Research Topics
| D S GoldsteinSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's diseaseDavid S Goldstein
Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, MD 20892 1620, USA
J Neurochem 123:932-43. 2012....
Temporary elimination of orthostatic hypotension by norepinephrine infusionDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Auton Res 22:303-6. 2012..v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH...- Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseasesDavid S Goldstein
National Instituteof Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Cell Mol Neurobiol 32:661-6. 2012..Parkinson disease might be a disease of the elderly because of allostatic load, which depends on genetic predispositions,environmental exposures, repeated stress-related catecholamine release, and time... - Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson's disease and other synucleinopathiesDavid S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disordersand Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Brain 135:1900-13. 2012..Parkinson's disease and pure autonomic failure involve differential dopaminergic versus noradrenergic lesions. Cerebrospinal fluid dihydroxyphenylacetic acid seems to provide a sensitive means to identify even early Parkinson's disease... - Neurocardiology: therapeutic implications for cardiovascular diseaseDavid S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Cardiovasc Ther 30:e89-106. 2012.... 
Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: a meta-analysisDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Endocr Regul 42:111-9. 2008..Here we report results of a meta-analysis of the literature, examining inter-relationships among AHS, HPA, and SNS responses to stressors, as measured by plasma epinephrine (EPI), corticotrophin (ACTH), and norepinephrine (NE) levels...- Catecholamines and stressDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1620, USA
Endocr Regul 37:69-80. 2003 - L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrugDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
Cardiovasc Drug Rev 24:189-203. 2006..L-DOPS holds promise for treating other much more common conditions involving decreased DBH activity or NE deficiency, such as a variety of syndromes associated with neurogenic orthostatic hypotension... - Association between supine hypertension and orthostatic hypotension in autonomic failureDavid S Goldstein
the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Hypertension 42:136-42. 2003..The finding of lower plasma NE levels in patients with than without supine hypertension suggests involvement of pressor mechanisms independent of the sympathetic nervous system... - Sympathetic innervation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's diseaseDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
J Pharmacol Exp Ther 306:855-60. 2003.... - Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromesDavid S Goldstein
Clinical Neurocardiology Section, NINDS, NIH, USA
Circulation 106:2358-65. 2002..Whether these conditions involve abnormal cardiac sympathetic innervation or function has been unclear... - Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotensionD S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
Neurology 60:1327-32. 2003..From the concept of a unitary sympathoadrenomedullary system, one might predict parallel sympathoneural and adrenomedullary abnormalities in NOH... - Sources and significance of plasma levels of catechols and their metabolites in humansDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620
J Pharmacol Exp Ther 305:800-11. 2003..This article provides an update about plasma levels of catechols and their metabolites and the relevance of those levels to some issues in human health and disease... - Computer models of stress, allostasis, and acute and chronic diseasesDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Ann N Y Acad Sci 1148:223-31. 2008..These models can be used to predict effects of environmental and genetic alterations on allostatic load and therefore on the development of multisystem disorders and failures... - Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotensionDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, U S A
Clin Sci (Lond) 104:649-54. 2003..41+/-1.77 nmol/l respectively; P =0.006). The findings are consistent with central noradrenergic deficiency in both MSA+OH and PAF. In MSA, central noradrenergic deficiency seems to relate specifically to OH... - Neuronal source of plasma dopamineDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
Clin Chem 54:1864-71. 2008..We tested in humans whether DA enters the plasma after corelease with NE during exocytosis from sympathetic noradrenergic nerves... - Cardiac sympathetic hypo-innervation in familial dysautonomiaDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive MSC 1620, Building 10 Room 6N252, Bethesda, MD 20892 1620, USA
Clin Auton Res 18:115-9. 2008..Whether such loss extends to sympathetic innervation of the heart has been unknown. This study used 6-[(18)F]fluorodopamine neuroimaging to assess cardiac sympathetic innervation and function in FD... - Central dopamine deficiency in pure autonomic failureDavid S Goldstein
Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
Clin Auton Res 18:58-65. 2008..A patient with PAF and another with PD had rapid postmortem striatal, nigral, and sympathetic ganglion sampling, with assays of catechols and tyrosine hydroxylase activity... - Diagnosis and localization of pheochromocytomaDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Hypertension 43:907-10. 2004..It also confirms that functional imaging by 6-[18F]fluorodopamine or 123I-metaiodobenzylguanidine scanning can localize pheochromocytoma in difficult cases in which other imaging tests are not diagnostic... - Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatmentDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Hypertension 46:1333-9. 2005..Parkinson disease with orthostatic hypotension features reflexive cardiovagal and sympathoneural failure and cardiac and partial extracardiac sympathetic denervation, independent of levodopa treatment... - Orthostatic hypotension as an early finding in Parkinson's diseaseDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892, USA
Clin Auton Res 16:46-54. 2006..In PD, OH can occur early in the disease, occasionally preceding or overshadowing the movement disorder... - Clinical catecholamine neurochemistry: a legacy of Julius AxelrodDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Cell Mol Neurobiol 26:695-702. 2006..2. Here, we provide examples of this aspect of Axelrod's scientific legacy... - Cardiac sympathetic denervation preceding motor signs in Parkinson diseaseDavid S Goldstein
Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
Clin Auton Res 17:118-21. 2007..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD... - Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failureDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Auton Res 14:363-8. 2004.... - Cardiac denervation in patients with Parkinson diseaseDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Cleve Clin J Med 74:S91-4. 2007.... - Evolution of concepts of stressDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
Stress 10:109-20. 2007..This systems concept of stress yields predictions that observation or experimentation can test and that are applicable to normal physiology and to a variety of acute and chronic disorders... - Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutationD S Goldstein
Clinical Neurocardiology Section, National Institutes on Neurological Disorders and Stroke, National Institute on Aging, NIH, Bethesda, MD 20892 1620, USA
Neurology 69:1580-4. 2007..Familial PD caused by mutation of the gene encoding alpha-synuclein or by alpha-synuclein gene triplication also features cardiac sympathetic denervation and baroreflex failure... - Painful sweatingDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurologic Disorders and Stroke, Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
Neurology 63:1471-5. 2004..The authors report a case of spontaneous and gustatory facial pain and sweating... - Functional neuroimaging of sympathetic innervation of the heartDavid S Goldstein
Building 10, Room 6N252, NINDS, NIH, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
Ann N Y Acad Sci 1018:231-43. 2004..Analogous abnormalities might help explain increased cardiovascular risk in psychiatric disorders such as melancholic depression... - Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophyDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Parkinsonism Relat Disord 14:600-7. 2008..This study compared neuroimaging, neurochemical, and olfactory potential biomarkers to detect central dopamine (DA) deficiency and distinguish PD from multiple system atrophy (MSA)... - Plasma catechols in familial dysautonomia: a long-term follow-up studyDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Building 10 Room 6N252, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
Neurochem Res 33:1889-93. 2008..In FD, plasma catechol profiles are sufficiently stable, at least over a decade, to be used as a biomarker of disease involvement. An increasing DOPA:DHPG ratio suggests slight but consistent, progressive loss of noradrenergic neurons... - Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: Preliminary observationsDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
Auton Neurosci 146:18-21. 2009..PAF entails cardiac sympathetic denervation, whereas cardiac sympathetic neuroimaging by thoracic 6-[(18)F]fluorodopamine scanning indicates intact myocardial sympathetic innervation in AAG... - Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptorDavid S Goldstein
Building 10, Room 6N252, Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
Clin Auton Res 12:281-5. 2002..The findings in this case support the concept that circulating antibodies to this receptor can interfere with ganglionic neurotransmission and produce autoimmune autonomic neuropathy... - Association of anosmia with autonomic failure in Parkinson diseaseDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive MSC 1620, Building 10 Room 5N220, Bethesda, MD 20892 1620, USA
Neurology 74:245-51. 2010..This observational study assessed whether in PD anosmia and autonomic failure are related to each other or to neuroimaging evidence of striatal dopamine deficiency... - Effects of carbidopa and entacapone on the metabolic fate of the norepinephrine prodrug L-DOPSDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
J Clin Pharmacol 51:66-74. 2011.... - Neuroscience and heart-brain medicine: the year in reviewDavid S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892 1620, USA
Cleve Clin J Med 77:S34-9. 2010..Lack of correlation between commonly used indices from power spectral analysis of heart rate variability and cardiac norepinephrine spillover casts doubt on the validity of power spectral analysis to indicate cardiac sympathetic tone... - Neurocirculatory abnormalities in chronic orthostatic intoleranceDavid S Goldstein
Clinical Neurocardiology Section, NINDS, National Institutes of Health, Bethesda, MD, USA
Circulation 111:839-45. 2005..This study addressed whether patients with COI and POTS or NCS have neurocirculatory abnormalities during supine rest... - Catecholamines 101David S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, 9000 Rockville Pike, Bldg 10 Rm 5N220, Bethesda, MD 20892, USA
Clin Auton Res 20:331-52. 2010.... - Adrenal responses to stressDavid S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N220, 9000 Rockville Pike, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
Cell Mol Neurobiol 30:1433-40. 2010..Instead, adrenomedullary responses to stressors are more closely tied to adrenocortical than to sympathetic noradrenergic responses. Distress involves concurrent activation of the HPA and adrenomedullary neuroendocrine systems... - Catechols in post-mortem brain of patients with Parkinson diseaseD S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
Eur J Neurol 18:703-10. 2011.... - Autonomic dysfunction in PD: a window to early detection?David S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
J Neurol Sci 310:118-22. 2011..In elderly patients with unexplained OH or other evidence of autonomic failure, it is reasonable for clinicians to look for subtle signs of parkinsonism, such as masked facies, cogwheel rigidity, and shuffling gate... - Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseasesD S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Endocr Regul 45:91-8. 2011..Parkinson disease might be a disease of the elderly because of allostatic load, which depends on genetic predispositions, environmental exposures, repeated stress-related catecholamine release, and time... - Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseasesDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke NINDS, NIH, Bethesda, Maryland 20892 1620, USA
J Clin Invest 121:3320-30. 2011..Vesicular uptake may constitute a novel target for diagnosis, treatment, and prevention... - Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathyDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Auton Res 22:57-61. 2012..In this case, neuroimaging evidence of cardiac noradrenergic denervation and subsequent progressive striatal dopaminergic denervation fit with Braak staging... - The wisdom of the body revisited: the adrenomedullary response to mild core hypothermia in humansD S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological and Stroke, Bethesda, MD, U S A
Endocr Regul 35:3-7. 2001..The present study used arterial levels of these catecholamines, to determine whether adrenomedullary stimulation occurs in response to decreased body temperature... - Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexesDavid S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Exp Physiol 96:1255-61. 2011..Manipulations and drugs that change LF power or LF:HF may do so not by affecting cardiac autonomic outflows directly but by affecting modulation of those outflows by baroreflexes... - Cardiac sympathetic neuroimaging: summary of the First International SymposiumDavid S Goldstein
Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, Bethesda, MA 20892 1620, USA
Clin Auton Res 19:137-48. 2009..Here, we review the background for the Symposium, provide an annotated summary of the lectures and posters, discuss some of the take-home points from the roundtable discussion, and propose a plan of action for the future... - Relative efficiencies of plasma catechol levels and ratios for neonatal diagnosis of menkes diseaseDavid S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Neurochem Res 34:1464-8. 2009..The relative diagnostic efficiencies of levels of catechol analytes, alone or in combination, in neonates at genetic risk of Menkes disease have been unknown... - Allostasis, homeostats, and the nature of stressDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 6N252, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
Stress 5:55-8. 2002..Applying these notions can aid in understanding how acute and chronic stress can exert adverse health consequences via allostatic load... - Orthostatic hypotension from sympathetic denervation in Parkinson's diseaseD S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
Neurology 58:1247-55. 2002..Patients with PD often have signs or symptoms of autonomic failure, including orthostatic hypotension. Cardiac sympathetic denervation occurs frequently in PD, but this has been thought to occur independently of autonomic failure... - Pioneer Award Address: ignorance isn't biased: comments on receiving the Pioneer AwardDavid S Goldstein
Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
Cleve Clin J Med 76:S31-6. 2009..Patients are a unique scientific resource because they tell us the truth. We experience the joy and thrill of a "sparkle of insight" when we realize what they teach... - Kinetic model for the fate of 6-[18F]fluorodopamine in the human heart: a novel means to examine cardiac sympathetic neuronal functionDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
Naunyn Schmiedebergs Arch Pharmacol 365:38-49. 2002..The model seems useful in predicting effects of altered cardiac sympathetic function on time-activity curves for myocardial 6-[18F]fluorodopamine-derived radioactivity in humans... - Cardiac sympathetic denervation preceding motor signs in Parkinson diseaseDavid S Goldstein
Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC 1620, Building 10, Room 6N252, Bethesda, MD 20892 1620, USA
Cleve Clin J Med 76:S47-50. 2009..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD... - Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseasesDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Parkinsonism Relat Disord 15:516-20. 2009.... - Cardiac ectopy in chronic autonomic failureDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, Building 10 Room 5N220, Bethesda, MD 20892 1620, USA
Clin Auton Res 20:85-92. 2010..This study assessed whether CAF is associated with an increased prevalence of cardiac ectopy... - Neurotransmitter specificity of sympathetic denervation in Parkinson's diseaseY Sharabi
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Neurology 60:1036-9. 2003..All 12 had normal QSART results. The sympathetic nervous system lesion in PD involves loss of postganglionic catecholaminergic but not cholinergic nerves... - Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypesG Eisenhofer
Clinical Neurocardiology Section and Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Clin Endocrinol Metab 86:1999-2008. 2001.... - A "pheo" lurks: novel approaches for locating occult pheochromocytomaK Pacak
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
J Clin Endocrinol Metab 86:3641-6. 2001..These novel approaches may be of value in difficult cases, where biochemical and clinical evidence of pheochromocytoma is compelling, yet conventional imaging modalities fail to locate the tumor... - Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotensionYehonatan Sharabi
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Mov Disord 23:1725-32. 2008..In contrast, the parasympathetic cholinergic and adrenomedullary hormonal components of the autonomic nervous system seem intact in PD+NOH... - Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2G Eisenhofer
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
N Engl J Med 340:1872-9. 1999..In this study we evaluated measurements of plasma normetanephrine and metanephrine for detecting pheochromocytomas in patients with von Hippel-Lindau disease or MEN-2... - A test of the "epinephrine hypothesis" in humansD S Goldstein
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
Hypertension 33:36-43. 1999..The findings are inconsistent with the epinephrine hypothesis... - Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytomaYehonatan Sharabi
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Hypertens 25:2286-95. 2007..We therefore examined sympathoadrenal function in patients with pseudopheochromocytoma compared with age-matched control subjects in whom there was no suspicion of pheochromocytoma... - Sources and physiological significance of plasma dopamine sulfateD S Goldstein
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 84:2523-31. 1999..The findings suggest an enzymatic gut-blood barrier for detoxifying exogenous dopamine and delimiting autocrine/paracrine effects of endogenous dopamine generated in a "third catecholamine system.".. - Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotensionRichard Imrich
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Parkinsonism Relat Disord 15:122-7. 2009..We studied the impact of such denervation on cardiac chronotropic and inotropic function... - Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 geneS O Castillo
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1766, USA
Mol Cell Neurosci 11:36-46. 1998..These findings provide evidence for a new mechanism of DA depletion in vivo and suggest a unique role for Nurr1 in fetal development and/or postnatal survival... - Positron emission imaging of cardiac sympathetic innervation and function using 18F-6-fluorodopamine: effects of chemical sympathectomy by 6-hydroxydopamineD S Goldstein
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892
J Hypertens 9:417-23. 1991..Combined assessments of PET time-activity curves and plasma levels of metabolites of 18F-6-fluorodopamine constitute a new, potentially clinically applicable means by which to examine cardiac sympathetic function... - Cardiac sympathetic nerve function in congestive heart failureG Eisenhofer
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 1424, USA
Circulation 93:1667-76. 1996..This study used a comprehensive neurochemical approach to examine the mechanisms responsible for these abnormalities... - 6-[18F]fluorodopamine positron emission tomographic (PET) scanning for diagnostic localization of pheochromocytomaK Pacak
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Hypertension 38:6-8. 2001..These findings justify a clinical trial of 6-[(18)F]fluorodopamine PET scanning as a diagnostic tool... - Alpha2-adrenoceptor-mediated restraint of norepinephrine synthesis, release, and turnover during immobilization in ratsO A Tjurmina
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Brain Res 826:243-52. 1999..In the PVN, alpha2-adrenoceptors do not appear to contribute to these processes tonically and exert relatively little restraint on IMMO-induced local noradrenergic activation... - Metabolic fate of the sympathoneural imaging agent 6-[18F]fluorodopamine in humansD S Goldstein
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1424, USA
Clin Exp Hypertens 19:155-61. 1997.... - Aging-related changes in cardiac sympathetic function in humans, assessed by 6-18F-fluorodopamine PET scanningSheng-Ting Li
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 44:1599-603. 2003..02). CONCLUSION: Cardiac uptake 1 activity decreases with normal human aging... - Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humansAlexander Neumeister
Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
Pharmacogenet Genomics 15:143-9. 2005..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk... - Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failureDnyanesh N Tipre
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 46:1775-81. 2005..In this study, we examined whether 6-(18)F-fluorodopamine can visualize sympathetic innervation in extracardiac organs and, if so, whether patients with PD+OH or PAF have neuroimaging evidence of extracardiac noradrenergic denervation... - Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplicationAmanda Singleton
Parkinson's Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Brain 127:768-72. 2004..These results indicate that both parkinsonism and cardiac sympathetic denervation can result from an excess of normal synuclein... - Local sympathetic function in human skeletal muscle and adipose tissue assessed by microdialysisSimon Bruce
NINDS, NIH, Bethesda, Maryland 20892 1620, USA
Clin Auton Res 12:13-9. 2002..This study examined the validity of microdialysis and measurements of microdialysate concentrations of catechols, to assess local sympathetic function in skeletal muscle and adipose tissue in humans... - Occipital horn syndrome and a mild Menkes phenotype associated with splice site mutations at the MNK locusS G Kaler
Section on Human Biochemical Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
Nat Genet 8:195-202. 1994..In both mutations, maintenance of some normal splicing is demonstrable by RT-PCR, cDNA sequencing and ribonuclease protection... - Attenuated pre-ejection period response to tyramine in patients with cardiac sympathetic denervationRichard Imrich
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Ann N Y Acad Sci 1148:486-9. 2008..05). One of the functional consequences of cardiac sympathetic denervation is failure to increase contractility in response to stimuli that depend on endogenous norepinephrine release... - Autoimmune autonomic failure in a patient with myeloma-associated Shy-Drager syndromeD S Goldstein
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
Clin Auton Res 6:17-21. 1996..Since in this case the monoclonal antibody produced by the myeloma bound specifically to LC cells, the results are consistent with the hypothesis that in this patient the Shy-Drager syndrome may have had an immune-mediated basis... - Glucagon does not affect catecholamine release in primary cultures of bovine adrenal chromaffin cellsY Sharabi
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Horm Metab Res 37:205-8. 2005..In this study, we tested whether the catecholamine secretory response to glucagon was present in bovine chromaffin cells or exclusive to the tumor cells... - Noninvasive detection of sympathetic neurocirculatory failureD S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Clin Auton Res 10:285-91. 2000..Abnormal pressure during these phases appears to identify SNF specifically. Noninvasive measurements can detect both of these abnormalities... - Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndromeG Eisenhofer
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Endocr Relat Cancer 11:897-911. 2004.... - Dopamine sulphate: an enigma resolvedG Eisenhofer
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Clin Exp Pharmacol Physiol Suppl 26:S41-53. 1999.... - Implications of plasma levels of catechols in the evaluation of sympathoadrenomedullary functionD S Goldstein
Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
Am J Hypertens 2:133S-139S. 1989..Positron emission tomography after injection of positron-emitting fluorodopamine may allow in vivo, noninvasive assessments of regional sympathetic function... - Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytomaK Pacak
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892 1583, USA
Ann Intern Med 134:315-29. 2001.... - A new sign of sympathetic neurocirculatory failure: premature ventricular contraction as a "one-beat Valsalva maneuver"D S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Clin Auton Res 10:63-7. 2000..Just as the absence of the overshoot of BP after release of the Valsalva maneuver supports a diagnosis of SNF, so does the absence of the overshoot after a PVC... - Myocardial perfusion and sympathetic innervation in patients with hypertrophic cardiomyopathyS T Li
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Am Coll Cardiol 35:1867-73. 2000..This study assessed left ventricular myocardial perfusion and sympathetic innervation and function in hypertrophied and nonhypertrophied myocardial regions of patients with hypertrophic cardiomyopathy (HCM)... - Diagnostic localization of pheochromocytoma: the coming of age of positron emission tomographyKarel Pacak
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
Ann N Y Acad Sci 970:170-6. 2002..In this report we provide an update regarding nuclear imaging of primary and metastatic pheochromocytoma, particularly using 6-[(18)F]fluorodopamine positron emission tomographic scanning... - Hypertension increases cerebral 6-18F-fluorodopa-derived radioactivityDavid S Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Nucl Med 50:1479-82. 2009..Supine hypertension (SH) might increase 6-(18)F-fluorodopa uptake... - Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter geneOlga A Tjurmina
Laboratory of Clinical Science, National Institute of Mental Health, and Clinical Neurocardiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 143:4520-6. 2002..Exaggerated adrenomedullary responses seem to be an autonomic correlate of the anxiety-like behaviors in 5-HTT knockout mice... - Sympathoadrenal imbalance before neurocardiogenic syncopeDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
Am J Cardiol 91:53-8. 2003..Sympathoadrenal imbalance may contribute to hemodynamic derangements precipitating neurocardiogenic syncope... - Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervationJeffrey P Moak
Children s National Medical Center, Washington, DC, USA
Heart Rhythm 4:1523-9. 2007..Alternatively, LF power might reflect baroreflexive modulation of autonomic outflows... - Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehydeCourtney Holmes
Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Chem 56:832-8. 2010.... - Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholiaPhilip W Gold
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
Proc Natl Acad Sci U S A 102:8303-8. 2005..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression... - Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromesYehonatan Sharabi
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Neuropharmacol 29:97-105. 2006.... - Neonatal diagnosis and treatment of Menkes diseaseStephen G Kaler
Unit on Pediatric Genetics, Program in Molecular Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, Rm 5 2571, 10 Center Dr, MSC 1832, Bethesda, MD 20892 1832
N Engl J Med 358:605-14. 2008.... - Leaky catecholamine stores: undue waste or a stress response coping mechanism?Graeme Eisenhofer
Building 10, Room 6N252, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
Ann N Y Acad Sci 1018:224-30. 2004.... - Prevalence of anti-locus coeruleus immunoreactivity in CSF of patients with autonomic failureRichard Imrich
Clinical Neurocardiology Section, NINDS NIH, Building 10, Room 6N252, 10 Center Drive, Bethesda, MD 20892, USA
Clin Auton Res 16:401-5. 2006..The results failed to confirm the previously reported high prevalence of immune binding to rat LC in CSF from patients with MSA... - Imaging of the autonomic nervous system: focus on cardiac sympathetic innervationDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1620, USA
Semin Neurol 23:423-33. 2003..As new ligands are developed, one may predict further discoveries of involvement of components of the autonomic nervous system in neurological diseases... - Failure of propranolol to prevent tilt-evoked systemic vasodilatation, adrenaline release and neurocardiogenic syncopeBasil A Eldadah
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Sci (Lond) 111:209-16. 2006..In this small, but tightly controlled, study, propranolol did not prevent tilt-induced vasodilatation, syncope or elevated plasma adrenaline... - Progressive loss of cardiac sympathetic innervation in Parkinson's diseaseSheng Ting Li
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Ann Neurol 52:220-3. 2002..In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying-back mechanism... - Effects of continuous and intermittent cold (SART) stress on sympathoadrenal system activity in ratsK Fukuhara
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA
J Neuroendocrinol 8:65-72. 1996..It appears that even short intervals of return to a normal environmental temperature, as in SART, are sufficient to diminish sympathetic adaptation to cold...