolbrich
    Chemistry and Drug Metabolism, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Anal Toxicol 30:501-10. 2006
    ..7 ng/mL). These data improve our knowledge of the pharmacokinetics of cocaine and its major and minor metabolites in plasma following controlled subcutaneous cocaine administration...
  36. pmc Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults
    Erin A Kolbrich
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ther Drug Monit 30:320-32. 2008
    ....
  37. doi request reprint Cannabinoids in exhaled breath following controlled administration of smoked cannabis
    Sarah K Himes
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD
    Clin Chem 59:1780-9. 2013
    ..9)-Tetrahydrocannabinol (THC), 11-nor-9-carboxy-THC (THCCOOH), and cannabinol (CBN) were measured in breath following controlled cannabis smoking to characterize the time course and windows of detection of breath cannabinoids...
  38. pmc Cannabinoids and metabolites in expectorated oral fluid following controlled smoked cannabis
    Garry Milman
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Clin Chim Acta 413:765-70. 2012
    ..9)-Tetrahydrocannabinol (THC) in oral fluid (OF) implies cannabis intake, but eliminating passive exposure and improving interpretation of test results requires additional research...
  39. pmc Delta9-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC plasma pharmacokinetics during and after continuous high-dose oral THC
    Eugene W Schwilke
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Biomedical Research Center, Baltimore, MD 21224, USA
    Clin Chem 55:2180-9. 2009
    ..Delta(9)-tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. No plasma pharmacokinetic data after repeated oral THC administration are available...
  40. pmc Urinary MDMA, MDA, HMMA, and HMA excretion following controlled MDMA administration to humans
    Tsadik T Abraham
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    J Anal Toxicol 33:439-46. 2009
    ..Measurement of urinary HMMA provides the longest detection of MDMA exposure yet is not included in routine monitoring procedures...
  41. pmc Cocaine craving and use during daily life
    Kenzie L Preston
    Treatment Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 207:291-301. 2009
    ..Craving is often assumed to cause ongoing drug use and relapse and is a major focus of addiction research. However, its relationship to drug use has not been adequately documented...
  42. pmc Longitudinal ECG changes in cocaine users during extended abstinence
    Kenneth H Levin
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 95:160-3. 2008
    ..Cocaine lengthens electrocardiographic QTc, QRS and PR intervals through blockade of sodium and potassium channels, but changes during withdrawal have not been well studied...
  43. doi request reprint Signal-averaged electrocardiogram in physically healthy, recently abstinent chronic cocaine users
    Praveen Kanneganti
    From the Department of Health and Human Services PK, MLC, RAN, SJB, DAG, Office of the Scientific Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health and Division of Cardiology RCZ, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
    J Addict Med 3:128-33. 2009
    ..Markers of ventricular late potentials, which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG) but not by standard ECG...
  44. pmc Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependence
    Ivan D Montoya
    Division of Treatment Research and Development and Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Clin Pharmacol Ther 75:34-48. 2004
    ..Its efficacy for cocaine dependence is uncertain. This study evaluated buprenorphine for the treatment of concomitant cocaine and opiate dependence...
  45. pmc Reliability and validity of a short form of the Marijuana Craving Questionnaire
    Stephen J Heishman
    Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Drug Alcohol Depend 102:35-40. 2009
    ..For use in research and clinical settings, we constructed a 12-item version of the MCQ by selecting three items from each of the four factors that exhibited the greatest within-factor internal consistency (Cronbach's alpha coefficient)...
  46. doi request reprint In vitro stability of free and glucuronidated cannabinoids in urine following controlled smoked cannabis
    Nathalie A Desrosiers
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Suite 200 Room 05A 721, Baltimore, MD, 21224, USA
    Anal Bioanal Chem 406:785-92. 2014
    ..Substantial THCCOOH-glucuronide deconjugation was observed at RT and 4 °C. Analysis should be conducted within 3 months if non-hydrolyzed THCCOOH or THCCOOH-glucuronide quantification is required. ..
  47. pmc Conditional substance abuse and dependence by diagnosis of mood or anxiety disorder or schizophrenia in the U.S. population
    Silvia S Martins
    Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, MD 21205 1900, USA
    Drug Alcohol Depend 119:28-36. 2011
    ..Little is known about the association of various psychiatric disorders with the risk of developing dependence or abuse among users of various psychoactive substances (conditional dependence, CD; conditional abuse, CA)...
  48. pmc MDMA and metabolite disposition in expectorated oral fluid after controlled oral MDMA administration
    Allan J Barnes
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Ther Drug Monit 33:602-8. 2011
    ..Oral fluid is an important alternative matrix for drug testing, but little is known about MDMA detection windows in oral fluid...
  49. ncbi request reprint EEG absolute power during extended cocaine abstinence
    Kenneth H Levin
    From the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD
    J Addict Med 1:139-44. 2007
    ..The findings suggest that chronic cocaine use is associated with EEG changes that may reflect persisting brain electrophysiological abnormalities during cocaine abstinence...
  50. pmc Disposition of MDMA and metabolites in human sweat following controlled MDMA administration
    Allan J Barnes
    Chemistry and Drug Metabolism and Office of Scientific Director, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore MD 21224, USA
    Clin Chem 55:454-62. 2009
    ..Understanding the excretion of 3,4-methylenedioxymethamphetamine (MDMA) and metabolites in sweat is vital for interpretation of sweat tests in drug treatment, criminal justice, and workplace programs...
  51. pmc Effects of the cannabinoid-1 receptor antagonist rimonabant on psychiatric symptoms in overweight people with schizophrenia: a randomized, double-blind, pilot study
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychopharmacol 31:86-91. 2011
    ..The endocannabinoid system remains a promising target for pharmacotherapy of schizophrenia and obesity...
  52. ncbi request reprint Serotonergic responsiveness in human cocaine users
    Udi E Ghitza
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Drug Alcohol Depend 86:207-13. 2007
    ..Studies of human cocaine users given a serotonergic challenge have produced inconsistent results...
  53. ncbi request reprint Effect of rate of administration on subjective and physiological effects of intravenous cocaine in humans
    Richard A Nelson
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Drug Alcohol Depend 82:19-24. 2006
    ..These findings provide support for the rate hypothesis as it applies to both subjective and cardiovascular effects of IV cocaine administration in humans...
  54. pmc EEG and cerebral blood flow velocity abnormalities in chronic cocaine users
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Clin EEG Neurosci 40:39-42. 2009
    ..EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence...
  55. ncbi request reprint A factor analysis of the Fagerström Test for Nicotine Dependence (FTND)
    Aleksandras Radzius
    Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224, USA
    Nicotine Tob Res 5:255-40. 2003
    ..These two dimensions may provide indirect assessment of a smoker's daily nicotine intake. Testing this hypothesis requires correlation of biomarkers and responses to specific items of the FTND...
  56. ncbi request reprint The Fagerstrom Test for Nicotine Dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?
    Eric T Moolchan
    Clinical Pharmacology and Therapeutics Research Branch, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore MD, 21224, USA
    Addict Behav 27:101-13. 2002
    ..Disagreements between the FTND and the DSM are likely to become greater with the changes in the DSM-IV...
  57. pmc Oral fluid cannabinoid concentrations following controlled smoked cannabis in chronic frequent and occasional smokers
    Sébastien Anizan
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, 251 Bayview Boulevard, Baltimore, MD, 21224, USA
    Anal Bioanal Chem 405:8451-61. 2013
    ..THCCOOH windows of detection for chronic, frequent cannabis smokers extended beyond 30 h, while they were shorter (0-24 h) for occasional cannabis smokers...
  58. doi request reprint Use of a 'microecological technique' to study crime incidents around methadone maintenance treatment centers
    Susan J Boyd
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Addiction 107:1632-8. 2012
    ..Methadone maintenance reduces crime among those treated, but the relationship between MTCs and neighborhood crime is unknown. We evaluated crime around MTCs...
  59. pmc Differential response to IV carfentanil in chronic cocaine users and healthy controls
    Carolynne P Minkowski
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA
    Addict Biol 17:149-55. 2012
    ..These findings suggest that cocaine users are less responsive than healthy controls to mOR agonist adverse effects despite having increased regional brain mOR binding potential...
  60. ncbi request reprint Calorie restriction increases cigarette use in adult smokers
    Lawrence J Cheskin
    Department of Health and Human Services, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 179:430-6. 2005
    ..This concern derives, in part, from the observation that calorie restriction increases self-administration of drugs of abuse in animals. This relationship has never been experimentally demonstrated in humans...
  61. ncbi request reprint Risk of psychoactive substance dependence among substance users in a trauma inpatient population
    Silvia S Martins
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Addict Dis 26:71-7. 2007
    ....
  62. ncbi request reprint Cannabis withdrawal among non-treatment-seeking adult cannabis users
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224 6823, USA
    Am J Addict 15:8-14. 2006
    ....
  63. pmc Open-label pilot study of bupropion plus bromocriptine for treatment of cocaine dependence
    Ivan D Montoya
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Drug Alcohol Abuse 28:189-96. 2002
    ..There were no significant differences in outcome between groups. These results suggest that the combination of bupropion and bromocriptine is safe in cocaine addicts, but provide ambiguous evidence of its efficacy...
  64. ncbi request reprint Imaging brain mu-opioid receptors in abstinent cocaine users: time course and relation to cocaine craving
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 57:1573-82. 2005
    ..Human data regarding this phenomenon are limited. We previously used positron emission tomography (PET) with [11C]-carfentanil to show increased mOR binding in brain regions of 10 cocaine-dependent men after 1 and 28 days of abstinence...
  65. ncbi request reprint Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats
    Gilberto N Carmona
    Intramural Research Programs, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Eur J Pharmacol 517:186-90. 2005
    ..These findings suggest that butyrylcholinesterase treatment may have benefits in enhancing cocaine metabolism and in increasing levels of ecgonine methylester, which may have a protective action against cocaine...
  66. ncbi request reprint Methods for clinical research involving cannabis administration
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Med 123:235-53. 2006
    ..Subjects should not be discharged from research participation until reevaluation has shown that they have returned to baseline status...
  67. ncbi request reprint Strategies for quitting among non-treatment-seeking marijuana smokers
    Susan J Boyd
    Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    Am J Addict 14:35-42. 2005
    ..Clinicians are likely to see marijuana users in their practice and should be proactive in offering assistance, incorporating the strategies reported here into treatment plans for their marijuana-using patients...
  68. ncbi request reprint Spending of remuneration by subjects in non-treatment drug abuse research studies
    Jacob E Kurlander
    Columbia University, New York, New York, USA
    Am J Drug Alcohol Abuse 32:527-40. 2006
    ..This study examines remuneration spending by drug-using participants in residential drug abuse research...
  69. pmc Regarding "Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system"
    David A Gorelick
    Biol Psychiatry 62:702; author reply 702. 2007
  70. ncbi request reprint Counseling plus buprenorphine-naloxone for opioid dependence
    David A Gorelick
    N Engl J Med 355:1736; author reply 1736-7. 2006
  71. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism
    Michael Soyka
    Psychiatric Hospital Meiringen, Meiringen, Switzerland
    World J Biol Psychiatry 9:6-23. 2008
    ..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...
  72. ncbi request reprint Management of alcohol withdrawal delirium. An evidence-based practice guideline
    Michael F Mayo-Smith
    Primary Care Service, Veterans Administration Medical Center, Manchester, NH 03104, USA
    Arch Intern Med 164:1405-12. 2004
    ..Alcohol withdrawal delirium is the most serious manifestation of alcohol withdrawal. Evidence suggests that appropriate care improves mortality, but systematic reviews are unavailable...
  73. ncbi request reprint The Lexington narcotic farm
    Thomas R Kosten
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Psychiatry 159:22. 2002