A M Goldstein
Affiliation: National Institutes of Health
- Goldstein A, Landi M, Tsang S, Fraser M, Munroe D, Tucker M. Association of MC1R variants and risk of melanoma in melanoma-prone families with CDKN2A mutations. Cancer Epidemiol Biomarkers Prev. 2005;14:2208-12 pubmed..Additional studies are needed to confirm these findings and to explore the mechanisms that may contribute to this relationship. ..
- Goldstein A, Chaudru V, Ghiorzo P, Badenas C, Malvehy J, Pastorino L, et al. Cutaneous phenotype and MC1R variants as modifying factors for the development of melanoma in CDKN2A G101W mutation carriers from 4 countries. Int J Cancer. 2007;121:825-31 pubmed..Differences in melanoma risk across geographic regions justify the need for individual studies in each country before counseling should be considered. ..
- Goldstein A, Martinez M, Tucker M, Demenais F. Gene-covariate interaction between dysplastic nevi and the CDKN2A gene in American melanoma-prone families. Cancer Epidemiol Biomarkers Prev. 2000;9:889-94 pubmed..8) versus those with CDKN2A mutations (OR, 3.3; 95% confidence interval, 1.1-10.0; complete-cases method). The CDKN2A-DN interaction illustrates the complex etiology of melanoma and needs to be confirmed in a larger sample of families...
- Goldstein A, Chidambaram A, Halpern A, Holly E, Guerry IV D, Sagebiel R, et al. Rarity of CDK4 germline mutations in familial melanoma. Melanoma Res. 2002;12:51-5 pubmed..In summary, although CDK4 is a melanoma susceptibility gene, it plays a minor role in hereditary melanoma. ..
- Goldstein A, Chan M, Harland M, Gillanders E, Hayward N, Avril M, et al. High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL. Cancer Res. 2006;66:9818-28 pubmed..This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available...
- Goldstein A, Stacey S, Olafsson J, Jonsson G, Helgason A, Sulem P, et al. CDKN2A mutations and melanoma risk in the Icelandic population. J Med Genet. 2008;45:284-9 pubmed publisher..This study adds to the geographic regions for which population based estimates of CDKN2A mutation frequencies are available. ..