David Goldman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Schizophrenia and psychotic symptoms in families of two American Indian tribes
    Robert W Robin
    Hopi Guidance Center, Second Mesa, AZ 86043, USA
    BMC Psychiatry 7:30. 2007
  2. ncbi request reprint Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes
    David Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    ScientificWorldJournal 7:124-30. 2007
  3. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
  4. pmc Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?
    Bikash K Mishra
    Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 3:20. 2007
  5. pmc The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
    Biol Psychiatry 67:20-7. 2010
  6. pmc Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
    Christina S Barr
    Primate Unit, Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Proc Natl Acad Sci U S A 101:12358-63. 2004
  7. ncbi request reprint Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates
    Christina S Barr
    National Institute on Alcoholism and Alcohol Abuse, Laboratory of Clinical Studies and National Institute of Child Health and Human Development, Laboratory of Comparative Ethology, National Institutes of Health, Poolesville, MD, USA
    Arch Gen Psychiatry 61:1146-52. 2004
  8. pmc GABRG1 and GABRA2 as independent predictors for alcoholism in two populations
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1245-54. 2009
  9. ncbi request reprint Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
    J Hum Genet 49:232-45. 2004
  10. ncbi request reprint Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 64:369-76. 2007

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. pmc Schizophrenia and psychotic symptoms in families of two American Indian tribes
    Robert W Robin
    Hopi Guidance Center, Second Mesa, AZ 86043, USA
    BMC Psychiatry 7:30. 2007
    ..These tribal groups were evaluated as part of a broader program of gene-environment investigations of alcoholism and other psychiatric disorders...
  2. ncbi request reprint Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes
    David Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    ScientificWorldJournal 7:124-30. 2007
    ....
  3. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...
  4. pmc Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?
    Bikash K Mishra
    Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 3:20. 2007
    ..We demonstrate an analytic method that we applied to 14 of these genes in 290 patients with acute sciatica, whose reduction in movement was estimated by items from the Roland-Morris Disability Questionnaire...
  5. pmc The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
    Biol Psychiatry 67:20-7. 2010
    ..Early life stress has been shown to alter GABRA2 expression in adult rodents. We hypothesized that childhood trauma, GABRA2 variation, and their interaction would influence addiction vulnerability...
  6. pmc Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
    Christina S Barr
    Primate Unit, Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Proc Natl Acad Sci U S A 101:12358-63. 2004
    ..This interactive effect may underlie the increased incidence of certain stress-related disorders in women...
  7. ncbi request reprint Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates
    Christina S Barr
    National Institute on Alcoholism and Alcohol Abuse, Laboratory of Clinical Studies and National Institute of Child Health and Human Development, Laboratory of Comparative Ethology, National Institutes of Health, Poolesville, MD, USA
    Arch Gen Psychiatry 61:1146-52. 2004
    ....
  8. pmc GABRG1 and GABRA2 as independent predictors for alcoholism in two populations
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1245-54. 2009
    ..05) extended haplotypes showed an association with AUD that was determined by GABRA2. Our results suggest that there are likely to be independent, complex contributions from both GABRG1 and GABRA2 to alcoholism vulnerability...
  9. ncbi request reprint Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
    J Hum Genet 49:232-45. 2004
    ..The SLC6A2 haplotype map and 25-marker panel (excluding the monomorphic one) is a comprehensive tool for genetic linkage studies on phenotypes related to NET function...
  10. ncbi request reprint Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 64:369-76. 2007
    ..In humans, a variant of the mu-opioid receptor gene (OPRM1A118G) increases receptor affinity, alcohol-induced euphoria, and risk for alcohol use disorders...
  11. ncbi request reprint Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Hum Genet 50:12-20. 2005
    ..The alpha2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknown alpha2-AR functional loci...
  12. ncbi request reprint Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations
    Zhifeng Zhou
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville 20852, USA
    Arch Gen Psychiatry 62:1109-18. 2005
    ..Tryptophan hydroxylase 2 (TPH2) encodes the rate-limiting enzyme for brain serotonin biosynthesis. It was recently reported that the TPH2 haplotype was linked to depression in humans...
  13. pmc Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 3:e3620. 2008
    ..Our results suggest a likely role for CRH-BP in stress-related alcoholism and highlight the use of the resting EEG as an intermediate phenotype for arousal-related behaviors such as anxiety and addiction...
  14. ncbi request reprint Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm
    Simona Spinelli
    National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, P O Box 529, Poolesville, MD 20837, USA
    Dev Psychopathol 19:977-87. 2007
    ....
  15. pmc Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations
    Jixia Liu
    From the Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    Alcohol Clin Exp Res 35:304-16. 2011
    ..We investigated whether variation in alcohol metabolism genes might alter the AD risk in four non-East Asian populations by performing systematic haplotype association analyses to maximize the chances of capturing functional variation...
  16. pmc Functional CRH variation increases stress-induced alcohol consumption in primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institutes on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:14593-8. 2009
    ..Our data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals...
  17. ncbi request reprint The FEZ1 gene shows no association to schizophrenia in Caucasian or African American populations
    Colin A Hodgkinson
    Section of Human Neurogenetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Neuropsychopharmacology 32:190-6. 2007
    ..Neuropsychopharmacology (2007) 32, 190-196. doi:10.1038/sj.npp.1301177; published online 16 August 2006...
  18. ncbi request reprint Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Depress Anxiety 25:383-92. 2008
    ..This refinement of the anxiety phenotype may have implications for therapeutic interventions...
  19. pmc Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
    ..In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence...
  20. ncbi request reprint Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892 9412, USA
    Alcohol Clin Exp Res 30:399-406. 2006
    ....
  21. pmc Genome-wide association identifies candidate genes that influence the human electroencephalogram
    Colin A Hodgkinson
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 107:8695-700. 2010
    ..We also found association of SGIP1 with alcoholism, an effect that may be mediated via the same brain mechanisms accessed by theta EEG, and which also provides validation of the use of EEG as an endophenotype for alcoholism...
  22. ncbi request reprint Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations
    Gabor Oroszi
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 29:303-9. 2005
    ..In two ethnically distinct populations, we tested whether the Thr105Ile polymorphism was associated with alcoholism and with harm avoidance, a dimensional measure of anxious personality...
  23. ncbi request reprint Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African Americans
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Hum Genet 13:341-51. 2005
    ..This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function...
  24. ncbi request reprint Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations
    Jordi Clarimon
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 31:546-54. 2007
    ..Recent studies, in humans and in rat and monkey models, have suggested that alpha-synuclein may play a role in the development and maintenance of certain addictive disorders...
  25. pmc Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations
    Francesca Ducci
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892, USA
    Alcohol 41:3-12. 2007
    ..Even in alcoholics with long-term exposure to the anxiogenic effects of repeated cycles of alcohol withdrawal, genetic and other familial influences seem to play a role in moderating anxiety...
  26. ncbi request reprint Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques
    Christina S Barr
    Laboratory of Clinical Studies, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Poolesville, Maryland 20837, USA
    Biol Psychiatry 55:733-8. 2004
    ..We wanted to determine whether serotonin transporter gene promoter variation (rh-5HTTLPR) and rearing condition would interact to influence endocrine responses to stress in infant rhesus macaques...
  27. ncbi request reprint Using ancestry-informative markers to define populations and detect population stratification
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    J Psychopharmacol 20:19-26. 2006
    ....
  28. pmc Addictions biology: haplotype-based analysis for 130 candidate genes on a single array
    Colin A Hodgkinson
    Laboratory of Neurogenetics, NIAAA, 5625 Fishers Lane, Room 3S32 MSC9412, Rockville, MD 20852 1728, USA
    Alcohol Alcohol 43:505-15. 2008
    ..To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety...
  29. pmc Leptin regulates dopamine responses to sustained stress in humans
    Paul R Burghardt
    Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:15369-76. 2012
    ..The capacity for leptin to influence stress-induced dopaminergic function is of importance for pathological states where dopamine is thought to play an integral role, such as mood, substance-use disorders, eating disorders, and obesity...
  30. pmc A clinical genetic method to identify mechanisms by which pain causes depression and anxiety
    Mitchell B Max
    Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 2:14. 2006
    ..We seek molecules that show a significant statistical interaction between (1) the amount of surgical pain relief, and (2) the alleles of the gene, on depression and anxiety during the first postoperative year...
  31. pmc Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    Xian Zhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Am J Hum Genet 78:815-26. 2006
    ..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD...
  32. ncbi request reprint Association of COMT Val158Met genotype with executive functioning following traumatic brain injury
    Robert H Lipsky
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    J Neuropsychiatry Clin Neurosci 17:465-71. 2005
    ....
  33. pmc Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:5277-81. 2008
    ..These findings suggest a role for OPRM1 variation in the expression of attachment behavior in human subjects, especially as a function of separation from the caregiver...
  34. pmc Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screen
    Inna Belfer
    National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA
    Int J Stroke 5:145-51. 2010
    ..The aim of this study was to evaluate the role of single-nucleotide polymorphisms (SNPs) and haplotypes in inflammatory genes as they relate to symptomatic carotid atherosclerosis...
  35. ncbi request reprint Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster
    Marta Radel
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Arch Gen Psychiatry 62:47-55. 2005
    ....
  36. ncbi request reprint Serotonin transporter genetic variation and the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 297:400-3. 2002
    ....
  37. ncbi request reprint Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion
    Abigail A Marsh
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 189:387-94. 2006
    ..Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed...
  38. ncbi request reprint The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasks
    Elizabeth C Finger
    Mood and Anxiety Disorders Program, Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 32:206-15. 2007
    ..Furthermore, they demonstrate behavioral differences in responses to punishing stimuli between long allele homozygotes and short allele carriers when serotonin levels are acutely reduced...
  39. ncbi request reprint An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk
    Xianzhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Alcohol Clin Exp Res 29:8-16. 2005
    ..One such intermediate phenotype is the low level of response (LR) to alcohol. This project used a case-control approach to search for genes that may contribute to LR...
  40. ncbi request reprint Zhou et al. reply
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 458:E7. 2009
    ..Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results...
  41. ncbi request reprint Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    Am J Med Genet B Neuropsychiatr Genet 141:599-607. 2006
    ..Our results suggest that within the distal GABRA2 region is a functional locus or loci that may differ between populations but that alters risk for alcoholism via the mediating action of anxiety...
  42. pmc GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats
    MARY ANNE ENOCH
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29369. 2012
    ....
  43. ncbi request reprint Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament
    Hyungsuk Kim
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 center Dr Building 10 Rm 1N103, Bethesda, MD 20892 1197, USA
    Pain 109:488-96. 2004
    ..Our observations demonstrate that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms...
  44. pmc Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholics
    Vibhuti Srivastava
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, MD 20851, USA
    Neuropsychopharmacology 35:1120-8. 2010
    ..The risk/protective effect was observed in alcoholics with lower levels of lifetime alcohol consumption. Highest levels of exposure may overwhelm the protective action of the SOD2 enzyme...
  45. ncbi request reprint Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay
    Guanshan Zhu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 12420 Parklawn Dr, Rockville, MD 20852, USA
    Psychopharmacology (Berl) 177:178-84. 2004
    ..However, disparate findings by another group who used the same method, but in lymphoblasts, raise the issues of tissue specificity, magnitude of differential expression, and identity of loci altering expression...
  46. pmc Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder
    Colin A Hodgkinson
    Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Am J Hum Genet 75:862-72. 2004
    ..These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders...
  47. ncbi request reprint Imaging genomics applied to anxiety, stress response, and resiliency
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcohollism, National Institute of Health, Rockville, MD 20852, USA
    Neuroinformatics 4:51-64. 2006
    ..These results suggest that functional variants of 5-HTT and COMT impact brain functions involved in stress and anxiety...
  48. pmc Expansion of the human mu-opioid receptor gene architecture: novel functional variants
    Svetlana A Shabalina
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Hum Mol Genet 18:1037-51. 2009
    ..Our results provide evidence for an essential role for MOR-1K isoforms in nociceptive signaling and suggest that genetic variations in alternative OPRM1 isoforms may contribute to individual differences in opiate responses...
  49. ncbi request reprint Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland 20852, USA
    Am J Med Genet 110:45-50. 2002
    ..Therefore, these data do not support an association between the OPRD1 gene and heroin dependence in the Chinese population...
  50. pmc A factor analysis of global GABAergic gene expression in human brain identifies specificity in response to chronic alcohol and cocaine exposure
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e64014. 2013
    ..These findings might have implications for combating stress-related craving and relapse...
  51. pmc Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    J Psychiatr Res 47:900-7. 2013
    ..25 in individuals without either risk variant. Our findings suggest that the 5' and 3'SLC6A4 functional variants have independent effects on the risk for suicidal behavior in CT exposed individuals...
  52. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
    ..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category...
  53. ncbi request reprint Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Arch Gen Psychiatry 61:597-606. 2004
    ..Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial...
  54. ncbi request reprint Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 60:889-96. 2003
    ..Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia...
  55. pmc Association of candidate genes with phenotypic traits relevant to anorexia nervosa
    Tammy L Root
    Johns Hopkins University School of Medicine, Division of General Internal Medicine, Baltimore, MD, USA
    Eur Eat Disord Rev 19:487-93. 2011
    ....
  56. pmc BDNF polymorphism-dependent OFC and DLPFC plasticity differentially moderates implicit and explicit bias
    Chad E Forbes
    Imaging Sciences Training Program, Radiology and Imaging Sciences, Clinical Center and National Institute of Biomedical Imaging and Bioengineering, National, Institutes of Health, Bethesda, MD 20892, USA
    Cereb Cortex 22:2602-9. 2012
    ..Findings suggest that plasticity within specific PFC regions modulates the type and degree of social bias that individuals' exhibit...
  57. ncbi request reprint Association of multiple DRD2 polymorphisms with anorexia nervosa
    Andrew W Bergen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Neuropsychopharmacology 30:1703-10. 2005
    ..Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN...
  58. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  59. ncbi request reprint Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing
    Jurgen Gallinat
    Laboratory for Clinical Psychophysiology, Department of Psychiatry, Free University, Berlin, Germany and National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 54:40-8. 2003
    ..It was predicted that homozygous Met allele carriers have a lower frontal P300 amplitude...
  60. pmc Loss of metabotropic glutamate receptor 2 escalates alcohol consumption
    Zhifeng Zhou
    Laboratories of Neurogenetics and Clinical and Translational Studies and Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 110:16963-8. 2013
    ..Together, these data point to mGluR2 as an origin of alcohol preference and a potential therapeutic target. ..
  61. ncbi request reprint Genetics of alcoholism using intermediate phenotypes
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 27:169-76. 2003
    ..It was organized by Mary-Anne Enoch and David Goldman and chaired by David Goldman...
  62. ncbi request reprint Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatr Genet 13:33-41. 2003
    ....
  63. pmc The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human
    Qiaoping Yuan
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA
    BMC Genet 13:52. 2012
    ....
  64. pmc Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol
    Zhifeng Zhou
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20849, USA
    Proc Natl Acad Sci U S A 108:6626-31. 2011
    ....
  65. pmc Genetics of emotion
    Laura Bevilacqua
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Trends Cogn Sci 15:401-8. 2011
    ..The effects of these genes can be validated by neuroimaging, neuroendocrine and other studies accessing intermediate phenotypes, deepening our understanding of mechanisms of emotion and variation in emotionality...
  66. ncbi request reprint Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress
    Christina S Barr
    Labortatory of Clinical Studies, Primate Unit, National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, PO Box 529, Building 112, Poolesville, MD 20837, USA
    Alcohol Clin Exp Res 27:812-7. 2003
    ..In addition, we have demonstrated that macaques separated from their mothers and reared in peer-only groups are more likely to consume alcohol as adults...
  67. ncbi request reprint Genetics of human prefrontal function
    Georg Winterer
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Brain Res Rev 43:134-63. 2003
    ..Special emphasis is also given to methodological concerns that need to be addressed when conducting research on the genetics of prefrontal function in humans...
  68. pmc Genetic approaches to addiction: genes and alcohol
    Francesca Ducci
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism NIH, Rockville, MD 20892, USA
    Addiction 103:1414-28. 2008
    ..Alcoholism is a chronic relapsing disorder with an enormous societal impact. Understanding the genetic basis of alcoholism is crucial to characterize individuals' risk and to develop efficacious prevention and treatment strategies...
  69. ncbi request reprint Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Anesthesiology 100:1562-72. 2004
  70. pmc Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans
    Mary R Lee
    National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 6:e24203. 2011
    ....
  71. pmc A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior
    Rickard L Sjoberg
    Uppsala University Centre for Clinical Research, Central Hospital, Vasteras, Sweden
    Neuropsychopharmacology 33:425-30. 2008
    ....
  72. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
    ..As such, CRH gene variation may influence risk for alcohol use and dependence...
  73. ncbi request reprint Non-human primate models of inheritance vulnerability to alcohol use disorders
    Christina S Barr
    NIH NIAAA, Laboratory of Clinical and Translational Studies, Poolesville, MD 20837, USA
    Addict Biol 11:374-85. 2006
    ..Non-human primate models may also have translational value for understanding of how variants within addiction and abuse vulnerability genes influence alcohol-induced neuroadaptation, neuropathology and treatment response...
  74. ncbi request reprint G x E: a NIAAA workshop on gene-environment interactions
    Lorraine Gunzerath
    NIAAA Office of Scientific Affairs, National Institutes of Health, 6000 Executive Blvd, Suite 409, Bethesda, MD 20892 7003, USA
    Alcohol Clin Exp Res 27:540-62. 2003
    ..Session coordinators included: Gayle Boyd, Kendall Bryant, Page Chiapella, Vivian Faden, David Goldman, and Antonio Noronha...
  75. ncbi request reprint The relationship between two intermediate phenotypes for alcoholism: low voltage alpha EEG and low P300 ERP amplitude
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
    J Stud Alcohol 63:509-17. 2002
    ..A few studies have demonstrated a modest correlation between pre-stimulus alpha power and P300 amplitude. We aimed to test this finding in community volunteers, hypothesizing that LVA would be associated with low P300 amplitude...
  76. ncbi request reprint The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  77. ncbi request reprint NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations
    Guanshan Zhu
    Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, USA
    Alcohol Clin Exp Res 27:19-24. 2003
    ..Recently, this polymorphism was also reported to be associated with an actual diagnosis of alcohol dependence...
  78. ncbi request reprint Problem drinking and alcoholism: diagnosis and treatment
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 8110, USA
    Am Fam Physician 65:441-8. 2002
    ....
  79. ncbi request reprint Single-nucleotide polymorphism allele frequencies determined by quantitative kinetic assay of pooled DNA
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism NIH, 12420 Parklawn Drive, Park 5 Building, Room 451, MSC 8110, Rockville, MD 20852, USA
    Clin Chem 48:1605-8. 2002
  80. ncbi request reprint The genetics of addictions: uncovering the genes
    David Goldman
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA
    Nat Rev Genet 6:521-32. 2005
    ....
  81. ncbi request reprint Alcoholism: genes and mechanisms
    Gabor Oroszi
    Laboratory of Neurogenetics, NIAAA, NIH, 5625 Fishers Lane, Room 3S32, MSC9412, Rockville, MD 20852, USA
    Pharmacogenomics 5:1037-48. 2004
    ....
  82. pmc Pharmacogenetic approaches to the treatment of alcohol addiction
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA nih gov
    Nat Rev Neurosci 12:670-84. 2011
    ....
  83. ncbi request reprint A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition
    Anil K Malhotra
    Unit of Molecular Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 159:652-4. 2002
    ..The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. The current study investigated whether prefrontal cognition varies with COMT genotype...
  84. ncbi request reprint Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population
    Connie J Mulligan
    Department of Anthropology, University of Florida, PO Box 117305, Gainesville, FL 32611, USA
    Hum Genet 113:325-36. 2003
    ..These data strengthen the support for ADH as a candidate locus for alcohol dependence and suggest further productive study...
  85. ncbi request reprint The human genome: mutations
    Michael Egan
    Am J Psychiatry 159:12. 2002
  86. ncbi request reprint Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence
    Andreas Heinz
    Department of Psychiatry, Campus Charite Mitte, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Psychopharmacology (Berl) 174:561-70. 2004
    ..The severity and time-course of recovery of these neuroadaptive changes may depend on the genetic constitution of monoamine transporters and receptors and contribute to the relapse risk of alcoholics...
  87. ncbi request reprint Biological and behavioral markers of alcohol sensitivity
    Kim Fromme
    Department of Psychology, The University of Texas at Austin, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 28:247-56. 2004
    ..Dr. David Goldman provides concluding remarks.
  88. ncbi request reprint A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence
    Salim Mottagui-Tabar
    Karolinska Institute, Center for Genomics and Bioinformatics, Stockholm, Sweden
    Alcohol Clin Exp Res 29:702-7. 2005
    ..The aim of this study was to examine whether polymorphic variants of the NPY gene are associated with the diagnosis of alcohol dependence...
  89. ncbi request reprint The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination
    Hiroki Oota
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven, CT 06520 8005, USA
    Ann Hum Genet 68:93-109. 2004
    ..D. above the mean for a reference distribution of 117 autosomal biallelic markers. These high Fst values may indicate selection has operated at these or very tightly linked sites...
  90. ncbi request reprint Human alcoholism studies of genes identified through mouse quantitative trait locus analysis
    Marissa A Ehringer
    Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue C236, Denver, CO 80262, USA
    Addict Biol 7:365-71. 2002
    ....
  91. pmc A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity
    Michael V Osier
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 71:84-99. 2002
    ..It seems unlikely that this haplotype, which is rare or unobserved in other populations, reached such high frequency because of random genetic drift alone...
  92. ncbi request reprint Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder
    Alessandro Rotondo
    Department of Psychiatry, University of Pisa, Italy
    Am J Psychiatry 159:23-9. 2002
    ....
  93. ncbi request reprint COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Science 299:1240-3. 2003
    ..The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli...
  94. ncbi request reprint Investigation of DUSP8 and CALCA in alcohol dependence
    Raquel L Hink
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Addict Biol 8:305-12. 2003
    ..Genotyping of this functional variant in 463 Southwestern Native Americans revealed no significant association between the DUSP8 C712T (Ala193Val) polymorphism and alcohol dependence (odds ratio = 1.48 95% CI 0.6-3.92)...
  95. ncbi request reprint Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases
    Jinong Feng
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Am J Med Genet B Neuropsychiatr Genet 133:50-3. 2005
    ..One uncommon missense variant was found in each of the RARbeta, RARgamma, and RXRgamma genes. We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia...
  96. ncbi request reprint Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
    Michael N Smolka
    Central Institute of Mental Health, 68159 Mannheim, Germany
    J Neurosci 25:836-42. 2005
    ....
  97. ncbi request reprint Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children
    Jennifer H Barnett
    University of Cambridge, Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Am J Psychiatry 164:142-9. 2007
    ..This polymorphism affects cognitive function in healthy adults and may contribute to risk for schizophrenia...
  98. ncbi request reprint Patterns of menstrual disturbance in eating disorders
    Andréa Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
    Int J Eat Disord 40:424-34. 2007
    ..To describe menstrual disturbance in eating disorders (ED)...
  99. ncbi request reprint Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Biol Psychiatry 61:1208-10. 2007
    ....
  100. ncbi request reprint Interaction between childhood trauma and serotonin transporter gene variation in suicide
    Alec Roy
    Psychiatry Service, Department of Veterans Affairs, New Jersey VA Health Care System, 385 Tremont Avenue, East Orange, NJ 07018, USA
    Neuropsychopharmacology 32:2046-52. 2007
    ..Childhood trauma interacts with low expressing 5-HTTLPR genotypes to increase the risk of suicidal behavior among patients with substance dependence...
  101. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....