Research Topics
Genomes and Genes | D W GongSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genesD W Gong
Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland, 20892 1770, USA
Biochem Biophys Res Commun 256:27-32. 1999..The data suggest that it is not a reduction in UCP2 or UCP3 expression that causes obesity in the susceptible mice...- Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptinD W Gong
Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
J Biol Chem 272:24129-32. 1997..The UCP3 gene is located close to that encoding UCP2, in a chromosomal region implicated in previous linkage studies as contributing to obesity... - Identification of TFIID components required for transcriptional activation by upstream stimulatory factorT Kokubo
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 268:17554-8. 1993..This suggests that p230 is an integral subunit of TFIID and that it may play a major role in tethering other subunits to TFIID tau... - Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIIDT Kokubo
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
Genes Dev 7:1033-46. 1993.... 
The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunitT Kokubo
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 90:5896-900. 1993..A binding study using various p230 mutants indicated that both p110 and TFIID tau interact with the N-terminal 352-amino acid portion of p230, suggesting a functional communication between p110 and TFIID tau via p230 interactions...- Thyroid hormone and other regulators of uncoupling proteinsM L Reitman
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1770, USA
Int J Obes Relat Metab Disord 23:S56-9. 1999..Since free fatty acids appear to regulate UCP3 expression and T3 stimulates lipolysis, further experiments are required to determine if T3 regulation of UCP3 expression is direct or not... - Identification of a placental enhancer for the human leptin geneS Bi
Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
J Biol Chem 272:30583-8. 1997..Upon triplication, the PLE3 element was a strong enhancer in choriocarcinoma cells but not in HeLa cells. The protein binding to the PLE3 motif appears to be a novel, placenta-specific transcription factor... - Analysis of cDNA encoding Drosophila transcription initiation factor TFIIF alpha (RAP74)D W Gong
Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, MD 20892
Nucleic Acids Res 21:1492. 1993 - Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3D W Gong
Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:16251-7. 2000..The phenotype of Ucp1/Ucp3 double knockout mice was indistinguishable from Ucp1 single knockout mice. These data suggest that Ucp3 is not a major determinant of metabolic rate but, rather, has other functions... - Genomic structure and promoter analysis of the human obese geneD W Gong
Molecular and Cellular Endocrinology Branch and Phoenix Epidemiology and Clinical Research Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 271:3971-4. 1996..A 3-kb 5'-flanking region of the gene was cloned and transient transfection assay with luciferase reporter confirmed the promoter activity in differentiated F442-A adipocytes. Potential regulatory elements are discussed in this report... - Molecular cloning of cDNA encoding the small subunit of Drosophila transcription initiation factor TFIIFD W Gong
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 23:1882-6. 1995..Thus we conclude that isolated cDNA encodes bona fide TFIIF beta. The structural domains of TFIIF beta and its sequence similarity to bacterial delta factors are discussed... - Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIBS Yamashita
Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 89:2839-43. 1992..This suggests that TFIIB has a more rigid structure, consistent with its function as a "bridging" protein between TFIID and RNA polymerase II. Further implications of the TFIIB structure are discussed... - Molecular cloning of Drosophila TFIID subunitsT Kokubo
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
Nature 367:484-7. 1994..Sequence similarities between p62/p42 and the histones H4/H3, respectively, suggest that these subunits have a functional relationship with chromatin... - Molecular cloning, expression, and characterization of the Drosophila 85-kilodalton TFIID subunitT Kokubo
National Institute of Child Health and Human Development, Bethesda, Maryland 20892
Mol Cell Biol 13:7859-63. 1993..These observations leave open the possibility of a distinct function for the WD-40 repeats, possibly in transducing signals by interactions with transcriptional regulators and/or other components of the basic transcriptional machinery... - Elucidation of three putative structural subdomains by comparison of primary structure of Xenopus and human RAP74D W Gong
Laboratory of Molecular Biology, NINDS, NIH, Bethesda, MD 20892
Nucleic Acids Res 20:6736. 1992 - Imperfect conservation of a sigma factor-like subregion in Xenopus general transcription factor RAP30D W Gong
Laboratory of Molecular Biology, NINDS, NIH, Bethesda, MD 20892
Nucleic Acids Res 20:6414. 1992