D W Gong

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland, 20892 1770, USA
    Biochem Biophys Res Commun 256:27-32. 1999
  2. ncbi request reprint Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    J Biol Chem 272:24129-32. 1997
  3. ncbi request reprint Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:17554-8. 1993
  4. ncbi request reprint Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Genes Dev 7:1033-46. 1993
  5. pmc The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:5896-900. 1993
  6. ncbi request reprint Thyroid hormone and other regulators of uncoupling proteins
    M L Reitman
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1770, USA
    Int J Obes Relat Metab Disord 23:S56-9. 1999
  7. ncbi request reprint Identification of a placental enhancer for the human leptin gene
    S Bi
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    J Biol Chem 272:30583-8. 1997
  8. pmc Analysis of cDNA encoding Drosophila transcription initiation factor TFIIF alpha (RAP74)
    D W Gong
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, MD 20892
    Nucleic Acids Res 21:1492. 1993
  9. ncbi request reprint Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:16251-7. 2000
  10. ncbi request reprint Genomic structure and promoter analysis of the human obese gene
    D W Gong
    Molecular and Cellular Endocrinology Branch and Phoenix Epidemiology and Clinical Research Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:3971-4. 1996

Detail Information

Publications16

  1. ncbi request reprint Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland, 20892 1770, USA
    Biochem Biophys Res Commun 256:27-32. 1999
    ..The data suggest that it is not a reduction in UCP2 or UCP3 expression that causes obesity in the susceptible mice...
  2. ncbi request reprint Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    J Biol Chem 272:24129-32. 1997
    ..The UCP3 gene is located close to that encoding UCP2, in a chromosomal region implicated in previous linkage studies as contributing to obesity...
  3. ncbi request reprint Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:17554-8. 1993
    ..This suggests that p230 is an integral subunit of TFIID and that it may play a major role in tethering other subunits to TFIID tau...
  4. ncbi request reprint Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Genes Dev 7:1033-46. 1993
    ....
  5. pmc The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:5896-900. 1993
    ..A binding study using various p230 mutants indicated that both p110 and TFIID tau interact with the N-terminal 352-amino acid portion of p230, suggesting a functional communication between p110 and TFIID tau via p230 interactions...
  6. ncbi request reprint Thyroid hormone and other regulators of uncoupling proteins
    M L Reitman
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1770, USA
    Int J Obes Relat Metab Disord 23:S56-9. 1999
    ..Since free fatty acids appear to regulate UCP3 expression and T3 stimulates lipolysis, further experiments are required to determine if T3 regulation of UCP3 expression is direct or not...
  7. ncbi request reprint Identification of a placental enhancer for the human leptin gene
    S Bi
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    J Biol Chem 272:30583-8. 1997
    ..Upon triplication, the PLE3 element was a strong enhancer in choriocarcinoma cells but not in HeLa cells. The protein binding to the PLE3 motif appears to be a novel, placenta-specific transcription factor...
  8. pmc Analysis of cDNA encoding Drosophila transcription initiation factor TFIIF alpha (RAP74)
    D W Gong
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, MD 20892
    Nucleic Acids Res 21:1492. 1993
  9. ncbi request reprint Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:16251-7. 2000
    ..The phenotype of Ucp1/Ucp3 double knockout mice was indistinguishable from Ucp1 single knockout mice. These data suggest that Ucp3 is not a major determinant of metabolic rate but, rather, has other functions...
  10. ncbi request reprint Genomic structure and promoter analysis of the human obese gene
    D W Gong
    Molecular and Cellular Endocrinology Branch and Phoenix Epidemiology and Clinical Research Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:3971-4. 1996
    ..A 3-kb 5'-flanking region of the gene was cloned and transient transfection assay with luciferase reporter confirmed the promoter activity in differentiated F442-A adipocytes. Potential regulatory elements are discussed in this report...
  11. pmc Molecular cloning of cDNA encoding the small subunit of Drosophila transcription initiation factor TFIIF
    D W Gong
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 23:1882-6. 1995
    ..Thus we conclude that isolated cDNA encodes bona fide TFIIF beta. The structural domains of TFIIF beta and its sequence similarity to bacterial delta factors are discussed...
  12. pmc Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB
    S Yamashita
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:2839-43. 1992
    ..This suggests that TFIIB has a more rigid structure, consistent with its function as a "bridging" protein between TFIID and RNA polymerase II. Further implications of the TFIIB structure are discussed...
  13. ncbi request reprint Molecular cloning of Drosophila TFIID subunits
    T Kokubo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Nature 367:484-7. 1994
    ..Sequence similarities between p62/p42 and the histones H4/H3, respectively, suggest that these subunits have a functional relationship with chromatin...
  14. pmc Molecular cloning, expression, and characterization of the Drosophila 85-kilodalton TFIID subunit
    T Kokubo
    National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    Mol Cell Biol 13:7859-63. 1993
    ..These observations leave open the possibility of a distinct function for the WD-40 repeats, possibly in transducing signals by interactions with transcriptional regulators and/or other components of the basic transcriptional machinery...
  15. pmc Elucidation of three putative structural subdomains by comparison of primary structure of Xenopus and human RAP74
    D W Gong
    Laboratory of Molecular Biology, NINDS, NIH, Bethesda, MD 20892
    Nucleic Acids Res 20:6736. 1992
  16. pmc Imperfect conservation of a sigma factor-like subregion in Xenopus general transcription factor RAP30
    D W Gong
    Laboratory of Molecular Biology, NINDS, NIH, Bethesda, MD 20892
    Nucleic Acids Res 20:6414. 1992