Frank J Gonzalez


Affiliation: National Institutes of Health
Country: USA


  1. Gonzalez F, Yu A. Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol. 2006;46:41-64 pubmed
    ..In an effort to generate more reliable in vivo systems to study and predict human response to xenobiotics, humanized mice are under development. ..
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    Gonzalez F, Shah Y. PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology. 2008;246:2-8 pubmed
    ..These mice do not exhibit downregulation of let-7c gene expression thus forming the basis for the resistance to hepatocellular carcinogenesis. ..
  3. Zhang Y, Yang X, Yang X, Xu W, Li F, Gonzezal F. Liquid Chromatography with Tandem Mass Spectrometry: A Sensitive Method for the Determination of Dehydrodiisoeugenol in Rat Cerebral Nuclei. Molecules. 2016;21:321 pubmed publisher
    ..The data herein demonstrate that our new LC-MS/MS method is highly sensitive and suitable for monitoring cerebral nuclei distribution of DDIE. ..
  4. Monte A, Brocker C, Nebert D, Gonzalez F, Thompson D, Vasiliou V. Improved drug therapy: triangulating phenomics with genomics and metabolomics. Hum Genomics. 2014;8:16 pubmed publisher
    ..This systems biology approach has the potential, in specific subsets of patients, to avoid drug therapy that will be either ineffective or unsafe. ..
  5. Khozoie C, Borland M, Zhu B, Baek S, John S, Hager G, et al. Analysis of the peroxisome proliferator-activated receptor-?/? (PPAR?/?) cistrome reveals novel co-regulatory role of ATF4. BMC Genomics. 2012;13:665 pubmed publisher
    ..Results from these studies are the first to demonstrate that differences in DNA binding of other transcription factors can directly influence the transcriptional activity of PPAR?/?. ..
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    Gonzalez F, Fernandez Salguero P, Lee S, Pineau T, Ward J. Xenobiotic receptor knockout mice. Toxicol Lett. 1995;82-83:117-21 pubmed
    ..To explore the function of AHR and PPAR alpha and to determine whether they participate in the adverse effects of dioxins and peroxisome proliferators, gene knockout mice were developed. ..
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    Gonzalez F, Fernandez Salguero P. The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metab Dispos. 1998;26:1194-8 pubmed
    ..AHR may directly or indirectly control levels of a cytochrome P450 that is responsible for catabolizing retinoic acid. ..
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    Gonzalez F, Kimura S. Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis. Cancer Lett. 1999;143:199-204 pubmed
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    Gonzalez F, Kimura S. Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice. Mutat Res. 2001;477:79-87 pubmed

More Information


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    Gonzalez F, Kimura S. Study of P450 function using gene knockout and transgenic mice. Arch Biochem Biophys. 2003;409:153-8 pubmed
    ..More recently, P450 humanized mice have been produced. ..
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    Gonzalez F. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res. 2005;569:101-10 pubmed
    ..CYP2E1 is thought to contribute to liver pathologies that result from alcoholic liver disease and non-alcoholic steatohepatitis. ..
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    Gonzalez F. CYP3A4 and pregnane X receptor humanized mice. J Biochem Mol Toxicol. 2007;21:158-62 pubmed